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Characteristics and geological significance of germanium in Taiyuan coal formation of Huainan Coalfield,Anhui,China

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International Journal of Coal Science & Technology 2020年第4期7卷 662-675页

作者： Dun Wu Wenyong ZHANG Guijian Liu Run Zhan Guangqing Hu School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026AnhuiChina Exploration Research Institute Anhui Provincial Bureau of Coal GeologyHefei 230088AnhuiChina Anhui Province Green Mine Engineering Research Center Hefei 230088AnhuiChina

HN-1#is the first fully working coring well of the Taiyuan Formation(Ty)in the Huinan Coalfield and exploration studies are currently underway on the associated resources of the coal-bearing strata.The HN-1#well is located in the Fufeng thrust nappe structural belt in the south of the Huainan Coalfield.Three coal samples from the Ty were collected from HN-1#and inductively-coupled plasma mass spectrometry and inductively-coupled plasma atomic emission spectrometry were used to determine the Ge content of each sample.Based on proximate and ultimate analyses,microscopy data,and analyses of the ash products,some important findings were made.The Ty coal samples had a relatively high total sulfur(Sud)content(4.24%),thus the coal was considered to be a lower ranked coal(high volatility bituminous coal),which also had a low coal ash composition index(k,1.87).Collodetrinite was the main submaceral of the Ty coal.Small amounts of pyrite particles were found in the coal seams of the Ty,while the contents of pyrite and algae in the top and bottom sections of the coal seam were relatively high,which meant that the swampy peat conditions which existed during the formation of the coal seams were affected by seawater;also the degree of mineralization of the coal seam was relatively high,which is consistent with reducing conditions in a coastal environment setting.Atomic force microscopy(AFM)experiments showed that the modes of occurrence of Ge in the Ty coal were mainly those for organic-bound and adsorbed Ge species.The organic carbon isotope values for the Ty coal ranged from-24.1‰to-23.8‰,with an average value of-24.0‰,which is equivalent to the value for terrestrial plants(average value-24.0‰).The Ge content of the Ty coal was 13.57 mg/kg.The Ge content was negatively correlated with volatile matter and the ash yield.

关键词： Germanium Modes of occurrence Chemical species ICP spectrometry Taiyuan coal formation Fufeng thrust nappe structural belt Huainan Coalfield

APFD:an effective approach to taxi route recommendation with mobile trajectory big data

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Frontiers of Information Technology & Electronic Engineering 2022年第10期23卷 1494-1510页

作者： Wenyong ZHANG Dawen XIA Guoyan CHANG Yang HU Yujia HUO Fujian FENG Yantao LI Huaqing LI College of Data Science and Information Engineering Guizhou Minzu UniversityGuiyang 550025China Department of Automotive Engineering Guizhou Traffic Technician and Transportation CollegeGuiyang 550008China College of Computer Science Chongqing UniversityChongqing 400044China College of Electronic and Information Engineering Southwest UniversityChongqing 400715China The Affiliated Hospital of Guizhou Medical University Guiyang 550001China

With the rapid development of data-driven intelligent transportation systems,an efficient route recommendation method for taxis has become a hot topic in smart cities.We present an effective taxi route recommendation approach(called APFD)based on the artificial potential field(APF)method and Dijkstra method with mobile trajectory big data.Specifically,to improve the efficiency of route recommendation,we propose a region extraction method that searches for a region including the optimal route through the origin and destination coordinates.Then,based on the APF method,we put forward an effective approach for removing redundant nodes.Finally,we employ the Dijkstra method to determine the optimal route recommendation.In particular,the APFD approach is applied to a simulation map and the real-world road network on the Fourth Ring Road in Beijing.On the map,we randomly select 20 pairs of origin and destination coordinates and use APFD with the ant colony(AC)algorithm,greedy algorithm(A*),APF,rapid-exploration random tree(RRT),non-dominated sorting genetic algorithm-II(NSGA-II),particle swarm optimization(PSO),and Dijkstra for the shortest route recommendation.Compared with AC,A*,APF,RRT,NSGA-II,and PSO,concerning shortest route planning,APFD improves route planning capability by 1.45%–39.56%,4.64%–54.75%,8.59%–37.25%,5.06%–45.34%,0.94%–20.40%,and 2.43%–38.31%,respectively.Compared with Dijkstra,the performance of APFD is improved by 1.03–27.75 times in terms of the execution efficiency.In addition,in the real-world road network,on the Fourth Ring Road in Beijing,the ability of APFD to recommend the shortest route is better than those of AC,A*,APF,RRT,NSGA-II,and PSO,and the execution efficiency of APFD is higher than that of the Dijkstra method.

