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The LXRB-SREBP1 network regulates lipogenic homeostasis by controlling the synthesis of polyunsaturated fatty acids in goat mammary epithelial cells

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Journal of Animal Science and Biotechnology 2023年第2期14卷 614-626页

作者： wenying zhang Changhui zhang Jun Luo Huifen Xu Jianxin Liu Juan JLoor Hengbo Shi Institute of Dairy Science College of Animal SciencesZhejiang UniversityHangzhou 310058China College of Animal Science and Technology Northwest A&F UniversityYangling 712100China College of Animal Science and Technology Henan Agricultural UniversityZhengzhou 450046China Key Laboratory of Molecular Animal Nutrition(Zhejiang University) Ministry of EducationHangzhou310058China Mammalian Nutrition Physiology Genomics Department of Animal Sciences and Division of Nutritional SciencesUniversity of IllinoisUrbanaIL 61801USA.

Background:In rodents,research has revealed a role of liver X receptors(LXR) in controlling lipid homeostasis and regulating the synthesis of polyunsaturated fatty acids(PUFA).Recent data suggest that LXRB is the predominant LXR subtype in ruminant mammary cells,but its role in lipid metabolism is *** was hypothesized that LXRB plays a role in lipid homeostasis via altering the synthesis of PUFA in the ruminant mammary *** used overexpression and knockdown of LXRB in goat primary mammary epithelial cells(GMEC) to evaluate abundance of lipogenic enzymes,fatty acid profiles,content of lipid stores and activity of the stearoyl-Co A desaturase(SCD1) ***:Overexpression of LXRB markedly upregulated the protein abundance of LXRB while incubation with si RNA targeting LXRB markedly decreased abundance of LXRB *** of LXRB plus T0901317(T09,a ligand for LXR) dramatically upregulated SCD1 and elongation of very long chain fatty acid-like fatty acid elongases 5–7(ELOVL 5–7),which are related to PUFA *** with the control,cells overexpressing LXRB and stimulated with T09 had greater concentrations of C16:0,16:1,18:1n7,18:1n9 and C18:2 as well as desaturation and elongation indices of C16:***,LXRB-overexpressing cells incubated with T09 had greater levels of triacylglycerol and *** of LXRB in cells incubated with T09 led to downregulation of genes encoding elongases and *** of LXRB attenuated the increase in triacylglycerol and cholesterol that was induced by *** cells treated with dimethylsulfoxide,knockdown of LXRB increased the concentration of C16:0 at the expense of C18:0,while a significant decrease in C18:2 was observed in cells incubated with both si LXRB and *** abundance of sterol regulatory element binding transcription factor 1 precursor(p SREBP1) and its mature fragment(n SREBP1) was upregulated by T09,but not LXRB *** the cells cultured with T

关键词： Elongase Lipid homeostasis Liver X receptor Mammary gland Polyunsaturated fatty acids

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Degradation of benzene derivatives in the CuMgFe-LDO/persulfate system:The role of the interaction between the catalyst and target pollutants

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Journal of Environmental Sciences 2020年第4期32卷 87-97页

作者： Yun Chen Da Ouyang wenying zhang Jingchun Yan Linbo Qian Lu Han Mengfang Chen Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China National Engineering Laboratory for Site Remediation Technologies Beijing 100015China

A novel insight on the role of interactions between target pollutants and the catalyst in the copper-containing layered double oxide(LDO)-catalyzed persulfate(PS)system was elucidated in the present study.4-Chlorophenol(4-CP),as a representative benzene derivative with a hydroxyl group,was completely removed within 5 min,which was much faster than the reaction of monochlorobenzene(MCB)without a hydroxyl group,with the degradation efficiency of 31.7%in 240 *** the use of radical quenching and surface inhibition experiments,it could be concluded that the interaction between 4-CP and CuMgFe-LDO,rather than free radicals,played a key role in the decomposition of 4-CP,while only the free radicals participated in the MCB degradation *** to electron paramagnetic resonance and Xray photoelectron spectroscopy data,the formation of a Cu(II)-complex between phenolic hydroxyl groups and surface Cu(II)was primarily responsible for the degradation of phenolic compounds,in which PS accepted one electron from the complex and generated sulfate radicals and chelated radical *** chelated radical cations transferred one electron to Cu(Ⅱ)followed by Cu(I)generation and pollutant degradation successively.

