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Bhlhe40 protects cochlear hair cell-like HEI-OC1 cells against H_(2)O_(2) ‑triggered oxidative injury

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BIOCELL 2024年第6期48卷 991-999页

作者： LITING WEN XIAOXIA zeng PEIXIONG CHEN DAPENG ZHAO YANGYANG LI XIANHAI zeng Department of Otorhinolaryngology Longgang Otorhinolaryngology Hospital and Shenzhen Key Laboratory of OtorhinolaryngologyShenzhen Institute of OtorhinolaryngologyShenzhenChina

Background:Cochlear hair cell injury is a common pathological feature of hearing *** basic helix-loop-helix family,member e40(Bhlhe40),a gene belonging to the basic helix-loop-helix(bHLH)family,exhibits strong transcriptional repression ***:Oxidative damage,in House Ear Institute-Organ of Corti 1(HEI-OC1)cells,was caused using hydrogen peroxide(H2O2).The Ad-Bhlhe40 particles were constructed to overexpress Bhlhe40 in HEI-OC1 *** assays including cell counting kit-8(CCK-8),terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay(TUNEL),ﬂow cytometry,immunoﬂuorescence,and corresponding commercial kits were employed to investigate the impacts of Bhlhe40 on cell viability,apoptosis,oxidative stress levels,mitochondrial membrane potential and cellular ***,a dual-luciferase reporter assay was performed to conﬁrm the targeting of the histone deacetylases 2(Hdac2)by ***:The results revealed that Bhlhe40 was downregulated in H_(2)O_(2)-treated HEI-OC1 cells,but its overexpression improved cell viability and mitigated H_(2)O_(2)-induced oxidative injury in HEI-OC1 cells with increase of superoxide dismutase(SOD),catalase(CAT)and glutathione peroxidase(GPx)activities and decrease of reactive oxygen species(ROS)***,overexpression of Bhlhe40 suppressed H_(2)O_(2)-triggered cell senescence,as evidenced by the fact that the upregulation of P53,P21,and P16 in HEI-OC1 cells treated with H2O2 were all alleviated by Bhlhe40 *** we further veriﬁed that overexpression of Bhlhe40 could inhibit the expression of Hdac2,which may be related to the repression of Hdac2 ***:This study suggests that Bhlhe40 plays a protective role against senescence and oxidative damage in cochlear hair cells exposed to H2O2.

关键词： Bhlhe40 Oxidative injury Cochlear hair cell Histone deacetylases 2

miR-99b-5p靶向FGFR3对紫杉醇诱导慢性神经病理性疼痛形成的影响

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中国疼痛医学杂志 2021年第10期27卷 737-743页

作者：韩聪徐力曾文玉辜文艳刘庆西南医科大学附属中医医院疼痛科西南医科大学附属中医医院手术室泸州646000

目的:探讨miR-99b-5p对紫杉醇诱导的大鼠慢性神经病理性疼痛的影响。方法:成年SD雄性大鼠,按照简单随机化的方法分为空白组(blank)、紫杉醇模型组(modle)、agomiR-99b-5p治疗组和agomiR-NC对照组,每组8只。采用隔日腹腔注射紫杉醇(2 mg/... 详细信息

目的:探讨miR-99b-5p对紫杉醇诱导的大鼠慢性神经病理性疼痛的影响。方法:成年SD雄性大鼠,按照简单随机化的方法分为空白组(blank)、紫杉醇模型组(modle)、agomiR-99b-5p治疗组和agomiR-NC对照组,每组8只。采用隔日腹腔注射紫杉醇(2 mg/kg,共4次)的方法制备紫杉醇诱导的慢性神经病理性疼痛大鼠模型。检测大鼠机械缩足反射阈值(mechanical withdrawal threshold,MWT)和热缩足反射潜伏期(thermal withdrawal latency,TWL);RT-qPCR检测miR-99b-5p的表达,判断agomiR-99b-5p的激活作用和背根神经节中炎症因子TNF-α、IL-6和IL-1β含量的变化;Western Blot检测背根神经节成纤维细胞生长因子受体3(fibroblast growth factor receptor 3,FGFR3)的变化;双荧光素酶报告基因实验检测miR-99b-5p对FGFR3的靶向作用。结果:agomiR-99b-5p能显著增加大鼠背根神经节miR-99b-5p的含量,降低紫杉醇诱导的慢性神经病理性疼痛大鼠的MWT和TWL,同时也能显著下调背根神经节的炎症因子水平。荧光素酶结果表明相对于NC模拟物(mimic)组,miR-99b-5p mimic能够抑制FGFR3的表达。结论:miR-99b-5p能够影响FGFR3的表达,进而抑制背根神经节炎症因子的含量,达到降低紫杉醇诱导大鼠慢性神经病理性疼痛的目的。

