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乙醛脱氢酶2在疼痛调节中的研究进展

国际麻醉学与复苏杂志 2024年第4期45卷 444-448页

作者：彭文一金世云李锐安徽医科大学第二附属医院麻醉与围术期医学科麻醉与围术期医学安徽普通高校重点实验室(安徽医科大学)合肥230601

疼痛是一种与实际或潜在的组织损伤相关的不愉快的感觉和情绪情感体验。活性醛作为氧化应激的触发剂和产物,是介导疼痛发生、发展的重要因素之一。研究发现,乙醇代谢限速酶——乙醛脱氢酶2(ALDH2)在体内活性醛的清理中发挥关键作用,可... 详细信息

疼痛是一种与实际或潜在的组织损伤相关的不愉快的感觉和情绪情感体验。活性醛作为氧化应激的触发剂和产物,是介导疼痛发生、发展的重要因素之一。研究发现,乙醇代谢限速酶——乙醛脱氢酶2(ALDH2)在体内活性醛的清理中发挥关键作用,可成为疼痛调节过程中有效的干预靶点。文章重点梳理了活性醛诱发疼痛产生的相关通路以及ALDH2在疼痛调控中的作用机制,以期为临床中疼痛的个体化治疗提供可能的途径。

关键词：疼痛氧化应激活性醛乙醛脱氢酶2

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德宏州咖啡产业高质量发展建议

热带农业科技 2024年第2期47卷 37-41页

作者：彭文忆赵秋芬于学安李维献李维锐赵国祥德宏州农业农村局云南芒市678400 云南省热带作物学会昆明650041

在对德宏州咖啡产业高质量发展三年行动计划推进中主要做法、推进落实完成情况进行专题调研的基础上,针对发现的问题及原因展开分析,提出高质量发展建议。

关键词：咖啡产业高质量发展德宏

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镍基复合涂层研究现状

江西科学 2024年第4期42卷 797-802页

作者：罗汝恺江龙发彭文屹魏仕勇周杰刘郅澄胡怡许翔宇邓志伟南昌海关技术中心南昌330038 南昌大学物理与材料学院南昌330031 铜基新材料江西省重点实验室江西省科学院应用物理研究所南昌330096

镍基复合涂层是目前广泛应用于碳钢,铝合金,钛合金表面改性的金属基复合涂层之一,因其性价比高,耐蚀性,耐磨性良好等特点而获得了航空航天,国防,化工等领域的关注,目前已经研究出如碳化钨强化镍基涂层等多种满足实际需求的镍基复合涂层... 详细信息

镍基复合涂层是目前广泛应用于碳钢,铝合金,钛合金表面改性的金属基复合涂层之一,因其性价比高,耐蚀性,耐磨性良好等特点而获得了航空航天,国防,化工等领域的关注,目前已经研究出如碳化钨强化镍基涂层等多种满足实际需求的镍基复合涂层。然而,现代工业应用要求更高的涂层性能,传统镍基复合涂层存在耐磨与耐蚀性能不足的问题,且基础机理研究尚不够深入。在此基础上,从制备工艺,典型的加强相以及涂层的功能性方面进行了分类综述,介绍了镍基功能涂层目前的研究进展与部分形成机理。最后提出了镍基复合涂层领域现存在的几个问题,并对其未来的研究进行展望。

关键词：镍基复合涂层耐磨性耐蚀性显微组织

Ultra-high spatio-temporal resolution imaging with parallel acquisition-readout structured illumination microscopy(PAR-SIM)

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Light(Science & Applications) 2024年第6期13卷 1140-1158页

作者： Xinzhu Xu wenyi Wang Liang Qiao Yunzhe Fu Xichuan Ge Kun Zhao Karl Zhanghao Meiling Guan Xin Chen Meiqi Li Dayong Jin peng Xi Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing100871China Wallace H.Coulter Dept.of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlanta30332GAUSA National Biomedical Imaging Center Peking UniversityBeijing100871China Department of Biomedical Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen518055GuangdongChina Airy Technologies Co. Ltd.Beijing100086China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingboZhejiang315200China School of Life Science Peking UniversityBeijing100871China Institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW2007Australia

