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Testicular cancer in patients after treatment of cryptorchidism

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The Chinese-German Journal of Clinical Oncology 2011年第1期10卷 40-42页

作者： Tao Ma Jingyang Guo wenzeng yang Hongyue Zhou Chunli Zhao Yanqiao Zhang Department of Urology Affiliated Hospital of Hebei University Baoding 071000 China

Objective: We summarized the relationship between the descent of a testicle into the scrotum and testicular ***: Twenty-eight patients with testicular cancer after surgical treatment of cryptorchidism were retrospective ***: All patients were performed surgical treatment of cryptorchidism from 2 to 28 years old (median,12 years;average,16 years).Testicular cancer age ranged from 19 to 53 years (median,33 years;average,36 years).Malignant transformation occurred from 3 to 25 years of operation time (average,18 years).Twenty-seven cases of malignant cryptorchidism ipsilateral,contralateral malignancy in 1 case,27 cases were underwent radical resection of testicular *** diagnosis was mainly *** lymph node dissection was done in 3 cases,18 cases were chemotherapy and radiotherapy in 3 ***: The undescended testicle is the most common genital malformation in *** diagnosed,it should be treated as early as possible,but successful treatment appears not to lessen the risk of testicular cancer,patients must be closely monitored follow-up.

关键词： cryptorchidism surgical treatment testicular cancer malignancy

Robot-Assisted Laparoscopic Resection of Large-Volume Pheochromocytoma through the Surface of the Kidney

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Surgical Science 2021年第12期12卷 391-398页

作者： Tao Ma Zhenyu Cui Shichao Song Yong Suo wenzeng yang Jingyang Guo Department of Urology Affiliated Hospital of Hebei University Baoding China

Objective: To investigate the clinical application of robot-assisted laparoscopic surgery on the treatment of large-volume pheochromocytoma. Methods: A retrospective analysis of 31 patients with pheochromocytoma disease admitted to the Department of Urology, Affiliated Hospital of Hebei University from May 2020 to August 2021. According to clinical data, the tumor volume was 62.4 ± 29.5 mm, including 16 males and 15 females, aged (35.6 ± 16.1) years old;17 cases on the left side and 14 cases on the right side. All patients underwent anatomical resection through the renal superficial approach, and underwent pheochromocytoma resection through the retroperitoneal approach. The operation time, blood loss, postoperative complications, retention time of drainage tube and postoperative follow-up were observed. Results: All the 31 operations were successful, and there were no obvious postoperative complications. The average operation time, blood loss, and drainage tube retention time were 71 min, 80 mL, and (1.2 ± 0.6) days, respectively. Postoperative pathology was confirmed to be pheochromocytoma. There was no tumor recurrence in the follow-up for 1

三维可视化成像技术在机器人辅助肾部分切除术治疗复杂肾肿瘤中的应用

维普期刊数据库评论

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现代肿瘤医学 2023年第7期31卷 1311-1314页

作者：杨小龙崔振宇马涛杨文增河北大学附属医院/临床医学院河北保定071000 河北大学附属医院泌尿外科河北保定071000

目的:探讨三维可视化成像技术在机器人辅助肾部分切除术(robot-assisted partial nephrectomy,RAPN)治疗复杂肾肿瘤中的应用价值。方法:回顾性分析我院2020年05月至2022年08月收治的92例复杂肾肿瘤患者的临床资料。43例患者(A组)术前行... 详细信息

目的:探讨三维可视化成像技术在机器人辅助肾部分切除术(robot-assisted partial nephrectomy,RAPN)治疗复杂肾肿瘤中的应用价值。方法:回顾性分析我院2020年05月至2022年08月收治的92例复杂肾肿瘤患者的临床资料。43例患者(A组)术前行三维可视化成像,其余49例患者(B组)未做。比较两组患者的手术时间、热缺血时间、术后24 h内血肌酐和血红蛋白变化值、术后拔管时间、术后住院时间等。结果:两组手术均顺利完成,无中转开放病例。A组相比B组热缺血时间显著缩短[(21.23±0.96)min vs (28.29±0.84)min,P0.05)。B组1例患者术后出现尿瘘,于术后第3天行输尿管支架置入术,后好转。结论:三维可视化成像技术可缩短RAPN治疗复杂肾肿瘤的热缺血时间、术后住院时间,减少术中出血量,降低并发症发生率,具有较大的临床应用价值。

