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Concentrations and distribution of novel brominated flame retardants in the atmosphere and soil of Ny-Alesund and London Island,Svalbard,Arctic

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Journal of Environmental Sciences 2020年第11期32卷 180-185页

作者： Yanfen Hao wenying meng Yingming Li Xu Han Huili Lu Pu Wang Ruiqiang Yang Qinghua Zhang Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Shenzhen Center for Disease Control and Prevention Shenzhen 518055China

Novel brominated flame retardants(NBFRs)were investigated in Arctic air and soil samples collected from Ny-?lesund and London Island,Svalbard,during Chinese scientific research expeditions to the Arctic during 2014–*** concentrations of 9 NBFRs in the Arctic air and soil were 4.9–8.7 pg/m3(average 6.8 pg/m3)and 101–201 pg/g dw(average 150 pg/g dw),*** atmospheric concentration of hexabromobenzene(HBB)was significantly correlated with that of pentabromotoluene(PBT)and pentabromobenzene(PBBz),suggesting similar source and environmental fate in the Arctic *** significant spatial difference was observed among the different sampling sites,both for air and soil samples,indicating that the effects of the scientific research stations on the occurrence of NBFRs in the Arctic were *** fugacities from soil to air of pentabromoethylbenzene(PBEB),2,3-dibromopropyl 2,4,6-tribromophenyl ether(DPTE),and decabromodiphenylethane 1,2-bis(pentabromophenyl)ethane(DBDPE)were lower than the equilibrium value,indicating a nonequilibrium state of these compounds between air and soil,the dominant impact of deposition and the net transport from air to *** correlation analysis between the measured and predicted soil-atmosphere coefficients based on the absorption model showed that the impact of the soil organic matter on the distribution of NBFRs in the Arctic region was *** the best of our knowledge,this work is one of the limited reports on atmospheric NBFRs in the Arctic and the first study to investigate the occurrence and fate of NBFRs in the Arctic soil.

关键词： Novel brominated flame retardants Arctic Soil Air Soil-atmosphere partitioning

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Asymptotics of the Density-dependent Incompressible Navier-Stokes Flows in Exterior Domains

Asymptotics of the Density-dependent Incompressible Navier-S...

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第十一届全国流体力学学术会议

作者： Xiaoli Li wenying meng Department of Mathematics School of ScienceBUPT

In this paper,we investigate the existence and uniqueness of time periodic solution to the density-dependent incompressible Navier-Stokes equations in exterior ***,we study the asymptotic stability of the periodic solution that is given by the same Landau *** we all know,the celebrated results by many mathematicians devoted to the constant density case are ***,an actual fluid is almost impossible homogeneous and *** expect to find an approach to study the solvability of Navier-Stokes equations with variable ***,we employ some technical methods and hypothesis to overcome the difficulties by variable *** theorems in this article can be regarded as an improvement extension by the work in ***,*** and ***-Peng(Communications in Partial Differential Equations,Volume 37,2012-Issue 10).

关键词： Navier-Stokes flows exterior domain existence and uniqueness asymptotic stability

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AI-Enhanced Secure Data Aggregation for Smart Grids with Privacy Preservation

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Computers, Materials & Continua 2025年第1期82卷 799-816页

作者： Congcong Wang Chen Wang wenying Zheng Wei Gu School of Software Nanjing University of Information Science and TechnologyNanjing210044China School of Information Science and Engineering Zhejiang Sci-Tech UniversityHangzhou310018China State Key Laboratory of Public Big Data Guizhou UniversityGuiyang550025China School of Computer Science and Technology(School of Artificial Intelligence) Zhejiang Sci-Tech UniversityHangzhou310018China School of Computer Science(School of Cyber Science and Engineering) Nanjing University of Information Science and TechnologyNanjing210044China

As smart grid technology rapidly advances,the vast amount of user data collected by smart meter presents significant challenges in data security and privacy *** research emphasizes data security and user privacy concerns within smart ***,existing methods struggle with efficiency and security when processing large-scale *** efficient data processing with stringent privacy protection during data aggregation in smart grids remains an urgent *** paper proposes an AI-based multi-type data aggregation method designed to enhance aggregation efficiency and security by standardizing and normalizing various data *** approach optimizes data preprocessing,integrates Long Short-Term Memory(LSTM)networks for handling time-series data,and employs homomorphic encryption to safeguard user *** also explores the application of Boneh Lynn Shacham(BLS)signatures for user *** proposed scheme’s efficiency,security,and privacy protection capabilities are validated through rigorous security proofs and experimental analysis.

