检索结果-南通市图书馆

Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第4期67卷 663-679页

作者： Yanfang liu Yan Wang Bing liu wenzhong liu Yuanyuan Ma Yiren Cao Shi Yan Panpan Zhang Lixin Zhou Qimin Zhan Nan Wu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Thoracic Surgery IIPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Thoracic Oncology IIPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of PathologyPeking University Cancer Hospital and InstituteBeijing 100142China Peking University International Cancer Institute Beijing 100191China Institute of Cancer Research Shenzhen Bay LaboratoryShenzhen 518132China

Chemoresistance is a significant barrier to effective cancer *** mechanisms for chemoresistance include reactive oxygen species(ROS)accumulation and expression of chemoresistance-promoting ***,we report a novel function of lncRNA16 in the inhibition of ROS generation and the progression of *** analyzing the serum levels of lncRNA16 in a cohort of 35 patients with non-small cell lung cancer(NSCLC)and paired serum samples pre-and post-treatment from 10 NSCLC patients receiving neoadjuvant platinum-based chemotherapy,performing immunohistochemistry(IHC)assays on 188 NSCLC tumor samples,using comprehensive identification of RNA-binding proteins by mass spectrometry(ChIRP-MS)assays,as well as RNA immunoprecipitation(RIP)and RNA pull-down analyses,we discovered that patients with increased serum levels of lncRNA16 exhibited a poor response to platinum-based *** expression of hemoglobin subunit beta(HBB)and NDUFAF5 significantly increases with the development of ***16 binds to HBB and promotes HBB accumulation by inhibiting ***16 can also inhibit ROS generation via the HBB/NDUFAF5 axis and function as a scaffold to facilitate the colocalization of HBB and NDUFAF5 in the ***,preclinical studies in mouse models of chemo-resistant NSCLC have suggested that lncRNA16 targeting by trivalent N-acetylgalactosamine(GalNAc)-conjugated siRNA restores chemosensitivity and results in tumor growth inhibition with no detectable toxicity in ***,lncRNA16 is a promising therapeutic target for overcoming chemoresistance,and the combination of first-line platinum-based chemotherapy with lncRNA16 intervention can substantially enhance anti-tumor efficacy.

关键词： chemoresistance lncRNARNA interference ROs chemosensitizer

LGFFN-GHI: A Local-Global Feature Fuse Network for Gastric Histopathological Image Classification

在线全文

学校读者我要写书评

暂无评论

Journal of Computer and Communications 2022年第11期10卷 91-106页

作者： Songsong Li wenzhong liu Sichuan University of Light Chemical Industry Zigong China

Gastric cancer remains the third most common cause of cancer-related death. Histopathological examination of gastric cancer is the gold standard for the diagnosis of gastric cancer. However, manual pathology examination is time-consuming and laborious. Computer-aided diagnosis (CAD) systems can assist pathologists in diagnosing pathological images, thus improving the efficiency of disease diagnosis. In this paper, we propose a two-branch network named LGFFN-GHI, which can classify histopathological images of gastric cancer into two categories: normal and abnormal. LGFFN-GHI consists of two parallel networks, ResNet18 and Pvt-Tiny, which extract local and global features of microscopic gastric tissue images, respectively. We propose a feature blending module (FFB) that fuses local and global features at the same resolution in a cross-attention manner. This enables ResNet18 to acquire the global features extracted by Pvt-Tiny, while enabling Pvt-Tiny to acquire the local features extracted by ResNet18. We conducted experiments on a novel publicly available subsize image database of gastric histopathology (GasHisSDB). The experimental results show that LGFFN-GHI achieves an accuracy of 96.814%, which is 2.388% and 3.918% better than the baseline methods ResNet18 and Pvt-Tiny, respectively. Our proposed network exhibits high classification performance, demonstrating its effectiveness and future potential for the gastric histopathology image classification (GHIC) task.

