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From nanoparticles via microtemplates and milliparticles to deep-sea nodules： biogenically driven mineral formation

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Frontiers of Materials Science 2012年第2期6卷 97-115页

作者： Xiao-Hong WANg Ute SCHLOI MACHeR Shun-Feng WANg Heinz C.SCHRODeR Matthias WleNS Renato BATeL werner e.g.muller National Research Center for geoanalysis Chinese Academy of Geological Sciences26 Baiwanzhuang DajieBeijing 100037China eRC Advanced grant Research group at the Institute for Physiological Chemistry University Medical Center of the Johannes Gutenberg University MainzDuesbergweg 6D-55128 MainzGermany Ruder Boakove Institute Center for Marine ResearchGiordano Paliaga 5HR-52210 RovinjCroatia

Deep-sea minerals in polymetallic nodules and seamount Co-rich crusts are not only formed by mineralization but also by biologically driven processes involving microorganisms （biomineralization）. Within the polymetallic nodules, free-living and biofilm-forming bacteria provide the matrix for manganese deposition, and in seamount Co-rich crusts, coccolithophores represent the dominant organisms that act as bio-seeds for an initial manganese deposition. These （bio）minerals are economically important： manganese is an important alloying component and cobalt forms part of special steels in addition to being used, along with other rare metals, in plasma screens, hard-disk magnets and hybrid car motors. Recent progress in our understanding of the participation of the organic matrices in the enrichment of these metals might provide the basis for feasibility studies of biotechnological applications.

关键词： polymetallic nodule biomineralization bacteria sustainable exploitation

Flashing light in sponges through their siliceous fiber network:A new strategy of “neuronal transmission” in animals

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Chinese Science Bulletin 2012年第25期57卷 3300-3311页

作者： WANg XiaoHong FAN XingTao SCHRODeR Heinz C muller werner e g National Research Center for geoanalysis Chinese Academy of Geological SciencesBeijing 100037China eRC Advanced grant Research group at the Institute for Physiological Chemistry University Medical Center of the Johannes GutenbergUniversityMainz D-55099Germany

Sponges(phylum Porifera) represent a successful animal taxon that evolved prior to the ediacaran-Cambrian boundary(542 million years ago).They have developed an almost complete array of cell-and tissue-based interaction systems necessary for the establishment of a functional,multicellular ***,a network of neurons,one cell/tissue-communication system is missing in *** fact is puzzling and enigmatic,because these animals possess receptors known to be involved in the nervous system in evolutionary younger animal *** an example,the metabotropic glutamate/gABA-like receptor has been identified and cloned by ***,we have identified a novel light transmission/light responsive system in sponges that is based on their skeletal elements,the siliceous glass fibers,termed *** classes of sponges,the Hexactinellida and the Demospongiae,possess a siliceous skeleton that is composed of *** the large spicules from hexactinellid sponges(>5 cm) revealed that these spicules are effective light-collecting optical *** we can report that the demosponge,Suberites domuncula,has a biosensor system consisting of the(organic) light producing luciferase and the(inorganic) light transducing silica *** light transmission features of these smaller spicules(200 μm) has been demonstrated and the ability of the sponge tissue to generate light had been *** for a luciferase gene in *** was *** the next step,we searched for a protein potentially involved in light *** a protein was identified,cloned and recombinantly expressed from *** protein sequence displays two domains characteristic of a cryptochrome,the N-terminal photolyase-related region and the C-terminal FAD-binding *** experimental data indicate that sponges may employ a network of luciferase-like proteins,a spicular system and a cryptochrome as the light source,optical waveguide and photosensor,***

关键词：海绵组织动物类群光纤网络硅质神经传导闪烁荧光素酶基因蛋白质序列

The physiological polyphosphate as a healing biomaterial for chronic wounds:Crucial roles of its antibacterial and unique metabolic energy supplying properties

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Journal of Materials Science & Technology 2023年第4期135卷 170-185页

作者： werner e.g.Müller Hadrian Schepler Meik Neufurth Shunfeng Wang Veronica Ferrucci Massimo Zollo Rongwei Tan Heinz C.Schröder Xiaohong Wang eRC Advanced Investigator grant Research group at the Institute for Physiological Chemistry University Medical Center of the Johannes Gutenberg UniversityDuesbergweg 6Mainz D-55128Germany Department of Dermatology University Clinic MainzLangenbeckstr.1Mainz D-55131Germany Dipartimento di Medicina Molecolare e Biotecnologie Mediche Universitàdegli Studi di Napoli Federico IIVia Sergio Pansini 5Naples 80131Italy Ceinge Biotecnologie Avanzate Francesco Salvatore Via G.Salvatore 486Naples 80145Italy Shenzhen Lando Biomaterials Co. Ltd.Shenzhen 518107China