关键词：肾肿瘤三维可视化成像机器人肾部分切除术

开放手术治疗复杂性肾门区肾癌保留肾单位22例报告

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东南大学学报（医学版） 2020年第3期39卷 354-357页

作者：付泽圣杨文增河北大学附属医院河北保定071000

目的:分享保留肾单位的肾癌手术的处理技巧。方法:回顾性分析2018年1月至10月复杂性肾门区肾癌患者的临床资料。根据肾脏肿瘤测量评分系统(R.E.N.A.L)进行评估,选取总分大于9分的患者,同时患者存在腹痛、腰痛、血尿,伴或不伴有副瘤综合... 详细信息

目的:分享保留肾单位的肾癌手术的处理技巧。方法:回顾性分析2018年1月至10月复杂性肾门区肾癌患者的临床资料。根据肾脏肿瘤测量评分系统(R.E.N.A.L)进行评估,选取总分大于9分的患者,同时患者存在腹痛、腰痛、血尿,伴或不伴有副瘤综合征表现。共入选患者22例,其中男14例,女8例;年龄52~75岁,平均(68.42±1.53)岁;肿瘤直径8~13 cm,平均(10.53±1.62)cm。均未发现有区域肿大淋巴结,分期均为T2N0M0。对患者均行保留肾单位的开放手术治疗。术后评估肾小球滤过率(GFR),并总结分析在保留肾单位的手术过程中的处理技巧、手术心得。结果:孤立肾肾门区肾癌患者10例,肾门区巨大肾癌(直径>10 cm)患者12例,经开放性肾癌保留肾单位手术治疗后均完全治愈。术后患者获1年随访,均全部存活,无肿瘤复发。手术过程中应用α-氰基丙烯酸正丁酯和娴熟的缝合技术可大大减少出血。其次,充分调动术者感官体验,更加完整地切除患肾肿瘤病灶,尽可能减少对残存肾单位的损伤,最大限度保留肾单位。结论:对复杂性肾门区肾癌行开放肾癌保留肾单位手术在当前仍为一种重要的手术选择,其具有暴露瘤体快、术中出血少、手术及热缺血时间短、手术切缘阳性率低、手术难度相对较小、术后并发症发生率低的优势,为一种行之有效的治疗措施。

关键词：复杂性肾癌肾单位开放性手术

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腹腔镜手术CO_2气腹对机体的影响

医学研究与教育 2013年第3期30卷 70-74页

作者：杨文增郭景阳河北大学附属医院泌尿外科河北保定071000

腹腔镜手术中需要CO2气腹维持操作空间,随着腹腔镜技术的进步,目前较大手术亦可以在腔镜下完成,手术时间相对延长,CO2气腹对内脏器官的压迫及气体的吸收均给患者的机体造成一定的影响,现就CO2气腹压力变化及气体吸收对机体功能的影响,... 详细信息

腹腔镜手术中需要CO2气腹维持操作空间,随着腹腔镜技术的进步,目前较大手术亦可以在腔镜下完成,手术时间相对延长,CO2气腹对内脏器官的压迫及气体的吸收均给患者的机体造成一定的影响,现就CO2气腹压力变化及气体吸收对机体功能的影响,给予综述。

关键词：腹腔镜手术 CO2气腹机体机能

Efficacy and safety of LY01005 versus goserelin implant in Chinese patients with prostate cancer: A multicenter, randomized, open-label, phase III, non-inferiority trial

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Chinese Medical Journal 2023年第10期136卷 1207-1215页

