检索结果-南通市图书馆

Research on aiming methods for small sample size shooting tests of two-dimensional trajectory correction fuse

Defence Technology（防务技术） 2024年第3期33卷 506-517页

作者： Chen liang Qiang Shen Zilong Deng Hongyun li wenyang Pu lingyun Tian Ziyang lin School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China

The longitudinal dispersion of the projectile in shooting tests of two-dimensional trajectory corrections fused with fixed canards is extremely large that it sometimes exceeds the correction ability of the correction fuse actuator.The impact point easily deviates from the target,and thus the correction result cannot be readily evaluated.However,the cost of shooting tests is considerably high to conduct many tests for data collection.To address this issue,this study proposes an aiming method for shooting tests based on small sample size.The proposed method uses the Bootstrap method to expand the test data;repeatedly iterates and corrects the position of the simulated theoretical impact points through an improved compatibility test method;and dynamically adjusts the weight of the prior distribution of simulation results based on Kullback-Leibler divergence,which to some extent avoids the real data being"submerged"by the simulation data and achieves the fusion Bayesian estimation of the dispersion center.The experimental results show that when the simulation accuracy is sufficiently high,the proposed method yields a smaller mean-square deviation in estimating the dispersion center and higher shooting accuracy than those of the three comparison methods,which is more conducive to reflecting the effect of the control algorithm and facilitating test personnel to iterate their proposed structures and algorithms.;in addition,this study provides a knowledge base for further comprehensive studies in the future.

关键词： Two-dimensional trajectory correction fuse Small sample size test Compatibility test KL divergence Fusion bayesian estimation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Model Tests on the Effect of Dip Angles on Flow Behavior of liquefied Sand

引用

Journal of Earth Science 2023年第2期34卷 381-385页

作者： wenyang li Yu Huang School of Geological Engineering and Geomatics Chang'an UniversityXi'an 710054China Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China

The flow behavior of liquefied sand is reported using a self-developed testing system that enables the flow processes of liquefied sand to be studied at different slopes of the soil layers.The test device is mainly composed of a vibrating table,a transparent model box and a high-speed video monitoring camera.The tests replicated the horizontal and sloping flows of saturated sand in the model box,which can be tilted to various angles to study the flow characteristics of liquefied sand.The high-speed video monitoring camera captured and recorded the processes within the flowing sand.With increasing downslope,the strain,strain rate,duration time,and sand flow distance increased.The results of our experiment indicate that when selecting sites for engineering structures,the surface downslopes should be taken into account if liquefiable soils are present.Finally,some suggestions regarding site assessment and structural design for sites prone to liquefaction were presented.

关键词： earthquake liquefied sand dip angle soil flow model test engineering geology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Immunomodulatory potential of exopolysaccharides from Lactiplantibacillus plantarum YY-112

引用

Food Science and Human Wellness 2024年

作者： Mengfan Luo Wanyi Zhou wenyang Tao Jianrong Xing Jingrui li Yuxing Guo Ying Yang Institute of Food Science Zhejiang Academy of Agricultural Sciences School of Food Science and Pharmaceutical Engineering Nanjing Normal University

In vitro simulated colonic fermentation studies have shown the prebiotic potential of exopolysaccharides from Lactiplantibacillus plantarum YY-112 (YEPS). Its immunomodulatory effects and related mechanisms were systematically investigated in this study. We observed that YEPS intervene in immune responses and improve intestinal microbial structure in normal mice， including significantly increasing the relative abundance of Enterorhabdus and norank＿f＿＿norank＿o＿＿Clostridia UCG-014 as well as decreasing that of unclassified＿c＿＿Bacilli (P li， Lachnoclostridium， Eubacterium＿xylanophilum＿group， and Desulfovibrio (P lication of YEPS as a novel potential food additive.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Growth asymmetry precedes differential auxin response during apical hook initiation in Arabidopsis

引用

Journal of Integrative Plant Biology 2022年第1期64卷 5-22页

作者： Yang Peng Dan Zhang Yuping Qiu Zhina Xiao Yusi Ji wenyang li Yiji Xia Yichuan Wang Hongwei Guo Department of Biology Institute of Plant and Food ScienceSchool of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China Department of Biology Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education InstitutesSchool of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China Department of Biology Faculty of ScienceHong Kong Baptist UniversityKowloon TongHong Kong 999077China Microlens Technologies Beijing 100086China