Insufficient metabolic energy,in the form of adenosine triphosphate(ATP),and bacterial infections are among the main causes for the development of chronic *** we showed that the physi-ological inorganic polymer polyphosphate(polyP)massively accelerates wound healing both in animals(diabetic mice)and,when incorporated into mats,in patients with chronic ***,we focused on a hydrogel-based gel formulation,supplemented with both soluble sodium polyP(Na-polyP)and amor-phous calcium polyP nanoparticles(Ca-polyP-NP).exposure of human epidermal keratinocytes to the gel caused a significant increase in extracellular ATP level,an effect that was even enhanced when Na-polyP was combined with ***,it is shown that the added polyP in the gel is converted into a coacervate,leading to encapsulation and killing of *** data on human chronic wounds showed that the administration of hydrogel leads to the complete closure of these *** analysis of biopsies showed an increased granulation of the wounds and an enhanced microvessel *** results indicate that the polyP hydrogel,due to its properties to entrap bacteria and generate metabolic energy,is a very promising formulation for a new therapy for chronic wounds.

关键词： Inorganic polyphosphate Nanoparticles Hydrogel Coacervate Human chronic wounds Antibacterial activity Metabolic energy

Biosilica-glass formation using enzymes from sponges [silicatein]： Basic aspects and application in biomedicine [bone reconstitution material and osteoporosis]

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Frontiers of Computer Science 2011年第3期5卷 266-281页

作者： Shun-Feng WANg Xiao-Hong WANg Lu gAN Matthias WIeNS Heinz C. SCHRODeR werner e, g. MOLLeR werner e. g. MOLLeR National Research Center for geoanalysis Chinese Academy of Geological Sciences 26 Baiwanzhuang Dajie Beijing 100037 China Institute of Physiological Chemistry University Medical Center of the Johannes Gutenberg University Mainz Duesbergweg 6 D-55128 Mainz Germany

In the last 15 years biomineralization, in particular biosilicification （i.e., the formation of biogenic silica, SiO2）, has become an exciting source of inspiration for the development of novel bionic approaches, following ＂Nature as model＂. Among the silica forming organisms there are the sponges that have the unique property to catalyze their silica skeletons by a specific enzyme termed silicatein. In the present review we summarize the present state of knowledge on silicatein-mediated ＂biosilica＂ formation in marine sponges, the involvement of further molecules in silica metabolism and their potential application in biomedicine. Recent advancements in the production of bone replacement material and in the potential use as a component in the treatment of osteoporosis are highlighted.

关键词： biomineralization biosilica medicine biomaterials osteoporosis

Instability after total hip arthroplasty

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World Journal of Orthopedics 2012年第8期3卷 122-130页

作者： Brian C werner Thomas e Brown Department of Orthopedic Surgery University of Virginia School of Medicine Charlottesville VA 22908 United States

Instability following total hip arthroplasty(THA) is an unfortunately frequent and serious problem that requires thorough evaluation and preoperative planning before surgical intervention. Prevention through optimal index surgery is of great importance, as the management of an unstable THA is challenging even for an experienced joints surgeon. However, even after well-planned surgery, a significant incidence of recurrent instability still exists. Non-operative management is often successful if the components are well-fixed and correctly positioned in the absence of neurocognitive disorders. If conservative management fails, surgical options include revision of malpositioned components; exchange of modular components such as the femoral head and acetabular liner; bipolar arthroplasty; tripolar arthroplasty; use of a larger femoral head; use of a constrained liner; soft tissue reinforcement and advancement of the greater trochanter.

关键词： Instability Total hip arthroplasty Revision Constrained liner Bipolar arthroplasty Large femoral head

Uncertainty relations for general phase spaces

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Frontiers of physics 2016年第3期11卷 51-60页

作者： Reinhard F. werner Institut fiir Theoretische Physik Leibniz Universitiit Hannover Germany

We describe a setup for obtain!ing uncertainty relations for arbitrary pairs of observables related by a Fourier transform. The physical examples discussed here are the standard position and momentum, number and angle, finite qudit systems, and strings of qubits for quantum information applications. The uncertainty relations allow for an arbitrary choice of metric for the outcome distance, and the choice of an exponent distinguishing, e.g., absolute and root mean square deviations. The emphasis of this article is on developing a unified treatment, in which one observable takes on values in an arbitrary locally compact Abelian group and the other in the dual group. In all cases, the phase space symmetry implies the eciuality of measurement and preparation uncertainty bounds. There is also a straightforward method for determining the optimal bounds.

