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Role of Immune Cells and Non-immune Cells with Immune Functions in the Pathogenesis of ALI/ARDS

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Medicinal Plant 2024年第4期15卷 51-58页

This review outlines the effects of different types of cells with immune function on acute lung injury(ALI)inflammation and the regulation of inflammatory responses between these cells via cell-cell *** is expected to provide some possible strategies for the research and treatment of ALI and acute respiratory distress syndrome(ARDS).

关键词： Acute lung injury(ALI) Immune cell Non-immune cells with immune functions Cell-cell interaction Pathogenesis

GC-MS/MS Method for Determination and Pharmacokinetics of main Components of Cang-Ai Volatile Oil in Rat Plasma after Intravenous Administration

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Medicinal Plant 2024年第4期15卷 92-98页

作者： wenyu ma Jincun LI Xuemei PAN Haoran NI Yuhuan XIE School of Chinese materia Medica Yunnan University of Chinese MedicineKunming 650500China Yunnan Provincial University Key Laboratory of Aromatic Chinese Herb Research Kunming 650500China Yunnan Innovation Team of Application Research on Traditional Chinese Medicine Theory of Disease Prevention at Yunnan University of TCM Kunming 650500China

[Objectives]To establish a gas chromatography-triple quadrupole mass spectrometry(GC-MS/MS)method based on multiple reaction monitoring(MRM)mode for the analysis of the major components in Cang-ai volatile oil(CAVO).[Methods]An ultrasensitive gas chromatography-tandem mass spectrometry(GC-MS/MS)method was developed and validated for the determination of three highly abundant components in rat plasma *** was used as an internal standard.A multiple reaction monitoring(MRM)model was employed for the quantification of the three major components of CAVO.[Results]The method demonstrated linearity over the range of 0.25 to 50μg/mL with a correlation coefficient(R 2)greater than *** lower limit of quantification was 0.25μg/***-day and inter-day accuracy and precision were within 15%.Extraction recovery and matrix effect values ranged from 90.1%to 110.6%and 0.1%to 2.1%,respectively.[Conclusions]This method was successfully applied to the simultaneous determination of the three components in high-level CAVO plasma samples,providing a basis for subsequent studies of CAVO.

关键词： GC-MS/MS Cang-ai volatile oil MRM mode Pharmacokinetics

A Novel Modularizing Design Method of 10 kV High Voltage Switchgear for Live maintenance

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Energy and Power Engineering 2020年第4期12卷 1-13页

作者： Yuan Yao Xudong Ouyang Guowei Zeng Qi Tang wenyu ma QingYuan Power Supply Bureau of Guangdong Power Grid Qingyuan China School of Automation Wuhan University of Technology Wuhan China

Due to imperfect manufacturing technology, design defects and environmental impact, the failure rate of 10 kV switchgear is very high. For this reason, based on taken present situation of traditional switchgear and the current technical requirements for switchgear into account, a new reliable and safe modular high voltage switchgear design method is presented in this paper, which can reduce the failure rate of switchgear and improve the reliability of power supply. The electric field and temperature rise simulation model are established to check the reasonability and validity. By using the finite element software, the simulation results show that the design in this paper has a maximum temperature rise of 55 K for the main cabinet and a maximum temperature rise of 45 K for the deputy cabinet, which is far below the international standard of 70 K. The areas where the partial discharge is likely to occur within the switchgear are places such as the connection between bus-bar and cabinet, bus-bar joint and bus-bar corner. In order to avoid potential dangers, the discharge point must be located in time to prevent insulation fault of electrical equipment of the high voltage switchgear. The simulation results demonstrate that the design method in this paper greatly improve the reliability of switchgear and meets the demands of power system.

关键词： Switchgear Finite Element Temperature Field Electric Field Improvement

A Novel Modularizing Design Method of 10 kV High Voltage Switchgear for Live maintenance

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A Novel Modularizing Design Method of 10 kV High Voltage Swi...

Coordinate-free k-coverage hole detection algorithm in wireless sensor networks

作者： Yuan Yao Xudong Ouyang Guowei Zeng Qi Tang wenyu ma QingYuan Power Supply Bureau of Guangdong Power Grid School of Automation Wuhan University of Technology

关键词： Switchgear Finite Element Temperature Field Electric Field Improvement

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Journal of Southeast University(English Edition) 2019年第1期35卷 8-15页

作者： ma wenyu Yan Feng Zuo Xuzhou Xia Weiwei Shen Lianfeng National Mobile Communications Research Laboratory Southeast UniversityNanjing 210096China School of Information and Software Engineering University of Electronic Science and Technology of ChinaChengdu 610054China

