检索结果-南通市图书馆

Smart drug delivery systems to overcome drug resistance in cancer immunotherapy

Cancer Biology & Medicine 2023年第4期20卷 248-267页

作者： wenzhe yi Dan Yan Dangge Wang Yaping Li State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Department of Pharmaceutics School of PharmacyNanjing Medical UniversityNanjing 211116China Yantai Key Laboratory of Nanomedicine&Advanced Preparations Yantai Institute of Materia MedicaYantai 264000China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264000China

Cancer immunotherapy,a therapeutic approach that inhibits tumors by activating or strengthening anti-tumor immunity,is currently an important clinical strategy for cancer treatment;however,tumors can develop drug resistance to immune surveillance,resulting in poor response rates and low therapeutic *** addition,changes in genes and signaling pathways in tumor cells prevent susceptibility to immunotherapeutic ***,tumors create an immunosuppressive microenvironment via immunosuppressive cells and secrete molecules that hinder immune cell and immune modulator infiltration or induce immune cell *** address these challenges,smart drug delivery systems(SDDSs)have been developed to overcome tumor cell resistance to immunomodulators,restore or boost immune cell activity,and magnify immune *** combat resistance to small molecules and monoclonal antibodies,SDDSs are used to co-deliver numerous therapeutic agents to tumor cells or immunosuppressive cells,thus increasing the drug concentration at the target site and improving ***,we discuss how SDDSs overcome drug resistance during cancer immunotherapy,with a focus on recent SDDS advances in thwarting drug resistance in immunotherapy by combining immunogenic cell death with immunotherapy and reversing the tumor immunosuppressive *** that modulate the interferon signaling pathway and improve the efficacy of cell therapies are also ***,we discuss potential future SDDS perspectives in overcoming drug resistance in cancer *** believe that this review will contribute to the rational design of SDDSs and development of novel techniques to overcome immunotherapy resistance.

关键词： Cancer immunotherapy drug resistance smart drug delivery system immunosuppressive microenvironment immune cell

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent advances in developing active targeting and multi-functional drug delivery systems via bioorthogonal chemistry

引用

Signal Transduction and Targeted Therapy 2023年第1期8卷 13-37页

作者： wenzhe yi Ping Xiao Xiaochen Liu Zitong Zhao Xiangshi Sun Jue Wang Lei Zhou Guanru Wang Haiqiang Cao Dangge Wang Yaping Li State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Yantai Key Laboratory of Nanomedicine&Advanced Preparations Yantai Institute of Materia MedicaYantai 264000China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264000China

Bioorthogonal chemistry reactions occur in physiological conditions without interfering with normal physiological *** metabolic engineering,bioorthogonal groups can be tagged onto cell membranes,which selectively attach to cargos with paired groups via bioorthogonal *** to its simplicity,high efficiency,and specificity,bioorthogonal chemistry has demonstrated great application potential in drug *** the one hand,bioorthogonal reactions improve therapeutic agent delivery to target sites,overcoming off-target *** the other hand,nanoparticles and biomolecules can be linked to cell membranes by bioorthogonal reactions,providing approaches to developing multi-functional drug delivery systems(DDSs).In this review,we first describe the principle of labeling cells or pathogenic microorganisms with bioorthogonal *** then highlight recent breakthroughs in developing active targeting DDSs to tumors,immune systems,or bacteria by bioorthogonal chemistry,as well as applications of bioorthogonal chemistry in developing functional bio-inspired DDSs(biomimetic DDSs,cell-based DDSs,bacteria-based and phage-based DDSs)and ***,we discuss the difficulties and prospective direction of bioorthogonal chemistry in drug *** expect this review will help us understand the latest advances in the development of active targeting and multi-functional DDSs using bioorthogonal chemistry and inspire innovative applications of bioorthogonal chemistry in developing smart DDSs for disease treatment.