Structured illumination microscopy(SIM)has emerged as a promising super-resolution fluorescence imaging technique,offering diverse configurations and computational strategies to mitigate phototoxicity during real-time imaging of biological *** efforts to enhance system frame rates have concentrated on processing algorithms,like rolling reconstruction or reduced frame reconstruction,or on investments in costly sCMOS cameras with accelerated row readout *** this article,we introduce an approach to elevate SIM frame rates and region of interest(ROI)coverage at the hardware level,without necessitating an upsurge in camera expenses or intricate ***,parallel acquisition-readout SIM(PAR-SIM)achieves the highest imaging speed for fluorescence imaging at currently available detector *** using the full frame-width of the detector through synchronizing the pattern generation and image exposure-readout process,we have achieved a fundamentally stupendous information spatial-temporal flux of 132.9 MPixels·s^(−1),9.6-fold that of the latest techniques,with the lowest SNR of−2.11 dB and 100 nm ***-SIM demonstrates its proficiency in successfully reconstructing diverse cellular organelles in dual excitations,even under conditions of low signal due to ultra-short exposure ***,mitochondrial dynamic tubulation and ongoing membrane fusion processes have been captured in live COS-7 cell,recorded with PAR-SIM at an impressive 408 *** posit that this novel parallel exposure-readout mode not only augments SIM pattern modulation for superior frame rates but also holds the potential to benefit other complex imaging systems with a strategic controlling approach.

关键词： hardware illumination resolution

Cracking Behaviour of Al_2O_3 Short Fibre/Al-5.5Zn Composite in TEM

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Journal of Materials Science & Technology 1997年第3期13卷 235-237页

作者： Xiyan ZHANG Tianxin TAN wenyi peng and Qing GAO (Southwest Jiaotong University, Chengdu 610031, China) Southwest Jiaotong University Chengdu 610031 China

The micromechanical behaviour of Al2O3 short fibre reinforced Al-5.5Zn matrix composite has been in-situ studied by using TEM. The results show that in the composite the nucleation and propagation of cracks take place mainly in the matrix, as well as in the region near the fibre/matrix interface. It has been also observed that the microcracks can close during *** the fracture property can be characterized by crack open displacement (COD). The cracking characteristic may result from the large strength difference between the matrix and fibre.

关键词： Cracking Behaviour of Al2O3 Short Fibre/Al-5.5Zn Composite in TEM Al Zn

Composition and phase structure dependence of mechanical and magnetic properties for AlCoCuFeNi_x high entropy alloys

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Journal of Materials Science & Technology 2019年第6期35卷 1175-1183页

作者： Cong Liu wenyi peng C.S. Jiang Hongmin Guo Jun Tao Xiaohua Deng Zhaoxia Chen School of Materials Science and Engineering Nanchang University Nanchang 330031 China Institute of Space Science and Technology. Nanchang University Nanchang 330031 China

In this study, the effects of composition and phase constitution on the mechanical properties and magnetic performance of AlCoCuFeNix(x = 0.5, 0.8, 1.0, 1.5, 2.0, 3.0 in molar ratio) high entropy alloys(HEAs)were investigated. The results show that Ni element could lead to the evolution from face centered cubic(FCC), body centered cubic(BCC) and ordered BCC coexisting phase structure to a single FCC phase. The change of phase constitution enhances the plasticity but reduces the hardness and strength. One of the interesting points is the excellent soft magnetic properties of AlCoCuFeNixHEAs. Soft magnetic performance is dependent on composition and phase transition. AlCoCuFeNi1.5 alloy, achieving a better balance of mechanical and magnetic properties, could be applied as structure materials and soft magnetic materials(SMMs). High Curie temperature(>900 K) and strong phase stability below 1350 K of AlCoCuFeNi0.5 alloy confirm its practicability in a high-temperature environment. Atomic size difference(δ) is utilized as the critical parameter to explain the lattice strain and phase transformation induced by Ni addition.

关键词： High entropy alloy Phase transformation Mechanical property Soft magnetic performance Atomic size difference

A novel FGFR1 inhibitor CYY292 suppresses tumor progression,invasion,and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis

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Genes & Diseases 2024年第1期11卷 479-494页

作者： Yanran Bi Ruiling Zheng Jiahao Hu Ruiqing Shi Junfeng Shi Yutao Wang peng Wang wenyi Jiang Gyudong Kim Zhiguo Liu Xiaokun Li Li Lin School of Pharmaceutical Science Wenzhou Medical UniversityWenzhouZhejiang 325035China College of Pharmacy and Research Institute of Drug Development Chonnam National UniversityGwangju 61186Republic of Korea Department of Dermatology Wenzhou Hospital of Integrated Traditional Chinese and Western MedicineWenzhouZhejiang 325000China Zhejiang Lab for Regenerative Medicine Oujiang LaboratoryWenzhouZhejiang 325035China