关键词： CuMgFe-LDO Persulfate Phenolic compounds Cu(Ⅱ)-Complex

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Numerical solutions of rotational normal modes of a triaxial two-layered anelastic Earth

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Geodesy and Geodynamics 2019年第2期10卷 118-129页

作者： Wenbin Shen Zhuo Yang Zhiliang Guo wenying zhang Department of Geophysics School of Geodesy and Geomatics/Key Laboratory of Geospace Environment and Geodesy of Ministry of EducationWuhan University State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan University

The Earth's rotational normal modes depend on Earth model used, including the layer structures,principal inertia moments of different layers and the compliances. This study focuses on providing numerical solution of the rotational normal modes of a triaxial two-layered anelastic Earth model without external forces but with considering the complex forms of compliances and the electromagnetic coupling between the core and mantle. Based on the present knowledge of the Chandler wobble(CW) and Free Core Nutation(FCN), we provide a set of complete compliances which could be used for reference in further investigations. There are eight rotational normal mode solutions, four of which might exist in nature. However, in reality only two of these four solutions correspond to the present motion status of the prograde CW and the retrograde FCN. On one hand, our numerical calculations show that the periods and quality factors(Qs) of CW and FCN are respectively 434.90 and 429.86 mean solar days(d) and 76.56 and 23988.47 under frequency-dependent assumption, and the triaxiality prolongs CW about 0.01 d and has hardly effect on FCN. On the other hand, we analyze the sensibility of compliances and electromagnetic coupling parameter on the periods and Qs of CW and FCN and find the sensitive parameters with respect to them.

关键词： Earth rotation Triaxial two-layered anelastic Earth model Compliances Rotational normal modes Numerical solution

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Mapping QTL for flowering time-related traits under three plant densities in maize

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The Crop Journal 2021年第2期9卷 372-379页

作者： Liwei Wang Zhiqiang Zhou Ronggai Li Jianfeng Weng Quanguo zhang Xinghua Li Baoqiang Wang wenying zhang Wei Song Xinhai Li The Key Laboratory of Crop Genetics and Breeding of Hebei Province Institute of Cereal and Oil CropsHebei Academy of Agriculture and Forestry SciencesShijiazhuang 050035HebeiChina Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China

Flowering time is an indicator of adaptation in maize and a key trait for selection in *** genetic basis of flowering time in maize,especially in response to plant density,remains *** objective of this study was to identify maize quantitative trait loci(QTL)associated with flowering time-related traits that are stably expressed under several plant densities and show additive effects that vary with plant *** hundred recombinant inbred lines(RIL)derived from a cross between Ye 478 and Qi 319,together with their parents,were planted at three plant densities(90,000,120,000,and 150,000 plants ha^(-1))in four *** five traits investigated were days to tasseling(DTT),days to silking(DTS),days to pollen shed(DTP),interval between anthesis and silking(ASI),and interval between tasseling and anthesis(TAI).A high-resolution bin map was used for QTL *** the RIL population,the DTT,DTS,and DTP values increased with plant density,whereas the ASI and TAI values showed negligible response to plant density.A total of 72 QTL were identified for flowering time-related traits,including 15 stably expressed across *** flowering time under different densities seems to be regulated by complex pathways rather than by several major genes or an independent *** effects of some stable QTL,especially qDTT8-1 and qDTT10-4,varied with plant *** mapping and cloning of these QTL will shed light on the mechanism of flowering time and assist in breeding earlymaturing maize inbred lines and hybrids.