For wireless sensor networks, a simple and accurate coordinate-free k-coverage hole detection scheme is proposed. First, an algorithm is presented to detect boundary cycles of 1-coverage holes. The algorithm consists of two components, named boundary edge detection and boundary cycle detection. Then, the 1-coverage hole detection algorithm is extended to k-coverage hole scenarios. A coverage degree reduction scheme is proposed to find an independent covering set of nodes in the covered region of the target field and to reduce the coverage degree by one through sleeping those nodes. Repeat the 1-coverage hole detection algorithm and the higher order of coverage holes can be found. By iterating the above steps for k-1 times, the boundary edges and boundary cycles of all k-coverage holes can be discovered. Finally, the proposed algorithm is compared with a location-based coverage hole detection algorithm. Simulation results indicate that the proposed algorithm can accurately detect over 99% coverage holes.

关键词： k-coverage hole detection k-coverage wireless sensor networks

Patterns of presence-absence variants in Upland cotton

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Science China(Life Sciences) 2020年第10期63卷 1600-1603页

作者： Junfang Liu Xianliang Zhang Lingling Dou Wei Li Xiaojian Zhou Yangai Liu Xiaoyu Pei Zhongying Ren Wensheng Zhang Huaizhu Li Wenbo Wang Changsong Zou Kunlun He Fei Zhang wenyu ma Haihong Shang Hongbin Li Daigang Yang Guanghui Xiao Xiongfeng ma State Key Laboratory of Cotton Biology Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyang 455000China School of Chemistry and Chemical Engineering Xianyang Normal UniversityXianyang 712000China Key Laboratory of Plant Stress Biology State Key Laboratory of Cotton BiologySchool of Life SciencesHenan UniversityKaifeng 475004China Key Laboratory of the Ministry of Education for Medicinal Plant Resources and Natural Pharmaceutical Chemistry National Engineering Laboratory for Resource Development of Endangered Crude Drugs in the Northwest of ChinaCollege of Life SciencesShaanxi Normal UniversityXi’an 710119China Zhengzhou Research Base State Key Laboratory of Cotton BiologyZhengzhou UniversityZhengzhou 450001China College of Life Sciences Shihezi UniversityShihezi 832003China

Dear Editor,Sources of genetic variations in genomes include small-scale sources(such as single-nucleotide polymorphisms(SNPs),insertions/deletions(InDels),and simple sequence repeats and larger-scale structural variations(mainly presence-absence variants(PAVs))and copy number variants).PAVs are sequences that are either inserted or missing in genomes in comparison with a reference sequence or *** can have a much longer sequence than SNPs and InDels,as illustrated in the human genome(Conrad et al.,2010).PAVs are important genomic structural variations that can directly affect genomic structure and key functional genes in the genome(Kumar et al.,2007).Moreover,the use of PAVs for studying quantitative traits has been valuable(Lam et al.,2010).

关键词： traits sequence insertion

Rice FLOURY ENDOSPERM22, encoding a pentatricopeptide repeat protein, is involved in both mitochondrial RNA splicing and editing and is crucial for endosperm development

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Journal of Integrative Plant Biology 2023年第3期65卷 755-771页

作者： Hang Yang Yunlong Wang Yunlu Tian Xuan Teng Zehui Lv Jie Lei Erchao Duan Hui Dong Xue Yang Yuanyan Zhang Yinglun Sun Xiaoli Chen Xiuhao Bao Rongbo Chen Chuanwei Gu Yipeng Zhang Xiaokang Jiang wenyu ma Pengcheng Zhang Yi Ji Yu Zhang Yihua Wang Jianmin Wan State Key Laboratory for Crop Genetics and Germplasm Enhancement Jiangsu Plant Gene Engineering Research CenterNanjing Agricultural UniversityNanjing 210095China National Key Facility for Crop Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Most of the reported P-type pentatricopeptide repeat(PPR) proteins play roles in organelle RNA stabilization and splicing. However, P-type PPRs involved in both RNA splicing and editing have rarely been reported, and their underlying mechanism remains largely unknown. Here, we report a rice floury endosperm22(flo22) mutant with delayed amyloplast development in endosperm cells. map-based cloning and complementation tests demonstrated that FLO22 encodes a mitochondrion-localized P-type PPR *** of FLO22 resulting in defective transsplicing of mitochondrial nad1 intron 1 and perhaps causing instability of mature transcripts affected assembly and activity of complex Ⅰ, and mitochondrial morphology and function. RNA-seq analysis showed that expression levels of many genes involved in starch and sucrose metabolism were significantly down-regulated in the flo22mutant compared with the wild type, whereas genes related to oxidative phosphorylation and the tricarboxylic acid cycle were significantly upregulated. In addition to involvement in splicing as a P-type PPR protein, we found that FLO22 interacted with DYW3, a DYW-type PPR protein, and they may function synergistically in mitochondrial RNA editing. The present work indicated that FLO22 plays an important role in endosperm development and plant growth by participating in nad1 maturation and multi-site editing of mitochondrial messager RNA.

