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International Journal of Digital Earth 2023年第1期16卷 1923-1943页

作者： wenyan yu Mi Jiang Xiao Cheng School of Geospatial Engineering and Science Sun Yat-sen UniversitySouthern Marine Science and Engineering Guangdong Laboratory(Zhuhai)ZhuhaiPeople’s Republic of China Key Laboratory of Comprehensive Observation of Polar Environment(Sun Yat-sen University) Ministry of EducationZhuhaiPeople’s Republic of China

Owing to continuous global warming,frozen soil degradation has become a universal phenomenon,leading to large-scale ground deformation that affects engineering construction and the fragile ecological balance.Geodetic observations,especially temporal InSAR,can quantify ground deformation.However,the accuracy of InSAR modelling in capturing the spatial–temporal variability of the freeze–thaw process depends on the spatial resolution of temperature measurements.This paper proposes a freeze–thaw amplitude model incorporating MODIS LST based on a single-master InSAR time-series deformation to calculate frozen soil deformation.We applied this model to the Qumalai-Zhiduo area of the Qinghai-Tibet Plateau and compared its results with those of the model using weather station temperature in terms of frozen soil deformation parameters,RSME,and characteristic targets.Our study found that the model incorporating MODIS LST performed better in areas far from weather stations,while both models produced similar results in areas of close proximity.Finally,we evaluated another commonly used method for calculating frozen soil deformation parameters and found that the method incorporating MODIS LST based on a single-master time-series deformation is more accurate and precise than the method based on a multi-master SBAS network.

关键词： InSAR deformation monitoring Qinghai Tibet plateau MODIS LST frozen soil

Monitoring landslide associated with reservoir impoundment using synthetic aperture radar interferometry: A case study of the Yalong reservoir

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Geodesy and Geodynamics 2022年第2期13卷 138-150页

作者： Zhe Liu Bing Xu Qijie Wang wenyan yu Zelang Miao School of Geosciences and Info-Physics Central South UniversityChangsha 410083China

The construction of large reservoirs can address the problem of uneven distribution of rivers in time and space,thereby meeting the needs of human production and living.However,the huge elevation of the water level in some areas may modify the distribution of the groundwater level,causing geological disasters,such as surface deformation and landslides.The Yalong reservoir supplies water to the downstream area of Shannan,Tibet;however,since the reservoir started storing water in 2017,the government has discovered two ancient landslides.In this study,to monitor the deformation of the Yalong reservoir since its construction in 2014,we first used synthetic aperture radar(SAR) data and the multidimensional small baseline subset(MSBAS) method to obtain the deformation in the east-west and vertical directions.The result indicated the presence of three large,slow-moving landslides:Landslides I and II,located on the right bank of the Yalong reservoir,which are consistent with the results obtained by the actual survey,and a new discovery,Landslide Ⅲ,located on the left side of the reservoir.Meanwhile,the experimental results indicated that the dam had undergone obvious deformation after impoundment,which should not be ignored.The global positioning system and interferometric SAR(InSAR) timeseries deformation residual data were used to verify the accuracy of the InSAR method.The results also showed that the deformation caused by the three landslides had te nded to accele rate after the rese rvoir’s impoundment,and that the failure mode was retrogressive landslide.We found that InSAR plays a vital role in landslide detection and failure mode research around reservoirs,and assists in providing early warning for subsequent landslide disasters.

关键词： Landslide monitoring Two-dimensional deformation Yalong reservoir SBAS-InSAR

Carrier-free programmed spherical nucleic acid for effective ischemic stroke therapy via self-delivery antisense oligonucleotide

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Nano Research 2023年第1期16卷 735-745页

作者： wenyan yu Cuiping Xuan Bingbing Liu Lei Zhou Na Yin Enpeng Gong Zhenzhong Zhang Yinchao Li Kaixiang Zhang Jinjin Shi School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou 450001China Collaborative Innovation Center of New Drug Research and Safety Evaluation Zhengzhou 450001China