关键词：紫杉醇慢性神经痛 miR-99b-5p 成纤维细胞生长因子受体3

Strain-tuned electronic and valley-related properties in Janus monolayers of SWSiX_(2)(X=N,P,As)

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Chinese Physics B 2024年第9期33卷 487-492页

作者： Yunxi Qi Jun Zhao Hui zeng New Energy Technology Engineering Laboratory of Jiangsu Province&School of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China School of Microelectronics Nanjing University of Science and TechnologyNanjing 210094China

Exploring novel two-dimensional(2D)valleytronic materials has an essential impact on the design of spintronic and valleytronic *** first principles calculation results reveal that the Janus SWSiX_(2)(X=N,P,As)monolayer has excellent dynamical and thermal *** to strong spin–orbit coupling(SOC),the SWSiX_(2)monolayer exhibits a valence band spin splitting of up to 0.49 eV,making it promising 2D semiconductor for valleytronic *** opposite Berry curvatures and optical selection rules lead to the coexistence of valley and spin Hall effects in the SWSiX2 ***,the optical transition energies can be remarkably modulated by the in-plane *** tensile(compressive)in-plane strains can achieve spin flipping in the SWSiN2 monolayer,and induce both SWSiP_(2)and SWSiAs_(2)monolayers transit from semiconductor to *** research provides new 2D semiconductor candidates for designing high-performance valleytronic devices.

关键词： first-principles calculations two-dimensional valleytronic spintronic

Mechanism of selective laser trabeculoplasty:a systemic review

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 963-968页

作者： Yu-Feng Chen Wen zeng Department of Ophthalmology Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina

Although selective laser trabeculoplasty(SLT)is a recognized method for the treatment of glaucoma,the exact changes in the target tissue and mechanism for its intraocular pressure lowing effect are still *** purpose of this review is to summarize the potential mechanisms of SLT on trabecular meshwork both in vivo and in vitro,so as to reveal the potential mechanism of *** may induce immune or inflammatory response in trabecular meshwork(TM)induced by possible oxidative damage etc,and remodel extracellular *** may also induce monocytes to aggregate in TM tissue,increase Schlemm’s canal(SC)cell conductivity,disintegrate cell junction and promote permeability through autocrine and paracrine *** provides a theoretical basis for SLT treatment in glaucoma.

关键词： mechanisms selective laser trabeculoplasty glaucoma trabecular meshwork

Photocontrolled polymer adhesives facilitate the assembly of hydrogels for soft robotics

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Science China Chemistry 2024年第10期67卷 3184-3186页

作者： Diling Yang Hao Zhang Hongbo zeng School of Materials and Environmental Engineering Hunan University of HumanitiesScience and TechnologyLoudi 417000China Department of Chemical and Materials Engineering University of AlbertaEdmontonAlberta T6G 1H9Canada

Both Sun Wukong in eastern mythology and Transformers in western science fiction animation have profoundly inspired the design of deformable materials and modern *** application scope of intelligent materials,also known as smart materials,which are capable of responding to external stimuli to achieve shape changes,structural reorganization,and functional reconfiguration,is wide-ranging,and it covers areas such as soft robotics and flexible electronics[1–3],4D printing[4,5],biomedical equipment[6,7],sensing devices[8],and energy harvesting systems[9].

