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High risk factors for pulmonary fungous infection in intensive care units of neurosurgery

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Frontiers of Medicine 2007年第3期1卷 299-303页

作者： zhu wenyu TAN Liping CHEN Xiangfeng HUANG Qiang LAN Qing Department of Neurosurgery Second Affiliated Hospital of Soochow UniversitySuzhou 215004China

By analyzing the high risk factors for pulmonary fungous infection in intensive care units of neurosurgery,the strategy of early diagnosis and treatment was *** to the domestic diagnostic standard on pulmonary fungous infection,clinical data on 58 patients with the infection in our department were *** hundred and seventeen strains of fungi were separated from the 58 *** was the most frequent type,accounting for 92.3%of the *** such as the severity of primary diseases,long-time coma,long-term use of broad-spectrum antibiotic,abuse of glucocorticoid,the open airway,and some invasive intubations,may be regarded as high risk factors for pulmonary fungous *** showed good clinical effects on the treatment of fungous *** eliminate these high risk factors,early diagnosis and the use of prophylactic antifungal agents can help reduce the incidence of pulmonary fungous infection.

关键词： intensive care units lung diseases,fungal infection neurosurgery

Current Trends and Challenges in Drug-Likeness Prediction:Are They Generalizable and Interpretable?

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Health Data Science 2023年第1期3卷 117-126页

作者： wenyu zhu Yanxing Wang Yan Niu Liangren Zhang Zhenming Liu State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University100191 BeijingP.R.China. Department of Medicinal Chemistry School of Pharmaceutical SciencesPeking University100191 BeijingP.R.China.

Importance:Drug-likeness of a compound is an overall assessment of its potential to succeed in clinical trials,and is essential for economizing research expenditures by filtering compounds with unfavorable properties and poor development *** this end,a robust drug-likeness prediction method is *** approaches,including discriminative rules,statistical models,and machine learning models,have been developed to predict drug-likeness based on physiochemical properties and structural ***,recent advancements in novel deep learning techniques have significantly advanced drug-likeness prediction,especially in classification ***:In this review,we addressed the evolving landscape of drug-likeness prediction,with emphasis on methods employing novel deep learning techniques,and highlighted the current challenges in drug-likeness prediction,specifically regarding the aspects of generalization and ***,we explored potential remedies and outlined promising avenues for future ***:Despite the hurdles of generalization and interpretability,novel deep learning techniques have great potential in drug-likeness prediction and are worthy of further research efforts.

关键词： spite prediction landscape

Risk Factors for Cardiovascular Diseases in Renal Transplant Recipients and Their Management

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器官移植内科学杂志 2010年第4期5卷 128-132页

作者： Youhua zhu wenyu Zhao Institute of Organ Transplantation of PLA Changzheng Hospital the Second Military Medical UniversityShanghai 200003 China

Chemical endemic diseases and their impact on population in china

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Journal of Environmental Sciences 1989年第1期1卷 107-114页

作者： Tan Jianan, zhu wenyu, Li Ribang Institute of Geography． Chinese Academy of Sciences． Beijing China．

This paper deals with some endemic diseases related to selenium, iodine and fluoride in eco-environment. Keshan disease and Kaschin-Beck disease are associated with low selenium, they mainly occur in a belt zone across China ranging from North-East to South-West. Selenium contents in food grains and human hair from the disease affected areas are usually below 0.020ppm and 0.20ppm respectively. The endemic goitre caused by iodine deficiency distributes extensively in China, mainly in mountainous and hilly districts, swamp and peat areas, some sand soil and limestone areas. Also there is another kind of endemic goitre which caused by iodine excess in interior and coast areas. Endemic cretinism usually occurs in the endemic goitre seriously affected areas. Endemic fluorosis is also widely distributed in China, but mainly occurs in dry or semi-dry areas of north China. The fluoride sources for causing endemic fluorisis are drinking water and food grains polluted by coal smoke in the backing process of maize and chilli.

关键词： endemic disease Selenium Iodine fluorosis.

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蒋骥《山带阁注楚辞》的篇目选择及其影响

中国文化研究 2015年第2期 122-128页

作者：朱闻宇中国传媒大学

由于注释目的和楚辞文体观的不同,楚辞注本的选目自汉至清也历经了发展变化的过程。明清之际,楚辞研究呈现出向屈原及其作品集中的趋势,蒋骥《山带阁注楚辞》受这种学风的影响,辨析了"二招"归属、《九歌》分章,收录屈原作品《离骚》《... 详细信息

由于注释目的和楚辞文体观的不同,楚辞注本的选目自汉至清也历经了发展变化的过程。明清之际,楚辞研究呈现出向屈原及其作品集中的趋势,蒋骥《山带阁注楚辞》受这种学风的影响,辨析了"二招"归属、《九歌》分章,收录屈原作品《离骚》《九歌》《天问》《九章》《远游》《卜居》《渔父》《招魂》《大招》。蒋骥的楚辞选目巩固和推进了上述趋势,对后世楚辞注本的选目以及域外楚辞研究产生了深刻的影响。

关键词：蒋骥山带阁注楚辞选目域外楚辞学

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RE-SEGNN:recurrent semantic evidence-aware graph neural network for temporal knowledge graph forecasting

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Science China(Information Sciences) 2025年

作者： wenyu CAI Mengfan LI Xuanhua SHI Yuanxin FAN Quntao zhu Hai JIN National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab Cluster and Grid Computing Lab School of Computer Science and TechnologyHuazhong University of Science and Technology

