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Mono-functionalized pillar[n]arenes: Syntheses, host–guest properties and applications

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Chinese Chemical Letters 2024年第1期35卷 16-30页

作者： wenzhi yang Wenjie Zhang Jingyu Chen Jiong Zhou Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China

Pillar[n]arenes are a novel class of macrocyclic hosts reported by Ogoshi and co-workers in 2008. Because of their rigid pillar structures, interesting host-guest properties and ease of modifications, pillar[n]arenes have been developed rapidly in the field of functional materials and biomedicine. The modifications of pillar[n]arenes at different positions can give them varied characteristics. Functional groups can be introduced into one position of pillar[n]arenes without changing host-guest properties of pillar[n]arenes. A series of pillar[n]arene dimers, trimers, tetramers and metallacycles can be constructed by mono-functionalized pillar[n]arenes. In this review, two synthetic methods of mono-functionalized pillar[n]arenes are summarized and structures containing mono-functionalized pillar[n]arenes are described. Furthermore, the applications of mono-functionalized pillar[n]arenes in different fields (e.g., supramolecular polymers, sensors, molecular machines, catalysis, biological applications and light-harvesting systems) are also introduced. Hopefully, this article will be useful for researchers studying pillar[n]arenes, especially the mono-functionalized pillar[n]arenes.

关键词： Pillar[n]arenes Host-guest properties Supramolecular polymer Molecular machines Biological application

Genetic benefits of female from extra-pair paternity are context dependent within the socially monogamous Tree Sparrow

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Avian Research 2024年第3期15卷 395-401页

作者： wenzhi yang Yue Shen Yuquan Miao Zhaocun Lin Yingmei Zhang Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution School of Life SciencesLanzhou UniversityLanzhou730000China School of Life Science Ningxia UniversityYinchuan750021China

Females actively seek extra-pair paternity(EPP)to acquire a fitness advantage for their ***“contextdependence hypothesis”posits that female extra-pair mate choice has plasticity in response to environmental conditions,and therefore magnitude of female genetic benefits from EPP depends on the environmental ***,chronic heavy metal pollution can cause adverse effects on fitness-related traits of wild ***,few studies were available on the interactions between heavy metal pollution and *** selected an area that was contaminated by heavy metals for more than 60 years(Baiyin,BY),a relatively unpolluted area(Liujiaxia,LJX),and Tree Sparrows(Passer montanus)as study species to explore the response of female extrapair mate choice and genetic benefits from EPP to heavy metal pollution in socially monogamous *** relatedness between social mates and extra-pair mates was ***,we compared the body size and heterozygosity of extra-pair offspring(EPO),within-pair offspring(WPO),social males and extra-pair males from the two Tree Sparrow *** found that at BY,female Tree Sparrows tended to choose extra-pair males with larger body size and lower genetic similarity,thereby producing higher heterozygosity and larger body size of EPO compared with those of ***,no similar phenomenon was observed in the Tree Sparrow population from *** addition,there was a significant interaction between population and paternity in the analyses of the fitness-related traits,suggesting that environmental variation could affect female genetic benefits from *** study confirmed the existence of presumed interactions between environmental pollution and EPP within the natural population of socially monogamous Tree *** findings shed lights on the possible effects of long-term environmental stress on mating system in wild birds.

关键词： Context-dependence Fitness advantage Heavy metal pollution Mating system Passer montanus Passerine

Modeling of the fibrin agarose plate assay and its application for thrombolytic analysis

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Chinese Science Bulletin 2012年第24期57卷 3233-3238页

作者： WANG MingQi yang wenzhi WU Qiang GU HongChen Nano Biomedical Research Center School of Biomedical Engineering and Med-X Research InstituteShanghai Jiao Tong UniversityShanghai 200030China Department of Ophthalmology The Sixth People's HospitalShanghai Jiao Tong UniversityShanghai 200233China

The fibrin agarose plate assay is widely used in the detection of thrombolysis efficacy. However, a rigorous mathematical model for analyzing data or comparing activities of different thrombolytics has been absent. This study investigated the relationship between thrombolysis radius, R, and diffusion time, t, of molecular medicines in an agarose hydrogel system by deriving a model based on Fick's law and experimental verification by the fibrin agarose plate assay method. The theoretical results showed that a plot of log(R) versus log(t) has a linear curve with the slope of 1/2 and this was verified by experimental results using urokinase as a modeling agent. Moreover, it was found that R÷t is constant for a specific thrombolytic and can be used as a parameter for evaluating activities of different thrombolytics. The theoretical model has potential for improving the understanding of mecha-nisms involved in molecular medicine diffusion and offers benefits for thrombolytic therapy.

关键词：琼脂糖凝胶纤维蛋白平板试验溶栓建模应用 Fick定律数学模型

Optimal analysis conditions for sperm motility parameters with a CASA system in a passerine bird, Passer montanus

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Avian Research 2019年第4期10卷 497-506页

作者： Ying yang Yingmei Zhang Jian Ding Shiwei Ai Rui Guo Xiaojuan Bai wenzhi yang Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution School of Life SciencesLanzhou UniversityLanzhou 730000China School of Public Health Lanzhou UniversityLanzhou 730000China

Background:Sperm motility parameters,which can be measured objectively and repeatedly by a computer-assisted sperm analysis(CASA)system,are important indicators of sperm ***,the sperm motility parameters assessed by a CASA system can be affected by various factors,including instrument components and settings,sperm preparation or analysis *** date,no standardized protocol is available that would permit to assess sperm kinetic characteristics in passerine birds and this lack precludes any comparison of sperm swimming ability and sperm quality across ***:In this study,we chose the Tree Sparrow(Passer montanus)as the object to evaluate sperm motility parameters,including sperm motility,sperm velocity and sperm movement trajectory,at different analysis time,temperatures and pH using the WLJY-9000 CASA ***:Sperm motility parameters remained statistically unchanged at 1‒9 *** motility was similar at 38℃ and 40℃,but a greater percentage of slow progressive sperm was detected at 38℃ compared to 40℃ and 42℃.Additionally,progressive motility was lower and immotility was higher at 42℃than 38℃and/or 40℃(close to the body temperature of the Tree Sparrow).The percentages of rapid progressive sperm,progressive sperm and immotile sperm were statistically similar at pH 7.0,7.5 and 8.0 with the exception of lower percentage of progressive sperm at pH 7.0 compared to pH *** addition,slower sperm velocity and worse sperm movement trajectory were found at pH 6.0 and 9.0 than those at pH 8.0,7.5 or ***:Our study indicates that the ideal conditions for sperm motility parameters assessment in Tree Sparrow are obtained between 1 and 9 min after dilution,an environment at body temperature(40℃)and a pH around *** results of this study provide a reference for the evaluation of sperm characteristics and sperm quality using a CASA system in passerine birds.

关键词： Analysis time Passerine bird Sperm motility parameters Temperature pH

Approaches to establish Q-markers for the quality standards of traditional Chinese medicines

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Acta Pharmaceutica Sinica B 2017年第4期7卷 439-446页

作者： wenzhi yang Yibei Zhang Wanying Wu Luqi Huang Dean Guo Changxiao Liu National Engineering Laboratory for Standardization of Traditional Chinese Medicine Shanghai Institute of Materia Medica Research Center for Chinese Medicinal Resources China Academy of Chinese Medical Sciences Research Center for New Drug Evaluation Tianjin Institute of Pharmaceutical Research

Traditional Chinese medicine(TCM) has played a pivotal role in maintaining the health of Chinese people and is now gaining increasing acceptance around the global scope. However, TCM is confronting more and more concerns with respect to its quality. The intrinsic "multicomponent and multitarget" feature of TCM necessitates the establishment of a unique quality and bioactivity evaluation system, which is different from that of the Western medicine. However, TCM is investigated essentially as"herbal medicine" or "natural product", and the pharmacopoeia quality monographs are actually chemicalmarkers-based, which can ensure the consistency only in the assigned chemical markers, but, to some extent, have deviated from the basic TCM theory. A concept of "quality marker"(Q-marker), following the "property-effect-component" theory, is proposed. The establishment of Q-marker integrates multidisciplinary technologies like natural products chemistry, analytical chemistry, bionics, chemometrics,pharmacology, systems biology, and pharmacodynamics, etc. Q-marker-based fingerprint and multicomponent determination conduce to the construction of more scientific quality control system of *** review delineates the background, definition, and properties of Q-marker, and the associated technologies applied for its establishment. Strategies and approaches for establishing Q-marker-based TCM quality control system are presented and highlighted with a few TCM examples.

关键词： Traditional Chinese medicine Q-marker Quality control Property-effect-component

Identification and differentiation of Panax ginseng,Panax quinquefolium, and Panax notoginseng by monitoring multiple diagnostic chemical markers

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Acta Pharmaceutica Sinica B 2016年第6期6卷 568-575页

作者： wenzhi yang Xue Qiao Kai Li Jingran Fan Tao Bo De-an Guo Min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences Agilent Technologies

To differentiate traditional Chinese medicines(TCM) derived from congeneric species in TCM compound preparations is usually challenging. The roots of Panax ginseng(PG), Panax quinquefolium(PQ) and Panax notoginseng(PN) are used as popular TCM. They contain similar triterpenoid saponins(ginsenosides) as the major bioactive constituents. Thus far, only a few chemical markers have been discovered to differentiate these three species. Herein we present a multiple marker detection approach to effectively differentiate the three Panax species, and to identify them in compound preparations. Firstly, 85 batches of crude drug samples(including 32 PG, 30 PQ, and 23 PN) were analyzed by monitoring 40 major ginsenosides in the extracted ion chromatograms(EICs) using a validated LC–MS fingerprinting method. Secondly, the samples were clustered into different groups by pattern recognition chemometric approaches using PLS-DA and OPLS-DA models, and17 diagnostic chemical markers were discovered. Aside from the previously known Rf and p-F11, ginsenoside Rs1 could be a new marker to differentiate PG from PQ. Finally, the above multiple chemical markers were used to identify the Panax species in 60 batches of TCM compound preparations.

关键词： Panax species Ginsenoside LC–MS fingerprinting Chemical marker TCM compound preparation

vCerberus:A DRTM System Based on Virtualization Technology

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Wuhan University Journal of Natural Sciences 2010年第3期15卷 185-189页

作者： CHEN wenzhi ZHANG Zhipeng yang Jianhua HE Qinming College of Computer Science Zhejiang University Hangzhou 310012 Zhejiang China

This paper presents vCerberus, a novel hypervisor to provide trusted and isolated code execution within virtual domains vCerberus is considerably tiny, while allowing secure sensitive codes to be executed in an isolated circumstance from the virtual ddmain, and can be attested by a remote party in an efficient way. These properties will be guaranteed even if the guest operating system is malicious. This protects the secure sensitive codes against the malicious codes in the Guest OS, e.g., the kernel rootkits. We present an approach to dynamically measure and isolate the launch environment on the virtual machines based on the para-virtualization technology and a novel virtualization of trusted platform module （TPM）. Our performance experiment result shows that the overhead introduced by vCerberus is minimized; the performance of the launch environment in vCerberus is as competitive as the guest OS running on mainstream hypervisors.

关键词： trusted computing para-virtualization dynamic root of trust for measurement (DRTM) trusted platform module (TPM)

Complete Convergence of Randomly Weighted Sums of NOD Random Variables

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Journal of Mathematical Research with Applications 2017年第6期37卷 743-753页

作者： Zhangrui ZHAO Xudong QIAO wenzhi yang Shuhe HU School of Mathematical Sciences Anhui University

In this paper,we investigate the complete convergence of double-indexed randomly weighted sums of negatively orthant dependent(NOD) random *** complete moment convergence and complete convergence of this dependent sequence are presented,Marcinkiewicz-Zygmund-type strong law of large numbers is also *** results extend some corresponding *** addition,some simulations are illustrated to show the convergence.

关键词： complete convergence randomly weighted NOD sequences strong law of large numbers

Dimension-Enhanced Ultra-High Performance Liquid Chromatography/Ion Mobility-Quadrupole Time-of-Flight Mass Spectrometry Combined with Intelligent Peak Annotation for the Rapid Characterization of the Multiple Components from Seeds of Descurainia sophia

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Phyton-International Journal of Experimental Botany 2022年第3期91卷 541-567页

作者： Simiao Wang Xue Li Boxue Chen Shitong Li Jiali Wang Jing Wang Mingshuo yang Xiaoyan Xu Hongda Wang wenzhi yang State Key Laboratory of Component-Based Chinese Medicine Tianjin Key Laboratory of TCM Chemistry and AnalysisTianjin University of Traditional Chinese MedicineTianjin301617China Waters Technology Co. Ltd.Beijing101102China School of Computing Science University of GlasgowGlasgowG128RZUK

The complex composition of herbal metabolites necessitates the development of powerful analytical techniques aimed to identify the bioactive *** seeds of Descurainia sophia(SDS)are utilized in China as a cough and asthma relieving ***,a dimension-enhanced integral approach,by combining ultra-high performance liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry(UHPLC/IMQTOF-MS)and intelligent peak annotation,was developed to rapidly characterize the multicomponents from *** chromatographic separation was achieved within 38 min on a UPLC CSH C18(2.1×100 mm,1.7μm)column which was eluted by 0.1%formic acid in water(water phase)and acetonitrile(organic phase).Collision-induced dissociation-MS^(2)data were acquired by the data-independent high-definition MS^(E)(HDMS^(E))in both the negative and positive electrospray ionization modes.A major components knockout strategy was applied to improve the characterization of those minor ingredients by enhancing the injection ***,a self-built chemistry library was established,which could be matched by the UNIFI software enabling automatic peak annotation of the obtained HDMS^(E)*** a result of applying the intelligent peak annotation workflows and further confirmation process,a total of 53 compounds were identified or tentatively characterized from the SDS,including 29 flavonoids,one uridine derivative,four glucosides,one lignin,one phenolic compound,and 17 ***,four-dimensional information related to the structure(e.g.,retention time,collision cross section,MS^(1)and MS^(2)data)was obtained for each component by the developed integral approach,and the results would greatly benefit the quality control of SDS.

关键词： Descurainia sophia multicomponent characterization ultra-high performance liquid chromatography ion mobility/quadrupole time-of-flight mass spectrometry high-definition MS^(E) flavonoid