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Impact of body composition on survival and morbidity after liver resection in hepatocellular carcinoma patients

Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 28-37页

作者： Andreas Kroh Diane Uschner Toine Lodewick Roman M Eickhoff wenzel sch?ning Florian T Ulmer Ulf P Neumann Marcel Binneb?sel Department of General Visceral and Transplant Surgery University Hospital RWTH Aachen Institute of Medical Statistics University Hospital RWTH Aachen Department of Surgery Maastricht University Medical Center Department of Radiology Zuyderland Medical Centre Department of Radiology Maastricht University Medical Centre

Background: Hepatocellular carcinoma is the most common innate liver tumor. Due to improved surgical techniques, even extended resections are feasible, and more patients can be treated with curative intent. As the liver is the central metabolic organ, preoperative metabolic assessment is crucial for risk stratification. Sarcopenia, obesity and sarcopenic obesity characterize body composition and metabolic status. Here we present the impact of body composition on survival after liver resection in patients with hepatocellular carcinoma. Methods: A retrospective database analysis of 70 patients who were assigned for liver resection due to hepatocellular carcinoma was conducted. For assessment of sarcopenia and obesity, skeletal muscle surface area was measured at lumbar vertebra 3 level(L3) in preoperative four-phase contrast enhanced abdominal CT scans, and L3 muscle index and body fat percentage were calculated. Results: Univariate analysis comparing the survival curves using the score test demonstrated superior postoperative overall survival for sarcopenic( P = 0.035) and sarcopenic obese( P = 0.048) patients as well as a trend favoring obese( P = 0.130) subjects. Whereas multivariate analysis could not identify significant difference in postoperative survival regarding sarcopenia, obesity or sarcopenic obesity. Only large tumor size, multifocal disease and male gender were risk factors for long-term survival. Conclusions: Sarcopenia, obesity and sarcopenic obesity are indeed no risk factors for poor postoperative survival in this study. Our data do not support the evaluation of sarcopenia, obesity and sarcopenic obesity before liver resection in hepatocellular carcinoma patients.

关键词： Hepatocellular carcinoma Sarcopenia Obesity Sarcopenic obesity Liver resection

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更高效的数字化仓库管理

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现代制造 2024年第9期 34-36页

作者： Stefanie wenzel 不详

Sanitar-Heinze公司在很短的时间里就实现了数字化仓库管理的最高效率。过去以纸张为主的物流过程现在都在全新的WMS仓库管理系统中实现了全面的数字化管理。而数字化管理带来的结果就是:物流工作流程更加透明,降低了失误率、物流职工... 详细信息

Sanitar-Heinze公司在很短的时间里就实现了数字化仓库管理的最高效率。过去以纸张为主的物流过程现在都在全新的WMS仓库管理系统中实现了全面的数字化管理。而数字化管理带来的结果就是:物流工作流程更加透明,降低了失误率、物流职工的工作效率更高。物流中心的仓储运输能力也成为企业价值增值链中的一个重要环节。

关键词：仓储运输物流过程数字化管理物流中心失误率价值增值链工作效率工作流程

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The transcriptomic signature of responses to larval crowding in Drosophila melanogaster

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Insect Science 2023年第2期30卷 539-554页

作者： Juliano Morimoto Marius wenzel Davina Derous Youn Henry Herve Colinet school of Biological Sciences University of AberdeenAberdeenUnited Kingdom Programa de Pos-graduacao em Ecologia e Conservacao Universidade Federal do ParanaCuritibaBrazil Institute of Mathematics King's CollegeUniversity of AberdeenAberdeenUnited Kingdom CNRS ECOBIO(Ecosystemesbiodiversiteévolution)—UMR 6553University of RennesRennesFrance Department of Ecology and Evolution University of LausanneLausanneSwitzerland