Temporal knowledge graph(TKG) reasoning, has seen widespread use for modeling real-world events, particularly in extrapolation settings. Nevertheless, most previous studies are embedded models, which require both entity and relation embedding to make predictions, ignoring the semantic correlations among different entities and relations within the same timestamp. This can lead to random and nonsensical predictions when unseen entities or relations occur. Furthermore, many existing models exhibit limitations in handling highly correlated historical facts with extensive temporal depth. They often either overlook such facts or overly accentuate the relationships between recurring past occurrences and their current counterparts. Due to the dynamic nature of TKG, effectively capturing the evolving semantics between different timestamps can be *** address these shortcomings, we propose the recurrent semantic evidenceaware graph neural network(RE-SEGNN), a novel graph neural network that can learn the semantics of entities and relations simultaneously. For the former challenge, our model can predict a possible answer to missing quadruples based on semantics when facing unseen entities or relations. For the latter problem, based on an obvious established force, both the recency and frequency of semantic history tend to confer a higher reference value for the current. We use the Hawkes process to compute the semantic trend, which allows the semantics of recent facts to gain more attention than those of distant facts. Experimental results show that RE-SEGNN outperforms all SOTA models in entity prediction on 6 widely used datasets, and 5 datasets in relation prediction. Furthermore, the case study shows how our model can deal with unseen entities and relations.

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我国生态农业政策和法律的缺陷及其完善

学术交流 2008年第12期 96-99页

作者：朱文玉东北林业大学人文社会科学学院

生态农业是农业可持续发展的一种重要实践模式,也是我国解决生态危机、发展农村经济的必要途径。我国的生态农业建设已取得一定成绩,但由于相应的政策和法律存在体系和立法上的两大缺陷,生态农业仍然没有成为我国农业与农村经济发展的... 详细信息

生态农业是农业可持续发展的一种重要实践模式,也是我国解决生态危机、发展农村经济的必要途径。我国的生态农业建设已取得一定成绩,但由于相应的政策和法律存在体系和立法上的两大缺陷,生态农业仍然没有成为我国农业与农村经济发展的基本模式。构建我国的生态农业政策和法律体系;制定我国发展生态农业的基本法,提出生态农业发展的总体战略目标、步骤、主要制度和措施;修改技术规程,进一步引入国际先进方法和技术;整合农产品认证标准,大力推行生态标签;完善科研和教育培训政策,形成较完整的农业科研和教育服务体系;制定激励机制,从财政、金融和税收等方面提供保障措施;变革考核制度,逐步实施绿色国民经济核算和绿色干部考核制度;加强宣传教育政策,以期利用市场机制促进我国生态农业健康、快速、高效的发展。

关键词：生态农业生态农业政策生态标签

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PM2.5事件与中国绿色公共领域的形成

科普研究 2015年第3期10卷 40-49页

作者：朱文瑜清华大学社科学院科技与社会北京100084 中国科学院中国现代化研究中心北京100190

绿色公共领域在一个国家的环境传播中起到重要作用。然而对中国公众来说,绿色公共领域还是一个相对新的概念。本文将论证在中国绿色公共领域的形成过程中,2011年发生在北京的PM2.5事件扮演着十分重要的角色。首先,我们将回顾上述PM2.5... 详细信息

绿色公共领域在一个国家的环境传播中起到重要作用。然而对中国公众来说,绿色公共领域还是一个相对新的概念。本文将论证在中国绿色公共领域的形成过程中,2011年发生在北京的PM2.5事件扮演着十分重要的角色。首先,我们将回顾上述PM2.5事件的一些细节并讨论绿色公共领域的基本理论。其次,我们将通过分析与主题相关的公共观点的形成、公众自由获取信息的权利、自由组织和参加会议、自由辩论等等来研究PM2.5事件在中国绿色公共领域形成过程中的作用。最后,我们提出绿色公共领域有复杂的扇区结构和分层特性。

关键词： PM2.5 绿色公共领域环境传播

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Effects of Ginsenoside Rb1 Babu Agent on the Amplitude of Microvascular Vasomotion

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Medicinal Plant 2018年第2期9卷 78-82页

作者： Yuxin zhu Yang GAO Qian ZHANG Tao ZHANG wenyu zhu Bo FENG Jianfang WANG Hong DONG Xiang MU College of Animal Science and Technology Beijing University of AgricultureBeijing Key Laboratory of Traditional Chinese Veterinary Medicine Beijing Huairou District Bureau of Agriculture College of Veterinary Medicine China Agricultural University

[Objectives] To study the effects of ginsenoside Rbl Babu agent on the amplitude of microvascular vasomotion. [Methods]The in vitro transdermal permeation of ginsenoside Rbl Babu agent was performed by using intelligent transdermal apparatus,and the percutaneous fluid was collected and analyzed by using high performance liquid chromatography( HPLC). The Babu agent was stuck on the skin of acupoint area,determined by Laser Doppler Flowmeter,and amplitude of microvascular vasomotion of acupoint area was recorded. [Results] With the extension of transdermal time,the cumulative permeation rate of ginsenoside Rbl increased. The amplitude of microvascular vasomotion could be significantly increased with the application of ginsenoside Rbl Babu agent( P < 0. 01). [Conclusions]The drug delivery system of ginsenoside Rbl Babu agent can release the drug into the acupoint,increase the amplitude of microvascular vasomotion,and achieve the effect of acupuncture. Therefore,ginsenoside Rbl Babu agent can replace the acupuncture clinically to treat diseases.

关键词： Ginsenoside Rbl Babu agent Microvessel Vasomotion Amplitude