关键词： functional orthogonal breakthrough

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

STING agonist-boosted mRNA immunization via intelligent design of nanovaccines for enhancing cancer immunotherapy

引用

National Science Review 2023年第10期10卷 123-138页

作者： Lei Zhou wenzhe yi Zehong Zhang Xiaoting Shan Zitong Zhao Xiangshi Sun Jue Wang Hao Wang Hualiang Jiang Mingyue Zheng Dangge Wang Yaping Li State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of Sciences China State Institute of Pharmaceutical Industry Univerisity of Chinese Academy of Sciences Drug Discovery and Design Center State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Precision Research Center for Refractory Diseases Shanghai General HospitalShanghai Jiao Tong University School of Medicine Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery

Messenger RNA(mRNA) vaccine is revolutionizing the methodology of immunization in ***,mRNA immunization is drastically limited by multistage biological barriers including poor lymphatic transport,rapid clearance,catalytic hydrolysis,insufficient cellular entry and endosome ***,we design a mRNA nanovaccine based on intelligent design to overcome these *** efficient nanovaccines are carried out with machine learning techniques from datasets of various nanocarriers,ensuring successful delivery of mRNA antigen and cyclic guanosine monophosphate-adenosine monophosphate(cGAMP) to *** activates stimulator of interferon genes(STING),promotes mRNA-encoded antigen presentation and boosts antitumour immunity in vivo,thus inhibiting tumour growth and ensuring long-term survival of tumour-bearing *** work provides a feasible and safe strategy to facilitate STING agonist-synergized mRNA immunization,with great translational potential for enhancing cancer immunotherapy.

关键词： vaccine mRNA STING cancer immunotherapy nanoparticles

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

一种基于SGX的轻量Fabric链码可信执行环境构建方法

引用

信息网络安全 2022年第7期 73-83页

作者： KELEKET GOMA Christy Junior Yannick 易文哲王鹃武汉大学国家网络安全学院武汉430072 武汉大学空天信息安全与可信计算教育部重点实验室武汉430072

Hyperledger Fabric是一个开源分布式账本平台,其不仅拥有公有链防篡改、分布式记账的特点,还具有身份识别、数据保密、低延迟、高吞吐率等优点。传统Fabric架构中的链码缺乏安全执行环境,其容器执行环境会带来隐私泄露风险,而现有的智... 详细信息

Hyperledger Fabric是一个开源分布式账本平台,其不仅拥有公有链防篡改、分布式记账的特点,还具有身份识别、数据保密、低延迟、高吞吐率等优点。传统Fabric架构中的链码缺乏安全执行环境,其容器执行环境会带来隐私泄露风险,而现有的智能合约隐私保护方案无法适用于Go语言链码架构,且性能开销较大。因此,文章提出一种基于SGX的轻量Fabric链码可信执行环境构建方法及E-Fabric架构,搭建支持原生Go语言的可信镜像和容器,为链码创建可信执行环境,并通过远程认证协议验证链码是否可信。理论评估和数据测试结果表明,SGX Enclave的构建会适当增加开销,与原Fabric架构相比,E-Fabric的延迟升高了8%左右,吞吐率下降了4%左右,但整体性能达到原网络的94%,并且具有较小的可信计算基和更好的安全性。

关键词：区块链 Hyperledger Fabric 链码可信执行环境 Intel SGX

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of tetrakis (hydroxymethyl) phosphonium sulfate pretreatment on characteristics of sewage sludge

引用

Journal of Environmental Sciences 2019年第4期31卷 174-182页

作者： Yunping Han wenzhe Zhang Xiao Yu Panfen Yu Benyi Xiao Hao yi Research Center for Eco-Environmental Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences College of Textiles and Clothing Qingdao University South China Institute of Environmental Sciences Ministry of Environmental Protection

Recently, tetrakis(hydroxymethyl)phosphonium sulfate(THPS) was found to play an important role in the sludge pretreatment process. However, the effects of THPS pretreatment on the characteristics of sewage sludge are still insufficiently *** properties of sludge after pretreatment with different concentrations of THPS were investigated in this study. The results showed that pH, dewatering ability, and particle size of sludge decreased with increase in THPS concentration. The volatile suspended solids(VSS) and total suspended solids(TSS) of sludge also decreased slightly with increase in THPS concentration. The specific oxygen uptake rate(SOUR) results suggested that lower THPS concentrations(≤ 1.87 mg/g VSS) enhanced the activity of sludge, but higher concentrations(≥ 1.87 mg/g VSS) inhibited it. Gram-negative bacteria with peritrichous flagellation(such as Pseudomonas, Escherichia, and Faecalibacterium) were extremely sensitive to THPS. The decrease in specific most probable numbers(MPNs) of pathogens(total coliforms and Escherichia coli) with the increase in THPS concentration also proved the sterilization ability of THPS in the sludge pretreatment process. Pretreatment of sludge with concentrations of THPS higher than 37.41 mg/g VSS would meet the pathogen requirements for land application of Class A biosolids.

