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Nano Research 2024年第5期17卷 4307-4313页

作者： Zhiquan Lang Guang-Ling Song Xingpeng Liao wenzhong huang Yixing Zhu Haipeng Wang Dajiang Zheng Center for Marine Materials Corrosion and Protection College of MaterialsXiamen UniversityXiamen 361005China Department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen 518055China State Key Laboratory of Physical Chemistry of Solid Surfaces Xiamen UniversityXiamen 361005China The University of Queensland St.LuciaOLD 4072Australia State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China

Controllable and scalable preparation of electrocatalyst materials holds significant importance for their practical application.Magnetron sputtering is a highly effective synthesis method,known for its producing uniform films and allowing easy control of component compositions.In this paper,we propose an in-situ synthesis method for layered double hydroxide(LDH)electrocatalysts through sacrificing magnetron sputtered films.The resulting FeCo-LDH catalyst demonstrated a low overpotential of only 300 mV at 10 mA·cm^(-2).Furthermore,we conducted spectroscopic analysis to investigate the surface changes of the catalysts during the oxygen evolution reaction(OER)process.Our findings indicated that the formation of Co oxyhydroxides plays a beneficial role in enhancing the catalytical performance of the FeCo-LDH for OER reaction.This restructuring strategy of converting a magnetron-sputtered sacrificial film into a catalytical LDH introduces a new avenue to the synthesis of transition metal-based electrocatalysts.

关键词： magnetron co-sputtering surface reconstruction electrocatalyst oxygen evolution reaction

Pyrotinib is effective in both trastuzumab-sensitive and primary resistant HER2-positive breast tumors

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Chinese Journal of Cancer Research 2024年第2期36卷 124-137页

作者： Jialin Zhang Gengshen Yin Chunmiao Ye Man Feng Changhua Ji wenzhong Zhou Fei Wang Lixiang Yu Shuya huang Zhigang Yu Department of Breast Surgery the Second Hospital of Shandong UniversityJinan 250033China Institute of Translational Medicine of Breast Disease Prevention and Treatment Shandong UniversityJinan 250033China Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease Jinan 250033China Department of Pathology the Third Affiliated Hospital of Shandong First Medical University(Affiliated Hospital of Shandong Academy of Medical Sciences)Jinan 250031China Department of Pathology the Second Hospital of Shandong UniversityJinan 250033China

Objective: Primary resistance to trastuzumab frequently occurs in human epidermal growth factor receptor 2(HER2)-positive(+) breast cancer patients and remains a clinical challenge. Pyrotinib is a novel tyrosine kinase inhibitor that has shown efficacy in the treatment of HER2+ breast cancer. However, the efficacy of pyrotinib in HER2+ breast cancer with primary trastuzumab resistance is unknown.Methods: HER2+ breast cancer cells sensitive or primarily resistant to trastuzumab were treated with trastuzumab, pyrotinib, or the combination. Cell proliferation, migration, invasion, and HER2 downstream signal pathways were analyzed. The effects of pyrotinib plus trastuzumab and pertuzumab plus trastuzumab were compared in breast cancer cells in vitro and a xenograft mouse model with primary resistance to trastuzumab.Results: Pyrotinib had a therapeutic effect on trastuzumab-sensitive HER2+ breast cancer cells by inhibiting phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT) and rat sarcoma virus(RAS)/rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)/extracellular-signal regulated kinase(ERK)pathways. In primary trastuzumab-resistant cells, pyrotinib inhibited cell growth, migration, invasion, and HER2 downstream pathways, whereas trastuzumab had no effects. The combination with trastuzumab did not show increased effects compared with pyrotinib alone. Compared with pertuzumab plus trastuzumab, pyrotinib plus trastuzumab was more effective in inhibiting cell proliferation and HER2 downstream pathways in breast cancer cells and tumor growth in a trastuzumab-resistant HER2+ breast cancer xenograft model.Conclusions: Pyrotinib-containing treatments exhibited anti-cancer effects in HER2+ breast cancer cells sensitive and with primary resistance to trastuzumab. Notably, pyrotinib plus trastuzumab was more effective than trastuzumab plus pertuzumab in inhibiting tumor growth and HER2 downstream pathways in HER2+ breast cancer with primary resistance to trastuzumab. These findings support clinical

关键词： Breast cancer HER2 pyrotinib trastuzumab primary resistance pertuzumab

Single-Atom Lithiophilic Sites Confined within Ordered Porous Carbon for Ultrastable Lithium Metal Anodes

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Energy & Environmental Materials 2023年第3期6卷 366-372页

作者： wenzhong huang Shanlin Liu Ruohan Yu Liang Zhou Zhenhui Liu Liqiang Mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Nanostructure Research Centre Wuhan University of TechnologyWuhan 430070China College of Material Science and Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu hydrogen ValleyFoshan 528200China

Attributing to the high specific capacity and low electrochemical reduction potential,lithium(Li)metal is regarded as the most promising anode for high-energy Li batteries.However,the growth of lithium dendrites and huge volume change seriously limit the development of lithium metal batteries.To overcome these challenges,an ordered mesoporous N-doped carbon with lithiophilic single atoms is proposed to induce uniform nucleation and deposition of Li metal.Benefiting from the synergistic effects of interconnected three-dimensional ordered mesoporous structures and abundant lithiophilic single-atom sites,regulated local current density and rapid mass transfer can be achieved,leading to the uniform Li deposition with inhibition of dendrites and buffered volume expansion.As a result,the as-fabricated anode exhibits a high CE of 99.8%for 200 cycles.A stable voltage hysteresis of 14 mV at 5 mA cm^(−2)could be maintained for more than 1330 h in the symmetric cell.Furthermore,the full cell coupled with commercial LiFePO_(4)exhibits high reversible capacity of 108 mAh g^(−1)and average Coulombic efficiency of 99.8%from 5th to 350th cycles at 1 C.The ordered mesoporous carbon host with abundant lithiophilic single-atom sites delivers new inspirations into rational design of high-performance Li metal anodes.

关键词： lithiophilic lithium metal battery ordered mesoporous carbon single atom

基于卷积注意力机制的阀门内漏声发射识别方法

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振动与冲击 2024年第9期43卷 105-114页

作者：黄鑫屈文忠肖黎武汉大学工程力学系武汉430072

阀门结构作为核电厂的关键设备部件之一,因长期处于高温高压环境下,其闸板或阀瓣易发生热变形或磨损导致密封不良,进而引发内漏事故。实时在线识别阀门的内漏状态,对提升核电机组热效率、提高阀门可靠性具有重要意义。因实际工业现场的... 详细信息

阀门结构作为核电厂的关键设备部件之一,因长期处于高温高压环境下,其闸板或阀瓣易发生热变形或磨损导致密封不良,进而引发内漏事故。实时在线识别阀门的内漏状态,对提升核电机组热效率、提高阀门可靠性具有重要意义。因实际工业现场的基底噪声极易掩盖阀门内漏的声发射信号,进而造成阀门内漏状态的误判。为实现阀门内漏状态的快速准确识别,搭建了阀门内漏检测试验台架,开发了基于声发射方法的阀门内漏检测分析系统,将卷积注意力机制引入卷积神经网络中,实现高效快速地识别阀门内漏状态。结果表明,基于阀门内漏的声发射信号频域数据,利用卷积注意力机制神经网络能有效准确地识别阀门内漏状态,在内漏率为26 L/h时,识别准确率高达98%,并且具有较好的可靠性和鲁棒性。

关键词：阀门结构内漏声发射卷积注意力模块卷积神经网络

Global climate change and human health:Pathways and possible solutions

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Eco-Environment & Health 2022年第2期1卷 53-62页

作者： Qi Zhao Pei Yu Rahini Mahendran wenzhong huang Yuan Gao Zhengyu Yang Tingting Ye Bo Wen Yao Wu Shanshan Li Yuming Guo Department of Epidemiology School of Public HealthCheeloo College of MedicineShandong UniversityJinanChina Department of Epidemiology and Preventive Medicine School of Public Health and Preventive MedicineMonash UniversityMelbourne3004Australia

Global warming has been changing the planet’s climate pattern,leading to increasing frequency,intensity and duration of extreme weather events and natural disasters.These climate-changing events affect various health outcomes adversely through complicated pathways.This paper reviews the main signs of climate change so far,e.g.,suboptimal ambient temperature,sea-level rise and other conditions,and depicts the interactive pathways between different climate-changing events such as suboptimal temperature,wildfires,and floods with a broad range of health outcomes.Meanwhile,the modifying effect of socioeconomic,demographic and environmental factors on the pathways is summarised,such that the youth,elderly,females,poor and those living in coastal regions are particularly susceptible to climate change.Although Earth as a whole is expected to suffer from climate change,this review article discusses some potential benefits for certain regions,e.g.,a more liveable environment and sufficient food supply.Finally,we summarise certain mitigation and adaptation strategies against climate change and how these strategies may benefit human health in other ways.This review article provides a comprehensive and concise introduction of the pathways between climate change and human health and possible solutions,which may map directions for future research.

关键词： Climate change Health Pathways Adaptation Mitigation

“Mosquito-Free Villages”:Practice,Exploration,and Prospects of Sustainable Mosquito Control--Zhejiang,China

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China CDC weekly 2019年第5期1卷 70-74页

作者： Song Guo wenzhong huang Jimin Sun Zhenyu Gong Feng Ling Hongzhao Wu Enfu Chen Department of Communicable Diseases Control and Prevention Zhejiang Center for Disease Control and PreventionHangzhouZhejiangChina Pu Jiang Center for Disease Control and Prevention PujiangZhejiangChina.

Mosquitoes and mosquito-borne diseases have always been a great threat to human health.Mosquito control based on sustainable vector management strategy is particularly important.In Zhejiang Province,exemplary villages of sustainable mosquito control(“mosquito-free villages”)have been successful operated,providing a new model of mosquito control in rural areas based on local conditions.The construction of“mosquito-free village”will apply environmentally-friendly and appropriate technologies to eliminate and transform mosquito breeding sites and to establish mechanisms of cultivating villagers’health literacy of scientific mosquito control and voluntary participation in control activities to keep mosquito density low longterm.

关键词： Sustainable eliminate breeding

In-situ surface self-reconstruction in ternary transition metal dichalcogenide nanorod arrays enables efficient electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2021年第4期30卷 10-16页

作者： Qiang Chen Yulu Fu Jialun Jin Wenjie Zang Xiong Liu Xiangyong Zhang wenzhong huang Zongkui Kou John Wang Liang Zhou Liqiang Mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070HubeiChina Department of Materials Science and Engineering National University of SingaporeSingapore 117574Singapore Foshan Xianhu Laboratory Foshan 528216GuangdongChina

Water splitting has received more and more attention because of its huge potential to generate clean and renewable energy.The highly active and durable oxygen evolution reaction(OER)catalysts play a decisive factor in achieving efficient water splitting.The identification of authentic active origin under the service conditions can prompt a more reasonable design of catalysts together with well-confined micro-/nano-structures to boost the efficiency of water splitting.Herein,Fe,Co,and Ni ternary transition metal dichalcogenide(FCND)nanorod arrays on Ni foam are purposely designed as an active and stable low-cost OER pre-catalyst for the electrolysis of water in alkaline media.The optimized FCND catalyst demonstrated a lower overpotential than the binary and unary counterparts,and a 27-fold rise in kinetic current density at the overpotential of 300 m V compared to the nickel dichalcogenide counterpart.Raman spectra and other structural characterizations at different potentials reveal that the in-situ surface self-reconstruction from FCND to ternary transition metal oxyhydroxides(FCNOH)on catalyst surfaces initiated at about 1.5 V,which is identified as the origin of OER activity.The surface selfreconstruction towards FCNOH also enables excellent stability,without fading upon the test for 50 h.

