检索结果-南通市图书馆

Leber遗传性视神经病变的临床及基因研究

在线全文

学校读者我要写书评

暂无评论

宁夏医学杂志 2020年第9期42卷 777-779页

作者：刘雅妮张金金盛迅伦张爽刘文舟赵志清徐伟刚宁夏回族自治区人民医院宁夏眼科医院宁夏银川750002 西北民族大学第一附属医院宁夏银川750002 宁夏致盲性眼病临床医学研究中心宁夏银川750002 宁夏回族自治区残疾人康复中心宁夏银川750002

目的分析Leber遗传性视神经病变(LHON)临床表型和致病基因的特征。方法收集10例LHON患者眼科临床检查资料,采集患者及其家系成员的DNA。采用Sanger测序进行线粒体DNA(mtDNA)突变位点的筛查,分析患者临床表型和基因突变的特点。结果10例L... 详细信息

目的分析Leber遗传性视神经病变(LHON)临床表型和致病基因的特征。方法收集10例LHON患者眼科临床检查资料,采集患者及其家系成员的DNA。采用Sanger测序进行线粒体DNA(mtDNA)突变位点的筛查,分析患者临床表型和基因突变的特点。结果10例LHON患者中男性9例,女性1例,发病年龄为4~39岁。全部患者最佳矫正视力为光感~0.6。急性期就诊2例,萎缩期就诊8例,其中首诊误诊为弱视4例,误诊为视神经炎2例,误诊为视神经萎缩1例,诊断为可疑LHON 3例。基因检测发现10例LHON患者均携带mtDNA突变,突变位点分别为m.14484T>C(1例),m.11778G>A(5例),m.11696G>A(1例),m.4171C>A(1例),m.3497C>T(1例),m.9055G>A和m.11696G>A双位点碱基突变(1例)。结论LHON早期缺乏典型的临床体征,易误诊为弱视、视神经炎及视神经萎缩。基因检测有助于明确LHON的诊断及评估预后。

关键词： Leber遗传性视神经病变临床特征基因检测

R&D Results of LAPECR3 Ion Source in 2019

在线全文

学校读者我要写书评

暂无评论

IMP & HIRFL Annual Report 2019年第1期 248-249页

作者： Li Jiaqing Cao Yun Zhang Xuezhen Guo Junwei Fang Xing liu wenzhou Jin Gang Guo Xupeng Li Cong Ma Junjie Wang Hui Lu Wang Zhao Huanyu Sun Liangting 不详

LAPECR3(Lanzhou All Permanent Electron Cyclotron Resonance ion source No.3)had been developed as the ion injector of Heavy Ion Medical Machine(HIMM)accelerator facility since 2009[1].

关键词： ECR Electron LAP

清创一期植骨及腓肠神经皮瓣治疗跟骨慢性骨髓炎伴软组织缺损

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

岭南现代临床外科 2013年第1期13卷 62-64,68页

作者：陈添侯念宗陈皓刘文宙陈炳豪阿迪宋卫东湛江市第二人民医院骨外科广东湛江524003 中山大学孙逸仙纪念医院骨外科广州510120

目的探讨清创、一期植骨联合腓肠神经皮瓣移植治疗跟骨慢性骨髓炎伴软组织缺损的疗效。方法 2008年11月～2011年11月,对12例合并软组织缺损的跟骨慢性骨髓炎患者采用清创、一期植骨联合腓肠神经皮瓣移植修复创面,观察术后皮瓣成活、骨... 详细信息

目的探讨清创、一期植骨联合腓肠神经皮瓣移植治疗跟骨慢性骨髓炎伴软组织缺损的疗效。方法 2008年11月～2011年11月,对12例合并软组织缺损的跟骨慢性骨髓炎患者采用清创、一期植骨联合腓肠神经皮瓣移植修复创面,观察术后皮瓣成活、骨髓炎治愈及踝关节功能情况。结果术后随访9～24个月,平均17个月。9例皮瓣Ⅰ期愈合,3例窦道形成或边缘坏死经处理后愈合;随访期间无骨髓炎复发;根据美国足踝外科协会(AOFAS)踝后足功能评分术后(89.4±7.8)较术前(42.8±15.3)明显提高,差异有统计学意义(P<0.05)。结论跟骨慢性髓炎合并软组织缺损通过彻底清创、一期植骨及腓肠神皮瓣移植取得良好的效果,该方法具有疗效确切、疗程短、简单易行等特点。

