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The blooming intersection of transcatheter hepatic artery chemoembolization and nanomedicine

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Chinese Chemical Letters 2020年第6期31卷 1375-1381,F0003页

作者： Hu Chen Hongwei Cheng wenying Wu Dengfeng Li Jingsong Mao Chengchao Chu Gang Liu State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361102China Department of Radiology Xiang'an Hospital of Xiamen UniversityXiamen 361102China Department of Radiological Intervention The First Hospital of China Medical UniversityShenyang 1W001China

Transcatheter hepatic artery chemoembolization(TACE)is a universal treatment for patients with hepatocellular carcinoma(HCC)that inhibits tumor growth by cutting off the blood supply and provides chemotherapeutics locally to the *** strategy of combining TACE formulation with image-guided ablation holds tremendous potential,but patient tolerance and undesired toxicity/immunosuppression remains a *** application of nanotechnology in TACE opens new doors for the treatment of ***,nanomaterials or nano-drugs dispersed in the TACE formulation can effectively improve the delivery efficiency of drugs by achieving both controlled and continuous *** addition,the utilization of multifunctional nanoparticles can provide guidance and monitoring for various advanced imaging methods for TACE treatment,and can realize the combination therapy of thermal ablation,microwave ablation,in situ radiotherapy,and other therapies,greatly expanding the therapeutic strategies available for HCC ***,the current exploration of nanotechnology in TACE of HCC is briefly summarized and the challenges of TACE with nanoformulations for clinical translation are comprehensively discussed.

关键词： Transcatheter hepatic artery chemoembolization Hepatocellular carcinoma Nanomedicine Theranostics Combination therapy

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小麦肽-维生素D微胶囊的稳定性及结构鉴定

食品科技 2024年第5期49卷 258-265,274页

作者：刘睿王华蕾吴晗硕任杰许润琦刘文颖侯俊财东北农业大学黑龙江哈尔滨150000 中国食品发酵工业研究院有限公司北京市蛋白功能肽工程技术研究中心北京100015

以小麦肽为壁材,维生素D(Vitamin D,VD)油作为芯材,利用喷雾干燥法制备小麦肽-VD微胶囊,并对其稳定性进行了初步研究。通过分析微胶囊的基础理化成分,以分子质量分布为指标,研究了pH值、温度和蛋白酶消化对微胶囊稳定性的影响。结果表明... 详细信息

以小麦肽为壁材,维生素D(Vitamin D,VD)油作为芯材,利用喷雾干燥法制备小麦肽-VD微胶囊,并对其稳定性进行了初步研究。通过分析微胶囊的基础理化成分,以分子质量分布为指标,研究了pH值、温度和蛋白酶消化对微胶囊稳定性的影响。结果表明,微胶囊中共含有17种氨基酸,必需氨基酸占比为15.8%,相对分子质量小于2000 u的水解物占比为97.79%;总蛋白质含量为74.78%,酸溶蛋白含量为71.65%。在pH值分别为2、4、6、8、10、37 ℃水浴2 h后,微胶囊各分子质量区间的比例变化不超过6%;分别于20、40、60、80 ℃和100 ℃下水浴2 h后,微胶囊各分子质量区间的比例变化不超过7%;分别经过胃蛋白酶、胰蛋白酶、胃蛋白酶及胰蛋白酶消化后,微胶囊各分子质量区间的比例变化不超过6%。该研究为小麦肽-VD微胶囊在食品工业中的应用提供了理论依据,同时也提供了保护VD活性和延长货架期的可行方法。

关键词：小麦肽维生素D 螯合稳定性

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资本主义社会片面追求效率与休闲的异化

消费经济 2005年第6期21卷 68-71页

作者：周觉北京信息科技大学经贸系北京100085

追求劳动效率推动了资本主义社会由追求绝对剩余价值向相对剩余价值转变,马克思指出这种转变给劳动者所带来的后果是劳动强度的增加与劳动的异化。劳动的异化会导致休闲的异化,表现为休闲的“物化”与“工作化”;劳动生产效率提高要求... 详细信息

追求劳动效率推动了资本主义社会由追求绝对剩余价值向相对剩余价值转变,马克思指出这种转变给劳动者所带来的后果是劳动强度的增加与劳动的异化。劳动的异化会导致休闲的异化,表现为休闲的“物化”与“工作化”;劳动生产效率提高要求休闲效率也相应提高,追求休闲效率在加剧时间稀缺性的同时导致休闲异化,表现为自由时间之不可能。