关键词： uncertainty relations phase space measurement uncertainty

Heisenberg, uncertainty, and the scanning tunneling microscope

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Frontiers of physics 2012年第2期7卷 218-222页

作者： werner A. Hofer (1) 1. Department of Physics University of Liverpool L69 3BX Liverpool UK

We show by a statistical analysis of high-resolution scanning tunneling microscopy （STM） exper- iments, that the interpretation of the density of electron charge as a statistical quantity leads to a conflict with the Heisenberg uncertainty principle. given the precision in these experiments we find that the uncertainty principle would be violated by close to two orders of magnitude, if this interpretation were correct. We are thus forced to conclude that the density of electron charge is a physically real, i.e., in principle precisely measurable quantity.

关键词： scanning tunneling microscope electron charge density functional theory uncertaintyrelations

生物无机化学范式的转变:硅质海绵动物中二氧化硅的酶促缩聚反应(英文)

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化学进展 2013年第4期25卷 435-445页

作者：王晓红甘露 Heinz C.Schrder werner e.g.Müller 国家地质实验测试中心中国地质科学院北京100037 德国美因茨约翰尼斯-古腾堡大学医学中心生理化学所美因茨55128

硅蛋白的发现导致了生物无机化学范式的转变,因为它是第一个可以催化无机单体合成无机聚合物分子的酶。分子生物学,生物化学和细胞生物学数据证实,两种硅质海绵动物,包括寻常海绵和六放海绵,它们的骨针都是由硅蛋白/酶催化合成的。这种... 详细信息

硅蛋白的发现导致了生物无机化学范式的转变,因为它是第一个可以催化无机单体合成无机聚合物分子的酶。分子生物学,生物化学和细胞生物学数据证实,两种硅质海绵动物,包括寻常海绵和六放海绵,它们的骨针都是由硅蛋白/酶催化合成的。这种酶不仅存在于硅质海绵骨针内部,而且也存在于硅质海绵骨针表面。在硅质海绵骨针生长过程中,它催化生物二氧化硅的合成而构建硅薄层,一层层的硅薄层逐步沉积从而形成硅质海绵骨针。寻常海绵动物Suberites domuncula体外实验获得的硅蛋白活性数据(催化生物二氧化硅的形成)反映了体内骨针生长所需的生物二氧化硅量。本文最后总结了在寻常海绵动物骨针生长和成熟过程中出现的生物熔合现象,即内部的硅薄层"烧结"在一起形成致密的硅棒。强壮的和坚硬的生物二氧化硅骨架的形成需要经历一个硬化过程,这个过程由海绵动物排水通道表面的细胞膜控制,排除生物二氧化硅缩聚反应过程中释放出的水分而使材料固化。

关键词：范式转变生物无机化学海绵动物硅蛋白生物硅结构层次

An Optimised Surface Structure for Passive, Unidirectional Fluid Transport Bioinspired by True Bugs

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Journal of Bionic engineering 2021年第2期18卷 375-386页

作者： Sebastian Lifka Florian Hischen Johannes Heitz werner Baumgartner Institute of Biomedical Mechatronics Johannes Kepler University LinzAltenberger Straße 694040 LinzAustria Institute of Applied Physics Johannes Kepler University LinzAltenberger Straße 694040 LinzAustria

Some true bug species use droplet-shaped,open-capillary structures for passive,unidirectional fluid transport on their body surface in order to spread a defensive fluid to protect themselves against *** this paper we investigated if the shape of the structures found on bugs(bug-structure)could be optimised with regard to better performance in unidirectional fluid ***,to use this kind of surface structure in technical applications where fluid surface interaction occurs,it is necessary to adapt the structure geometry to the contact angle between fluid and *** on the principal of operation of the droplet-shaped structures,we optimised the structure shape for better performance in targeted fluid flow and increase in flexibility in design of the structure *** adapt the structure geometry and the structure spacing to the contact angle,we implemented an equilibrium simulation of the,the structure surrounding,*** order to verify the functionality of the optimised structure,we designed and manufactured a *** testing this prototype with pure water used as fluid,the functionality of the optimised structure and the simulation could be *** kind of structure may be used on technical surfaces where targeted fluid transport is needed,*** of condensate in order to prevent the surface from mold growth,microfluidics,lab-on-a-chip applications and on microneedles for efficient drug/vaccine coating.

关键词： biomimetics true bugs liquid-surface interaction passive unidirectional fluid transport microfluidics lab-on-a-chip