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抑郁症患者血清紧密连结蛋白-5和内源性配体-13水平变化及其与病情发展和睡眠障碍的关系

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实用医学杂志 2024年第12期40卷 1677-1682页

作者：丁志强董强利梁英石文元酒泉市人民医院神经内科甘肃酒泉735000 兰州大学第二医院心理卫生科兰州730030

目的探讨抑郁症患者血清紧密连结蛋白-5(claudin-5)和内源性配体-13(Apelin-13)水平变化及其与病情发展和睡眠障碍的关系。方法选取2021年6月至2023年7月期间酒泉市人民医院收治的128例抑郁症患者作为观察组,另选取同期体检者128例作为... 详细信息

目的探讨抑郁症患者血清紧密连结蛋白-5(claudin-5)和内源性配体-13(Apelin-13)水平变化及其与病情发展和睡眠障碍的关系。方法选取2021年6月至2023年7月期间酒泉市人民医院收治的128例抑郁症患者作为观察组,另选取同期体检者128例作为对照组。分析抑郁症患者血清claudin-5、Apelin-13表达水平与汉密顿抑郁量表(HAMD)评分的相关性以及血清claudin-5和Apelin-13对抑郁症患者病情严重程度的诊断价值。结果观察组患者血清claudin-5表达水平高于对照组,随病情严重程度的加重而升高(P<0.05),与HAMD评分呈正相关(r=0.713,P<0.05),且睡眠障碍组患者血清claudin-5表达水平高于无睡眠障碍组(P<0.05),Apelin-13表达水平变化趋势与之相反;年龄、首发抑郁年龄和claudin-5为抑郁症患者睡眠障碍的危险因素,Apelin-13为保护因素(P<0.05);血清claudin-5和Apelin-13联合检测优于各自单独检测(Z_(二者联合-claudin-5)=2.393、Z_(二者联合-Apelin-13)=1.964,P=0.016、0.044)。结论抑郁症患者血清claudin-5和Apelin-13表达水平与病情发展及睡眠障碍有关,二者联合检测对重度抑郁症具有较高的诊断价值。

关键词：抑郁症紧密连结蛋白-5 内源性配体-13 睡眠障碍

Magic angles and flat Chern bands in alternating-twist multilayer graphene system

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Journal of Materials Science & Technology 2022年第16期111卷 28-34页

作者： Zhiyong Liu wenyuan shi Teng Yang Zhidong Zhang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Western Reserve Academy 115 College Street HudsonOhio 44236United States

Based on the effective continuum model,we study alternating-twist multilayer graphene system and emergence of magic angles and flat band *** the alternating-twist multilayer graphene system(from triple layers to few layers)are found to have flat bands at magic angles where the area of AA stacking equals n-fold(n is an integer)electron cyclotron *** the pseudo-Landau-level representation,there is always an isolated Dirac band in the alternating-twist graphene system constructed by odd number of *** each pair of flat bands can be perceived as the zeroth pseudo-Landau-levels in two dimensional Dirac fermions,electron in the flat band pair can feel a pseudo-magnetic field with the same magnitude but the opposite *** Chern number for each flat band is+1(or-1)which can be tuned by twisting in the vicinity of magic angles or by *** concurrent appearance of strong correlation and band topology of flat bands in the alternating-twist multilayer graphene may pave an avenue for the new understanding of superconductivity observed in triple-layered graphene,and supply a new playground for realizing(quantum)anomalous Hall effect.

关键词： Alternating-twist multilayer graphene Magic angle Flat band Band topology

Coordinate scheduling approach for EDS observation tasks and data transmission jobs

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Journal of Systems Engineering and Electronics 2016年第4期27卷 822-835页

作者： Hao Chen Jiangjiang Wu wenyuan shi Jun Li Zhinong Zhong School of Electronics Science and Engineering National University of Defense Technology First Engineers Scientific Research Institute of General Armaments Department People's Liberation Army

Electromagnetic detection satellite（EDS） is a type of Earth observation satellite（EOS）. Satellites observation and data down-link scheduling plays a significant role in improving the efficiency of satellite observation systems. However, the current works mainly focus on the scheduling of imaging satellites, little work focuses on the scheduling of EDSes for its specific *** current works mainly schedule satellite resources and data down-link resources separately, not considering them in a globally optimal perspective. The EDSes and data down-link resources are scheduled in an integrated process and the scheduling result is searched globally. Considering the specific constraints of EDS, a coordinate scheduling model for EDS observation tasks and data transmission jobs is established and an algorithm based on the genetic algorithm is proposed. Furthermore, the convergence of our algorithm is proved. To deal with some specific constraints, a solution repairing algorithm of polynomial computing time is designed. Finally, some experiments are conducted to validate the correctness and practicability of our scheduling algorithms.

