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肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍

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中华高血压杂志 2016年第10期24卷 927-927页

作者：刘莉叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C wenzel p

肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法：与常规饲养的小鼠（conventionally raised rats,CONV-R）比较,未受任何细菌影响的... 详细信息

肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法：与常规饲养的小鼠（conventionally raised rats,CONV-R）比较,未受任何细菌影响的无菌小鼠（GF）表现出较为严重的全身性辅助性T细胞1型滞后。

关键词：血管功能障碍肠道菌群血管紧张素Ⅱ 高血压辅助性T细胞1型免疫细胞功能无菌小鼠肠道微生物

The transcriptomic signature of responses to larval crowding in Drosophila melanogaster

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Insect Science 2023年第2期30卷 539-554页

作者： Juliano Morimoto Marius wenzel Davina Derous Youn Henry Herve Colinet School of Biological Sciences University of AberdeenAberdeenUnited Kingdom programa de pos-graduacao em Ecologia e Conservacao Universidade Federal do ParanaCuritibaBrazil Institute of Mathematics King's CollegeUniversity of AberdeenAberdeenUnited Kingdom CNRS ECOBIO(Ecosystemesbiodiversiteévolution)—UMR 6553University of RennesRennesFrance Department of Ecology and Evolution University of LausanneLausanneSwitzerland

Intraspecific competition at the larval stage is an important ecological factor affecting life-history,adaptation and evolutionary trajectory in holometabolous ***,the molecular pathways underpinning these ecological processes are poorly *** reared Drosophila melanogaster at three egg densities(5,60,and 300 eggs/mL)and sequenced the transcriptomes of pooled third-instar *** also examined emergence time,egg-to-adult viability,adult mass,and adult sex-ratio at each *** crowding had minor detrimental effects on adult phenotypes compared to low density and yielded 24 differentially expressed genes(DEGs),including several chitinase *** contrast,high crowding had substantial detrimental effects on adult phenotypes and yielded 2107 *** these,upregulated gene sets were enriched in sugar,steroid and amino acid metabolism as well as DNA replication pathways,whereas downregulated gene sets were enriched in ABC transporters,taurine,Toll/Imd signaling,and p450 xenobiotics metabolism ***,our findings show that larval crowding has a large consistent effect on several molecular pathways(i.e.,core responses)with few pathways displaying density-specific regulation(i.e.,idiosyncratic responses).This provides important insights into how holometabolous insects respond to intraspecific competition during development.

关键词： intraspecific competition larval crowding life-history trade-offs transcriptomics

Impact of body composition on survival and morbidity after liver resection in hepatocellular carcinoma patients

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Hepatobiliary & pancreatic Diseases International 2019年第1期18卷 28-37页

作者： Andreas Kroh Diane Uschner Toine Lodewick Roman M Eickhoff wenzel Sch?ning Florian T Ulmer Ulf p Neumann Marcel Binneb?sel Department of General Visceral and Transplant Surgery University Hospital RWTH Aachen Institute of Medical Statistics University Hospital RWTH Aachen Department of Surgery Maastricht University Medical Center Department of Radiology Zuyderland Medical Centre Department of Radiology Maastricht University Medical Centre

Background: Hepatocellular carcinoma is the most common innate liver tumor. Due to improved surgical techniques, even extended resections are feasible, and more patients can be treated with curative intent. As the liver is the central metabolic organ, preoperative metabolic assessment is crucial for risk stratification. Sarcopenia, obesity and sarcopenic obesity characterize body composition and metabolic status. Here we present the impact of body composition on survival after liver resection in patients with hepatocellular carcinoma. Methods: A retrospective database analysis of 70 patients who were assigned for liver resection due to hepatocellular carcinoma was conducted. For assessment of sarcopenia and obesity, skeletal muscle surface area was measured at lumbar vertebra 3 level(L3) in preoperative four-phase contrast enhanced abdominal CT scans, and L3 muscle index and body fat percentage were calculated. Results: Univariate analysis comparing the survival curves using the score test demonstrated superior postoperative overall survival for sarcopenic( p = 0.035) and sarcopenic obese( p = 0.048) patients as well as a trend favoring obese( p = 0.130) subjects. Whereas multivariate analysis could not identify significant difference in postoperative survival regarding sarcopenia, obesity or sarcopenic obesity. Only large tumor size, multifocal disease and male gender were risk factors for long-term survival. Conclusions: Sarcopenia, obesity and sarcopenic obesity are indeed no risk factors for poor postoperative survival in this study. Our data do not support the evaluation of sarcopenia, obesity and sarcopenic obesity before liver resection in hepatocellular carcinoma patients.