关键词： printing harvesting smart

Navigating Epstein–Barr virus autoimmunity:role of NK cells and T cells in multiple sclerosis

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Signal Transduction and Targeted Therapy 2024年第3期9卷 833-835页

作者： Chu Xie Cong Sun Mu-Sheng zeng State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouP.R.China

In a recent study published in Cell,Vietzen and colleagues discovered the novel role of natural killer(NK)cells and EBVspecific CD8+T cell response in controlling EBV-inducing autoimmune response and collectively def... 详细信息

关键词： Epstein sclerosis killer

Switching,explosion,and chaos of multi-wavelength soliton states in ultrafast fiber lasers

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 82-90页

作者： Zhi-zeng Si Yue-Yue Wang Chao-Qing Dai College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityLin’an 311300China

Because of the complexity and difficulty of realizing a multi-wavelength soliton state,reports on its internal dynamic characteristics are *** this study,the switching and periodic soliton explosion processes of the multi-wavelength soliton state in a negative dispersion passively mode-locked fiber laser are *** generation of the multi-wavelength soliton state undergoes the process of noise,oscillation,and stable mode-locking,and the splitting and annihilation of solitons with different group velocities directly impact the generation and disappearance of three *** and negative dispersion lead to different group velocities of *** presence and displacement of solitons with different group velocities cause soliton collisions,which lead to soliton explosions.A soliton experiences relative phase oscillation,chaos,and oscillation,as well as convergence and separation before and after an *** an increase in parameters related to pump power,single-soliton oscillation,multi-wavelength solitons,and chaos are found in experiments and simulations,proving the relevance and reliability between simulation and experimental *** work promotes the dynamical study of multi-soliton collisions in nonlinear science and the development of chaos theory in multi-comb lasers.

关键词： multi-wavelength fiber laser soliton explosion chaos state switching real-time dynamics

Recent advances in halide perovskite memristors:From materials to applications

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Frontiers of physics 2024年第2期19卷 73-104页

作者： Sixian Liu Jianmin zeng Qilai Chen Gang Liu Department of Micro/Nano Electronics School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Aerospace Science&Industry Shenzhen(Group)Co.Ltd. Shenzhen 518000China

With the emergence of the Internet of Things(IoT)and the rapid growth of big data generated by edge devices,there has been a growing need for electronic devices that are capable of processing and transmitting data at low power and high *** Complementary Metal-Oxide-Semiconductor(CMOS)devices are nonvolatile and often limited by their ability for certain IoT applications due to their unnecessary power consumption for data movement in von Neuman architecture-based *** has led to a surge in research and development efforts aimed at creating innovative electronic components and systems that can overcome these shortcomings and meet the evolving needs of the information era,which share features such as improved energy efficiency,higher processing speeds,and increased *** are a novel type of electronic device that has the potential to break down the barrier between storage and *** storing data and processing information within the same device,memristors can minimize the need for data movement,which allows for faster processing speeds and reduced energy *** further improve the energy efficiency and reliability of memristors,there has been a growing trend toward diversifying the selection of dielectric materials used in *** perovskites(HPs)have unique electrical and optical properties,including ion migration,charge trapping effect caused by intrinsic defects,excellent optical absorption efficiency,and high charge mobility,which makes them highly promising in applications of *** this paper,we provide a comprehensive overview of the recent development in resistive switching behaviors of HPs and the underlying ***,we summarize the diverse range of HPs,their respective performance metrics,as well as their applications in various ***,we critically evaluate the current bottlenecks and possible opportunities in the future research of HP memristors.

关键词： halide perovskite memristor mechanism neuromorphic computing non-volatile memory

Effects of formal credit on pastoral household expense: Evidence from the Qinghai-Xizang Plateau of China

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Journal of Integrative Agriculture 2024年第5期23卷 1774-1785页

作者： Yan Zhang Yi Huang Fan Zhang zeng Tang State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou 730020China

Formal credit is critical in agricultural production,allowing more expenditure and productive input,thereby improving farmers'*** pastoral China,formal financial institutions are gradually ***,a limited understanding remains of how formal credit affects herders'household *** on a survey of 544 herders from the Qinghai-Xizang Plateau of China,this study adopted the propensity score matching approach to identify the effect of formal credit on herders'total household expenses,daily expenses,and productive *** results found that average age,grassland mortgage,and other variables significantly affected herders'participation in formal *** credit could significantly improve household expenses,especially productive expenses.A heterogeneity analysis showed that formal credit had a greater impact on the household total expense for those at higher levels of wealth;however,it significantly affected the productive expense of herders at lower wealth ***,the mediating effect indicated that formal credit could affect herders'household income,thus influencing their household ***,this study suggests that policies should improve herders'accessibility to formal credit.

关键词： formal credit herders expense Qinghai-Xizang Plateau