关键词： Smart grid data security privacy protection artificial intelligence data aggregation

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一种PIN二极管参数的提取方法与应用

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电子元件与材料 2019年第4期38卷 32-36页

作者：孟文营穆卓王身云南京信息工程大学应用电磁研究中心江苏南京210044

采用夹具测量微波元件参数时会引入夹具误差。本文设计了一款适用于SMP-1320-079LF型号PIN二极管散射参数测量的夹具和对应的TRL校准套件,并利用TRL校准方法测试了该型号PIN二极管在UHF频段的实际散射参数。然后,建立了PIN二极管在两种... 详细信息

采用夹具测量微波元件参数时会引入夹具误差。本文设计了一款适用于SMP-1320-079LF型号PIN二极管散射参数测量的夹具和对应的TRL校准套件,并利用TRL校准方法测试了该型号PIN二极管在UHF频段的实际散射参数。然后,建立了PIN二极管在两种工作状态下的等效电路模型,并根据测试参数,提取了等效电路参数。基于UHF-RFID系统应用需求,将PIN二极管应用于三端口开关馈电网络的设计,其工作频段为900～950 MHz。结果表明,改变PIN二极管的输入输出阻抗,三端口馈电网络均具有较好的开关特性,仿真与实测结果吻合。

关键词： TRL 校准件 PIN 二极管可重构三端口网络

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妊娠晚期孕妇感染B族链球菌对母婴结局的影响

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中国医师杂志 2020年第5期22卷 718-722页

作者：韩松筠孟文颖李小庆北京市通州区妇幼保健院妇产科 101100

目的对比分析孕晚期B族链球菌(GBS)感染和未感染孕妇临床资料,分析GBS感染孕妇正规治疗和未完成正规治疗的母婴结局情况。方法选取2018年7月至2019年6月在本院产科门诊进行例行产检的妊娠晚期孕妇,对其进行问卷调查和GBS采样。根据GBS... 详细信息

目的对比分析孕晚期B族链球菌(GBS)感染和未感染孕妇临床资料,分析GBS感染孕妇正规治疗和未完成正规治疗的母婴结局情况。方法选取2018年7月至2019年6月在本院产科门诊进行例行产检的妊娠晚期孕妇,对其进行问卷调查和GBS采样。根据GBS检测结果分为GBS感染组与无GBS感染组。根据孕妇接受治疗的情况,进一步将GBS感染组分为完成正规治疗组和未完成正规治疗组。对所有入选的研究对象进行追踪随访,观察和记录产妇及新生儿结局情况。结果本次研究共1127例孕妇完成了GBS采样检测和随访,年龄(26.5±4.8)岁,孕周(36.6±0.9)周。142例孕妇感染了GBS,感染率为12.6%,其中104例(73.2%)在分娩前完成了正规的治疗。GBS感染组孕妇产后感染发生率(4.9%vs 0.9%,P=0.001),新生儿感染发生率(2.1%vs 0.1%,P=0.003),新生儿窒息发生率(2.8%vs 0.5%,P=0.017),羊水污染发生率(4.2%vs 1.1%,P=0.013)均显著高于无GBS感染组。GBS感染患者未完成正规治疗组产后感染的发生率(13.2%vs 1.9%,P=0.021),羊水污染的发生率(15.8%vs 0,P<0.001)均显著高于正规治疗组产妇。结论妊娠晚期GBS感染对母婴产生不良的后果,GBS感染若不采取规范的治疗措施,母婴结局会更差,因此有必要对妊娠晚期孕妇开展B族链球菌筛查,并及早给以规范化治疗。

关键词：妊娠末期 B族链球菌感染妊娠结局

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Ent-pimarane and ent-kaurane diterpenoids from Siegesbeckia pubescens and their anti-endothelial damage effect in diabetic retinopathy

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Chinese Journal of Natural Medicines 2025年第02期23卷 234-244页

作者： mengjia Liu Tingting Luo Rongxian Li wenying Yin Fengying Yang Di Ge Na Liu School of Biological Science and Technology University of Jinan

Diabetic retinopathy, a prevalent and vision-threatening microvascular complication of diabetes mellitus, is the leading cause of blindness among middle-aged and elderly *** diterpenoids isolated from Siegesbeckia pubescens demonstrate potent anti-inflammatory properties. This study aimed to identify novel bioactive diterpenoids from S. pubescens and investigate their effects on oxidative stress and inflammatory responses in diabetic retinopathy, both in vitro and in vivo. Three new ent-pimarane-type diterpenoids(1–3) and six known compounds(4–9) were isolated from the aerial parts of S. pubescens. Their structures were elucidated through spectroscopic data interpretation, and absolute configurations were determined by comparing calculated and experimental electronic circular dichroism(ECD) spectra. Among these compounds, 14β,16-epoxy-ent-3β,15α,19-trihydroxypimar-7-ene(5) exhibited the most potent protective effect against high glucose and interleukin-1β(IL-1β)-stimulated human retinal endothelial cells. Mechanistically, compound 5 promoted endothelial cell survival while ameliorating oxidative stress and inflammatory response in diabetic retinopathy, both in vivo and in vitro. These findings not only suggest that diterpenoids such as compound 5 are important anti-inflammatory constituents in S. pubescens, but also indicate that compound 5 may serve as a lead compound for preventing or treating vascular complications associated with diabetic retinopathy.