关键词： electromagnetic detection satellites scheduling satellites and ground stations coordinate scheduling constraint handling solution repairing method genetic algorithm

Germylene-Fe complexes caused by heterometallic coupling and investigation into the 3d-4p bonding

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Chinese Chemical Letters 2024年第3期35卷 304-307页

作者： Yingying Qin Yongmei Kang Lei Zhang Jianping Sun Zhijing Zhang Jialei Xu Fanlong Zeng Anyang Li wenyuan Wang Weiqun shi Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi'an 710127China Laboratory of Nuclear Energy Chemistry Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Shaanxi Coal and Chemical Industry Xi'an 710054China

The interpretation of heterometallic bonding nature is a basic work of inorganic *** means of intermetallic substitution of germylene anions with iron halide complexes CpFe(CO)_(2)I andβ-diketiminato Fe^Ⅱchloride,the ferrogermylene complexes 3a,3b and 4a were synthesized and structurally *** structural and IR characterizations show the presence of the Ge←Feπbackbonding in molecules 3a,3b and *** computational works on frontier molecular orbitals and their comparison of energy states confirmed thatσdonation andπbackbonding are both weak in these molecules,despite three complexes have longer Ge-Fe bonds,whose strength decreases slightly with the degressive electron density around Fe environment in a sequence from 3a,3b to 4a.

关键词： Metallic bonding Germylene Iron Crystal structure σbond πbackbond

粪肠球菌在不同营养状态下产生过氧化氢的检测方法建立及应用

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粪肠球菌在不同营养状态下产生过氧化氢的检测方法建立及应用

第十六次全国牙体牙髓病学学术大会

作者：相豆豆 Pu-Ting Dong Xuesong He wenyuan shi 余擎口颌系统重建与再生全国重点实验室国家口腔疾病临床医学研究中心陕西省口腔医学重点实验室第四军医大学口腔医院牙体牙髓病科 Department of Oral Medicine Infection and ImmunityHarvard School of Dental Medicine

目的:课题组前期实验证明,作为根管再次感染重要致病菌的粪肠球菌（Enterococcus faecalis,Ef）具备产生过氧化氢（HO）的能力,可能抑制与其互作的其他重要致病菌。为了系统的检测Ef在不同营养条件下的HO产生情况,本研究拟建立并应用针... 详细信息

目的:课题组前期实验证明,作为根管再次感染重要致病菌的粪肠球菌（Enterococcus faecalis,Ef）具备产生过氧化氢（HO）的能力,可能抑制与其互作的其他重要致病菌。为了系统的检测Ef在不同营养条件下的HO产生情况,本研究拟建立并应用针对Ef的系列细胞内及细胞外HO检测方法,对Ef在不同条件下的HO产生情况进行测定分析。方法:建立不同营养状态下的Ef体外模型。设计并应用不同条件下Ef细胞内以及细胞外HO的系列定性及定量测定方法。结果:成功建立了Ef的细胞内及细胞外HO的系列检测方法;首次在Ef中成功应用细胞内成像技术并检测到不同营养条件下Ef细胞内的HO产生水平;与富营养状态相比,饥饿条件下Ef的HO产量显著增加（P>0.05）,产量约达167μM;在874 cm处可观察到显着的拉曼峰。结论:我们成功建立Ef的HO系列检测方法。定性与定量系列测定结果均表明,饥饿状态可以明显促进Ef产生HO。

关键词：粪肠球菌过氧化氢饥饿状态细胞内过氧化氢检测细胞外过氧化氢检测

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构建儿科介入超声人才规范化培养模式

中华医学超声杂志（电子版） 2022年第3期19卷 193-194页

作者：石文媛倪鑫国家儿童医学中心(北京)首都医科大学附属北京儿童医院超声科 100045 国家儿童医学中心(北京)首都医科大学附属北京儿童医院耳鼻咽喉头颈外科 100045

介入超声是指在超声监视或引导下进行诊断与治疗操作的总称^([1])。近三十年来,随着超声影像技术的开发与应用,介入超声得到了快速发展。介入性超声技术与临床的完美结合日益受到临床医师和患者的青睐,在不断完善、提高和创新的基础上,... 详细信息

介入超声是指在超声监视或引导下进行诊断与治疗操作的总称^([1])。近三十年来,随着超声影像技术的开发与应用,介入超声得到了快速发展。介入性超声技术与临床的完美结合日益受到临床医师和患者的青睐,在不断完善、提高和创新的基础上,目前已广泛应用于内科、外科、妇产科、儿科等众多领域疾病的微创诊疗,涉及范围涵盖了肝、胆囊、胰腺、脾、泌尿、男性生殖系、女性盆腔、肺、纵隔、甲状腺、乳腺、浅表淋巴结及肌肉骨骼等几乎所有系统和器官的病变^([2-4]),其应用规模仍在继续扩大。

