检索结果-南通市图书馆

Hollow mesoporous polyaniline nanoparticles with high drug payload and robust photothermal capability for cancer combination therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2021年第10期34卷 221-228页

作者： Yinfeng Zhang Fang Fang Yongjie Chen Min li li li wenyue li Jinfeng Zhang International Medical Center Beijing Friendship HospitalCapital Medical UniversityBeijing100050China Key Laboratory of Molecular Medicine and Biotherapy School of Life SciencesBeijing Institute of TechnologyBeijing 100081China College of Pharmacy Chongqing Medical UniversityChongqing 400016China School of Electrical Computer and Energy EngineeringArizona State UniversityTempeArizonaUSA

In recent years,synergistic chemo-photothermal therapy has revealed promising potential in treatments against various kinds of ***,the development of superb photothermal agents with high drug loading capacity is still highly *** this work,a hollow mesoporous polyaniline nanoparticle(HPANI NP)has been developed for encapsulating chemotherapeutic drug doxorubicin(DOX)with an remarkable drug loading content as high as 37.5%.Additional PEG modification endowed the drugloaded HPANI NPs with improved water-dispersibility and *** PEG-HPANI-DOX NPs exhibited strong NIR absorbance and robust photothermal conversion capacity,exhibiting highly efficient synergistic cancer *** interestingly,the responsively released DOX molecules could emit strong red fluorescence,which could be employed to monitor the cellular endocytosis and drug release profile of PEG-HPANI-DOX ***,the as-fabricated NPs showed good biocompatibility and low toxicity,serving as a promising nanoagent for highly efficient drug delivery and cancer combination therapy.

关键词： Hollow mesoporous polyaniline nanoparticles Drug delivery Nanocarriers Chemo-photothermal therapy Cancer combination therapy

Hydroxyl radical intensified Cu2O NPs/H2O2 process in ceramic membrane reactor for degradation on DMAc wastewater from polymeric membrane manufacturer

在线全文

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2020年第6期14卷 123-134页

作者： wenyue li Min Chen Zhaoxiang Zhong Ming Zhou Weihong Xing State Key Laboratory of Materials Orented Chemical Engineein National Engineering Research Center for Specilized Separation MembranesNanjing Tech UniversityNanjing 21000China

High-concentration industrial wastewater containing N,N-dimethylacetamide(DMAc)from polymeric membrane manufacturer was degraded in Cu2O NPs/H2O2 *** the membrane assisted Fenton process DMAc removal rate was up to 98%with 120 min which was increased by 23%over the batch *** was found that:OH quench time was extended by 20 min and the maximum:0H productivity was notably 88.7%higher at 40 *** degradation reaction rate constant was enhanced by 2.2 times with membrane dispersion(k=0.0349 min^-1).DMAc initial concentration(C0)and H202 flux (Jp)had major influence on mass transfer and kinetics,meanwhile,membrane pore size(rp)and length(L)also affected the Treaction *** intensifed radical yield,fast mass transfer and nanoparticles high activity all contributed to improve pollutant degradation ***-resolved DMAC degradation pathway was analyzed as hydroxylation,demethylation and oxidation leading to the finai products of CO2;H20 and NO3^-(*** NH,from biodegradation).Continuous process was operated in the dual-membrane configuration with in situ reaction and *** five cycling,tests,DMAc removal was all above 95%for the initial[DMAc]0=14,000 mg/L in wastewater and stability of the catalyst and the membrane maintained weil.

关键词： Ceramic membrane reactor AyV-dimethylacetamide Fenton process Cu20 Wastewater treatment

Lysine-specific demethylase 1 inhibitor rescues the osteogenic ability of mesenchymal stem cells under osteoporotic conditions by modulating H3K4 methylation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2016年第4期4卷 217-231页

作者： Longwei Lv Wenshu Ge Yunsong liu Guanyou Lai Hao liu wenyue li Yongsheng Zhou Department of Prosthodontics Peking University School and Hospital of Stomatology Beijing 100081 China Department of General Dentistry II Peking University School and Hospital of Stomatology Beijing 100081 China National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing 100081 China

Bone tissue engineering may be hindered by underlying osteoporosis because of a decreased osteogenic ability of autologous seed cells and an unfavorably changed microenvironment in these patients. Epigenetic regulation plays an important role in the developmental origins of osteoporosis; however, few studies have investigated the potential of epigenetic therapy to improve or rescue the osteogenic ability of bone marrow mesenchymal stem cells(BMMSCs) under osteoporotic conditions. Here, we investigated pargyline, an inhibitor of lysine-specific demethylase 1(LSD1), which mainly catalyzes the demethylation of the di- and mono-methylation of H3K4. We demonstrated that 1.5 mmol·Lpargyline was the optimal concentration for the osteogenic differentiation of human BMMSCs. Pargyline rescued the osteogenic differentiation ability of mouse BMMSCs under osteoporotic conditions by enhancing the dimethylation level of H3K4 at the promoter regions of osteogenesis-related genes. Moreover, pargyline partially rescued or prevented the osteoporotic conditions in aged or ovariectomized mouse models, respectively. By introducing the concept of epigenetic therapy into the field of osteoporosis, this study demonstrated that LSD1 inhibitors could improve the clinical practice of MSC-based bone tissue engineering and proposes their novel use to treat osteoporosis.