关键词： Maize Flowering time Plant density Recombinant inbred lines(RIL) Genetic basis

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Effect of chemical regulators on the recovery of leaf physiology,dry matter accumulation and translocation,and yield-related characteristics in winter wheat following dry-hot wind

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Journal of Integrative Agriculture 2024年第1期23卷 108-121页

作者： Yanan Xu Yue Wu Yan Han Jiqing Song wenying zhang Wei Han Binhui Liu Wenbo Bai Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China Institute of Dryland Farming Research Hebei Academy of Agriculture and Forestry SciencesHengshui 053000China Shandong General Station of Agricultural Technology Extension Jinan 250100China

Dry-hot wind stress causes losses in wheat productivity in major growing regions worldwide,especially winter wheat in the Huang-Huai-Hai Plain of China,and both the occurrence and severity of such events are likely to increase with global climate *** investigate the recovery of physiological functions and yield formation using a new noncommercial chemical regulator(NCR)following dry-hot wind stress,we conducted a three-year field experiment(2018-2021)with sprayed treatments of tap water(control),monopotassium phosphate(CKP),NCR at both the jointing and flowering stages(CFS),and NCR only at the jointing stage(FSJ)or flowering stage(FSF).The leaf physiology,biomass accumulation and translocation,grain-filling process,and yield components in winter wheat were *** the single spraying treatments,the FSJ treatment was beneficial for the accumulation of dry matter before anthesis,as well as larger increases in the maximum grain-filling rate and mean grain-filling *** FSF treatment performed better in maintaining a high relative chlorophyll content as indicated by the SPAD value,and a low rate of excised leaf water loss in flag leaves,promoting dry matter accumulation and the contribution to grain after anthesis,prolonging the duration of grain filling,and causing the period until the maximum grain-filling rate reached *** CFS treatment was better than any other treatments in relieving the effects of dry-hot *** exogenous NCR treatments significantly increased grain yields by 12.45-18.20% in 2018-2019,8.89-13.82% in 2019-2020,and 8.10-9.00% in *** conventional measure of the CKP treatment only increased grain yield by 6.69% in *** CFS treatment had the greatest mitigating effect on yield loss under dry-hot wind stress,followed by the FSF and FSJ treatments,and the CKP treatment only had a minimal *** summary,the CFS treatment could be used as the main chemical control measure for wheat stress resistance and yield

关键词： preparation stress foliar spraying grain-filling remobilization

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Health promoting activities and corresponding mechanism of(–)-epicatechin-3-gallate

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Food Science and Human Wellness 2022年第3期11卷 568-578页

作者： Zhiliang Li Changchun Feng Hongjin Dong Weibin Jin wenying zhang Jianfeng Zhan Shuzhen Wang College of Life Science Huanggang Normal UniversityHubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive UtilizationHubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie MountainsHubei Zhongke Research Institute of Industrial TechnologyHuanggang 438000China College of Agriculture Yangtze UniversityJingzhou 434000China

(–)-Epicatechin-3-gallate(ECG),a bioactive polyphenolic compound,has contributed a lot to the health benefits of green *** attention has been focused on(–)-epigallocatechin-3-gallate(EGCG),but limited research has been performed towards *** EGCG,ECG also possesses various pharmacological and physiological properties,such as mediation of antioxidant activities,anti-inflammation response,regulation of cell proliferation and apoptosis,as well as anticancer properties during angiogenesis,invasion and metastasis *** ECG has various molecular targets within the cells,including CYP enzymes,phaseⅡdetoxification and antioxidant enzymes,as well as pro-inflammatory *** antineoplastic mechanism contains inhibition of phase 1 CYP enzymes,induction of phaseⅡdetoxification and antioxidant enzymes,high anti-inflammatory efficacy,arrest of cell cycle progression,regulation of apoptosis,as well as mediation of metastasis *** particular,the gallate moiety of ECG is critical for mediating inhibitory effects towards cancer *** regulation of intracellular signaling pathways,ECG also inhibits RNase A and matrix metalloproteinase enzymatic activity via chelating metals(copper and zinc)in cancer *** review has summarized recent studies on pharmacological properties of ECG,and discussed corresponding mechanism on modulation of cellular signaling events by ECG,hoping to broaden its multiple usage.