关键词： Sewage sludge Tetrakis(hydroxymerhyl) phosphonium sulfate Physicochemical properties Microbial community Pathogens

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Schaftoside inhibits 3CL^(pro)and PL^(pro)of SARS-CoV-2 virus and regulates immune response and inflammation of host cells for the treatment of COVID-19

引用

Acta Pharmaceutica Sinica B 2022年第11期12卷 4154-4164页

作者： Yang yi Meng Zhang Heng Xue Rong Yu Yang-Oujie Bao yi Kuang Yue Chai Wen Ma Jing Wang Xiaomeng Shi wenzhe Li Wei Hong Junhua Li Elishiba Muturi Hongping Wei Joachim Wlodarz Szczepan Roszak Xue Qiao Hang Yang Min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China CAS Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Bejing 100049China Faculty of Science and Technology University of SilesiaKatowice 40-007Poland Department of Phrysical and Quantum Chenmistry Faculty of ChemistryWroclaw University of Science and Technology Wroclaw 50-370Poland

It is an urgent demand worldwide to control the coronavirus disease 2019(COVID-19)pandemic caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** 3-chymotrypsin-like protease(3CL^(pro))and papain-like protease(PL^(pro))are key targets to discover SARS-CoV-2 *** screening 12 Chinese herbal medicines and 125 compounds from licorice,we found that a popular natural product schaftoside inhibited 3CL^(pro)and PL^(pro)with IC_(50)values of 1.73±0.22 and 3.91±0.19μmol/L,respectively,and inhibited SARS CoV-2 virus in Vero E6 cells with EC_(50)of 11.83±3. 23μmol/L. Hydrogen-deuterium exchange mass spectrometry analysis, quantum mechanics/molecular mechanics calculations, together with site-directed mutagenesis indicated the antiviral activities of schaftoside were related with non-covalent interactions with H41, G143 and R188 of3CLpro, and K157, E167 and A246 of PLpro. Moreover, proteomics analysis and cytokine assay revealed that schaftoside also regulated immune response and inflammation of the host cells. The antiinflammatory activities of schaftoside were confirmed on lipopolysaccharide-induced acute lung injury mice. Schaftoside showed good safety and pharmacokinetic property, and could be a promising drug candidate for the prevention and treatment of COVID-19.

关键词： COVID-19 SARS-CoV-2 3-Chymotrypsin-like protease Papain-like protease Licorice Schaftoside Immune response Infammation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Regulation of the order-disorder phase transition in a Cs_(2)NaFeCl_(6) double perovskite towards reversible thermochromic application

引用

Journal of Semiconductors 2021年第7期42卷 44-57页

作者： wenzhe Li Naveed Ur Rahman Yeming Xian Hang yin Yunkai Bao yi Long Songyang Yuan Yangyi Zhang Yaxuan Yuan Jiandong Fan Institute of New Energy Technology Department of Electronic Science and EngineeringCollege of Information Science and TechnologyJinan UniversityGuangzhou 510632China

Multifunctional lead-free double perovskites demonstrate remarkable potential towards applications in various ***,an environmentally-friendly,low-cost,high-throughput Cs_(2)NaFeCl_(6) single crystal with exceedingly high thermal stability is designed and *** obtains a cubic lattice system in the temperature range of 80-500 K,accompanied by a completely reversible chromatic variation ranging from yellow to ***,the intriguing thermochromism is proved to own extremely high reproducibility(over 1000 cycles)without a hysteretic effect,originating from its structural flexibility that including(i)the noteworthy distortion/deformation of[NaCl_(6)]5−and[FeCl_(6)]3−octahedra;(ii)order-disorder arrangement transition of[NaCl_(6)]5−and[FeCl6]3−octahedra as the function of *** study paves the way towards a new class of smart windows and camouflage coatings with an unprecedented colour range based on a Cs_(2)NaFeCl_(6) perovskite.