关键词：效率休闲异化

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驾驶员情绪状态研究

心理科学 2003年第3期26卷 438-440页

作者：朱国锋何存道浙江交通职业技术学院杭州311112 华东师范大学心理系上海200062

采用驾驶员情绪状态量表(DPOMS),对265名客车驾驶员的情绪状态进行了问卷调查。结果表明:(1)年龄对驾驶员的疲劳状态有显著影响,对其余各种情绪状态没有显著影响;(2)女驾驶员的紧张情绪显著高于男驾驶员,积极情绪(精力)显著于低于男驾驶... 详细信息

采用驾驶员情绪状态量表(DPOMS),对265名客车驾驶员的情绪状态进行了问卷调查。结果表明:(1)年龄对驾驶员的疲劳状态有显著影响,对其余各种情绪状态没有显著影响;(2)女驾驶员的紧张情绪显著高于男驾驶员,积极情绪(精力)显著于低于男驾驶员;(3)出租汽车驾驶员的愤怒、疲劳、紧张等消极情绪显著高于公交大客车驾驶员,积极情绪(精力)显著低于公交大客车驾驶员;(4)事故组驾驶员的愤怒、疲劳、紧张、慌乱等消极情绪显著高于安全组驾驶员,积极情绪(精力)显著低于安全组驾驶员。

关键词：女性驾驶员情绪状态 DPOMS 交通事故疲劳状态男性积极情绪出租汽车愤怒情绪疲劳情绪紧张情绪公交大客车消极情绪慌乱情绪

Insight into MgO promoter with low concentration for the carbon-deposition resistance of Ni-based catalysts in the CO_2 reforming of CH_4

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Chinese Journal of Catalysis 2018年第1期39卷 88-98页

作者： Xiangdong Feng Jie Feng wenying Li Key Laboratory of Coal Science and Technology Taiyuan University of Technology Taiyuan 030024 Shanxi China Training Base of State Key Laboratory of Coal Science and Technology Jointly Constructed by Shanxi Province and Ministry of Science and Technology Taiyuan University of Technology Taiyuan 030024 Shanxi China

The CO2reforming of CH4is studied over MgO‐promoted Ni catalysts,which were supported on alumina prepared from *** presents an improved stability compared with non‐promoted *** introduction of the MgO promoter was achieved through the‘‘memory effect’’of the Ni‐Al hydrotalcite structure,and ICP‐MS confirmed that only0.42wt.%of Mg2+ions were added into the Ni‐Mg/Al *** no differences in the Ni particle size and basicity strength were observed,the Ni‐Mg/Al catalyst showed a higher catalytic stability than the Ni/Al catalyst.A series of surface reaction experiments were used and showed that the addition of a MgO promoter with low concentration can promote CO2dissociation to form active surface oxygen arising from the formation of the Ni‐MgO interface ***,the carbon‐resistance promotion by nature was suggested to contribute to an oxidative environment around Ni particles,which would increase the conversion of carbon residues from CH4cracking to yield CO on the Ni metal surface.?2018,Dalian Institute of Chemical Physics,Chinese Academy of *** by Elsevier *** rights reserved.

关键词： CO2 reforming of CH4 Carbon‐deposition resistant Activation of CO2 Ni‐based catalyst Low concentration MgO promoter

基于深度学习的镜下矿石矿物的智能识别实验研究

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岩石学报 2018年第11期34卷 3244-3252页

作者：徐述腾周永章广东省地质过程与矿产资源探查重点实验室广州510275 中山大学地球环境与地球资源研究中心广州510275 中山大学地球科学与工程学院广州510275

矿石矿物鉴定的智能化是智能地质学和智能矿床学的基础技术之一。计算机视觉技术和深度学习理论使矿石矿物鉴定的智能化成为可能。本研究基于深度学习系统Tensor Flow,以吉林夹皮沟金矿和河北石湖金矿的黄铁矿、黄铜矿、方铅矿、闪锌矿... 详细信息

矿石矿物鉴定的智能化是智能地质学和智能矿床学的基础技术之一。计算机视觉技术和深度学习理论使矿石矿物鉴定的智能化成为可能。本研究基于深度学习系统Tensor Flow,以吉林夹皮沟金矿和河北石湖金矿的黄铁矿、黄铜矿、方铅矿、闪锌矿等硫化物矿物为例,设计有针对性的unet卷积神经网络模型,有效自动提取矿相显微镜下矿石矿物的深层特征信息,实现镜下矿石矿物智能识别与分类。实验显示,模型在训练过程中,随着训练次数的增加,模型精度在不断增大,损失函数不断减小;经过3000个批处理之后,模型精度和损失函数基本趋于稳定。训练出的模型对测试集中的显微镜镜下矿石矿物照片的识别成功率均高于90%,说明实验所建立的模型,具有很好的图像特征提取能力,能完成镜下矿石矿物智能识别的任务。

关键词：卷积神经网络算法深度学习矿物自动识别地质大数据智能地质学机器学习

STI571 combined with vincristine greatly suppressed the tumor formation of multidrug-resistant K562 cells in a human-nude mice xenograft model