The development of a hook-like structure at the apical part of the soil-emerging organs has fascinated botanists for centuries,but how it is initiated remains unclear.Here,we demonstrate with highthroughput infrared imaging and 2-D clinostat treatment that,when gravity-induced root bending is absent,apical hook formation still takes place.In such scenarios,hook formation begins with a de novo growth asymmetry at the apical part of a straightly elongating hypocotyl.Remarkably,suchde novo asymmetric growth,but not the following hook enlargement,precedes the establishment of a detectable auxin response asymmetry,and is largely independent of auxin biosynthesis,transport and signaling.Moreover,we found that functional cortical microtubule array is essential for the following enlargement of hook curvature.When microtubule array was disrupted by oryzalin,the polar localization of PIN proteins and the formation of an auxin maximum became impaired at the to-be-hook region.Taken together,we propose a more comprehensive model for apical hook initiation,in which the microtubuledependent polar localization of PINs may mediate the instruction of growth asymmetry that is either stochastically taking place,induced by gravitropic response,or both,to generate a significant auxin gradient that drives the full development of the apical hook.

关键词： apical hook initiation asymmetric auxin response cortical microtubule array de novo growth asymmetry PINs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polycarcin V induces DNA-damage response and enables the profiling of DNA-binding proteins

引用

National Science Review 2022年第11期9卷 19-28页

作者： Zongwei Yue Fan Wu Fusheng Guo Jiyeong Park Jin Wang liyun Zhang Daohong liao wenyang li Orlando D.Sch?rer Xiaoguang Lei Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationDepartment of Chemical BiologyCollege of Chemistry and Molecular Engineering Synthetic and Functional Biomolecules CenterPeking University Peking-Tsinghua Center for life Science Academy for Advanced Interdisciplinary Studies Peking University Center for Genomic Integrity Institute for Basic Science Jiangsu JITRI Molecular Engineering Inst.Co. Ltd. Department of Biological Sciences School of Life Sciences Ulsan National Institute of Science and Technology Institute for Cancer Research Shenzhen Bay Laboratory

To maintain genomic integrity and avoid diseases, the DNA-damage response(DDR) not only detects and repairs DNA lesions, but also contributes to the resistance to DNA-damaging chemotherapeutics.Targeting the DDR plays a significant role in drug discovery using the principle of synthetic lethality. The incomplete current knowledge of the DDR encouraged us to develop new strategies to identify and study its components and pathways. Polycarcin V, belonging to the C-aryl glycoside natural products, is a light-activatable DNA-intercalating agent that causes DNA damage by forming a covalent [2+2]cycloadduct with thymine residue under 365–450 nm of light irradiation in a DNA-sequence-independent manner. Taking advantage of the light-activatable feature and temporal control of DDR, we designed and synthesized polycarcin V-based bifunctional chemical probes, including one that cross-links DNA to DNA-binding protein to explore the DDR induced by polycarcin V and uncover novel DNA–protein interactions. Utilizing this chemical probe and activity-based protein profiling-stable isotope labeling with amino acids in cell culture, we identified 311 DNA-binding protein candidates, including known DDR factors and additional proteins that may be of interest in discovering new biology. We validated our approach by showing that our probe could specifically cross-link proteins involved in nucleotide excision repair(NER) that repair bulky DNA adducts. Our studies showed that the [2+2] cycloadduct formed by polycarcin V could indeed be repaired by NER in vivo. As a DNA-damaging agent, polycarcin V or its drug-like derivative plus blue light showed promising properties for psoriasis treatment, suggesting that it may itself hold promise for clinic applications.

关键词： polycarcin V [2+2] DNA photoadduct light-activatable chemical probe ABPP for DNA-binding protein proteomics psoriasis treatment

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

土工离心模拟高速滑坡碎屑流冲击过程的科氏效应研究

引用

中国科学：技术科学 2024年第4期54卷 734-746页

作者：张贝李文阳黄雨长安大学地质工程与测绘学院西安710054 同济大学土木工程学院上海200092

土工离心模拟是土木工程、地质工程等相关领域的重要技术.但在高速滑坡碎屑流模拟方面的应用仍然受限,主要原因在于科氏效应的影响难以避免且缺乏详细研究.本文特别针对高速滑坡碎屑流冲击效应这一防灾减灾工程重要问题,开展了一系列的... 详细信息