关键词： Hepatocellular carcinoma Sarcopenia Obesity Sarcopenic obesity Liver resection

Wheat yield prediction by zero sink and equilibrium-type soil phosphorus tests

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pedosphere 2022年第4期32卷 543-554页

作者： Walter W.wenzel Cornelia MESMER Eric J.FLORIDA Markus pUSCHENREITER Holger KIRCHMANN Institute of Soil Research Department of Forest and Soil SciencesUniversity of Natural Resources and Life Sciences ViennaKonrad-Lorenz-Straße 24Tulln A-3430Austria College of Agriculture and Forestry Mindanao State University at NaawanNaawan 9023Philippines Department of Soil and Environment Swedish University of Agricultural SciencesBox 701475007 UppsalaLennart Hjelms väg 9Uppsala 75651Sweden

Diffusive gradients in thin films(DGT)measurements have been shown to outperform other phosphorus(p)tests in soils with strong p sorption,but this has not been confirmed for moderately weathered European *** compared the performance of DGT in predicting wheat grain yield in Swedish long-term fertility experiments with those of standard intensity(water-extractable p(p-H2O))and quantity(ammonium lactate-extractable p(p-AL))tests.A Mitscherlich-type model was used to fit wheat yield response to p application rates(0,15,30 or 35,and 45 kg p ha-1 year-1)in each individual trial replicate to estimate the maximum *** trials with clear plateau-type yield responses and the goodness of fit(R2)>0.75,relative yields(RYs)were calculated for each p treatment and plotted against the soil p test results(n=143).The goodness of the Mitscherlich-type fits decreased in the following order:DGT-measured p(p-DGT)(R2=0.35)>p-H2O(R2=0.18)>p-AL(R2=0.13).When excluding soils with p-AL:p-DGT≥0.1 L g-1,R2 was considerably improved to 0.55 for p-AL,0.46 for p-H2O,and 0.65 for p-DGT(n=61).At 95%of maximum yield,the upper limit of p deficiency for p-DGT was 44.8(the soils with p-AL:p-DGTported for other European and Australian soils(6.0–142μg L-1).We show that in the investigated Swedish soils,DGT performed better than the quantity and intensity tests,which is attributed to its ability to capture p diffusion and resupply from the soil solid phase,similar to plant roots in the rhizosphere.

关键词： ammonium lactate-extractable phosphorus diffusive gradients in thin films(DGT) distribution coefficient long-term field experiment Mitscherlich-type model

Warm HTK donor pretreatment reduces liver injury during static cold storage in experimental rat liver transplantation

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Hepatobiliary & pancreatic Diseases International 2015年第6期14卷 596-602页

作者： wenzel Schoening Veeravorn Ariyakhagorn Thomas Schubert peter Olschewski Andreas Andreou peter Neuhaus Johann pratschke Gero puhl Allgemein- Visceral- & TransplantationschirurgieCharite Campus Virchow Klinikum General and Vascular Surgery Bumrungrad International Hospital Department of pathology University of Erlangen

BACKGROUND： Organ shortage has led to an increased number of transplantations from extended criteria donors. These organs are more vulnerable to ischemia-reperfusion injury. Thus, improvement of organ preservation is needed. HTK is a widely used preservation solution for static cold storage in liver transplantation. The present study was to investigate the beneficial effect of warm HTK donor pretreatment on liver preservation.

关键词： experimental liver transplantation static cold storage organ preservation ischemia-reperfusion injury

Loco-regional hepatocellular carcinoma treatment services as a bridge to liver transplantation

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Hepatobiliary & pancreatic Diseases International 2019年第3期18卷 228-236页

作者： Sophia Schmitz Georg Lurje Florian Ulmer Anne Andert philipp Bruners Maximilian Schulze-Hagen Ulf Neumann wenzel Schoening Department of General- Visceral- and Transplantation Surgery University Hospital of RWTH Aachen Aachen Germany Department of Diagnostic and Interventional Radiology University Hospital of RWTH Aachen Aachen Germany Department of Surgery Maastricht University Medical Center (MUMC) Maastricht Netherlands Department of Surgery Charité– University Medicine at Berlin Germany