关键词： Big data analytics Region extraction Artificial potential field Dijkstra Route recommendation GPS trajectories of taxis

DsbA-DsbAmut fusion chaperon improved soluble expression of human trypsinogen-1 in Escherichia coli

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Frontiers of Chemical Science and Engineering 2015年第4期9卷 511-521页

作者： Ye Liu Wenyong ZHANG Xubin Yang Guangbo Kang Damei Wang He Huang Key Laboratory of System Bioengineering Department of Biochemical Engineering School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072 China College of Food Engineering and Biotechnology Tianjin University of Science and Technology Tianjin 300072 China Gan & Lee Pharmaceuticals Beijing 101100 China Taiyuan Institute of Technology Taiyuan 030000 China

A co-expressing system ofDsbA-DsbAmut was suggested for the first time to enhance the soluble expression of human trypsin-1. As a control, leaderless DsbA chaperone was also co-expressed with human trypsin-1. Vectors pET39b-trypsin and pET28a-DsbA- DsbAn^ut-trypsin with the above two DsbA fusion tag were constructed. The strain with vector pET39b-trypsin expressed fusion protein DsbA-trypsin in form of inclusion bodies. While in E. coli BL21 （DE3） strain with vector pET28a-DsbA-DsbAmUt-trypsin, the soluble expression of trypsin fusion protein was achieved. Under the optimized expression conditions, the soluble fraction accounted for about 49.43% of total DsbA-DsbAmUt-trypsin proteins in crude supernatant. The purification yield was 4.15% by nickel chelating chromatography and 3.3 mg activated trypsin with a purity of 88.68% was obtained from 1 L LB broth. To detect the possible functions of DsbA series chaperons in trypsin fusion protein, we analyzed the primary three-dimensional structure of fusion proteins, mainly focusing on the compatibleness between trypsin and fusion chaperons. The results suggested that （1） besides the primary function in periplasm, leaderless DsbA or DsbAmut may also act as a signal sequences-like leader targeted to periplasm that partly relieved the pressure from fusion protein overexpression and inclusion body formation, and （2） as there was significant soluble expression of DsbA-DsbAmUt-trypsin compared with DsbA-trypsin, DsbArout may function as charge or hydrophobic balance in recombinant protein DsbA-DsbAmut- trypsin.

关键词： DsbA DsbA-DsbAmut soluble expression,trypsin chaperon

Research on application of kyanite in plastic refractory

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Chinese Journal Of Geochemistry 2013年第3期32卷 326-330页

作者： zhang Wei MENG Qian DAI wenyong Plibrico (Dalian) Industries Co.Ltd.

Effect of kyanite addition on properties of plastic refractories that based on Chinese calcined flint clay were investigated with the Chinese calcined flint clay as raw materials, aluminum sulfate and fireclay as binding systems. After 24 h curing after demoulding and another 24 h curing at 110 ℃, the specimens were heat-treated at 1000, 1300 and 1500℃ for 3 h, respectively. Thepermanent linear change, bulk density, modulus of rupture, clod crushing strength, thermal expansion coefficient and thermal shock resistance were examined. The results show that the shrinkage of plastic refractory decreased with increasing kyanite addition after heat-treated at 1000 and 1300℃ , and its expansivity increased with increasing kyanite addition after heat-treated at 1500 ℃. The strength can be increased when kyanite was added into the plastic refractory. The thermal expansion coefficient and the expansivity were increased, and the shrinkage can be reduced at high temperature when kyanite addition was more than 10%. On the condition of this experiment, the thermal shock resistance of plastic refractory was the best when kyanite addition is w(kyanite)=10%.