Antisense oligonucleotide(ASO)for anti-apoptosis is emerging as a highly promising therapeutic agents for ischemic stroke with complex pathological environment.However,its therapeutic efficacy is seriously limited by a number of challenges including inefficient internalization,low blood-brain barrier(BBB)penetration,poor stability,and potential toxicity of the carrier.Herein,a carrier-free programmed spherical nucleic acid nanostructure is developed for effective ischemic stroke therapy via integrating multifunctional modules into one DNA structure.By co-encoding caspase-3-ASO and transferrin receptor(TfR)aptamer into circle template,the spherical nucleic acid nanostructure(TD)was obtained via self-assembly.The experimental results demonstrated that the developed TD displayed efficient BBB penetration capability(6.4 times)and satisfactory caspase-3 silence effect(2.3 times)due to the dense DNA packaging in TD.Taken together,our study demonstrated that the carrier-free programmed spherical nucleic acid nanostructure could significantly improve the therapeutic efficacy of ischemic stroke and was a promising therapeutic tool for various brain damage-related diseases.

关键词： antisense oligonucleotide caspase-3 blood-brain barrier(BBB)penetration anti-apoptosis ischemic stroke

Hydrogel-mediated drug delivery for treating stroke

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中国化学快报:英文版 2023年第9期34卷 65-75页

作者： wenyan yu Enpeng Gong Bingbing Liu Lei Zhou Chengyuan Che Shu Hu Zhenzhong Zhang Junjie Liu Jinjin Shi School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou 450001China Collaborative Innovation Center of New Drug Research and Safety Evaluation Zhengzhou 450001China

Stroke is a common disease and is the major cause of death and disability.It occurs and generates devastating neurological deficits when cerebral blood vessel is blocked(ischemic stroke,IS)or ruptured(hemorrhagic stroke,HS).Hydrogel,being biodegradable and biocompatible,have shown attractive advantages in stroke therapy as a new biomaterial with desirable mechanical properties and tunability of structure,owing to special ability to load different cargoes for multiple treatment strategies,such as pharmacotherapy based on drug-delivery systems and cell therapy including mesenchymal stem cells(MSCs)and neural progenitor cells(NPCs)for improving functional outcomes.However,a comprehensive review of the functional hydrogel for treatment of stroke is still lacking.Therefore,in this work,the main pathological mechanisms of stroke including IS and HS are comprehensively described.The benefits of hydrogel for stroke treatment are also summarized regarding the natural advantages and the delivery advantages.Simultaneously,the application development of hydrogel for treatment of stroke is highlighted.Finally,the unique considerations and challenges in the design and application of hydrogel is discussed for treatment of stroke and clinical application in the future.

关键词： Drug delivery Functional hydrogel Stroke therapy Bioactive biomaterials Biological applications

Research on the Evolution of Global Internet Network Interconnection Relationship in 21 Years

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China Communications 2020年第8期17卷 158-167页

作者： yuan Li wenyan yu Xiang Li Ziyang Yang China Information and Communication Technology Beijing 100037China

The global Internet is composed of tens of thousands of autonomous system networks that are interconnected through a border gateway protocol. The analysis of changes in the interconnected relationships of the global Internet network is essential for studying the evolutionary trend of the global Internet. In addition, this analysis can also contribute toward the research on China's Internet development gaps. This article draws on the global Internet network status map for 21 years, starting from 1998 to 2019, based on inter-domain routing data sets of international third parties and China Academy of Information and Communications Technology. Moreover, the article also conducts a big data analysis on the relationship between global Internet network changes. The research results show that the global Internet network interconnection has increased, by nearly 60 times in the past 21 years. Peer-to-peer interconnection has gradually surpassed transit interconnection as the main mode of global interconnection. Furthermore, large Internet companies are playing an increasingly important role in global interconnection. Simultaneously, the results indicate the gradual movement of China's Internet base toward the global core and the continuous improvements of the global network's status.