Background: Liver transplantation remains the main curative treatment option for hepatocellular carcinoma(HCC) patients. In the Eurotransplant area Milan criteria are used to assign priority extra points(exceptional MELD, ex MELD) for patients on the waiting list. To prevent patients from tumor progression, loco-regional(neoadjuvant) treatment(LRT) is used. For patients unlikely to timely receive an organ via primary allocation,“extended critera donor(ECD) organs” are used. The present study aimed to investigate the survival after LT with a strategy of minimizing waiting list dropouts by using LRT for bridging and transplanting ECD organs if possible and necessary. Methods: Between October 2010 and May 2015, 50 liver transplants for HCC were included in this retrospective study. Of those, 42(84%) met the Milan criteria according to the preoperative radiological examination. Forty-one patients(82%) received LRT. The waiting time was analyzed according to LRT. Kaplan-Meier curves with log-rank statistics were used for survival analyses. Results: One-and five-year overall survival within Milan criteria was 94.3% and 83.7% compared with 91.7% and 67.9% beyond Milan criteria, though statistical significance was not reached( p = 0.487). LRT had no impact on overall survival( p = 0.629). Median waiting time was shorter if no LRT was performed(4.6 months vs. 1.5 months, p = 0.006) and there were no cases of waiting list dropouts. Using ECD organs had no impact on overall survival( p = 0.663). Conclusions: patients with an expected waiting time to transplantation of > 6 months could be successfully treated with LRT as a bridge to transplant. Overall and disease-free survival for patients within and beyond Milan criteria was comparable and the use of ECD organs in this cohort of HCC patients proved to be a safe option.

关键词： Hepatocellular carcinoma Liver transplantation Therapeutic embolization Liver neoplasms Organ transplantation

Validation of the Enhanced Recovery after Surgery (ERAS) society recommendations for liver surgery: a prospective, observational study

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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 20-36,I0003-I0006页

作者： Moritz Schmelzle Felix Krenzien paul Dahlke Alina Krombholz Nora Nevermann Linda Feldbrügge Axel Winter wenzel Schoning Christian Benzing Johann pratschke Jens Neudecker Department of Surgery Campus Charite Mitte and Campus Virchow-KlinikumCharite-Universitatsmedizincorporate member of Freie Universität BerlinHumboldt-Universitat zu BerlinBerlinGermany Berlin Institute of Health(BIH) BerlinGermany

Twenty-three recommendations were summarized by the Enhanced Recovery After Surgery(ERAS)society for liver *** aim was to validate the protocol especially with regard to adherence and the impact on ***:Using the ERAS Interactive Audit System(EIAS),ERAS items were evaluated in patients undergoing liver *** a period of 26 months,304 patients were prospectively enrolled in an observational study(DRKS00017229).Of those,51 patients(non-ERAS)were enrolled before and 253 patients(ERAS)after the implementation of the ERAS *** adherence and complications were compared between the two ***:Overall adherence increased from 45.2%in the non-ERAS group to 62.7%in the ERAS group(pprovements in the preoperative and postoperative phase(ppatient and intraoperative phase(both p>0.05).Overall complications decreased from 41.2%(n=21)in the non-ERAS group to 26.5%(n=67)in the ERAS group(p=0.0423),which was mainly due to the reduction of grade 1-2 complications from 17.6%(n=9)to 7.6%(n=19)(p=0.0322).As for patients undergoing open surgery,implementation of ERAS lead to a reduction of overall complications in patients scheduled for minimally invasive liver surgery(MILS)(p=0.036).Conclusions:Implementation of the ERAS protocol for liver surgery according to the ERAS guidelines of the ERAS Society reduced Clavien-Dindo grade 1-2 complications particularly in patients who underwent *** ERAS guidelines are beneficial for the outcome,while adherence to the various items has not yet been satisfactorily defined.

关键词： Enhanced Recovery After Surgery(ERAS) prehabilitation liver surger

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电动和机械混合驱动式冷却水泵

汽车与新动力 2012年第1期44卷 18-20+55页

作者： Keller p Roby J wenzel W Becker M 范明强不详

BorgWarner公司新开发的混合驱动式冷却水泵将电动和机械驱动式水泵的优点集为一体:在电动驱动模式下,它可柔性调节,而在机械驱动模式下又能十分高效率地工作。广泛的模拟计算表明,这种混合驱动式冷却水泵具有更大的节油潜力。

关键词：混合驱动式冷却水泵发动机热管理燃油耗