关键词： lead-free perovskite Cs_(2)NaFeCl_(6)single crystal thermochromism crystallographic structure order-disorder phase transition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A MESSAGE-DRIVING FORMALISM FOR MODELING AND SIMULATION OF MULTI-AGENT SUPPLY CHAIN SYSTEMS

引用

Journal of Systems Science and Systems Engineering 2011年第4期20卷 385-399页

作者： wenzhe TAN1 Yueting CHAI2 yi LIU3 1Department of Automation, Tsinghua University, Beijing, 100084, China 2Department of Automation, Tsinghua University, Beijing, 100084, China 3Department of Automation, Tsinghua University, Beijing, 100084, China Department of Automation Tsinghua University Beijing China

To acquire a competitive advantage in the expanding market, manufacturing enterprises should be able to manage their supply chains as effectively as possible. It is now becoming popular to model supply chains as multi-agent systems and use discrete event simulation to learn more about their behaviors or investigate the implications of alternative configurations. In order to enhance the computational efficiency and keep the simulation credibility, this paper proposes a message-driving formalism for the simulation of multi-agent supply chain systems. Through the message-driving formalism, the problem of shared variables is addressed and the parallel operation of agents is implemented. Simulation experiments with a prototype implementation show that the message-driving formalism is able to provide credible results in significantly less simulation time.

关键词： Supply chain multi-agent system modeling and simulation parallel discrete event simulation message-driving formalism

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

脉冲激光法连续制备纳米铁溶胶及其分散稳定性的研究

引用

化学学报 2003年第1期61卷 141-145页

作者：章仪陈文哲章文贡福州大学材料学院福建师范大学高分子研究所福州350007

提出脉冲激光轰击浸于流动液相中铁靶的新方法,连续制备得到纳米铁乙醇溶胶并采用TEM,FT IR,UV vis对其进行表征.透射电镜发现其粒径分布在 10～ 30nm,傅立叶红外光谱发现乙醇分子基团振动波长受纳米铁颗粒的影响,可见-紫外光谱的分析... 详细信息

提出脉冲激光轰击浸于流动液相中铁靶的新方法,连续制备得到纳米铁乙醇溶胶并采用TEM,FT IR,UV vis对其进行表征.透射电镜发现其粒径分布在 10～ 30nm,傅立叶红外光谱发现乙醇分子基团振动波长受纳米铁颗粒的影响,可见-紫外光谱的分析结果表明其在 2 37 82nm,2 72 93nm,30 8 43nm处附近有吸收.通过UV vis及TEM研究了添加十二烷醇聚氧乙烯醚(OP 10 )对纳米铁溶胶的分散稳定性的影响.结果表明,加入 0 10

关键词：脉冲激光法纳米材料铁溶胶分散稳定性乙醇

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation

引用

Journal of Pharmaceutical Analysis 2024年第1期14卷 115-127页

作者： Yang yi wenzhe Li Kefang Liu Heng Xue Rong Yu Meng Zhang Yang-Oujie Bao Xinyuan Lai Jingjing Fan Yuxi Huang Jing Wang Xiaomeng Shi Junhua Li Hongping Wei Kuanhui Xiang Linjie Li Rong Zhang Xin Zhao Xue Qiao Hang Yang Min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing100191China Yunnan Baiyao International Medical Research Center Peking UniversityBeijing100191China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China CAS Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking University Health Science CenterPeking UniversityBeijing100191China Hubei Jiangxia Laboratory Wuhan430000China Shenzhen Children's Hospital ShenzhenGuangdong518036China

Currently,human health due to corona virus disease 2019(COVID-19)pandemic has been seriously *** coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)spike(S)protein plays a crucial role in virus transmission and several S-based therapeutic approaches have been approved for the treatment of ***,the efficacy is compromised by the SARS-CoV-2 evolvement and *** we report the SARS-CoV-2 S protein receptor-binding domain(RBD)inhibitor licorice-saponin A3(A3)could widely inhibit RBD of SARS-CoV-2 variants,including Beta,Delta,and Omicron BA.1,XBB and ***,A3 could potently inhibit SARS-CoV-2 Omicron virus in Vero E6 cells,with EC50 of 1.016μ*** mechanism was related to binding with Y453 of RBD determined by hydrogen-deuterium exchange mass spectrometry(HDX-MS)analysis combined with quantum mechanics/molecular mechanics(QM/MM)***,phosphoproteomics analysis and multi fluorescent immunohistochemistry(mIHC)respectively indicated that A3 also inhibits host inflammation by directly modulating the JNK and p38 mitogen-activated protein kinase(MAPK)pathways and rebalancing the corresponding immune *** work supports A3 as a promising broad-spectrum small molecule drug candidate for COVID-19.

关键词： COVID-19 Inflammation Licorice-saponin A3 Receptor-binding domain(RBD) SARS-CoV-2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：