作者： Chengyuan Gu Zengjun Wang Tianxin Lin Zhiyu Liu Weiqing Han Xuhui Zhang Chao Liang Hao Liu yang Yu Zhenzhou Xu Shuang Liu Jingen Wang Linghua Jia Xin Yao Wenfeng Liao Cheng Fu Zhaohui Tan Guohua He Guoxi Zhu Rui Fan wenzeng yang Xin Chen Zhizhong Liu Liqiang Zhong Benkang Shi Degang Ding Shubo Chen Junli Wei Xudong Yao Ming Chen Zhanpeng Lu Qun Xie Zhiquan Hu Yinhuai Wang Hongqian Guo Tiwu Fan Zhaozhao Liang Peng Chen Wei Wang Tao Xu Chunsheng Li Jinchun Xing Hong Liao Dalin He Zhibin Wu Jiandi Yu Zhongwen Feng Mengxiang yang Qifeng Dou Quan Zeng Yuanwei Li Xin Gou Guangchen Zhou Xiaofeng Wang Rujian Zhu Zhonghua Zhang Bo Zhang Wanlong Tan Xueling Qu Hongliang Sun Tianyi Gan Dingwei Ye Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Urology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120China Department of Urology The Second Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116023China Department of Urology The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityHunan Cancer CenterChangshaHunan 410013China Department of Urology First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030000China Department of Urology Jiangxi Provincial People’s HospitalSchool of MedicineNanchang UniversityNanchangJiangxi 330006China Department of Urology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Urology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyangLiaoning 110043China Department of Urology Inner Mongolia People’s HospitalHohhotInner Mongolia 010010China Department of Urinary Surgery Taizhou Hospital of Traditional Chinese MedicineTaizhouJiangsu 225300China Department of Urology Linfen People’s HospitalLinfenShanxi 041000China Department of Urology Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhouHenan 450006China Department of Urology The Affiliated Hospital of Hebei UniversityBaodingHebei 071000China Department of Urology Chifeng Municipal HospitalChifeng Clinical Medical College of Inner Mongolia Medical UniversityChifengInner Mongolia 024000China Department of Urology Baogang HospitalBaotouInner Mongolia 014010China Department of Oncology The Second People’s Hospital of YibinYibinSichuan 644000China Department of Urology Qilu Hospital of Shandong UniversityJinanShandong 250014China Department of Urology Henan Provincial People’s Hos

Background:LY01005(Goserelin acetate sustained-release microsphere injection)is a modified gonadotropin-releasing hormone(GnRH)agonist injected *** phase III trial study aimed to evaluated the efficacy and safety of LY01005 in Chinese patients with prostate ***:We conducted a randomized controlled,open-label,non-inferiority trial across 49 sites in *** study included 290 patients with prostate cancer who received either LY01005 or goserelin implants every 28 days for three *** primary efficacy endpoints were the percentage of patients with testosterone suppression≤50 ng/dL at day 29 and the cumulative probability of testosterone≤50 ng/dL from day 29 to ***-inferiority was prespecified at a margin of-10%.Secondary endpoints included significant castration(≤20 ng/dL),testosterone surge within 72 h following repeated dosing,and changes in luteinizing hormone,follicle-stimulating hormone,and prostate specific antigen ***:On day 29,in the LY01005 and goserelin implant groups,testosterone concentrations fell below medical-castration levels in 99.3%(142/143)and 100%(140/140)of patients,respectively,with a difference of-0.7%(95%confidence interval[CI],-3.9%to 2.0%)between the two *** cumulative probabilities of maintaining castration from days 29 to 85 were 99.3%and 97.8%,respectively,with a between-group difference of 1.5%(95%CI,-1.3%to 4.4%).Both results met the criterion for *** endpoints were similar between *** treatments were ***01005 was associated with fewer injection-site reactions than the goserelin implant(0%vs.1.4%[2/145]).Conclusion:LY01005 is as effective as goserelin implants in reducing testosterone to castration levels,with a similar safety *** registration:***,NCT04563936.

关键词： Prostatic neoplasms LY01005 Gonadotropin-releasing hormone agonist Efficacy Safety

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经皮肾镜通道建立的临床研究

临床泌尿外科杂志 2011年第2期26卷 87-88,91页

作者：杨文增郭景阳魏若晶古德强张伟张萌河北大学附属医院泌尿外科河北保定071000

目的:总结经皮肾镜通道建立的经验、体会。方法:回顾性分析因结石住院行经皮肾镜碎石术的1200例患者临床资料,1 200例均行经皮肾镜碎石术。结果:1 192例患者均1次通道建立成功,另8例患者中2例择期2次穿刺成功、3例要求转院,另外3例在专... 详细信息

目的:总结经皮肾镜通道建立的经验、体会。方法:回顾性分析因结石住院行经皮肾镜碎石术的1200例患者临床资料,1 200例均行经皮肾镜碎石术。结果:1 192例患者均1次通道建立成功,另8例患者中2例择期2次穿刺成功、3例要求转院,另外3例在专家指导下穿刺成功,该8例患者均在开展该项目的早期阶段。结论:经皮肾镜是治疗上尿路结石的较好方法,具有创伤小、恢复快的优点,其关键是通道的建立,注重术中的经验体会及刻意的B超水平训练是成功建立通道的关键。