关键词： autonomous system inter-domain routing system internet governance

立体化阅读推广的模式创新与实践探索——基于浙江工业大学图书馆的多案例研究

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新世纪图书馆 2024年第4期 40-48页

作者：李玲梅池晓波于文艳浙江工业大学图书馆浙江杭州310000

立体阅读推广的兴起是对阅读媒介变革的积极回应,其本质是媒介混合时代下发生在阅读推广领域的“媒介融合”策略与实践。为更好地揭示立体化阅读推广的内涵,阐述阅读推广媒介及其相关要素的融合与渗透,论文基于拉斯韦尔的传播学5W模式... 详细信息

立体阅读推广的兴起是对阅读媒介变革的积极回应,其本质是媒介混合时代下发生在阅读推广领域的“媒介融合”策略与实践。为更好地揭示立体化阅读推广的内涵,阐述阅读推广媒介及其相关要素的融合与渗透,论文基于拉斯韦尔的传播学5W模式及其新发展内涵,建构了一个含7大要素、3大流程的“7W3C”立体化阅读推广模式。基于此框架对浙江工业大学图书馆立体阅读推广案例进行分析、评估并提出策略建议,为立体阅读推广从概念化的理论转化为可描述、可量化、可执行的实践模式提供参考。

关键词：阅读推广立体阅读媒介融合 5W传播模式高校图书馆

基于频率切换的S/LCL补偿恒流恒压型WPT系统研究

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河南师范大学学报（自然科学版） 2024年第3期52卷 17-24页

作者：杨林邵帅余文彦周学斌河南师范大学电子与电气工程学院河南新乡453007 湖南科技学院智能制造学院湖南永州425199

由于传统的插入式系统结构繁杂且频繁插拔容易发生电火花等危险,因此无线电能传输(wireless power transfer,WPT)系统凭借其固有的优势得到了广泛的研究,逐渐融入各种工业应用中.为了确保电池的性能及使用寿命,有效地为电池提供所需的... 详细信息

由于传统的插入式系统结构繁杂且频繁插拔容易发生电火花等危险,因此无线电能传输(wireless power transfer,WPT)系统凭借其固有的优势得到了广泛的研究,逐渐融入各种工业应用中.为了确保电池的性能及使用寿命,有效地为电池提供所需的恒定充电电流和恒定充电电压是非常必要的.然而在充电过程中,电池的等效电阻会发生显著变化从而导致系统很难在近似零相位角(zero phase angle,ZPA)运行下同时实现与负载无关的恒流输出和恒压输出.鉴于此,提出1种基于S/LCL补偿的WPT系统,该系统可以在2个固定频率下实现具有ZPA运行的恒流和恒压输出.最后,搭建了1台恒流充电为3 A和恒压充电为80 V的验证性实验样机,验证了所设计的WPT系统的正确性和可行性.

关键词：无线电能传输 S/LCL 零相位角恒流输出恒压输出

某热电联产电厂双机组跳闸事故分析及解决措施

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东北电力技术 2024年第2期45卷 41-46页

作者：宋正余文彦杨林河南师范大学河南新乡453007

电网系统发生线路外部破坏事故时,某热电联产电厂双机组同时跳闸,引发全厂停电及1台锅炉发生干锅事故。对比两侧保护动作情况列出动作时序图,分析机组跳闸原因,提出解决措施。全面提高了该热电联产电厂机组的运行可靠性,降低了线路外部... 详细信息

电网系统发生线路外部破坏事故时,某热电联产电厂双机组同时跳闸,引发全厂停电及1台锅炉发生干锅事故。对比两侧保护动作情况列出动作时序图,分析机组跳闸原因,提出解决措施。全面提高了该热电联产电厂机组的运行可靠性,降低了线路外部发生破坏事故时对电厂及电力系统的影响,保证了电力系统安全稳定运行。

