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Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients

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World Journal of Gastroenterology 2009年第4期15卷 449-456页

作者： Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami werner Godderz klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler 1st Medical Department Johannes Gutenberg-University Outpatient Clinic Outpatient Clinic of City Hospital Outpatient Clinic of 1st Medical Department Outpatient Clinic of 2nd Medical Department Leopoldina Krankenhaus

AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient *** received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 *** treatment choice of bevacizumab was at the discretion of the *** endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,*** complete responses were *** median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,*** median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically *** the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient *** gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal.

关键词：肠癌结肠癌直肠癌老年人化疗疗效

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Stroke MRI 1

An Optimised Surface Structure for Passive, Unidirectional Fluid Transport Bioinspired by True Bugs

2003年

作者： Jochen B. Fiebach klaus Sartor Sabine Heiland Peter D. Schellinger werner Hacke Steven Warach

来源：畅想之星图书光盘版（南... 评论

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Journal of Bionic Engineering 2021年第2期18卷 375-386页

作者： Sebastian Lifka Florian Hischen Johannes Heitz werner Baumgartner Institute of Biomedical Mechatronics Johannes Kepler University LinzAltenberger Straße 694040 LinzAustria Institute of Applied Physics Johannes Kepler University LinzAltenberger Straße 694040 LinzAustria

Some true bug species use droplet-shaped,open-capillary structures for passive,unidirectional fluid transport on their body surface in order to spread a defensive fluid to protect themselves against *** this paper we investigated if the shape of the structures found on bugs(bug-structure)could be optimised with regard to better performance in unidirectional fluid ***,to use this kind of surface structure in technical applications where fluid surface interaction occurs,it is necessary to adapt the structure geometry to the contact angle between fluid and *** on the principal of operation of the droplet-shaped structures,we optimised the structure shape for better performance in targeted fluid flow and increase in flexibility in design of the structure *** adapt the structure geometry and the structure spacing to the contact angle,we implemented an equilibrium simulation of the,the structure surrounding,*** order to verify the functionality of the optimised structure,we designed and manufactured a *** testing this prototype with pure water used as fluid,the functionality of the optimised structure and the simulation could be *** kind of structure may be used on technical surfaces where targeted fluid transport is needed,*** of condensate in order to prevent the surface from mold growth,microfluidics,lab-on-a-chip applications and on microneedles for efficient drug/vaccine coating.

关键词： biomimetics true bugs liquid-surface interaction passive unidirectional fluid transport microfluidics lab-on-a-chip

Bioorganic Municipal Waste Management to Deploy a Sustainable Solid Waste Disposal Practice in China

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过程工程学报 2006年第2期6卷 255-260页

作者： Bernhard Raninger werner Bidlingmaier 李润东冯磊 Mining University Leoben A–8700 Leoben Austria CIM D- 60325 Frankfurt am Main Germany Int. Transfer Center Environ. Technol. Inst. at Bauhaus Univ. Weimar Weimar D-99423 Germany Inst. Clean Energy & Environ. Eng. (ICEEE) Hangkong University

The utilization of bioorganic municipal waste (BMW) is considered essentially for the further development of integrated waste management practice in China. Awareness and knowledge about the importance of BMW management and source separation of waste on household level, as a precondition for the implementation of an economically feasible integrated waste management infrastructure, were developed in Europe during the last decade. The Sino–German RRUBMW Project is facilitating applied research investigations in 4 pilot areas in Shenyang to assess the population’s behavior to develop the design criteria for appropriate process technologies and to provide the basis to adopt BMW management policy in China.

关键词：有机废水废水处理堆肥沼气

Formation of Superheavy Nuclei in Massive Fusion Reactions

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原子核物理评论 2009年第S1期26卷 168-174页

作者： Scheid werner Institut fr Theoretische Physik der Universitt

Within the concept of the dinuclear system(DNS),by incorporating the coupling of the relative motion to the nucleon transfer process,a dynamical model is proposed for describing the formation of superheavy residue nucleus in massive fusion reactions,in which the capture of two heavy colliding nuclei,the formation of compound nucleus and the de-excitation process are calculated using empirical coupled channel model,solving master equation numerically and statistical theory,respectively. By using the DNS model,the evaporation-residue excitation functions in the 48Ca induced fusion reactions and in the cold fusion reactions are investigated systematically and compared with available experimental data. Optimal evaporation channels and combinations as well as the corresponding excitation energies are proposed. The possible factors that influencing the isotopic dependence of the production cross sections are analyzed. The formation of the superheavy nuclei based on the isotopes U with different projectiles are also investigated.

关键词： DNS model massive fusion reaction evaporation-residue excitation function

Recent results of laparoscopic surgery in inflammatory bowel disease

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World Journal of Gastroenterology 2011年第9期17卷 1116-1125页

作者： Hermann Kessler Jonas Mudter werner Hohenberger Department of Surgery University of Erlangen Department of Internal Medicine 1 GastroenterologyUniversity of Erlangen

