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Advances in functional coatings on biliary stents

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Regenerative Biomaterials 2024年第2期3卷 55-75页

作者： Kaining Yang Wenxin Sun Lanyue Cui Yuhong zou Cuie Wen Rongchang Zeng Department of Bioengineering College of Chemical and Biological EngineeringShandong University of Science and TechnologyQingdao 266590China Corrosion Laboratory for Light Metals College of Materials Science and EngineeringShandong University of Science and TechnologyQingdao 266590China school of Engineering RMIT UniversityMelbourneVIC3001Australia

Biliary stenting is an important interventional method for the prevention and treatment of biliary tract ***,complications,such as postoperative biliary infection and re-stenosis,frequently occur due to the extensive scope of the biliary system and the complex composition of *** com-bination of coating technology and biliary stents is expected to bring new approaches to the solution of these *** cutting-edge advance on functional coatings on biliary stents is reviewed from seven perspectives:anticorrosion,-bacterial,-tumor,stone-dissolving,X-ray visibility,anti-stent migration and functional composite *** de-velopment trend is also *** performance of the numerous functional coatings for various purposes is generally up to expectations,but the balance between the medica tions'effectiveness and their safety needs to be further *** contemporary investigations have advanced to the leve of animal experiments,offering crucial fundamental assurance for broader human *** combination of biliary stent and functional coatings is an innovative idea with great potential for future development.

关键词： biliary stent coating anticorrosion antibacterial antitumor stone-dissolving X-ray visibility antistent migration

Vesicular drug delivery systems for oral absorption enhancement

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Chinese Chemical Letters 2024年第7期35卷 73-88页

作者： Linghui zou Meng Cheng Kaili Hu Jianfang Feng Liangxing Tu Jiangxi University of Chinese Medicine Nanchang 330006China Guangxi University of Chinese Medicine Nanning 530200China Shanghai University of Traditional Chinese Medicine Shanghai 201203China

Oral administration is the most acceptable route of drug delivery at this stage due to its convenience,safety,and ***,drugs given orally are exposed to a complex gastrointestinal environment,causing a tremendous challenge for their successful absorption into the *** the past decades,researchers have developed various novel pharmaceutical technologies to improve oral absorption,among which the vesicular drug delivery system(like liposomes,niosomes and transfersomes)has received extensive ***,there have been several investigations confirming the improved effect of vesicular drug delivery systems on oral drug ***,the clinical translation of oral vesicular drug delivery systems has been less impressive than implied by the positive results,and few vesicular formulations for oral use have been marketed *** this background,this article provides an overview of the current applications and challenges associated with the vesicular delivery systems available for oral drug delivery,specifically liposomes,niosomes,transfersomes,chitosomes and *** composition,formation mechanism,drug delivery advantages and application cases of these carriers in oral drug delivery are *** possible mechanisms by which vesicular carriers enhance oral drug absorption are analyzed in terms of the in vivo process of oral ***,the challenges that oral vesicular carriers now face,such as safety,undefined in vivo fate,and scale-up production,are summarized,while possible strategies to deal with them are *** reviewing the aforementioned,it can facilitate a more comprehensive knowledge of vesicular systems that can be used for oral drug delivery,providing a theoretical basis and reference for the design of oral formulations.

关键词： Vesicular Oral Mechanism Drug delivery Liposome Niosomes Transfersomes Chitosomes Bilosomes

Detecting bulk and edge exceptional points in non-Hermitian systems through generalized Petermann factors

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Frontiers of physics 2024年第2期19卷 169-177页

作者： Yue-Yu zou Yao Zhou Li-Mei Chen Peng Ye School of Physics State Key Laboratory of Optoelectronic Materials and Technologiesand Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSun Yat-sen UniversityGuangzhou 510275China

Non-orthogonality in non-Hermitian quantum systems gives rise to tremendous exotic quantum phenomena,which can be fundamentally traced back to *** this paper,we introduce an interesting quantity(denoted asη)as a new variant of the Petermann factor to directly and efficiently measure non-unitarity and the associated non-Hermitian *** tuning the model parameters of underlying non-Hermitian systems,we find that the discontinuity of bothηand its first-order derivative(denoted as■η)pronouncedly captures rich physics that is fundamentally caused by *** concretely,in the 1D non-Hermitian topological systems,two mutually orthogonal edge states that are respectively localized on two boundaries become non-orthogonal in the vicinity of discontinuity ofηas a function of the model parameter,which is dubbed"edge state transition".Through theoretical analysis,we identify that the appearance of edge state transition indicates the existence of exceptional points(EPs)in topological edge *** the discontinuity of■η,we investigate a two-level non-Hermitian model and establish a connection between the points of discontinuity of■ηand EPs of bulk *** studying this connection in more general lattice models,we find that some models have discontinuity of■η,implying the existence of EPs in bulk states.