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Chinese Medical Journal 2006年第11期119卷 911-918页

作者： GA0 Lei CHEN Li FEI Xin-hong QIu Hui-ying zh.u Hong WANG Jian-min Department of Hematology Changhai Hospital Second Military Medical University Shanghai 200433 China

Background The development of the targeted signal transduction inhibitor STI571 has prompted us to treat chronic myeloid leukemia in different ways. Since STI571 may reverse multidrug-resistance of K562/MDR cells in vitro, we studied the effect of STI571 on multidrug-resistant K562 cells in vivo. Methods Multidrug-resistant human leukemia cell line K562-n/VCR expresses both bcr/abl fusion gene and multi-drug resistance （mdrl） gene. It is a vincristine resistant cell line subcloned from the vincristine （VCR） sensitive cell line K562-n induced by vincristine in vitro. K562-n and K562-n/VCR cells were inoculated subcutaneously into both sides of nude mice breast （5×10^6 cells/each） to establish a human leukemia xenograft model. The incidence and volume of tumor were observed. In the tumor-bearing nude mice, anti-tumor drugs vincristine, daunorubicin （DNR）, STI571, and STI571 plus VCR for the treatment of mdrl and bcr/abl double positive leukemia were studied respectively. Results The tumor incidence was 100% in the nude mice inoculated with either K562-n or K562-n/VCR. The transcription of the mdrl gene and expression of P-gp were negative in K562-n cells but positive in K562-n/VCR cells. The intracellular accumulation of DNR in K562-n cells was higher than that in K562-n/VCR cells （P〈0.05） The tumor incidence of K562-n/VCR cells in nude mice was much higher than that of K562-n cells in chemotherapy groups, and the mean volume of the tumors was also larger （P〈0.05）. STI571 combined with VCR significantly suppressed the proliferation of K562-n/VCR cells. Conclusions The MDR characteristics of K562-n/VCR in vivo were the same as in vitro. STI571 had a significant tumor-suppressing effect on VCR-sensitive leukemia ceils and a moderate effect on MDR leukemia cells. VCR combined with STI571 had an excellent tumor-suppressing effect on both K562-n/VCR and K562-n in the human-nude mice xenograft model.

关键词： K562 cells leukemia multidrug-resistance imatinib mesylate xenograft model antitumor assays

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我国老年保健品营销现状与策略选择

消费经济 2005年第2期21卷 59-61页

作者：周露阳绍兴文理学院经济与管理学院浙江绍兴312000

随着我国步入老龄化社会,老年保健品市场蕴藏着无限的商机和潜力。本文从相关背景的分析出发,分析了我国老年保健品市场的营销现状,并给出了相应的营销策略选择———人性化营销。

关键词：老年保健品人性化营销营销策略中国顾客满意度

Comparison of Influenza Outbreaks in the Republic of Kazakhstan and Russia Induced by 2009 Yearly New Variant of А(H1N1) Influenza Virus

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Virologica Sinica 2011年第5期26卷 306-314页

作者： Karpova L S Popovtseva N M Stolyarova T P Stolyarov K A Mamadaliyev S M Khairullin B M Sandybayev N T Kydyrbayev zh K Orynbayev M B Ospanov K S Baiserkin B S Boibosinov E u FSBI Research Institute of Influenza (RII) Ministry of Health and Social Development of RussiaSaint-PetersburgPopova street15/17197376Russian Federation RGE Research Institute for Biological Safety Problems (RIBSP) Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan GvardeiskiyKordaiskiy rayonZhambulskaya oblast 080409Republic of Kazakhstan Scientific-Practical Center of Sanitary and Epidemiological Expertise and Monitoring Epidemiology Committee of state sanitary and epidemic supervision of the Ministry of Health Care of the Republic of Kazakhstan (MHC RK) AlmatyAuezov street 84050008Republic of Kazakhstan

The aim of the work is the comparison of the epidemiology of influenza and acute respiratory virus infections (ARVI) in the Republic of Kazakhstan with the corresponding influenza epidemic in Russia induced by influenza pandemic virus A/California/07/2009 in *** on influenza and ARVI from the Republic of Kazakhstan and Federal Center of influenza was collected and investigated over the course of several weeks from hospitalized patients with the same diagnosis among all population and in age groups on 16 territories of Kazakhstan and in 49 major cities of *** epidemic in Kazakhstan resembled the Russian epidemic in terms of its abnormally early beginning,expression of monoaetiology,the spread of the epidemic into all territories and start of the epidemics among adult *** percentage of hospitalized people and lethal outcome were registered in this *** of epidemic process character in corresponding border-line territories of both countries was found out.

关键词： Epidemic Influenza outbreak Acute respiratory viral infection Morbidity