关键词： endosperm development Oryza sativa PPR proteins RNA editing RNA splicing

黑果枸杞原花青素对小鼠皮肤衰老模型的保护作用研究

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中国全科医学 2019年第15期22卷 1851-1854页

作者：马嘉艺郭砚冶娟马文宇青海大学研究生院青海省西宁市810001 青海大学附属医院医学美容科青海省西宁市810001

背景青藏高原地区居民长期处在高海拔、强紫外线和缺氧干燥的环境中,光损伤性皮肤病特别是皮肤光老化发病率高。青海地区因其独特的生态环境孕育着其特有的植被资源,本文选用当地植物青海黑果枸杞,对其抗衰老性进行研究。目的探讨青海... 详细信息

背景青藏高原地区居民长期处在高海拔、强紫外线和缺氧干燥的环境中,光损伤性皮肤病特别是皮肤光老化发病率高。青海地区因其独特的生态环境孕育着其特有的植被资源,本文选用当地植物青海黑果枸杞,对其抗衰老性进行研究。目的探讨青海黑果枸杞原花青素对小鼠皮肤衰老模型的保护作用。方法 2016年10月—2017年12月,选取45日龄SPF级昆明种雌性小鼠50只,随机分为正常组(A组)、皮肤衰老模型组(B组)、皮肤衰老模型+维生素E滴剂组(C组)、皮肤衰老模型+低剂量黑果枸杞原花青素组(D组)、皮肤衰老模型+高剂量黑果枸杞原花青素组(E组),每组10只。A组小鼠正常光照饲养,B组、C组、D组、E组小鼠采用D-半乳糖皮下注射联合长波黑斑效应紫外线(UVA)、中波红斑效应紫外线(UVB)共同照射建立皮肤衰老模型。造模第11天,A组、B组小鼠给予0.9%氯化钠溶液灌胃0.5 ml/d,C组小鼠给予维生素E滴剂灌胃0.5 ml/d,D组、E组小鼠给予果枸杞原花青素灌胃,剂量分别为50 mg·kg^(-1)·d^(-1)和100 mg·kg^(-1)·d^(-1),连续用药30 d。第42天检测各组小鼠皮肤真皮层厚度、胶原纤维、弹力纤维的改变及基质金属蛋白酶-2(MMP-2)mRNA、基质金属蛋白酶-9(MMP-9)mRNA表达水平。结果光镜(×40)下,肉眼可见B组较A组真皮层厚度明显减小,C组、D组、E组较B组真皮层厚度稍增厚。光镜(×400)下,肉眼可见B组较A组真皮层胶原纤维及弹力纤维缺失、排列紊乱、结构松散,出现断裂、卷曲,C组较B组可见纤维组织增多、网状排列,仍可见断裂、卷曲,D组、E组较B组、C组明显可见新生纤维组织、排列整齐,断裂、卷曲明显减少,且E组较D组新生纤维更成熟。B组小鼠MMP-2 mRNA、MMP-9 mRNA表达水平高于A组、D组、E组(P<0.05);D组小鼠MMP-2 mRNA、MMP-9 mRNA表达水平高于E组(P<0.05)。结论黑果枸杞原花青素对小鼠皮肤衰老模型具有保护作用,有潜在的抗皮肤衰老应用价值。

关键词：皮肤衰老枸杞原花青素类胶原纤维弹力纤维

来华留学生在线学习投入:维度、收获与提升策略

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煤炭高等教育 2024年第1期42卷 62-70页

作者：马文瑜新疆财经大学公共管理学院新疆乌鲁木齐830012

来华留学教育作为中国高等教育和教育强国战略的重要组成部分,其教育质量要符合高校国际化办学提质增效、内涵式发展的内在要求。通过问卷调查方法和访谈法,以来华留学生为研究对象,对来华留学生在线学习投入的现状及在线学习投入对学... 详细信息

来华留学教育作为中国高等教育和教育强国战略的重要组成部分,其教育质量要符合高校国际化办学提质增效、内涵式发展的内在要求。通过问卷调查方法和访谈法,以来华留学生为研究对象,对来华留学生在线学习投入的现状及在线学习投入对学习收获的影响展开实证研究。研究发现:来华留学生在线学习投入的总体情况较好;汉语水平、授课语言对来华留学生在线学习投入的影响较大;行为投入和情感投入对留学生学习收获的影响较为显著。为保障来华留学生的在线学习质量,高校需要创设相对真实的语言交流环境提升其学习体验,增强其在线自主学习能力。

关键词：来华留学生在线学习投入学习收获