关键词： (-)-Epicatechin-3-gallate Polyphenolic compounds Pharmacological properties Anticarcinogenic agent Natural antioxidants Antimicrobial properties

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Chlorogenic Acid Metabolism:The Evolution and Roles in Plant Response to Abiotic Stress

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Phyton-International Journal of Experimental Botany 2022年第2期91卷 239-255页

作者： Deka Reine Judesse Soviguidi Rui Pan Yi Liu Liping Rao wenying zhang Xinsun Yang Engineering Research Centre of Ecology and Agricultural Use of Wetland Ministry of EducationHubei Collaborative Innovation Center for Grain IndustryYangtze UniversityJingzhou434025China Hubei Sweetpotato Engineering and Technology Research Centre Hubei Academy of Agricultural SciencesWuhan430064China

During the evolution,plants acquired the ability to synthesize different phenylpropanoid compounds like chlorogenic acid(CGA),which plays vital roles in resistance mechanisms to abiotic *** environmental factors,including heavy metal,cold,heat,ultraviolet(UV)light,drought,and salinity affect the plant physiological processes,resulting in massive losses of agriculture *** plants evolve from green algae to bryophytes,ferns,gymnosperms and angiosperms,phenylpropanoids are produced and accumulated in different tissues,giving the plant the capacity to counteract the harmful effects of the adverse *** have been performed on the metabolic evolution of rosmarinic acid,flavonoids and lignin,showing that the biosynthesis of phenylpropanoids begins in green algae until the emersion of genes found in angiosperms;however,the evolution of the CGA pathway has not yet been *** hypothesize that CGA could also be synthesized from algae to *** the present review,the evolutionary analysis of CGA pathway and the function of this compound in plant tolerance to abiotic stresses are *** analyzes were carried out on CGA-related genes across 37 plant species and revealed that the metabolic pathway starts in algae and gradually increases until it becomes complete in *** key genes exhibited different expression patterns in stress and plant ***,some genes accumulated rapidly during evolution and were more sensitive to environmental stresses,while others appeared only later in *** studies are needed to better understand the evolution of the CGA metabolic pathway in plants under environmentally stressed conditions.

关键词： Chlorogenic acid biosynthesis evolution plant abiotic stress

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Transcriptome analysis reveals key differentially expressed genes involved in wheat grain development

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The Crop Journal 2016年第2期4卷 92-106页

作者： Yonglong Yu Dong Zhu Chaoying Ma Hui Cao Yaping Wang Yanhao Xu wenying zhang Yueming Yan College of Life Sciences Capital Normal University Hubei Collaborative Innovation Center for Grain Industry/Yangtze University

Wheat seed development is an important physiological process of seed maturation and directly affects wheat yield and quality. In this study, we performed dynamic transcriptome microarray analysis of an elite Chinese bread wheat cultivar(Jimai 20) during grain development using the Gene Chip Wheat Genome Array. Grain morphology and scanning electron microscope observations showed that the period of 11–15 days post-anthesis(DPA) was a key stage for the synthesis and accumulation of seed starch. Genome-wide transcriptional profiling and significance analysis of microarrays revealed that the period from 11 to 15 DPA was more important than the 15–20 DPA stage for the synthesis and accumulation of nutritive *** test of cluster analysis of differential genes revealed five statistically significant gene expression profiles. Gene ontology annotation and enrichment analysis gave further information about differentially expressed genes, and Map Man analysis revealed expression changes within functional groups during seed development. Metabolic pathway network analysis showed that major and minor metabolic pathways regulate one another to ensure regular seed development and nutritive reserve accumulation. We performed gene co-expression network analysis to identify genes that play vital roles in seed development and identified several key genes involved in important metabolic pathways. The transcriptional expression of eight key genes involved in starch and protein synthesis and stress defense was further validated by q RT-PCR. Our results provide new insight into the molecular mechanisms of wheat seed development and the determinants of yield and quality.