Inflammatory bowel diseases are an ideal indication for the laparoscopic surgical approach as they are basically benign diseases not requiring lymphadenectomy and extended mesenteric excision;well-established surgical procedures are available for the conventional *** alterations and fragility of the bowel and mesentery,however,may demand a high level of laparoscopic experience.A broad spectrum of operations from the rather easy enterostomy formation for anal Crohn’s disease(CD)to restorative proctocolectomies for ulcerative colitis(UC)may be managed *** current evidence base for the use of laparoscopic techniques in the surgical therapy of inflammatory bowel diseases is *** limited to the terminal ileum has become a common indication for laparoscopic surgical *** severe anal CD, laparoscopic stoma formation is a standard procedure with low morbidity and short operative *** comparing conventional and laparoscopic bowel resections,have found shorter times to first postoperative bowel movements and shorter hospital stays as well as lower complication rates in favour of the laparoscopic *** complicated cases with previous surgery,abscess formation and enteric fistulas may be op-erated on laparoscopically with a low *** UC, restorative proctocolectomy is the standard procedure in elective *** demanding laparoscopic approach is increasingly used,however,mainly in major centers; its feasibility has been proven in various *** increased body mass index and acute inflammation of the bowel may be relative *** and longterm outcomes like quality of life seem to be equivalent for open and laparoscopic *** studies have proven that the laparoscopic approach to CD and UC is a safe and successful alternative for selected patients. The appropriate selection criteria are still under *** considerations are playing an important role for the co

关键词：肠道疾病手术方法腹腔镜炎症溃疡性结肠炎手术治疗标准程序技术因素

Adaptation to Fluctuating Neuronal Signal Traffic for Brain Connectivity

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Advances in Bioscience and Biotechnology 2023年第5期14卷 237-244页

作者： Gerhard werner Bernhard J. Mitterauer Department of Biomedical Engineering University of Texas Austin USA Voltronics-Institute for Basic Research Psychopathology and Brain Philosophy Salzburg Austria

Brain connectivity is commonly studied in terms of causal interaction or statistical dependency between brain regions. In this analysis paper, we draw attention to the constraining effect the dynamics of fiber tract connections may impose on neuronal signal traffic. We propose a model developed by Copelli and Kinouchi (l.c.) for a different purpose to safeguard signal transmission for brain connectivity by ensuring dynamic adaptation of signal reception to a wide frequency range of traffic flow over connecting fiber tracts. Gap junction connectivity would confer to neuronal groups the capacity of acting as collectives for dynamical adaptability to impinging neural traffic thereby forestalling traffic congestion and overload. It is suggested that applying this model to signal reception in brain connectivity would deliver the required functionality as a collective achievement of the interrelations between neurons and gap junctions, the latter regulated by glia.

关键词： Brain Connectivity White Matter Neuronal Groups Gap Junctions

The proton radius:from a puzzle to precision

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Science Bulletin 2020年第4期65卷 257-258页

作者： Hans-werner Hammer Ulf-GMeiBner Institut für Kernphysik Technische Universitat Darmstadt64289 DarmstadtGermany ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH64291 DarmstadtGermany Helmholtz Institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universitat BonnD-53115 BonnGermany Institute for Advanced Simulation and Institut für Kernphysik Forschungszentrum JülichD-52425 JülichGermany Tbilisi State University 0186 TbilisiGeorgia

The proton charge radius rP is a fundamental quantity in particle physics,as it challenges our understanding of the so successful Standard Model in the non-perturbative regime of the strong *** is defined by the slope of the proton charge form factor GE p etT at zero momentum transfer,with t the invariant four-momentum transfer *** proton charge radius was first indirectly measured in the Nobel prize winning electron scattering experiments by Hofstadter et al.[1,2],who fitted the form factor data with a dipole form and extracted the radius from the slope of the dipole.

关键词： DISPERSION-THEORETICAL ANALYSIS FORM-FACTORS NUCLEON SCATTERING HYDROGEN SIZE

Dynamics of dead wood decay in Swiss forests

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Forest Ecosystems 2020年第3期7卷 462-477页

作者： Oleksandra Hararuk werner A.Kurz Markus Didion Department of Biology University of Central Florida4110 Libra DrOrlandoFL32816USA Pacific Forestry Centre 506 Burnside Road WestVictoriaBritish ColumbiaV8Z 1M5Canada Swiss Federal Research Institute WSL Zürcherstrasse 1118903BirmensdorfSwitzerland

Background: Forests are an important component of the global carbon(C) cycle and can be net sources or sinks of CO2, thus mitigating or exacerbating the effects of anthropogenic greenhouse gas emissions. While forest productivity is often inferred from national-scale yield tables or from satellite products, forest C emissions resulting from dead organic matter decay are usually simulated, therefore it is important to ensure the accuracy and reliability of a model used to simulate organic matter decay at an appropriate scale. National Forest Inventories(NFIs) provide a record of carbon pools in ecosystem components, and these measurements are essential for evaluating rates and controls of C dynamics in forest ecosystems. In this study we combine the observations from the Swiss NFIs and machine learning techniques to quantify the decay rates of the standing snags and downed logs and identify the main controls of dead wood ***: We found that wood decay rate was affected by tree species, temperature, and precipitation. Dead wood originating from Fagus sylvatica decayed the fastest, with the residence times ranging from 27 to 54 years at the warmest and coldest Swiss sites, respectively. Hardwoods at wetter sites tended to decompose faster compared to hardwoods at drier sites, with residence times 45–92 and 62–95 years for the wetter and drier sites, *** wood originating from softwood species had the longest residence times ranging from 58 to 191 years at wetter sites and from 78 to 286 years at drier ***: This study illustrates how long-term dead wood observations collected and remeasured during several NFI campaigns can be used to estimate dead wood decay parameters, as well as gain understanding about controls of dead wood dynamics. The wood decay parameters quantified in this study can be used in carbon budget models to simulate the decay dynamics of dead wood, however more measurements(e.g. of soil C dynamics at the same plots)

关键词： Carbon residence time Carbon dynamics National Forest Inventory