关键词：跟骨骨髓炎清创自体骨腓肠神经营养皮瓣 AOFAS踝后足评分

A 30-year overview of sodium-ion batteries

在线全文

学校读者我要写书评

暂无评论

Carbon Energy 2024年第6期6卷 56-98页

作者： Yun Gao Hang Zhang Jian Peng Lin Li Yao Xiao Li Li Yang liu Yun Qiao Shu-Lei Chou School of Environmental and Chemical Engineering Shanghai UniversityShanghaiChina College of Chemistry and Materials Engineering Wenzhou UniversityWenzhouZhejiangChina Institute for Superconducting and Electronic Materials University of WollongongWollongongNew South WalesAustralia

Sodium-ion batteries(NIBs)have emerged as a promising alternative to commercial lithium-ion batteries(LIBs)due to the similar properties of the Li and Na elements as well as the abundance and accessibility of Na *** of the current research has been focused on the half-cell system(using Na metal as the counter electrode)to evaluate the performance of the cathode/anode/*** relationship between the performance achieved in half cells and that obtained in full cells,however,has been neglected in much of this ***,the trade-off in the relationship between electrochemical performance and cost needs to be given more ***,systematic and comprehensive insights into the research status and key issues for the full-cell system need to be gained to advance its ***,this review evaluates the recent progress based on various cathodes and highlights the most significant challenges for full *** strategies have also been proposed to enhance the electrochemical performance of NIBs,including designing electrode materials,optimizing electrolytes,sodium compensation,and so ***,perspectives and outlooks are provided to guide future research on sodium-ion full cells.

关键词： commercial application electrode electrolyte sodium-ion full cell strategies

Endoscopic retrograde appendicitis treatment for periappendiceal abscess: A case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第4期12卷 801-805页

作者： Qiao-Mei Li Bin Ye Jun-Wei liu Shang-Wen Yang Department of Gastroenterology Lishui Central HospitalThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Acute appendicitis is the most common abdominal *** present,the main treatments for periappendiceal abscess include antibiotics and ***,the complications and mortality of emergency surgery are *** preferred therapy is conservative treatment with antibiotics first,ultrasound-guided puncture drainage or surgical treatment is followed when *** retrograde appendicitis therapy(ERAT)for acute uncomplicated appendicitis have been proved clinically effective,but it is rarely used in periap-pendiceal *** SUMMARY We report a patient admitted to hospital because of“right lower abdominal pain for six days”.The computerized tomography(CT)of patient showed that appendicitis with fecaliths and abscess in the *** patient was treated by CT-guided puncture and drainage of abdominal abscess combined with ERAT to remove appendiceal fecaliths,irrigation and stent *** The patient did not receive surgery because of impoverished *** pain did not recur during the follow-up *** case confirms the value of ERAT in the treatment of periappendiceal abscess.

关键词： Transparent cap Colonoscopy Endoscopic retrograde appendicitis therapy Periappendiceal abscess Case report

生物信息学方法对影响肺癌发生发展关键基因的初步筛选

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国肺癌杂志 2012年第11期15卷 642-645页

作者：王俊龙石俊杰刘文洲孙宇周华富广西医科大学第一附属医院心胸外科南宁530021

背景与目的肺癌是最常见的恶性肿瘤之一。对于肺癌基因芯片的研究已在很多报道里提及,但是鲜有报道汇总所有的基因芯片数据来研究肺癌的共同表达通路从而挖掘出特殊的基因标记来作为治疗肺癌的靶点。本研究从肺癌相关的基因芯片数据库(G... 详细信息

背景与目的肺癌是最常见的恶性肿瘤之一。对于肺癌基因芯片的研究已在很多报道里提及,但是鲜有报道汇总所有的基因芯片数据来研究肺癌的共同表达通路从而挖掘出特殊的基因标记来作为治疗肺癌的靶点。本研究从肺癌相关的基因芯片数据库(GEO DataSets)中初步筛选出与肺癌发生发展有关键联系的基因与通路。方法运用基因富集(geneset enrichment analysis,GSEA)等生物信息学方法比较选择出的6套肺癌基因芯片表达谱数据,初步筛选出在转录水平上影响肺癌的通路及基因。结果用GSEA方法分析6组芯片集中所得的通路对比,上调中皆有的通路有3条;下调中皆有的通路有26条。本研究挑选共同存在于6套芯片数据集的下调通路即紧密连接(tightjunction)通路里的基因进行meta分析,可得差异有统计学意义(P<0.05)的基因11个。结论紧密连接通路在肺癌发生发展过程中的共性可能有一定研究意义,可在后续研究中探讨通路里的显著性基因。

关键词：肺肿瘤基因富集 Meta分析关键基因紧密连接通路

Petrogenesis and Mineralization of Two-Stage A-Type Granites in Jiuyishan,South China:Constraints from Whole-rock Geochemistry, Mineral Composition and Zircon U-Pb-Hf Isotopes