关键词：耐火可塑料蓝晶石应用加热处理耐火材料膨胀系数耐热冲击性粘土塑料

Three-dimensional frequency-domain full waveform inversion based on the nearly-analytic discrete method

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Earth and Planetary Physics 2021年第2期5卷 149-157页

作者： DeYao zhang wenyong Pan DingHui Yang LingYun Qiu XingPeng Dong WeiJuan Meng Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China Key Laboratory of Petroleum Resource Research Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Yau Mathematical Sciences Center Tsinghua UniversityBeijing 100084China

The nearly analytic discrete(NAD)method is a kind of finite difference method with advantages of high accuracy and stability.Previous studies have investigated the NAD method for simulating wave propagation in the time-domain.This study applies the NAD method to solving three-dimensional(3D)acoustic wave equations in the frequency-domain.This forward modeling approach is then used as the“engine”for implementing 3D frequency-domain full waveform inversion(FWI).In the numerical modeling experiments,synthetic examples are first given to show the superiority of the NAD method in forward modeling compared with traditional finite difference methods.Synthetic 3D frequency-domain FWI experiments are then carried out to examine the effectiveness of the proposed methods.The inversion results show that the NAD method is more suitable than traditional methods,in terms of computational cost and stability,for 3D frequency-domain FWI,and represents an effective approach for inversion of subsurface model structures.

关键词： three-dimension frequency-domain NAD method forward modeling full waveform inversion

Targeted peptide-Au cluster binds to epidermal growth factor receptor (EGFR) in both active and inactive states： a clue for cancer inhibition through dual pathways

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Science Bulletin 2018年第6期63卷 349-355页

作者： Peng zhang Jiao Zhai Xueyun Gao Hongkang Zhao wenyong Su Lina Zhao School of Physics Beijing Institute of Technology Beijing 100081 China Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Department of Chemistry and Chemical Engineering. Beijing University of Technology Beijing 100124 China

The epidermal growth factor receptor(EGFR) has become an important target protein in anticancer drug development. Meanwhile, peptide-Au cluster has been proposed as potential targeted nano-drug assembled by targeting peptide. Here, we designed and synthesized a novel peptide-Au cluster as Au_(10)Peptide_5 to target to EGFR. We found Au_(10)Peptide_5 could target to the natural binding sites of all EGFRs at membrane in both active and inactive states by molecular simulations. Its targeted ability was further verified by the co-localization and blocking experiments. We also study the configuration modifications of both active and inactive EGFRs after binding by Au_(10)Peptide_5. For active EGFR, the absorbed Au_(10)Peptide_5 might replace the natural ligand in EGFR endocytosis process. Then, the peptide-Au cluster in endochylema could inhibit the cancer relating enzyme activity including thioredoxin reductase1(TrxR1) and induce the oxidative stress mediated apoptosis in tumor cells. For inactive EGFR, it was retained in inactive state by Au_(10)Peptide_5 binding to inhibit dimerization of EGFR for anticancer. Both pathways might be applied in anticancer drug development based on the theoretical and experimental study here.

关键词：生长因素指向状态受体表皮癌症小径 apoptosis

Method for evaluation of the cleanliness grade of coal resources in the Huainan Coalfield,Anhui,China:a case study

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International Journal of Coal Science & Technology 2021年第4期8卷 534-546页

作者： Guangqing Hu Guijian Liu Dun Wu Wenyong ZHANG Biao Fu School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026AnhuiChina Green Mining Engineering Technology Research Center of Anhui Province Exploration Research InstituteAnhui Provincial Bureau of Coal GeologyHefei 230088AnhuiChina

Based on analysis of a large data set and supplementary sampling and analysis for hazardous trace elements in coal samples from the Huainan Coalfield,a generalized contrast-weighted scale index method was used to establish a model to evaluate the grade of coal cleanliness and its regional distribution in the main coal seam(No.13-1)The results showed that:(1)The contents of Cr,Mn and Ni in the coal seam are relatively high and the average values are greater than 20μg/g.The contents of Se and Hg are at a high level while most other trace elements are at normal levels.(2)The cleanliness grade of the coal seam is mainly grade III-IV,which corresponds to a relatively good-medium coal cleanliness grade.However,some parts of the seam are at grade V(relatively poor coal cleanliness).(3)Coal of relatively good cleanliness grade(grade III)is distributed mainly in the regions corresponding to the Zhuji-Dingji-Gubei coal mines and in the eastern periphery of the Panji coal mine.Coal of medium cleanliness(grade IV)is distributed mainly in the regions of the Panji-Xiejiaji and Kouzidong coalmines.Relatively poor grade coal(grade V)is distributed in the southwest regions of the coalfield and the contents of Cr,As and Hg in coal collected from the relatively poor coal cleanliness regions often exceed the regulatory standards for the maximum concentration limits.