关键词：介入超声女性盆腔肌肉骨骼临床医师超声监视介入性超声技术男性生殖超声影像技术

Radiochemical studies of deep - sea manganese nodules

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Acta Oceanologica Sinica 1989年第2期8卷 253-261页

作者： Huang Yipu, Luo Shangde, shi wenyuan Chen Zhen Department of Oceanography, Xiamen University, Xiamen , china Dept. of Oceanography Xiamen Univ. Xiamen China China

Five manganese nodules collected from the Northern Mid - Pacific have been analysed for their U and Th *** is found that the enrichment of thorium compared to uranium is universal in deep- sea manganese, nodules and in the top sides of the nodules there are large excesses of Th and Pa decreasing exponentially with depth. For each of the nodules, the concordant growth rates are obtained from three different methods: 230Thex 230Thex/232Th and *** growth rates of manganese nodules are closely related to the chemical compositions of the nodules and the types of the underlying sediments. The growth rates of five nodules are determined to be in the range of 0.79-7.4 mm/106a, in agreement with those predicted from the chemical compositions of the nodules. By the comparison of the extrapolated 230Thex,230Thex/232 Th and 231PaeX data from the top and bottom surfaces of the nodule from Site M21 yields, the nodule turnover time is (9.83-13.7)×104a.

关键词： Th rate sea manganese nodules Radiochemical studies of deep

芩蒌清利汤结合火针治疗湿疹(湿热证)临床疗效观察

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中华中医药学刊 2022年第4期40卷 191-194页

作者：涂焱华时文远袁朵十堰市人民医院湖北医药学院附属人民医院湖北十堰442099 深圳市龙华区妇幼保健院广东深圳518040

目的探究芩蒌清利汤结合火针治疗湿疹(湿热证)临床疗效及安全性。方法研究共计纳入湿疹(湿热证)患者68例,均由医院中医科2018年1月—2021年1月收治,并采取随机数字表法将纳入的68例患者平均分成两组,对照组患者采取西医常规治疗方法,观... 详细信息

目的探究芩蒌清利汤结合火针治疗湿疹(湿热证)临床疗效及安全性。方法研究共计纳入湿疹(湿热证)患者68例,均由医院中医科2018年1月—2021年1月收治,并采取随机数字表法将纳入的68例患者平均分成两组,对照组患者采取西医常规治疗方法,观察组患者采取西医常规治疗方法+芩蒌清利汤结合火针治疗,比较两组患者治疗效果、治疗前后患者中医证候(皮损、瘙痒无休、身热心烦、口渴便干、尿短赤等)积分变化、患者治疗后起效时间、治疗前后患者湿疹严重程度指数(EASI)评分变化及瘙痒严重程度评分变化(视觉模拟疼痛评分法,VAS)、皮损评分变化、治疗前后患者血清炎症因子水平变化、不良反应情况。结果观察组与对照组有效率比较,观察组更高,P0.05,治疗后各组患者中医证候(皮损、瘙痒无休、身热心烦、口渴便干、尿短赤等)积分、EASI评分及VAS评分、皮损评分、血清炎症因子IL-2及IL-4水平等指标改善,观察组患者治疗后中医证候(皮损、瘙痒无休、身热心烦、口渴便干、尿短赤等)积分、EASI评分及VAS评分、皮损评分、血清炎症因子IL-2及IL-4水平等指标均优于对照组(P0.05。结论芩蒌清利汤结合火针治疗湿疹(湿热证)临床疗效显著,患者瘙痒、皮损等症状改善,恢复较好、恢复快,不良反应少,安全可行,值得应用及推广。

关键词：湿疹湿热证芩蒌清利汤火针疗效湿疹严重程度指数瘙痒严重程度皮损

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儿童难治性甲状腺功能亢进症临床治疗进展

中华医学超声杂志（电子版） 2023年第10期20卷 1012-1015页

作者：丁娇娇宋艳宁石文媛国家儿童医学中心(北京)首都医科大学附属北京儿童医院超声科 100045 国家儿童医学中心(北京)首都医科大学附属北京儿童医院内分泌遗传代谢科 100045

儿童甲状腺功能亢进症(简称甲亢)特指内源性甲状腺激素合成和分泌过多导致的一系列高代谢症候群。儿童甲亢最常见的病因是Graves病,约占95%以上。儿童和青少年的Graves病发病率因国家和地区而异,为1/10万~14/10万,且处于上升趋势^([1-3])。

关键词： Graves病甲状腺功能亢进症分泌过多高代谢症候群临床治疗进展儿童和青少年儿童甲亢难治性