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2019年第4期93卷 874-900页

作者： liu Ye LAI Jianqing XIAO wenzhou Dick JEFFREY DU Rijun LI Shuanglian liu Chaoyun WEN Chunhua YU Xiaohang Key Laboratory of Metaallogenic Prediction of Nonferrous Metals and Geological Enironment Monitoring Ministry of EducationCentral South UniversityChangsha 410083China School of Geosciences and Info-Physics Central South UniversityChangsha 410083China Hunan Institute of Geological Survey Changsha 410116China College of Marine Science and Technology China University of GeosciencesWuhan 430074China

The Jiuyishan complex massif,located in the northern section of the Nanling region,is a combination of five plutons,namely,the Xuehuading,Jinjiling,Pangxiemu,Shaziling and Xishan ***-rock geochemistry,Imineral electron microprobe analysis,zircon U-Pb dating and Hf isotope analysis were carried out for the Jinjiling and Pangxiemu *** zircon U-Pb dating yields weighted mean ages of 152.9±0.9 Ma for the Jinjiling pluton and 151.7±1.5 Ma for the Pangxiemu pluton,with a narrow gap between *** Jinjiling and Pangxiemu plutons both have geochemical characteristics of high SiO2,Al2 O3,Na2 O,K2 O and low TiO2,MgO,CaO,P2 O5 contents,with intense depletions in Sr,Ba,Ti,Eu and enrichments in Ga,FeoOT and HFSE,and these characteristics reflect an A-type *** the Jinjiling to the Pangxiemu plutons,the mineral composition of mica changes from lepidomelane to zinnwaldite,with increases in F,Li2 O and Rb2 O *** mineral composition of zircon changes from low Zr/Hf to high Zr/Hf,with increasing HfO2,P2 O5 and UO2+ThO2+Y2 O3 *** mineral compositions of feldspar indicate that the Pangxiemu pluton contains more alkali feldspar than the Jinjiling *** whole-rock geochemistry and mineral compositions reveal a higher degree of differentiation for the Pangxiemu *** nearly uniformεHf(t)indicates the same source region for the two plutons:both were derived from partial melting of the lower crust,with small contributions of mantle *** addition,higher F,lower Nb/Ta and Zr/Hf ratios in the Pangxiemu Pluton suggest a closer relationship with the rare metal mineralization than for the Jinjiling pluton.

关键词： zircon U-Pb dating mineral composition A-type granite rare metal mineralization Jinjiling pluton Pangxiemu pluton

pH-Responsive polymer boosts cytosolic siRNA release for retinal neovascularization therapy

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第2期14卷 781-794页

作者： Shuai Guo Chunhui Li Changrong Wang Xiaowen Cao Xinyue liu Xing-Jie Liang Yuanyu Huang Yuhua Weng School of Medical Technology Advanced Research Institute of Multidisciplinary ScienceSchool of Life ScienceKey Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China School of Pharmacy Shandong New Drug Loading&Release Technology and Preparation Engineering LaboratoryBinzhou Medical UniversityYantai 264003China School of Ophthalmology and Optometry School of Biomedical EngineeringThe Eye HospitalWenzhou Medical UniversityWenzhou 325027China Chinese Academy of Sciences(CAS) Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China

Small interfering RNA(siRNA)has a promising future in the treatment of ocular diseases due to its high efficiency,specificity,and low toxicity in inhibiting the expression of target genes and ***,due to the unique anatomical structure of the eye and various barriers,delivering nucleic acids to the retina remains a significant *** this study,we rationally design PACD,an A-B-C type non-viral vector copolymer composed of a hydrophilic PEG block(A),a siRNA binding block(B)and a pH-responsive block(C).PACDs can self-assemble into nanosized polymeric micelles that compact siRNAs into polyplexes through simple *** evaluating its pH-responsive activity,gene silencing efficiency in retinal cells,intraocular distribution,and anti-angiogenesis therapy in a mouse model of hypoxia-induced angiogenesis,we demonstrate the efficiency and safety of PACD in delivering siRNA in the *** are surprised to discover that,the PACD/siRNA polyplexes exhibit remarkable intracellular endosomal escape efficiency,excellent gene silencing,and inhibit retinal *** study provides design guidance for developing efficient nonviral ocular nucleic acid delivery systems.

关键词： SiRNA Oculardeliverysystem Block polymer Endosomalescape Retinal neovascularization Blood-retinal barrier VEGFA Safety

Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2024年第1期11卷 50-79页

作者： Shuai liu Jiang-Ming Yu Yan-Chang Gan Xiao-Zhong Qiu Zhe-Chen Gao Huan Wang Shi-Xuan Chen Yuan Xiong Guo-Hui liu Si-En Lin Alec McCarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering