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Frontiers in Energy 2019年第3期13卷 483-493页

作者： Xiang LI wenzheng zhang Zhong HUANG Dehao JU Li HUANG Mingzhi FENG Xingcai LU Zhen HUANG Key Laboratory of Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China Shanghai Marine Diesel Engine Research Institute Shanghai 201108China

Liquefied natural gas (LNG), mainly composed of methane, is in progress to substitute diesel fuel in heavyduty marine engine for practical, economic, and environmental considerations. However, natural gas is relatively difficult to be ignited in a large bore combustion chamber. A combustion enhancement technique called prechamber turbulent jet ignition (TJI) can permit combustion and flame propagation in a largebore volume. To investigate the effect of air-fuel equivalence ratio and pre-mixed pressure on pre-chamber TJI of methane/air mixtures with multiple orifices in a large bore volume, experimental tests and computational simulations were implemented to study the discharge of hot turbulent jets from six orifices of the pre-chamber. Different initial pressures and air-fuel equivalence ratios were considered to analyze the characteristics of TJI. The asymmetry of the turbulent jet actuated from six different orifices were found due to the asymmetric orientation of the spark plug, resulting in the inhomogeneous distribution of combustion in the constant volume chamber, which should be considered seriously in the marine engine design. Besides,as the premixed pressure increases, it has more effect on the flame propagation and plays a more important role, as it further increases.

关键词： marine engine natural gas methane turbulent jet ignition (TJI) pre-chamber

An Artificial Intelligence‑Assisted Flexible and Wearable Mechanoluminescent Strain Sensor System

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Nano-Micro Letters 2025年第3期17卷 217-231页

作者： Yan Dong wenzheng An Zihu Wang Dongzhi zhang College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580People’s Republic of China

The complex wiring,bulky data collection devices,and difficulty in fast and on-site data interpretation significantly limit the practical application of flexible strain sensors as wearable *** tackle these challenges,this work develops an artificial intelligenceassisted,wireless,flexible,and wearable mechanoluminescent strain sensor system(AIFWMLS)by integration of deep learning neural network-based color data processing system(CDPS)with a sandwich-structured flexible mechanoluminescent sensor(SFLC)*** SFLC film shows remarkable and robust mechanoluminescent performance with a simple structure for easy *** CDPS system can rapidly and accurately extract and interpret the color of the SFLC film to strain values with auto-correction of errors caused by the varying color temperature,which significantly improves the accuracy of the predicted strain.A smart glove mechanoluminescent sensor system demonstrates the great potential of the AIFWMLS system in human gesture ***,the versatile SFLC film can also serve as a encryption *** integration of deep learning neural network-based artificial intelligence and SFLC film provides a promising strategy to break the“color to strain value”bottleneck that hinders the practical application of flexible colorimetric strain sensors,which could promote the development of wearable and flexible strain sensors from laboratory research to consumer markets.

关键词： Mechanoluminescent Strain sensor Flexible Deep learning Wireless

Distribution and geological significance of 17α(H)-diahopanes from different hydrocarbon source rocks of Yanchang Formation in Ordos Basin

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Science China Earth Sciences 2009年第10期52卷 965-974页

作者： zhang wenzheng YANG Hua HOU LiHui LIU Fei Institute of Exploration Development and Research of PetroChina Company Limited Changqing Oilfield BranchXi’an 710018China PetroChina Company Limited Changqing Oilfield Branch Xi’an 710018China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou 510640China

Based on GC-MS testing data of many saturated hydrocarbon samples, 17α(H)-C30 diahopanes (C30*) are extensively distributed in the lacustrine hydrocarbon source rocks of the Yanchang Formation in Ordos Basin, but show remarkable differences in relative abundance among various source rocks. Generally, Chang 7 high-quality source rock (oil shale) developed in deep lake anoxic environment shows lower C30* content, whereas Chang 6-9 dark mudstone developed in shallow to semi-deep lake, sub-oxidizing environment shows relatively high to high C30* value. Particularly, Chang 7 and Chang 9 black mudstones in Zhidan region in the northeast of the lake basin show extremely high C30* value. A comparative analysis was made based on lithology, organic types and various geochemical parameters indicative of redox environment, and the results indicate that environmental factors such as redox settings and lithology are key factors that control the C30* relative abundance, while organic types and maturity may be minor factors. High to extremely high C30* values are indicative of sub-oxidizing environment of fresh-brackish water and shallow to semi-deep lake. Therefore, research on C30* relative content and distribution in lacustrine hydrocarbon source rocks in the Yanchang Formation, especially on the difference in C30* between Chang 7 high-quality source rocks (oil shale) and Chang 6-91 source rocks (dark mudstone), will provide an important approach for classification of Mesozoic lacustrine crudes and detailed oil-source correlation in the basin.

关键词： diahopane neohopane sedimentary environment Yanchang Formation Ordos Basin

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A self-assembling prodrug nanosystem to enhance metabolic stability and anticancer activity of gemcitabine

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Chinese Chemical Letters 2022年第5期33卷 2481-2485页

作者： Mei Cong Guangling Xu Shaoyou Yang Jing zhang wenzheng zhang Dinesh Dhumal Erik Laurini Kaiyue zhang Yi Xia Sabrina Pricl Ling Peng Weidong Zhao School of Pharmacy Xinxiang Medical UniversityXinxiang 453003China Henan Key Laboratory of Immunology and Targeted Drugs School of Laboratory MedicineXinxiang Medical UniversityXinxiang 453003China Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine School of Laboratory MedicineXinxiang Medical UniversityXinxiang 453003China Aix-Marseille Université CNRSCenter Interdisciplinaire de Nanoscience de MarseilleUMR 7325Equipe Labellisépar La LigueMarseille 13288France Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical SciencesChongqing UniversityChongqing 401331China Molecular Biology and Nanotechnology Laboratory Department of Engineering and ArchitectureUniversity of TriesteTrieste 34127Italy Department of General Biophysics Faculty of Biology and Environmental ProtectionUniversity of LodzLodz 90-236Poland

Self-assembly is a powerful approach in molecular engineering for biomedical applications,in particu-lar for creating self-assembling ***,we report a self-assembling prodrug of the anticancer drug gemcitabine(Gem)based on amphiphilic dendrimer *** prodrug reported in this study demonstrates high drug loading(40%)and robust ability to self-assemble into small nanomicelles,which increase the metabolic stability of Gem and enable entry into cells via endocytosis,hence bypassing transport-mediated *** addition,this prodrug nanosystem exhibited an effective pH-and enzyme-responsive release of Gem,resulting in enhanced anticancer activity and reduced *** ad-vantageous features of both prodrug-and nanotechnology-based drug delivery,this self-assembling Gem prodrug nanosystem constitutes a promising anticancer *** study also offers new perspectives of the amphiphilic dendrimer nanoplatforms for the development of self-assembling prodrugs.

关键词： Self-assembling prodrug Gemcitabine Amphiphilic dendrimer Anticancer candidate Nanomicelles

Epigenetics of epithelial Na^+ channel-dependent sodium uptake and blood pressure regulation

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World Journal of Nephrology 2015年第3期4卷 363-366页

作者： wenzheng zhang Graduate School of Biomedical Sciences the University of Texas Health Science Center at Houston Department of Internal Medicine University of Texas Medical School at Houston

The epithelial Na^＋ channel （ENaC） consists of α, β, γ subunits. Its expression and function are regulated by aldosterone at multiple levels including transcription. ENaC plays a key role in Na^＋ homeostasis and blood pressure. Mutations in ENaC subunit genes result in hypertension or hypotension, depending on the nature of the mutations. Transcription of αENaC is considered as the rate-limiting step in the formation of functional ENaC. As an aldosterone target gene, αENaC is activated upon aldosterone- mineralocorticoid receptor binding to the cis-elements in the αENaC promoter, which is packed into chromatin. However, how aldosterone alters chromatin structure to induce changes in transcription is poorly understood. Studies by others and us suggest that Dot1a-Af9 complex represses αENaC by directly binding and regulating targeted histone H3 K79 hypermethylation at the specific subregions of αENaC promoter. Aldosterone decreases Dot1a-Af9 formation by impairing expression of Dot1a and Af9 and by inducing Sgk1, which, in turn, phosphorylates Af9 at S435 to weaken Dot1a-Af9 interaction. MR attenuates Dot1a-Af9 effect by competing with Dot1a for binding Af9. Af17 relieves repression by interfering with Dot1a-Af9 interaction and promoting Dot1a nuclear export. Af17^-/- mice exhibit defects in ENaC expression, renal Na^＋ retention, and blood pressure control. This review gives a brief summary of these novel fndings.

关键词： Gene transcription Chromatin Epithelial sodium channel Histone Blood pressure

Tourist Perception and Development Strategies on Culture and Commerce in a Historic Area: A Case Study of Dayan Ancient Town in Lijiang

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China City Planning Review 2024年第3期33卷 62-74页

作者： zhang wenzheng Hu Yike Liu Jinxin(Translated) School of Architecture Tianjin University 不详

The development of tourism in historic areas imposes immense pressure on heritage conservation, leading to issues such as commercial encroachment and the loss of cultural uniqueness in many domestic areas. Dayan Ancient Town, as an integral part of the Old Town of Lijiang, a World Cultural Heritage Site, faces increasing challenges due to commercialization. This paper explores the cultural and commercial development of Dayan Ancient Town from the perspective of tourist perception. Using the Analytic Hierarchy Process(AHP), this study develops an evaluation system and visualization to analyze both cultural and commercial perceptions of tourists. The findings reveal that tourists' cultural perception of the town is limited, while their commercial perception is prominent. Furthermore, the study examines the distribution of cultural attractions and commercial establishments, revealing that the current cultural attractions can't contribute to high and continuous cultural perception results. The study finally proposes recommendations for enhancing tourist perception of the ancient town, such as establishing multi-level protection and development strategies, infusing cultural attributes into business, and expanding cultural attraction clusters.

关键词： historic area Dayan Ancient Town tourist perception heritage conservation commercialization

Crystal structure of human Gadd45 reveals an active dimer

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Protein & Cell 2011年第10期2卷 814-826页

作者： wenzheng zhang Sheng Fu Xuefeng Liu Xuelian Zhao Wenchi zhang Wei Peng Congying Wu Yuanyuan Li Xuemei Li Mark Bartlam Zong-Hao Zeng Qimin Zhan Zihe Rao National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Tianjin Key Laboratory of Protein Science College of Life SciencesNankai UniversityTianjin 300071China Laboratory of Structural Biology Tsinghua UniversityBeijing 100084China State Key Laboratory of Molecular Oncology Cancer InstituteChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

The human Gadd45 protein family plays critical roles in DNA repair,negative growth control,genomic stability,cell cycle checkpoints and *** we report the crystal structure of human Gadd45,revealing a unique dimer formed via a bundle of four parallel helices,involving the most conserved residues among the Gadd45 *** analysis of human Gadd45 identified a conserved,highly acidic patch in the central region of the dimer for interaction with the proliferating cell nuclear antigen(PCNA),p21 and cdc2,suggesting that the parallel dimer is the active form for the *** assays indicate that:(1)dimerization of Gadd45 is necessary for apoptosis as well as growth inhibition,and that cell growth inhibition is caused by both cell cycle arrest and apoptosis;(2)a conserved and highly acidic patch on the dimer surface,including the important residues Glu87 and Asp89,is a putative interface for binding proteins related to the cell cycle,DNA repair and *** results reveal the mechanism of self-association by Gadd45 proteins and the importance of this self-association for their biological function.

关键词： crystal structure Gadd45 dimer DNA repair growth inhibition apoptosis

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从相变出发理解和计算变体间位向差

金属学报 2009年第8期45卷 897-905页

作者：吴静张文征清华大学材料科学与工程系先进材料实验室北京100084

本文从相变出发,结合母相对称性建立相变与变体位向差之间的定量联系,详细介绍了如何计算相变矩阵和以之为基础的变体间位向差,并以fcc→bcc相变系统为例,运用相变矩阵和对称操作矩阵计算了N W位向关系下变体间位向差,结果与前人从位向... 详细信息

本文从相变出发,结合母相对称性建立相变与变体位向差之间的定量联系,详细介绍了如何计算相变矩阵和以之为基础的变体间位向差,并以fcc→bcc相变系统为例,运用相变矩阵和对称操作矩阵计算了N W位向关系下变体间位向差,结果与前人从位向关系出发计算结果一致.本文方法有助于理解位向差的成因,特别有助于开展对无理位向关系引起的变体间位向差的分析.文中还进一步运用点群理论讨论了立方系N-W,K-S,Bain位向关系下独立存在的变体数目,并且推导了相变矩阵与位向关系矩阵之间的转换关系.

关键词：变体相变晶体学对称性位向关系

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双相不锈钢中表面浮凸的测量与表征

金属学报 2005年第9期41卷 897-904页

作者：邱冬张文征清华大学材料科学与工程系北京100084

在马氏体相变表面浮凸测量的传统手段基础上,发展了双面金相位移合成法;综合运用原子力显微术(AFM)和背散射电子衍射技术(EBSD),对双相不锈钢中铁素体/奥氏体相变伴随的表面浮凸进行了系统的测量,包括奥氏体片条与铁素体基体的位向关系... 详细信息

在马氏体相变表面浮凸测量的传统手段基础上,发展了双面金相位移合成法;综合运用原子力显微术(AFM)和背散射电子衍射技术(EBSD),对双相不锈钢中铁素体/奥氏体相变伴随的表面浮凸进行了系统的测量,包括奥氏体片条与铁素体基体的位向关系、惯习面取向以及产生浮凸的位移矢最和最大浮凸角,并用O线模型进行了初步的解释.

关键词：双相不锈钢相变表面浮凸晶体学

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沉淀相变晶体学模型的研究进展

金属学报 2006年第4期42卷 341-349页

作者：邱冬张文征清华大学材料科学与工程系北京100084

相变晶体学是对工程材料进行组织设计的重要理论基础．本文综述了国内外沉淀相变晶体学模型的最新研究进展,对各个模型的使用前提、适用条件、求解思路以及自身的局限性分别进行了评述;通过比较不同模型在求解能力方面的差异,指出采用 ... 详细信息

相变晶体学是对工程材料进行组织设计的重要理论基础．本文综述了国内外沉淀相变晶体学模型的最新研究进展,对各个模型的使用前提、适用条件、求解思路以及自身的局限性分别进行了评述;通过比较不同模型在求解能力方面的差异,指出采用 O线模型和近重位位置模型相结合的方法将为理解相变晶体学特征提供更有力的理论工具．

关键词：沉淀相变晶体学理论模型位向关系惯习面