Glioblastoma(GBM)is a malignant brain tumor that grows quickly,spreads widely,and is resistant to *** growth factor receptor(FGFR)1 is a receptor tyrosine kinase that regulates cellular processes,including proliferation,survival,migration,and ***1 was predominantly expressed in GBM tissues,and FGFR1 expression was negatively correlated with overall *** rationally designed a novel small molecule CYY292,which exhibited a strong affinity for the FGFR1 protein in GBM cell lines in ***292 also exerted an effect on the conserved Ser777 residue of ***292 dose-depen-dently inhibited cell proliferation,epithelial-mesenchymal transition,stemness,invasion,and migration in vitro by specifically targeting the FGFR1/AKT/Snail pathways in GBM cells,and this effect was prevented by pharmacological inhibitors and critical gene *** vivo experiments revealed that CYY292 inhibited U87MG tumor growth more effectively than ***292 also efficiently reduced GBM cell proliferation and increased survival in orthotopic GBM *** study further elucidates the function of FGFR1 in the GBM and reveals the effect of CYY292,which targets FGFR1,on downstream signaling pathways directly reducing GBM cell growth,invasion,and metastasis and thus impairing the recruitment,activation,and function of immune cells.

关键词： Blood-brain barrier EMT FGFR1 FGFR1 inhibitor Glioblastoma

Effects of TiB2 Content on the Microstructures and Mechanical Properties of Low-Cobalt Ti（C,N）-TiB2 Cermets Fabricated by Vacuum Hot Pressing

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Journal of Wuhan University of Technology(Materials Science) 2019年第5期34卷 1077-1084页

作者：方一航 ZHANG Mengxian ZHAO Xianrui FENG Shangshen peng wenyi CHEN Nan 杜国平 School of Materials Science and Engineering Nanchang UniversityNanchang 330031China Zhejiang Provincial Key Laboratory for Cutting Tools Taizhou UniversityTaizhou 318000China

Ti(C,N)-TiB2 cermets were fabricated from Ti(C,N), TiB2, Co and WC powder mixtures via a vacuum hot pressing process. The influence of TiB2 content on their microstructures and mechanical properties was investigated. As a result of the elevated TiB2 contents, two types of corerim microstructures were present in the Ti(C,N)-TiB2 cermets, and remarkably improved mechanical properties were achieved. With the increase of TiB2 content, the flexural strength, fracture toughness and hardness of the Ti(C,N)-TiB2 cermets first increased, and then decreased, while their relative density consistently decreased. Attributed to an integration of the intergranular and intrangranular fracture behaviors, the Ti(C,N)-TiB2 cermets with 20 wt% TiB2 content exhibited the best overall properties with the relative density, hardness, fracture toughness and flexural strength at 99.3%, 1 995 HV, 7.92 MPa·m1/2 and 1 114 MPa, respectively. The underlying mechanism for their enhanced properties was studied in detail.

关键词： Ti(C,N)-TiB2 cermets vacuum hot pressing mechanical properties fracture behavior

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石墨烯/硅基异质集成光电子器件

半导体光电 2022年第6期43卷 1020-1028页

作者：彭文怡严思琦唐明华中科技大学光学与电子信息学院武汉430074

石墨烯/硅基异质集成的光子器件研究在近年来取得了巨大进展,因石墨烯所具有的诸多独特的物理性质如超高载流子迁移率、超高非线性系数等,石墨烯/硅基异质集成器件展现出了诸如超大带宽、超低功耗等优异性能。文章介绍了近年来报道的典... 详细信息

石墨烯/硅基异质集成的光子器件研究在近年来取得了巨大进展,因石墨烯所具有的诸多独特的物理性质如超高载流子迁移率、超高非线性系数等,石墨烯/硅基异质集成器件展现出了诸如超大带宽、超低功耗等优异性能。文章介绍了近年来报道的典型石墨烯/硅基异质集成器件,包括石墨烯/硅基电光调制器、石墨烯/硅基热光调制器和石墨烯/硅基光电探测器,简要阐述了其原理与性能,并对其未来的应用与发展做出了展望。

关键词：硅基异质集成光子器件石墨烯调制器探测器