关键词： Diabetic retinopathy Inflammatory response Natural diterpenoid Oxidative stress Siegesbeckia pubescens

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Predicting Diabetic Retinopathy Using a Machine Learning Approach Informed by Whole-Exome Sequencing Studies

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Biomedical and Environmental Sciences 2025年第1期38卷 67-78页

作者： Chongyang She wenying Fan Yunyun Li Yong Tao Zufei Li Department of Ophthalmology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing 100176China Department of Otorhinolaryngology Head and Neck SurgeryBeijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China

Objective To establish and validate a novel diabetic retinopathy(DR)risk-prediction model using a whole-exome sequencing(WES)-based machine learning(ML)*** WES was performed to identify potential single nucleotide polymorphism(SNP)or mutation sites in a DR pedigree comprising 10 members.A prediction model was established and validated in a cohort of 420 type 2 diabetic patients based on both genetic and demographic *** contribution of each feature was assessed using Shapley Additive explanation *** efficacies of the models with and without SNP were *** WES revealed that seven SNPs/mutations(rs116911833 in TRIM7,1997T>C in LRBA,1643T>C in PRMT10,rs117858678 in C9orf152,rs201922794 in CLDN25,rs146694895 in SH3GLB2,and rs201407189 in FANCC)were associated with ***,the model including rs146694895 and rs201407189 achieved better performance in predicting DR(accuracy:80.2%;sensitivity:83.3%;specificity:76.7%;area under the receiver operating characteristic curve[AUC]:80.0%)than the model without these SNPs(accuracy:79.4%;sensitivity:80.3%;specificity:78.3%;AUC:79.3%).Conclusion Novel SNP sites associated with DR were identified in the DR *** of rs146694895 and rs201407189 significantly enhanced the performance of the ML-based DR prediction model.

关键词： Machine learning Diabetic retinopathy Whole exome sequencing Type 2 diabetes mellitus

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Establishment of goat mammary organoid cultures modeling the mammary gland development and lactation

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Journal of Animal Science and Biotechnology 2025年第1期16卷 193-205页

作者： Lei Jia wenying Zhang Tao Luo Yongtao Li Jianhong Shu Julie Strand Yuan Yue Stig Purup Jianxin Liu Hengbo Shi Zhejiang Key Laboratory of Cow Genetic Improvement&Milk Quality Research Institute of Dairy ScienceCollege of Animal SciencesZhejiang UniversityHangzhou 310058China College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018China Department of Animal and Veterinary Sciences Aarhus UniversityTjele DK‑8830Denmark Ministry of Education Key Laboratory of Molecular Animal Nutrition Zhejiang UniversityHangzhou 310058China

Background Although several cell culture systems have been developed to investigate the function of the mam-mary gland in dairy livestock,they have potential limitations,such as the loss of alveolar structure or genetic and phe-notypic differences from their native *** these challenges is crucial for lactation *** of protocols to establish lactating organoid of livestock represents a promising goal for the *** this study,we developed a protocol to establish a culture system for mammary organoids in dairy goats to model the mammary gland development and lactation *** The organoids cultured within an extracellular matrix gel maintained a bilayer structure that closely resem-bled the native architecture of mammary *** expansion of mammary organoids was significantly promoted by growth factors containing epidermal growth factor and fibroblast growth factor 2 whereas the proliferative index of the organoids was significantly inhibited by the treatment with WNT *** stimulation with a lactogenic medium containing prolactin,the mammary organoids exhibited efficient lactation,characterized by the accumu-lation of lipid droplets in the lumen *** lactation could be sustained for more than 3 ***,the expression patterns of genes related to fatty acid synthesis and milk proteins in lactating organoids closely mirrored those observed in mammary *** observations were confirmed by data from proteomic analysis that the bulk of milk proteins was produced in the lactating *** This study is the first to establish a mammary organoid culture system modeling the mammary gland development and lactation process in *** efficient induction of lactation in ruminant mammary organoids holds promises for advancing the field of cell-based milk bio-manufacture in the food industry.