关键词： Deep Learning Gastric Cancer Screening Histopathological Images Transformer

Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2015年第1期4卷 197-206页

作者： Ji Yi wenzhong liu Siyu Chen Vadim Backman Nader Sheibani Christine M.Sorenson Amani A.Fawzi Robert A.Linsenmeier Hao F.Zhang Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA McPherson Eye Research Institute University of WisconsinMadisonWI 53705USA Department of Ophthalmology Northwestern UniversityChicago Illinois 60611USA Department of Neurobiology Northwestern UniversityEvanstonIL 60208USA

The lack of capability to quantify oxygen metabolism noninvasively impedes both fundamental investigation and clinical diagnosis of a wide spectrum of diseases including all the major blinding diseases such as age-related macular degeneration,diabetic retinopathy,and *** visible light optical coherence tomography(vis-OCT),we demonstrated accurate and robust measurement of retinal oxygen metabolic rate(rMRO2)noninvasively in rat *** continuously monitored the regulatory response of oxygen consumption to a progressive hypoxic *** found that both oxygen delivery,and rMRO2 increased from the highly regulated retinal circulation(RC)under hypoxia,by 0.2860.08 μL min(^-1)(p,0.001),and 0.2060.04 μL min(^-1)(p,0.001)per 100 mmHg systemic pO2 reduction,*** increased oxygen extraction compensated for the deficient oxygen supply from the poorly regulated choroidal *** from an oxygen diffusion model based on previous oxygen electrode measurements corroborated our in vivo *** believe that vis-OCT has the potential to reveal the fundamental role of oxygen metabolism in various retinal diseases.

关键词： oxygen metabolism retinal circulation visible light optical coherence tomography

维普期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

气井井下管串腐蚀影响因素的电化学认识

钻采工艺 2005年第2期28卷 87-89,106页

作者：刘文忠西南油气田分公司重庆工程造价站

从化学反应速度、弱电离理论、物质溶度积、气体溶解度等多角度认识天然气中H2 S、CO2 气体对气井井下管串在不同情况、不同井段的腐蚀作用,阐述了多因素的共同影响。

关键词：气井管串腐蚀认识

Quality Assessment of Attribute Data in GIS Based on Simple Random Sampling

在线全文

学校读者我要写书评

暂无评论

Geo-Spatial Information Science 2003年第2期6卷 13-19页

作者： liu Chun SHI wenzhong liu Dajie liu Chun, Ph. D, postdoctoral fellow, Department of Surveying and Geo-informatics, Tongji University, 1239 Siping Road, Shanghai 200092, China. Department of Surveying and Geo-informatics Tongji University 1239 Siping Road Shanghai 200092 China

On the basis of the principles of simple random sampling, the statistical model of rate of disfigurement (RD) is put forward and described in detail. According to the definition of simple random sampling for the attribute data in GIS, the mean and variance of the RD are deduced as the characteristic value of the statistical model in order to explain the feasibility of the accuracy measurement of the attribute data in GIS by using the RD. Moreover, on the basis of the mean and variance of the RD, the quality assessment method for attribute data of vector maps during the data collecting is discussed. The RD spread graph is also drawn to see whether the quality of the attribute data is under control. The RD model can synthetically judge the quality of attribute data, which is different from other measurement coefficients that only discuss accuracy of classification.

关键词： quality assessment simple random sampling rate of disfigurement attributedata

《幽门螺杆菌感染的处理:马斯特里赫特Ⅵ/佛罗伦萨共识报告》解读

在线全文

学校读者我要写书评

暂无评论

胃肠病学 2021年第11期26卷 676-686页

作者：刘文忠上海交通大学医学院附属仁济医院消化内科上海市消化疾病研究所 200001

最近发表的《幽门螺杆菌感染的处理:马斯特里赫特Ⅵ/佛罗伦萨共识报告》在5个方面就幽门螺杆菌感染处理的87条陈述达成共识,包括:①适应证/关联,②诊断,③治疗,④预防/胃癌,⑤幽门螺杆菌与胃肠道菌群。本文对该共识进行详细解读。