土工离心模拟是土木工程、地质工程等相关领域的重要技术.但在高速滑坡碎屑流模拟方面的应用仍然受限,主要原因在于科氏效应的影响难以避免且缺乏详细研究.本文特别针对高速滑坡碎屑流冲击效应这一防灾减灾工程重要问题,开展了一系列的物理离心试验与数值试验.相关结果表明,科氏加速度的方向对高速滑坡碎屑流冲击过程的影响更为显著,发散科氏作用强化了滑坡碎屑流与拦挡结构的相互作用,表现在其具有更高的流动性、更强的冲击效应、更大的堆积体高度.离心应力水平对压缩科氏效应作用效果的影响更为显著,且随着离心应力水平的增大,模拟结果向着无科氏条件影响结果的方向发展.因此,高速滑坡碎屑流冲击效应的土工离心模拟建议在发散科氏条件下开展,且不必刻意选取较小的离心应力水平.

关键词：离心模拟技术高速滑坡碎屑流冲击过程科氏效应离散元模拟

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

DELLA proteins interact with FLC to repress flowering transition

引用

Journal of Integrative Plant Biology 2016年第7期58卷 642-655页

作者： Mingzhe li Fengying An wenyang li Mengdi Ma Ying Feng Xing Zhang Hongwei Guo State Key Laboratory of Protein and Plant Gene Research College of Life Sciences Peking-Tsinghua Center for Life Sciences Peking University

Flowering is a highly orchestrated and extremely ct critical process in a plant＇s life cycle. Previous study has ademonstrated that SUPPRESSOR OF OVEREXPRESSION OF pCONSTANS 1（SOC1） and FLOWERING LOCUS T（FT） integrate m^-1 the gibberellic acid（GA） signaling pathway and vernalization higpathway in regulating flowering time, but detailed molecular Hmechanisms remain largely unclear. In GA signaling pathway,DELLA proteins are a group of master transcriptional regulators, while in vernalization pathway FLOWERING LOCUS C（FLC） is a core transcriptional repressor that down-regulates the expression of SOC1 and FT. Here, we report that DELLA proteins interact with FLC in vitro and in vivo, and the LHRI domains of DELLAs and the C-terminus of MADS domain of FLC are required for these interactions.Phenotypic and gene expression analysis showed that mutation of FLC reduces while over-expression of FLC enhances the GA response in the flowering process. Further,DELLA-FLC interactions promote the repression ability of FLC on its target genes. In summary, these findings report that the interaction between MADS box transcription factor FLC and GRAS domain regulator DELLAs may integrate various signaling inputs in flowering time control, and shed new light on the regulatory mechanism both for FLC and DELLAs in regulating gene expression.

关键词： Arabidopsis co-repressor DELLAs FLC flowering

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

高旋弹二维修正引信双旋结构气动特性及气动力表征

引用

北京理工大学学报 2024年第4期44卷 359-368页

作者：申强仇李良蒲文洋李红云北京理工大学机电学院北京100081

针对配二维弹道修正引信高旋弹具有弹体气动参数非对称、纵向和横向修正紧密耦合等问题,为了准确表征高旋弹气动参数、明确修正弹丸气动特性和产生机理,提出了基于CFD(computational fluid dynamics)仿真的双旋结构气动力计算分析方法.... 详细信息

针对配二维弹道修正引信高旋弹具有弹体气动参数非对称、纵向和横向修正紧密耦合等问题,为了准确表征高旋弹气动参数、明确修正弹丸气动特性和产生机理,提出了基于CFD(computational fluid dynamics)仿真的双旋结构气动力计算分析方法.在构建双滚转域流场仿真模型的基础上,对比了二维修正引信不同控制状态下的弹丸受力情况;明确了高旋弹固有气动力和二维修正引信所引起的气动力;建立并推导了攻角与滚转角耦合情况下的舵片受力模型.研究表明:针对二维修正组件,需要考虑合攻角与舵滚转角的相对位置关系以计算诱导阻力;受迎背风和舵片绕流影响,舵片受力模型和弹体的横、纵向气动力均随攻角、滚转角及马赫数变化.