关键词： Cell-based milk production Lactation Mammary gland Organoid

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远程胎心监护、血清UA、CRP水平与妊娠期高血压孕妇产前疾病严重程度及新生儿结局的关系

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中国计划生育学杂志 2022年第8期30卷 1860-1863,1868页

作者：周丽孟文颖北京市通州区妇幼保健院 101100

目的:探讨妊娠期高血压孕妇远程胎心监护及血清尿酸(UA)、C反应蛋白(CRP)水平与疾病严重程度及新生儿不良结局关系。方法:选取2019年7月-2020年6月本院住院分娩的妊娠期高血压疾病孕妇180例,根据疾病严重程度将其分为妊娠期高血压组与... 详细信息

目的:探讨妊娠期高血压孕妇远程胎心监护及血清尿酸(UA)、C反应蛋白(CRP)水平与疾病严重程度及新生儿不良结局关系。方法:选取2019年7月-2020年6月本院住院分娩的妊娠期高血压疾病孕妇180例,根据疾病严重程度将其分为妊娠期高血压组与子痫前期组;根据新生儿结局分为良好结局组和不良结局组。检测孕妇血清UA、CRP水平,采用远程胎心监护仪及无应激试验(NST)对孕妇远程胎心监护;Spearman法分析妊娠期高血压疾病严重程度及新生儿不良结局与远程胎心监护、血清UA、CRP水平的相关性,logistic回归分析影响因素。结果:子痫前期组血清UA(496.23±45.27μmol/L)、CRP(10.02±1.21 mg/L)水平及远程胎心监护异常孕妇比例(31.0%)均高于妊娠期高血压组(359.34±37.62μmol/L、6.76±1.18 mg/L、12.5%),新生儿不良结局组血清UA(482.81±36.94μmol/L)、CRP(10.24±1.32 mg/L)水平及远程胎心监护异常孕妇比例(39.1%)均高于新生儿良好结局组(379.14±32.17μmol/L、6.52±1.13 mg/L、11.2%)(均P<0.05)。远程胎心监护异常、血清UA、CRP水平升高均与妊娠期高血压疾病严重程度及新生儿不良结局呈正相关(P<0.05),且均为独立危险因素(P<0.05)。结论:远程胎心监护异常及血清UA、CRP水平升高均与妊娠期高血压孕妇产前疾病加重及新生儿不良结局发生有关,提示可作为产前监测指标,以及时干预改善新生儿结局。

关键词：妊娠期高血压远程胎心监护尿酸 C反应蛋白新生儿结局

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妊娠期血清转铁蛋白、总铁结合力与妊娠期代谢综合征相关性

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中国计划生育学杂志 2020年第12期28卷 2098-2101页

作者：周丽孟文颖北京市通州区妇幼保健院 101100

目的:分析妊娠期孕妇血清转铁蛋白(TRF)、总铁结合力(TIBC)与妊娠期代谢综合征(GMS)的相关性。方法:选取2018年2月—2020年1月于本院产科定期产前检查并住院分娩的GMS患者72例(观察组),同期正常妊娠孕妇80例为对照组。收集两组孕周、孕... 详细信息

目的:分析妊娠期孕妇血清转铁蛋白(TRF)、总铁结合力(TIBC)与妊娠期代谢综合征(GMS)的相关性。方法:选取2018年2月—2020年1月于本院产科定期产前检查并住院分娩的GMS患者72例(观察组),同期正常妊娠孕妇80例为对照组。收集两组孕周、孕前体质指数、基础收缩压、基础舒张压、空腹血糖、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等。免疫比浊法检测血清中TRF;全自动生化分析仪检测血清TIBC水平。多因素logistic回归分析发生GMS的影响因素;受试者工作特征曲线(ROC)分析TRF、TIBC对发生GMS的预测价值。结果:观察组血清TRF(411.72±51.46 mg/dl)、TIBC(92.46±10.83μmol/L)均高于对照组(278.65±36.38 mg/dl、61.58±9.72μmol/L)(P0.05),TRF、TIBC水平偏高是发生GMS的危险因素(P<0.05)。ROC分析,TRF、TIBC预测妊娠期发生GMS的曲线下面积(AUC)分别为0.839(95%CI:0.757-0.921)、0.815(95%CI:0.730-0.900)。结论:TRF、TIBC在GMS孕妇血清中水平升高,是孕妇发生GMS的危险因素,对GMS有一定预测价值,可能作为潜在的诊断妊娠期孕妇发生GMS的标志物。

关键词：妊娠期代谢综合征转铁蛋白总铁结合力预测价值

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