Intraspecific competition at the larval stage is an important ecological factor affecting life-history,adaptation and evolutionary trajectory in holometabolous ***,the molecular pathways underpinning these ecological processes are poorly *** reared Drosophila melanogaster at three egg densities(5,60,and 300 eggs/mL)and sequenced the transcriptomes of pooled third-instar *** also examined emergence time,egg-to-adult viability,adult mass,and adult sex-ratio at each *** crowding had minor detrimental effects on adult phenotypes compared to low density and yielded 24 differentially expressed genes(DEGs),including several chitinase *** contrast,high crowding had substantial detrimental effects on adult phenotypes and yielded 2107 *** these,upregulated gene sets were enriched in sugar,steroid and amino acid metabolism as well as DNA replication pathways,whereas downregulated gene sets were enriched in ABC transporters,taurine,Toll/Imd signaling,and P450 xenobiotics metabolism ***,our findings show that larval crowding has a large consistent effect on several molecular pathways(i.e.,core responses)with few pathways displaying density-specific regulation(i.e.,idiosyncratic responses).This provides important insights into how holometabolous insects respond to intraspecific competition during development.

关键词： intraspecific competition larval crowding life-history trade-offs transcriptomics

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Mosaic theory revised:inflammation and salt play central roles in arterial hypertension

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Cellular & Molecular Immunology 2022年第5期19卷 561-576页

作者： Felicitas E.Hengel Jean-Pierre Benitah Ulrich O.wenzel Ⅲ.Department of Medicine University Hospital Hamburg-EppendorfHamburgGermany Inserm UMR-S 1180 Faculty of PharmacyUniversity Paris SaclayGif-sur-YvetteFrance

The mosaic theory of hypertension was advocated by Irvine Page~80 years ago and suggested that hypertension resulted from the close interactions of different *** evidence indicates that hypertension and hypertensive end-organ damage are not only mediated by the proposed mechanisms that result in hemodynamic *** plays an important role in the pathophysiology and contributes to the deleterious consequences of arterial *** intake is indispensable for normal body function but can be detrimental when it exceeds dietary *** data show that sodium levels also modulate the function of monocytes/macrophages,dendritic cells,and different T-cell *** of these effects are mediated by changes in the microbiome and metabolome due to high-salt *** purpose of this review is to propose a revised and extended version of the mosaic theory by summarizing and integrating recent advances in salt,immunity,and hypertension *** and inflammation are placed in the middle of the mosaic because both factors influence each of the remaining pieces.

关键词： Arterial hypertension salt innate and adaptive immunity renin angiotensin aldosterone system mineralocorticoid receptor angiotensinⅡreceptor

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ISOLATION PURIFICATION AND PRELIMINARY CHARACTERIZATION OF A PROTEIN SPECIFIC FOR WHEAT PLANTS·NONINFECTED EY PSEUDOCERCOSPORELLA HERPOTRICHOIDES

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植物病理学报 1993年第1期 37-42页

作者： V.Lind G.wenzel D-8059 Grunbach Germany Institute for Resistance Genetics

A wide range of plants respond to pathogen attack with production ofpathogenesis-related proteins This paper describes another kind of proteins-healthy specific proteins,which only appear in healthy wheat plants,whenplants are infected by ***,they disappear One of this kind ofproteins,Pc2,was purified by DEAE-cellulose ion exchange,Sephadex G-100

关键词： ISOLATION PURIFICATION AND PRELIMINARY CHARACTERIZATION OF A PROTEIN SPECIFIC FOR WHEAT PLANTS NONINFECTED EY PSEUDOCERCOSPORELLA HERPOTRICHOIDES

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Blind Spots on Achilles’ Heel:The Limitations of Vulnerability and Resilience Mapping in Research

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International Journal of Disaster Risk Science 2014年第1期5卷 74-85页

作者： Jessica Heesen Daniel F.Lorenz Michael Nagenborg Bettina wenzel Martin Voss International Center for Ethics in the Sciences and Humanities(IZEW) University of Tu¨bingen72074 TubingenGermany Disaster Research Unit(DRU) Freie Universita¨t Berlin12165 BerlinGermany Department of Philosophy University of Twente7500 AE EnschedeNetherlands

The mapping of vulnerability and resilience has become an important tool for vulnerability and resilience *** definition,maps are selective ***,the predominant methods of mapping also have *** addressing vulnerability and resilience,these limitations,barriers,and blind spots have to be taken into *** aspects cannot be easily mapped,such as specific forms of knowledge and interpretation,the processuality of vulnerability and resilience,the dynamics of social processes,the context of origin,the establishment of contingent interpretations,and so *** limitations are not only theoretically important,but also are practically significant,since maps themselves become *** are regarded as representations of reality,shape particular interpretations of vulnerability and resilience,and are used as a basis for *** the unmapped preconditions of mapping remain unconsidered,this can lead to problematic side effects.

关键词： Cartographic bias Foucault Mapping constraints Vulnerability mapping

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Wheat yield prediction by zero sink and equilibrium-type soil phosphorus tests

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Pedosphere 2022年第4期32卷 543-554页

作者： Walter W.wenzel Cornelia MESMER Eric J.FLORIDA Markus PUschENREITER Holger KIRCHMANN Institute of Soil Research Department of Forest and Soil SciencesUniversity of Natural Resources and Life Sciences ViennaKonrad-Lorenz-Straße 24Tulln A-3430Austria College of Agriculture and Forestry Mindanao State University at NaawanNaawan 9023Philippines Department of Soil and Environment Swedish University of Agricultural SciencesBox 701475007 UppsalaLennart Hjelms väg 9Uppsala 75651Sweden

Diffusive gradients in thin films(DGT)measurements have been shown to outperform other phosphorus(P)tests in soils with strong P sorption,but this has not been confirmed for moderately weathered European *** compared the performance of DGT in predicting wheat grain yield in Swedish long-term fertility experiments with those of standard intensity(water-extractable P(P-H2O))and quantity(ammonium lactate-extractable P(P-AL))tests.A Mitscherlich-type model was used to fit wheat yield response to P application rates(0,15,30 or 35,and 45 kg P ha-1 year-1)in each individual trial replicate to estimate the maximum *** trials with clear plateau-type yield responses and the goodness of fit(R2)>0.75,relative yields(RYs)were calculated for each P treatment and plotted against the soil P test results(n=143).The goodness of the Mitscherlich-type fits decreased in the following order:DGT-measured P(P-DGT)(R2=0.35)>P-H2O(R2=0.18)>P-AL(R2=0.13).When excluding soils with P-AL:P-DGT≥0.1 L g-1,R2 was considerably improved to 0.55 for P-AL,0.46 for P-H2O,and 0.65 for P-DGT(n=61).At 95%of maximum yield,the upper limit of P deficiency for P-DGT was 44.8(the soils with P-AL:P-DGT<0.1 L g-1)and 61.9μg L-1(all soils),falling within the range reported for other European and Australian soils(6.0–142μg L-1).We show that in the investigated Swedish soils,DGT performed better than the quantity and intensity tests,which is attributed to its ability to capture P diffusion and resupply from the soil solid phase,similar to plant roots in the rhizosphere.

关键词： ammonium lactate-extractable phosphorus diffusive gradients in thin films(DGT) distribution coefficient long-term field experiment Mitscherlich-type model

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Crown and leaf traits as predictors of subtropical tree sapling growth rates

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Journal of Plant Ecology 2017年第1期10卷 136-145页

作者： Ying Li wenzel Kröber Helge Bruelheide Werner Härdtle Goddert von Oheimb Faculty of Sustainability Leuphana University LüneburgInstitute of EcologyScharnhorststraße 1D-21335 LüneburgGermany Martin Luther University Halle Wittenberg Institute of Biology/Geobotany and Botanical GardenAm Kirchtor 1D-06108 HalleGermany German Centre of Integrative Biodiversity Research(iDiv)Halle-Jena-Leipzig Deutscher Platz 5eD-04103 LeipzigGermany Faculty of Environmental Sciences Technische Universität DresdenInstitute of General Ecology and Environmental ProtectionPienner Straße 7D-01735 TharandtGermany

Aims Growth rates of plants are driven by factors that influence the amount of resources captured and the efficiency of resource *** trees,the amount of light captured and the efficiency of light use strongly depends on crown characteristics and leaf *** theory predicts that both crown and leaf traits affect tree growth,few studies have yet to integrate these two types of traits to explain species-specific growth *** 37 broad-leaved tree species of subtropical forests in SE China,we investigated how interspecific differences in wood volume growth rates were affected by crown and leaf *** tested the hypotheses that(i)larger crown dimensions promote growth rates,(ii)species-specific growth rates are positively related to leaf stomatal conductance,leaf water potential and leaf chemical components,and negatively related to leaf C/N and leaf toughness and(iii)the two sets of traits better explain growth rates in combination than either *** Our study was conducted in a large-scale forest Biodiversity and Ecosystem Functioning experiment in China(BEF-China),located in a mountainous region in Jiangxi *** related 17 functional traits(two crown dimension and three crown structure traits;six physiological and six morphological leaf traits)to the mean annual growth rate of wood volume of young trees of the studied *** between crown and leaf traits were analyzed using principal component *** linear regression analysis was used to test the effect of each trait *** used multiple regression analysis to establish the relationship of growth rate to each set of traits(crown traits,physiological and morphological leaf traits)and to the combination of all types of *** coefficients of determination(R^(2)_(adj))of the best multiple regression models were compared to determine the relative explanatory power of crown and leaf traits and a combination of *** Findings The species-spec

关键词： BEF China crown characteristics physiological leaf traits morphological leaf traits wood volume

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Near-Real-Time Analysis of Publicly Communicated Disaster Response Information

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International Journal of Disaster Risk Science 2014年第3期5卷 165-175页

作者： Trevor Girard Friedemann wenzel Bijan Khazai Tina Kunz-Plapp James E.Daniell Susan A.Brink Center for Disaster Management and Risk Reduction Technology Karlsruhe Institute of Technology76187 KarlsruheGermany

Analysis of a disaster event can identify strengths and weaknesses of the response implemented by the disaster management system;however, analysis does not typically occur until after the response phase is *** result is that knowledge gained can only benefit future responses rather than the response under investigation. This article argues that there is an opportunity to conduct analysis while the response is operational due to the increasing availability of information within hours and days of a disaster event. Hence, this article introduces a methodology for analyzing publicly communicated disaster response information in near-real-time. A classification scheme for the disaster information needs of the public has been developed to facilitate analysis and has led to the establishment of best observed practice standards for content and timeliness. By comparing the information shared with the public within days of a disaster to these standards,information gaps are revealed that can be investigated further. The result is identification of potential deficiencies in communicating critical disaster response information to the public at a time when they can still be corrected.

关键词： Disaster response information Forensic disaster analysis Near-real-time analysis Post disaster evaluation

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Warm HTK donor pretreatment reduces liver injury during static cold storage in experimental rat liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2015年第6期14卷 596-602页

作者： wenzel schoening Veeravorn Ariyakhagorn Thomas schubert Peter Olschewski Andreas Andreou Peter Neuhaus Johann Pratschke Gero Puhl Allgemein- Visceral- & TransplantationschirurgieCharite Campus Virchow Klinikum General and Vascular Surgery Bumrungrad International Hospital Department of Pathology University of Erlangen

BACKGROUND： Organ shortage has led to an increased number of transplantations from extended criteria donors. These organs are more vulnerable to ischemia-reperfusion injury. Thus, improvement of organ preservation is needed. HTK is a widely used preservation solution for static cold storage in liver transplantation. The present study was to investigate the beneficial effect of warm HTK donor pretreatment on liver preservation.

关键词： experimental liver transplantation static cold storage organ preservation ischemia-reperfusion injury

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