关键词：高旋弹二维弹道修正 CDF仿真计算固定舵双旋体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effectiveness and safety of combined nimotuzumab and S-1 chemotherapy with concurrent radiotherapy for locally advanced esophageal cancer in malnourished and elderly patients:A prospective phase Ⅱ study

引用

Chinese Journal of Cancer Research 2024年第3期36卷 270-281页

作者： Guojie Feng Jiao li Nuo Yu Ziyu Zheng Xiongtao Yang Lei Deng Tao Zhang Wenqing Wang wenyang liu Jianyang Wang Qinfu Feng Jima Lyu Zefen Xiao Zongmei Zhou Nan Bi Jianjun Qin Xin Wang Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

Objective: Definitive chemoradiotherapy(dCRT) is the standard treatment for unresectable locally advanced esophageal cancer. However, this treatment is associated with substantial toxicity, and most malnourished or elderly patients are unable to complete this therapy. Therefore, there is a need for a more suitable radiotherapy combination regimen for this population. This study was aimed to evaluate the efficacy and safety of a combination regimen comprising chemotherapy with nimotuzumab and S-1 and concurrent radiotherapy for patients with fragile locally advanced esophageal cancer with a high Nutritional Risk Screening 2002(NRS-2002) score.Methods: Eligible patients with unresectable esophageal carcinoma who had an NRS-2002 score of 2 or higher were enrolled. They were treated with S-1 and nimotuzumab with concurrent radiotherapy, followed by surgery or definitive radiotherapy. The primary endpoint was the locoregional control(LRC) rate.Results: A total of 55 patients who met the study criteria were enrolled. After completion of treatment, surgery was performed in 15 patients and radiotherapy was continued in 40 patients. The median follow-up period was 33.3[95% confidence interval(95% CI), 31.4-35.1)] months. The LRC rate was 77.2%(95% CI, 66.6%-89.4%) at 1 year in the entire population. The overall survival(OS) rate and event-free survival(EFS) rate were 57.5% and 51.5% at 3 years, respectively. Surgery was associated with better LRC [hazard ratio(HR)=0.16; 95% CI,0.04-0.70; P=0.015], OS(HR=0.19; 95% CI, 0.04-0.80; P=0.024), and EFS(HR=0.25; 95% CI, 0.08-0.75;P=0.013). Most adverse events were of grade 1 or 2, and no severe adverse events occurred.Conclusions: For malnourished or elderly patients with locally advanced esophageal cancer, radiotherapy combined with nimotuzumab and S-1 is effective and has a good safety profile.

关键词： Esophageal carcinoma squamous cell carcinoma nutritional risk score nimotuzumab S-1 definitive chemoradiotherapy

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Survey on Main Drive Methods Used in Humanoid Robotic Upper limbs

引用

Cyborg and Bionic Systems 2021年第1期2021卷 102-113页

作者： Yiwei Wang wenyang li Shunta Togo Hiroshi Yokoi Yinlai Jiang Department of Mechanical Engineering and Intelligent Systems The University of Electro-CommunicationsJapan Center for Neuroscience and Biomedical Engineering The University of Electro-CommunicationsTokyoJapan Beijing Advanced Innovation Center for Intelligent Robots and System Beijing Institute of TechnologyBeijingChina

Humanoid robotic upper limbs including the robotic hand and robotic arm are widely studied as the important parts of a humanoid robot.A robotic upper limb with light weight and high output can perform more tasks.The drive system is one of the main factors affecting the weight and output of the robotic upper limb,and therefore,the main purpose of this study is to compare and analyze the effects of the different drive methods on the overall structure.In this paper,we first introduce the advantages and disadvantages of the main drive methods such as tendon,gear,link,fluid(hydraulic and pneumatic),belt,chain,and screw drives.The design of the drive system is an essential factor to allow the humanoid robotic upper limb to exhibit the structural features and functions of the human upper limb.Therefore,the specific applications of each drive method on the humanoid robotic limbs are illustrated and briefly analyzed.Meanwhile,we compared the differences in the weight and payload(or grasping force)of the robotic hands and robotic arms with different drive methods.The results showed that the tendon drive system is easier to achieve light weight due to its simple structure,while the gear drive system can achieve a larger torque ratio,which results in a larger output torque.Further,the weight of the actuator accounts for a larger proportion of the total weight,and a reasonable external placement of the actuator is also beneficial to achieve light weight.

关键词： Human robot Upper

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：