关键词： Lysine-specific demethylase 1 inhibitor rescues the osteogenic ability of mesenchymal stem cells under osteoporotic conditions by modulating H3K4 methylation OM stem BMD

Exosomes derived from human adipose-derived stem cells ameliorate osteoporosis through miR-335-3p/Aplnr axis

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第10期15卷 9135-9148页

作者： Chunhui Sheng Xiaodong Guo Zhuqing Wan Xiaoqiang Bai Hao liu Xiao Zhang Ping Zhang Yunsong liu wenyue li Yongsheng Zhou Longwei Lv National Center of Stomatology&National Clinical Research Center for Oral Disease National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing Key Laboratory of Digital StomatologyKey Laboratory of Digital StomatologyDepartment of ProsthodonticsPeking University School and Hospital of StomatologyBeijing 100081China Department of Stomatology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China.

Treatment of osteoporosis is still a challenge in clinic,which leads to an increasing social burden as the aging of *** originated from human adipose-derived stem cells(hASCs)hold promise to promote osteogenic differentiation,thus may ameliorate *** main purpose of this study was to investigate the novel usage of hASC-derived exosomes in the treatment of osteoporosis and their underlying *** types of exosomes,i.e.,exosomes derived from hASCs cultured in proliferation medium(P-Exos)and osteogenic induction medium(O-Exos),were *** compared with P-Exos,O-Exos could promote the osteogenic differentiation of mouse bone marrow-derived stem cells(mBMSCs)from osteoporotic mice in vitro and ameliorated osteoporosis in ***,microRNA(miRNA)-335-3p was identified to be the key differentially expressed microRNA between the two exosomes by small RNA sequencing,gene overexpression and knock-down,qRT-PCR,and dual-luciferase reporter assay,and Aplnr was confirmed to be the potential target gene of *** addition,miR335-3p inhibitor-optimized O-Exos were established by transfection of miR-335-3p inhibitor,which significantly enhanced the osteogenic differentiation of mBMSCs in vitro,and bone density and number of trabecular bones in vivo compared with unoptimized *** results indicated that the ASC-exosome-based therapy brings new possibilities for osteoporosis ***,engineered exosomes based on transfection of miRNA are a promising strategy to optimize the therapeutic effect of exosomes on osteoporosis.

关键词： osteoporosis adipose-derived mesenchymal stem cells exosomes microRNA osteogenic differentiation

Engineering biomimetic silk fibroin hydrogel scaffolds with“organic-inorganic assembly”strategy for rapid bone regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2024年第10期40卷 541-556页

作者： Renjie liang Rui li Weidong Mo Xianzhu Zhang Jinchun Ye Chang Xie wenyue li Zhi Peng Yuqing Gu Yuxuan Huang Shufang Zhang Xiaozhao Wang Hongwei Ouyang Department of Sports Medicine of the Second Affiliated Hospital and Liangzhu LaboratoryZhejiang University School of MedicineHangzhouChina Dr.li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine Zhejiang University School of MedicineHangzhouChina Zhejiang University-University of Edinburgh Institute Zhejiang University School of MedicineHainingChina China Orthopedic Regenerative Medicine Group(CORMed) HangzhouChina Department of Orthopedics The First Affiliated HospitalZhejiang University School of Medicine79 Qingchun RdHangzhouChina

Although natural polymers have been widely used in constructing bone scaffolds,it still remains challenging to fabricate natural polymer-derived bone scaffolds with biomimetic mechanical properties as well as outstanding osteogenic properties for large-size and weight-bearing bone defects ***,an“organic-inorganic assembly”strategy is developed to construct silk fibroin(SF)-based bone scaffolds with the aforementioned *** secondary structure reshuffling,the 3.3-fold increment ofβ-sheet structures in SF hydrogel resulted in a 100-fold improvement of mineral-assembly efficacy via influencing the ion adsorption process and providing templates for mineral ***,abundant minerals were deposited within the hydrogel and also on the surface,which indicated entire mineral-assembly,which ensured the biomimetic mechanical properties of the digital light processing 3D printed SF hydrogel scaffolds with haversian-mimicking *** vitro experiments proved that the assembly between the mineral and SF results in rapid adhesion and enhanced osteogenic differentiation of human bone marrow-derived mesenchymal stem *** vivo experiments further proved that the mineral-assembled SF hydrogel scaffold could significantly enhance integration and bone regeneration at the weight-bearing site within one *** SF-based“organic-inorganic assembly”strategy sheds light on constructing cell-free,growth factor-free and natural polymer-derived bone scaffolds with biomimetic 3D structure,mechanical properties and excellent osteogenic properties.

关键词： Silk fibroin Organic-inorganic assembly Mineralization DLP 3D printing Bone regeneration

基于全转速综合性能评价的可变循环发动机配气优化

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

机械工程学报 2012年第18期48卷 117-123页

作者：邸立明李文跃夏怀成赵永生燕山大学车辆与能源学院秦皇岛066004 燕山大学机械工程学院秦皇岛066004

针对可变循环发动机(Variable-cycle engine,VCE)二行程模式配气形式的特殊性和配气参数优化问题,以某单缸四行程发动机为基础,建立VCE四行程和二行程工作模式仿真模型,利用缸压试验验证模型的正确性,提出基于多性能评价指标的发动机综... 详细信息

针对可变循环发动机(Variable-cycle engine,VCE)二行程模式配气形式的特殊性和配气参数优化问题,以某单缸四行程发动机为基础,建立VCE四行程和二行程工作模式仿真模型,利用缸压试验验证模型的正确性,提出基于多性能评价指标的发动机综合性能量化指标复合性能系数,通过算例和模糊物元法验证了其有效性。根据复合性能系数最大化原则,对VCE二行程模式的三种缸侧排气口方案进行系列化仿真分析,得出在四圆角矩形排气口方案的气口下边沿与下止点重合情况下,当进气门在下止点前46°开启,下止点后86°关闭,排气口宽为30 mm,高为14 mm时,在全转速范围内的综合性能最好。研究表明,复合性能系数能高效地对发动机全转速范围的综合性能进行量化评价比较。

关键词：可变循环发动机参数优化综合评价性能系数

在线全文

学校读者我要写书评

暂无评论

振动台开环系统辨识与LSTM网络模拟

地震工程与工程振动 2022年第3期42卷 87-94页

作者：纪金豹李文月武剑峰北京工业大学工程抗震与结构诊治北京市重点实验室北京100124

建立准确的地震模拟振动台系统模型是开展系统分析和算法优化的必要条件。文中通过白噪声试验辨识得到某振动台的单轴闭环传递函数,通过闭环-开环模型转换获得对应的开环传递函数模型,并基于开环传递函数模型生成训练和测试数据,对构建... 详细信息

建立准确的地震模拟振动台系统模型是开展系统分析和算法优化的必要条件。文中通过白噪声试验辨识得到某振动台的单轴闭环传递函数,通过闭环-开环模型转换获得对应的开环传递函数模型,并基于开环传递函数模型生成训练和测试数据,对构建的LSTM网络模型进行训练和测试。测试结果表明,LSTM网络可以很好复现振动台的单轴开环系统特性,可用于系统仿真与算法测试的控制对象。文中的研究工作为复杂振动台开环系统模型的获取提供了一种可行的思路,相关研究工作可为基于神经网络的振动台智能控制研究提供参考和借鉴。

关键词：地震模拟振动台系统辨识 LSTM网络智能控制试验方法

磁共振成像应用于经颅磁刺激抗抑郁治疗的靶点定位和疗效预测的研究进展

在线全文

学校读者我要写书评

暂无评论

中华精神科杂志 2021年第2期54卷 147-149页

作者：邓咏妍李雯玥张宾广州医科大学附属脑科医院(广州市惠爱医院) 510370

抑郁症是一种病程长且易反复发作的心境障碍。经颅磁刺激作为一种无创的非侵入性抗抑郁治疗手段,其疗效和安全性已得到充分证实,但由于无法精确进行治疗靶点定位和疗效预测等问题,仍存在一定局限性。目前磁共振成像应用于经颅磁刺激治... 详细信息

抑郁症是一种病程长且易反复发作的心境障碍。经颅磁刺激作为一种无创的非侵入性抗抑郁治疗手段,其疗效和安全性已得到充分证实,但由于无法精确进行治疗靶点定位和疗效预测等问题,仍存在一定局限性。目前磁共振成像应用于经颅磁刺激治疗抑郁症的靶点定位和疗效预测的研究越来越多,本文中旨在整理相关研究,总结该技术的应用进展。

关键词：抑郁症经颅磁刺激磁共振成像定位疗效预测

在线全文

学校读者我要写书评

暂无评论

地震模拟振动台基础设计与建造技术综述

北京工业大学学报 2022年第8期48卷 888-897页

作者：纪金豹武剑峰李文月北京工业大学工程抗震与结构诊治北京市重点实验室北京100124

基于国内外典型振动台设计建造案例,首先总结了振动台基础结构的分类,并提出应综合考虑振动强度、结构形式和实际场地情况进行选型;其次分析了部分关键参数对振动台系统特性的影响,如基础质量在设计时不可盲目增大,需结合结构形式进行... 详细信息

基于国内外典型振动台设计建造案例,首先总结了振动台基础结构的分类,并提出应综合考虑振动强度、结构形式和实际场地情况进行选型;其次分析了部分关键参数对振动台系统特性的影响,如基础质量在设计时不可盲目增大,需结合结构形式进行综合设计;接着对《动力机器基础设计规范》方法、《基础工程手册》方法及Lysmer比拟法3种振动台基础动力计算方法进行了比较分析,归纳了每种方法的适用性;最后总结了振动台基础在施工建造过程中应考虑的关键问题,包括大体积混凝土开裂、基坑支护和预埋件安装精度,并给出解决方案.

关键词：地震模拟振动台设备基础结构选型动力计算方法施工建造基础设计