关键词： Wheat Transcriptome microarray Differentially expressed genes Grain development

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AMPK-ChREBP axis mediates de novo milk fatty acid synthesis promoted by glucose in the mammary gland of lactating goats

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Animal Nutrition 2022年第3期10卷 234-242页

作者： Hengbo Shi Nannan Jiang Ling Wei Jie Cai wenying zhang Qianming Jiang Juan JLoor Jianxin Liu Institute of Dairy Science College of Animal SciencesZhejiang UniversityHangzhou310058China College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou310018China Mammalian Nutrition Physiology Genomics Department of Animal Sciences and Division of Nutritional SciencesUniversity of IllinoisUrbanaIL61801USA

To investigate the role of glucose in regulating milk fatty acid synthesis,6 lactating Guanzhong dairy goats were infused with 0,60,or 100 g/d glucose via the external pubic artery in a 33 repeated Latin square experiment.A concomitant in vitro experiment was conducted to investigate possible mechanisms whereby glucose regulates milk fatty acid *** sequencing was used for cellular transcriptome ***,MK-2206,rapamycin,and dorsomorphin were used to block cellular mammalian AMP-activated protein kinase(AMPK),AKT serine/threonine kinase 1,and mechanistic target of rapamycin kinase signaling pathways,*** response element binding protein(ChREBP)was knockdown and overexpressed to investigate its role in regulating milk fatty acid synthesis in mammary epithelial *** infusion linearly elevated the concentration of C8:0(P=0.039)and C10:0(P=0.041)in milk fat while it linearly decreased(P=0.049)that of C16:*** result was in agreement with the upregulation of genes related to de novo synthesis of fatty acids and lipid droplet formation,including adipose differentiation-related protein,butyrophilin subfamily 1 member A1,fatty acid synthase(FASN)and *** expression increased(P<0.05)linearly in the lactating goat mammary *** vitro,glucose linearly stimulated the expression of genes related to de novo synthesis of fatty acids and cellular triacylglycerol in cultured mammary epithelial *** sequencing and inhibition studies revealed that glucose induced transcriptomic changes increasing lipogenic pathways,with AMPK responding to glucose by controlling ChREBP and *** and overexpression of ChREBP highlighted its essential role in *** knockdown and overexpression of ChREBP protein also revealed an essential role in regulating the de novo synthesis of fatty ***,our data highlight that glucose supplementation promotes de novo fatty acid synthesis via the AMPK-ChREBP axis,hence i

关键词： Milk fat Glucose infusion Mammary gland Carbohydrate response element binding protein De novo synthesis

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Index selection on seed traits under direct,cytoplasmic and maternal effects in multiple environments

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Journal of Genetics and Genomics 2009年第1期36卷 41-49页

作者： wenying zhang Haiming Xu Jun Zhu Institute of Bioinformatics College of Agriculture and Biotechnology Zhefiang University Hangzhou 310029 China Institute of Plant Genetics and Breeding College of Agriculture Yangtze University Jingzhou 434025 China

Crop seeds are important sources of protein, oil, and carbohydrates for food, animal feeds, and industrial products. Recently, much attention has been paid to quality and functional properties of crop seeds. However, seed traits possess some distinct genetic characteristics in comparison with plant traits, which increase the difficulty of genetically improving these traits. In this study, diallel analysis for seed models with genotype by environment interaction （GE） effect was applied to estimate the variance-covariance components of seed traits. Mixed linear model approaches were used to estimate the genetic covariances between pair-wise seed and plant traits. The breeding values （BV） were divided into two categories for the seed models. The first category of BV was defined as the combination of direct additive, cytoplasmic, and maternal additive effects, which should be utilized for selecting stable cultivars over multi-environments. The three genetic effects, together with their GE interaction, were included in the second category of BV for selecting special lines to be grown in specific ecosystems. Accordingly, two types of selection indices for seed traits, i.e., general selection index and interaction selection index, were developed and constructed on the first and the second category BV, respectively. These proposed selection indices can be applied to solve the difficult task of simultaneously improving multiple seed traits in various environments. Data of crop seeds with regard to four seed traits and four yield traits based on the modified diallel crosses in Upland cotton （Gossypium hirsutum L.） were used as an example for demonstrating the proposed methodology.

关键词： index selection seed trait mixed linear model approach genotype by environment interaction

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