关键词：幽门螺杆菌诊断根除胃癌预防共识 13 C-尿素呼气试验柠檬酸

在线全文

学校读者我要写书评

暂无评论

难治性幽门螺杆菌感染的处理:共识和争议

胃肠病学 2021年第7期26卷 385-388页

作者：刘文忠上海交通大学医学院附属仁济医院消化内科上海市消化疾病研究所200001

幽门螺杆菌(Hp)感染的危害已得到充分认识,根除Hp预防和治疗Hp相关疾病具有很高的成本-效益优势。“治疗所有Hp阳性者,除非有抗衡因素”的观点已被普遍接受。然而,目前临床Hp根除率逐渐下降,影响了Hp感染的防控。目标虽已统一,但具体实... 详细信息

幽门螺杆菌(Hp)感染的危害已得到充分认识,根除Hp预防和治疗Hp相关疾病具有很高的成本-效益优势。“治疗所有Hp阳性者,除非有抗衡因素”的观点已被普遍接受。然而,目前临床Hp根除率逐渐下降,影响了Hp感染的防控。目标虽已统一,但具体实施时遇到困难,使得“难治性Hp感染”的处理成为当前研究热点。本文就“难治性Hp感染”定义的争议、造成“难治性”的原因和相关对策进行详细阐述。

关键词：幽门螺杆菌根除难治性共识

在线全文

学校读者我要写书评

暂无评论

“幽门螺杆菌胃炎京都全球共识”解读

胃肠病学 2015年第8期20卷 449-456页

作者：刘文忠上海交通大学医学院附属仁济医院消化内科上海市消化疾病研究所 200001

2014年1月31日-2月1日,"幽门螺杆菌(Hp)胃炎全球共识"会议在日本京都召开,制订了下述内容共识:1Hp胃炎是一种感染性疾病;2临床上如何区别Hp引起的消化不良与功能性消化不良;3胃炎适当的诊断评估;4何时、何人、如何治疗Hp胃炎。所有22个... 详细信息

2014年1月31日-2月1日,"幽门螺杆菌(Hp)胃炎全球共识"会议在日本京都召开,制订了下述内容共识:1Hp胃炎是一种感染性疾病;2临床上如何区别Hp引起的消化不良与功能性消化不良;3胃炎适当的诊断评估;4何时、何人、如何治疗Hp胃炎。所有22个临床问题的24个陈述均达到>80%的共识水平。本文对这些内容进行详细解读。

关键词：幽门螺杆菌胃炎传染性疾病根除消化不良胃肿瘤共识

日本《消化性溃疡循证临床实践指南(2015年)》解读

在线全文

学校读者我要写书评

暂无评论

胃肠病学 2016年第3期21卷 129-137页

作者：刘文忠上海交通大学医学院附属仁济医院消化内科 200001

2015年,日本胃肠病学会修订了消化性溃疡循证临床实践指南。修订的内容包括以下几项:出血性胃和十二指肠溃疡、幽门螺杆菌(Hp)根除治疗、非根除Hp治疗、药物诱发的溃疡、非Hp-非非甾体消炎药(NSAID)溃疡和外科手术治疗。该指南详细陈述... 详细信息

2015年,日本胃肠病学会修订了消化性溃疡循证临床实践指南。修订的内容包括以下几项:出血性胃和十二指肠溃疡、幽门螺杆菌(Hp)根除治疗、非根除Hp治疗、药物诱发的溃疡、非Hp-非非甾体消炎药(NSAID)溃疡和外科手术治疗。该指南详细陈述了上述内容,是我们临床实践中良好的参考材料。为此,本文对该指南作详细解读。

关键词：消化性溃疡出血幽门螺杆菌消炎药,非甾类低剂量阿司匹林质子泵抑制剂内镜治疗预防