关键词： non-Hermitian Su−Schrieffer−Heeger(SSH)model exceptional point

Lateral earth pressure of granular backfills on retaining walls with expanded polystyrene geofoam inclusions under limited surcharge loading

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1388-1397页

作者： Kewei Fan Guangqing Yang Weilie zou Zhong Han Yang Shen Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing210098China School of Civil Engineering Wuhan UniversityWuhan430072China State Key Laboratory of Mechanical Behavior and System Safety of Traffic Engineering Structures Shijiazhuang Tiedao UniversityShijiazhuang050043China

Existing studies have focused on the behavior of the retaining wall equipped with expanded polystyrene(EPS)geofoam inclusions under semi-infinite surcharge loading rather than limited surcharge *** this paper,the failure mode and the earth pressure acting on the rigid retaining wall with EPS geofoam inclusions and granular backfills(henceforth referred to as EPS-wall),under limited surcharge loading are investigated through two-and three-dimensional model *** testing results show that different from the sliding of almost all the backfill in the EPS-wall under semi-infinite surcharge loading,only an approximately triangular backfill slides in the wall under limited surcharge *** distribution of the lateral earth pressure on the EPS-wall under limited surcharge loading is non-linear,and the distribution changes from the increase of the wall depth to the decrease with the increase of the limited surcharge *** approach based on the force equilibrium of a differential element is developed to predict the lateral earth pressure behind the EPS-wall subjected to limited surcharge loading,and its performance was fully validated by the three-dimensional model tests.

关键词： Retaining wall Expanded polystyrene(EPS)geofoam Limited surcharge loading Lateral earth pressure Model test Prediction

Boosted sustained-release with iron-based MOF-derived mesoporouscarbon-spheres as a nitroimidazole drugs carrier

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Particuology 2024年第3期86卷 269-280页

作者： Danping Wu Jiaying zou Junyi Chen Yan Li Na Ma Wei Dai College of Chemistry and Materials Science Zhejiang Normal UniversityJinhua321004China College of Life Sciences Zhejiang Normal UniversityJinhua321004China College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua321004China

Metal-organic framework(MoF)with a buildable internal structure has aroused great interest focus as self-sacrificing precursors of porous carbon(PC).However,as a drug carrier,the MOF-derived PC developed thus far are generally composed of irregular powder shape due to their crystalline nature,which consequently causing the cerebral infarction,cerebral thrombosis,and other blood *** this article,we propose a novel approach to constructing amorphous carbon microspheres(AcMs)by dis-torting the topological network through hydrothermal treatment precursors of MIL-101(Fe).Then,a distinctive MIL-101(Fe)-derived spherical porous carbons(MSPC)is achieved through high temperature calcination toward *** of the glucose initial concentration and hydrothermal treatment time on the sphericity of the as-prepared mesoporous MsPC were investigated in *** the loading capacities and sustained-release performances of nitroimidazole drugs over MsPC through simulation internal environment of human body at different pH values was systematically *** nitro-imidazole drugs loading rate and release time of MsPC are 10% and 17 h under preferred ***,the MSPC exhibited very low toxicity on Hela cells and 293T cells at the concentrations tested(10-800μg mL^(-1)).This study,therefore,supports the potential of the mesoporous carbon spheres as a carrierfor nitroimidazole drug delivery.

关键词： Ornidazole Metronidazole Carbon spheres Sustained-release performance Biocompatibility

Numerical and theoretical study of large-scale failure of strata overlying sublevel caving mines with steeply dipping discontinuities

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1799-1815页

作者： Kaizong Xia Zhiwei Si Congxin Chen Xiaoshuang Li Junpeng zou Jiahao Yuan State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China School of Urban Construction Changzhou UniversityChangzhou 213164China Faculty of Engineering China University of Geosciences(Wuhan)Wuhan 430074China