关键词：经皮肾镜工作通道建立方法

前列腺偶发癌根治性前列腺切除术后的疗效随访

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中华泌尿外科杂志 2017年第9期38卷 702-706页

作者：高超杨文增崔振宇郭景阳宋士超河北大学附属医院泌尿外科保定071000

目的探讨良性前列腺增生（BPH）术后发现前列腺偶发癌（incidental prostate cancer,IPCa）患者接受根治性前列腺切除术（radical prostatectomy,RP）后的长期疗效,分析IPCa患者行BPH手术后前列腺癌残留及RP术后生化复发的危险因素.方... 详细信息

目的探讨良性前列腺增生（BPH）术后发现前列腺偶发癌（incidental prostate cancer,IPCa）患者接受根治性前列腺切除术（radical prostatectomy,RP）后的长期疗效,分析IPCa患者行BPH手术后前列腺癌残留及RP术后生化复发的危险因素.方法回顾性分析2004年1月至2016年10月我院收治的45例IPCa患者的临床病理及随访资料,患者均为BPH术后病理诊断为前列腺癌并接受RP.包括年龄、BPH术前及术后的PSA、前列腺体积、BPH术后前列腺癌T分期（T1a、T1b）及Gleason评分、RP术后前列腺癌T分期（pT0、pT2、pT3）及Gleason评分、生化复发情况.通过Logistic多元回归分析与BPH术后前列腺癌残留相关的因素,应用Cox回归分析RP术后生化复发的危险因素.结果 45例患者中T1a期21例,T1b期24例,其中7例（15.6％） BPH术后无前列腺癌残留,即为pT0期.logistic回归多因素分析结果显示,BPH术前PSA（RR =2.58,95％ CI 1.27 ～ 5.42,P=0.04）、BPH术后PSA（RR =4.26,95％ CI2.57 ～7.64,P=0.01）及BPH术后Gleason评分（RR =3.98,95％ CI1.85 ～5.77,P =0.02）是显著影响BPH术后前列腺癌残留的相关因素.术后随访5～44个月,平均54个月.5年和10年的总体无生化复发生存率分别为95.6％和86.7％.多因素Cox回归分析结果显示BPH术后PSA（RR=4.79,95％ CI2.57 ～ 7.64,P=0.02）及BPH术后Gleason评分（RR =2.01,95％ CI 1.74 ～5.21,P=0.04）是RP术后生化复发的独立危险因素.而BPH术后T分期（T1a、T1b）与BPH术后前列腺癌残留及RP术后生化复发无明显相关性（均P＞0.05）.结论 BPH术后发现IPCa的患者接受RP可获得良好的长期肿瘤控制效果,BPH术前PSA、BPH术后PSA及BPH术后Gleason评分是显著影响BPH术后前列腺癌残留的相关因素,而BPH术后PSA和RP术后Gleason评分是影响RP术后生化复发的独立危险因素.

关键词：前列腺肿瘤偶发癌根治性前列腺切除术生化复发

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双侧精索扭转6例诊治体会

临床泌尿外科杂志 2010年第5期25卷 333-334,336页

作者：马涛杨文增周洪月赵春利魏若晶李昱河北大学附属医院泌尿外科河北保定071000

目的:探讨精索扭转的诊断和治疗方法。方法:回顾性分析6例双侧精索扭转患者的诊断和治疗经验。结果:6例患者均为双侧发病。1例双侧睾丸同时扭转,5例双侧睾丸相继扭转;2例行单侧睾丸切除,其余扭转睾丸行复位固定。结论:精索扭转需早期诊... 详细信息

目的:探讨精索扭转的诊断和治疗方法。方法:回顾性分析6例双侧精索扭转患者的诊断和治疗经验。结果:6例患者均为双侧发病。1例双侧睾丸同时扭转,5例双侧睾丸相继扭转;2例行单侧睾丸切除,其余扭转睾丸行复位固定。结论:精索扭转需早期诊断并及时手术探查行复位固定,患侧复位固定同时可行健侧固定,如不行健侧固定必须严密监测随访。手法复位可作为有益尝试。

关键词：精索扭转诊断治疗复位