关键词：热电联产双机组跳闸动作时序图可靠性线路外部破坏

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轮辐冲压工艺优化及起皱控制方法

锻压技术 2024年第5期49卷 36-44页

作者：赵帅石光林王文枫玉文雁彭金何世明彭蔚杰广西科技大学机械与汽车工程学院广西柳州545006 广西泰坦宇翔钢圈股份公司广西柳州545027

针对高强度车轮钢采用多道次成形或热成形工艺而导致生产成本高、生产效率低等问题,以某商用汽车轮辐为研究对象,通过减少冲压道次,改进现有冲压方案,分析板料冲压起皱临界状态以及压边力的变化规律,预测起皱位置,确定抑制起皱缺陷的冲... 详细信息

针对高强度车轮钢采用多道次成形或热成形工艺而导致生产成本高、生产效率低等问题,以某商用汽车轮辐为研究对象,通过减少冲压道次,改进现有冲压方案,分析板料冲压起皱临界状态以及压边力的变化规律,预测起皱位置,确定抑制起皱缺陷的冲压工艺参数,并对轮辐冲压成形过程进行模拟仿真,通过优化模具结构以及添加局部拉延筋改变冲压时材料的流动阻力,改善起皱与减薄等缺陷,并对优化后的工艺方案进行试验验证。结果表明:豁口处材料缺失使各区域所需压边力不同是导致起皱缺陷的主要原因,改变模具结构并添加拉延筋后,轮辐成形质量良好,起皱缺陷得到抑制,优化后产品减薄率控制在5%。

关键词： B500CL钢冲压成形起皱压边力模具结构拉延筋

不同制备工艺伏立康唑注射剂在大鼠体内的代谢情况

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中国药物与临床 2024年第7期24卷 465-469页

作者：沈佩霞吴思雯郁闻彦嘉兴学院附属医院(嘉兴市第一医院)药学部浙江嘉兴314001

目的分析不同制备工艺伏立康唑注射剂在大鼠体内的代谢情况。方法16只雄性Sprague-Dawley大鼠按照随机数字表法分为2组,经大鼠尾静脉注射国产(四川美大康华康药业有限公司生产)与进口(美国辉瑞制药有限公司生产)伏立康唑注射剂,剂量40 m... 详细信息

目的分析不同制备工艺伏立康唑注射剂在大鼠体内的代谢情况。方法16只雄性Sprague-Dawley大鼠按照随机数字表法分为2组,经大鼠尾静脉注射国产(四川美大康华康药业有限公司生产)与进口(美国辉瑞制药有限公司生产)伏立康唑注射剂,剂量40 mg/kg,采用高效液相色谱-串联质谱(HPLC-MS/MS)法测定5、30、60、120、240、360、480、720、1440 min不同制备工艺伏立康唑注射剂血药浓度,采用DAS2.0药动学软件分析伏立康唑注射剂血药浓度-时间数据,并对比不同制备工艺伏立康唑注射剂血浆药物动力学参数的差异。结果国产与进口伏立康唑注射剂在大鼠体内主要药代动力学参数到达最大血药浓度的时间(Tmax)、最大血药浓度(Cmax)、清除率(CL)、24 h药物浓度-时间曲线下面积(AUC 0~24 h)以及平均滞留时间(MRT)比较[(5.00±0.10)min、(28.4±2.4)μg/ml、(3.5±1.6)ml·h^(-1)·kg^(-1)、(249±27)μg·h^(-1)·ml^(-1)、(7.7±1.3)h和(5.00±0.20)min、(30.1±2.3)μg/ml、(2.4±0.6)ml·h^(-1)·kg^(-1)、(233±20)μg·h^(-1)·ml^(-1)、(6.8±1.0)h],差异均无统计学意义(P>0.05);大部分组织在给药后480 min逐渐降低,各主要脏器以及组织药物浓度与血浆药物消除具有一致性。结论不同制备工艺伏立康唑注射剂在大鼠体内的药代动力学参数接近,在不同脏器组织内的暴露也无明显差异,药代动力学过程无明显差异。

关键词：伏立康唑大鼠代谢高效液相色谱-串联质谱