关键词： Coal cleanliness Hazardous trace elements Evaluation method Huainan coalfield

Development of Chinese herbal medicine for sensorineural hearing loss

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Acta Pharmaceutica Sinica B 2024年第2期14卷 455-467页

作者： Yunhao Wu Jingwen zhang Qiuping Liu Zhuang Miao Renjie Chai wenyong Chen State Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologyAdvanced Institute for Life and HealthJiangsu Province HighTech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096China Department of Otolaryngology-Head and Neck the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Department of Otolaryngology-Head and Neck Surgery Affiliated Hospital of Jiangnan UniversityWuxi 214000China Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610000China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Institute for Stem Cell and Regeneration Chinese Academy of ScienceBeijing 100085China Beijing Key Laboratory of Neural Regeneration and Repair Capital Medical UniversityBeijing 100069China

According to the World Health Organization’s world report on hearing,nearly 2.5 billion people worldwide will suffer from hearing loss by 2050,which may contribute to a severe impact on individual life quality and national economies.Sensorineural hearing loss(SNHL)occurs commonly as a result of noise exposure,aging,and ototoxic drugs,and is pathologically characterized by the impairment of mechanosensory hair cells of the inner ear,which is mainly triggered by reactive oxygen species accumulation,inflammation,and mitochondrial dysfunction.Though recent advances have been made in understanding the ability of cochlear repair and regeneration,there are still no effective therapeutic drugs for SNHL.Chinese herbal medicine which is widely distributed and easily accessible in China has demonstrated a unique curative effect against SNHL with higher safety and lower cost compared with Western medicine.Herein we present trends in research for Chinese herbal medicine for the treatment of SNHL,and elucidate their molecular mechanisms of action,to pave the way for further research and development of novel effective drugs in this field.

关键词： Sensorineural hearing loss Chinese herbal medicine Molecular mechanism Active ingredients Prescriptions Ototoxic drugs Noise Hair cells

Metamorphic Petrology of Clinopyroxene Amphibolite from the Xigaze Ophiolite,Southern Tibet: P-T Constraints and Phase Equilibrium Modeling

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Journal of Earth Science 2019年第3期30卷 549-562页

作者： Yancheng zhang Xu-Ping Li Guangming Sun Zeli Wang wenyong Duan Shandong Provincial Key Laboratory of Depositional Mineralization & Sedimentary Minerals College of Earth Science & EngineeringShandong University of Science and Technology

The clinopyroxene amphibolite from the Bailang terrane is located in the central section of the Yarlung Zangbo suture zone(YZSZ),southern Tibet.The study of it is expected to provide important clues for the subduction of the Neo-Tethyan Ocean below the Asian Plate and thus for better understanding of the development of the India-Asia collision zone.Based on integrated textural,mineral compositional,metamorphic reaction history and geothermobarometric studies of the clinopyroxene amphibolite within a serpentinite mélange,four overprinted metamorphic stages are established.They are the first metamorphic record of M1 stage indicated by a relict assemblage of plagioclase+clinopyroxene+amphibole,an early M2 stage characterized by an assemblage of medium-grained clinopyroxene+amphibole+plagioclase+quartz as well as rutile inclusion in titanite,which is formed during burial process,an isobaric cooling M3 stage which is characterized by an assemblage of clinopyroxene+amphibole+plagioclase+titanite,and a decomposing retrograde stage M4,which is represented by the amphibolite+plagioclase symplectite+titanite+rutile+quartz.By applying the THERMOCALC(versions 6.2 and 6.3)technique in the NCFMASHTO system,the P-T conditions estimated from M1 to M4 stages are ca.8.6 kbar/880℃,10.8–13.4 kbar/800–840℃,12.7–13.2 kbar/650–660℃ and<11.2 kbar/640℃,respectively.The mineral assemblages and their P-T conditions define a counterclockwise P-T path for the clinopyroxene amphibolite of the Xigaze ophiolite,suggesting that the rocks underwent a cooling process during burial from magmatic protolith,and a decompressing stage after the pressure peak metamorphic conditions,which implies that the Bailang terrane of the Xigaze ophiolite may have experienced subduction/collision-related tectonic processes.The peak metamorphism reaches to the transitional P-T conditions among amphibolite facies,granulite facies and eclogite facies with a burial depth of 30–40 km.After exhumation of the ophiolitic unit to the shallow crustal levels,the clinopyroxene

关键词： clinopyroxene amphibolite thermodynamic modeling P-T conditions counterclock P-T path Bailang terrane Xigaze ophiolite Tibet