关键词： Surface self-reconstruction Transition metal dichalcogenide Transition metal oxyhydroxide Oxygen evolution reaction Water splitting

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腰果酚改性酚醛树脂的合成及其模塑料的性能

塑料工业 2024年第1期52卷 40-45页

作者：黄世俊罗尧森翟苏宇赖文忠黄继涛黄梦芸朱光明张振伟曾佳美三明学院资源与化工学院福建三明365004 沙县宏盛塑料有限公司福建三明365500 宁德师范学院化学与材料学院福建宁德352000

资源化、环保化与低成本化是传统材料的重要发展方向,本文在硼酸的辅助下,采用腰果酚对酚醛树脂进行改性,探讨了腰果酚和硼酸的引入及其用量对树脂性能的影响,以改性树脂为基体制备了酚醛模塑料,并对其性能进行的测试。结果显示:腰果酚... 详细信息

资源化、环保化与低成本化是传统材料的重要发展方向,本文在硼酸的辅助下,采用腰果酚对酚醛树脂进行改性,探讨了腰果酚和硼酸的引入及其用量对树脂性能的影响,以改性树脂为基体制备了酚醛模塑料,并对其性能进行的测试。结果显示:腰果酚的引入和用量会显著影响树脂的性能,高的替代量使树脂软化点和热稳定性下降,在硼酸的辅助下,则能够实现对改性树脂性能的有效调控,并且以该改性树脂制备的模塑料显示出较好的韧性和热稳定性。

关键词：腰果酚硼酸酚醛树脂改性酚醛模塑料

侯外庐青年观的历史发展及其对新时代青年成长的启示

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北京青年研究 2024年第3期33卷 99-110页

作者：崔存明黄开宇刘文忠北京印刷学院北京联合大学

侯外庐青年观植根于中华民族优秀传统文化,又深受马克思主义的影响,伴随侯外庐在新民主主义革命时期、社会主义建设时期和改革开放后的实践活动不断深化,始终以爱国主义为主线。侯外庐青年观具有十分丰富的内涵,包括青年使命观、青年学... 详细信息

侯外庐青年观植根于中华民族优秀传统文化,又深受马克思主义的影响,伴随侯外庐在新民主主义革命时期、社会主义建设时期和改革开放后的实践活动不断深化,始终以爱国主义为主线。侯外庐青年观具有十分丰富的内涵,包括青年使命观、青年学习观和青年培养观,其核心要义在于怎样培养青年、培养什么样的青年以及青年如何通过学习练就过硬本领。新时代青年要以侯外庐青年观为借鉴,加强自我修炼,知行结合,完成“自修修人的本分任务”;有强烈的使命感,做到“个人与社会的统一”;继往开来,加强历史学习,以青年之力兴今日中国。

关键词：侯外庐青年观历史发展新时代青年成长启示

Open HD map service model:an interoperable high-Definition map data model for autonomous driving

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International Journal of Digital Earth 2023年第1期16卷 2089-2110页

作者： Fengyuan Zhang wenzhong Shi Min Chen Wei huang Xintao Liu Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityKowloonHong Kong Smart Cities Research Institute The Hong Kong Polytechnic UniversityKowloonHong Kong Key Laboratory of Virtual Geographic Environment(Ministry of Education of PRC) Nanjing Normal UniversityNanjingPeople’s Republic of China College of Surveying and Geo-Informatics Tongji UniversityShanghaiPeople’s Republic of China Guangdong–Hong Kong-Macao Joint Laboratory for Smart Cities ShenzhenPeople’s Republic of China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application NanjingPeople’s Republic of China State Key Laboratory Cultivation Base of Geographical Environment Evolution(Jiangsu Province) NanjingPeople’s Republic of China

With the growth in the vehicle industry,autonomous driving has become a hot topic worldwide and has attracted increasing attention from both industrial and academic sectors.Maps,as pivotal geospatial information carriers,play a vital role in route planning and navigation service.Compared with conventional maps,high-definition(HD)maps possesses higher precision,richer information,and various services and are regarded as critical infrastructure for autonomous driving.However,heterogeneous HD map data standards and models have different characteristics and advantages,and thus they rarely meet all autonomous driving requirements for different driving objectives.This research presents an interoperable map data model,the Open HD Map Service Model(OHDMSM),to provide a reference for HD map development.The designed OHDMSM,which contains three data layers and a set of corresponding interfaces,demonstrates high interoperability for HD map data fusion and application.As a proof of concept,an HD map data system is implemented with all functions following the designed data model and interfaces of OHDMSM.The design and development of OHDMSM data structures,interfaces and systems will benefit data requesting,updating,and interoperation for HD map data worldwide,which can be helpful for developing autonomous driving and intelligent transportation in the Digital Earth.

关键词： HD map data interoperation autonomous driving data standards smart cities