The deformation and fracture evolution mechanisms of the strata overlying mines mined using sublevel caving were studied via numerical ***,an expression for the normal force acting on the side face of a steeply dipping superimposed cantilever beam in the surrounding rock was deduced based on limit equilibrium *** results show the following:(1)surface displacement above metal mines with steeply dipping discontinuities shows significant step characteristics,and(2)the behavior of the strata as they fail exhibits superimposition ***,failure first occurs in certain superimposed strata slightly far from the ***,with the constant downward excavation of the orebody,the superimposed strata become damaged both upwards away from and downwards toward the *** process continues until the deep part of the steeply dipping superimposed strata forms a large-scale deep fracture plane that connects with the *** deep fracture plane generally makes an angle of 12°-20°with the normal to the steeply dipping *** effect of the constant outward transfer of strata movement due to the constant outward failure of the superimposed strata in the metal mines with steeply dipping discontinuities causes the scope of the strata movement in these mines to be larger than *** strata in the metal mines with steeply dipping discontinuities mainly show flexural toppling ***,the steeply dipping structural strata near the goaf mainly exhibit shear slipping failure,in which case the mechanical model used to describe them can be simplified by treating them as steeply dipping superimposed cantilever *** taking the steeply dipping superimposed cantilever beam that first experiences failure as the key stratum,the failure scope of the strata(and criteria for the stability of metal mines with steeply dipping discontinuities mined using sublevel caving)can be obtained via iterative computations from the ke

关键词： sublevel caving mines universal distinct element code(UDEC)numerical approach large-scale ground movement steeply dipping superimposed cantilever beam toppling failure

Grain size and surface micro-texture characteristics and their paleoenvironmental significance of Holocene sediment in southern margin of the Gurbantunggut Desert,China

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Journal of Arid Land 2024年第5期16卷 632-653页

作者： MA Yunqiang LI Zhizhong TAN Dianjia zou Xiaojun TAO Tonglian School of Geographical Sciences Fujian Normal UniversityFuzhou 350117China Key Laboratory for Humid Subtropical Eco-geographical Processes of the Ministry of Education Fujian Normal UniversityFuzhou 350117China Institute of Geography Fujian Normal UniversityFuzhou 350117China

The southern margin of the Gurbantunggut Desert,China,is characterized by alternating layers of aeolian and alluvial *** the characteristics of arenaceous sediment in this area is of significant importance for understanding the interactive processes of wind and water forces,as well as the provenance of ***,there are relatively few investigations on the characteristics of such sediment at *** this study,we researched three aeolian-alluvial interactive stratigraphic profiles and different types of surface sediment on the desert-oasis transitional zone of southern margin of the Gurbantunggut *** on the optically stimulated luminescence(OSL)dating of aeolian sand and analyses of quartz sand grain size and surface micro-texture,we explored the aeolian-alluvial environmental change at southern margin of the desert in Holocene,as well as the provenance of *** results indicated that the grain size characteristics of different types of sediment in the stratigraphic profiles were similar to those of modern dune sand,interdune sand,muddy desert surface soil,and riverbed *** frequency curves were unimodal or bimodal,and cumulative probability curves were two-segment or three-segment,mainly composed of suspension load and saltation *** quartz sand in the sediment at southern margin of the desert had undergone alternating transformation of various exogenic forces,with short transportation distance and time,and sedimentary environment was relatively *** Holocene,southern margin of the desert primarily featured braided river deposits,and during intermittent period of river activity,there were also aeolian deposits such as sand sheet deposits,stabilized dune deposits,and mobile dune *** provenance for Holocene alluvial deposits at southern margin of the desert remains relatively constant,with the debris of the Tianshan Mountains being the primary *** sand is mainly near-source recharge,

关键词： aeolian-alluvial deposition grain size surface micro-texture sedimentary environment Holocene

Nanocrystalline WSe_(2)excels at high-performance anode for Na storage via a facile one-pot hydrothermal method

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Tungsten 2024年第1期6卷 248-258页

作者： Hai-Yan zou Lei Fang Gang Yu Dong Wang State Key Laboratory of Chem/Bio-Sensing and Chemometrics Provincial Hunan Key Laboratory for Graphene Materials and DevicesCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Changxing County Quality and Technology Supervision and Testing Center Huzhou 313100China

For the next large-scale energy storage systems,sodium-ion batteries(SIBs)with excellent electrochemical performance are ***,the exploration of anode materials with high specific capacity,fascinating cycling stability and rate capability is still *** transition metal dichalcogenides(TMDs),tungsten diselenide(WSe_(2))has been regarded as an effective anode material for SIBs and has been extensively studied,due to high theoretical capacity and unique twodimensional layered ***,nanocrystalline WSe_(2)is prepared by a facile one-pot hydrothermal *** with the micro-scale WSe_(2),benefiting from the high specific surface area of highly ordered nano-flake structures and short ion/electron transport paths,nanocrystalline WSe_(2)shows excellent electrochemical performance in Na *** 1000 cycles at a current density of 2 A·g^(-1),a high specific capacity of 264.4 mA·h·g^(-1)is still *** full cell matched with the Na_(3)V_(2)(PO_(4))_(3) cathode can deliver an excellent reversible specific capacity of 196.5 mA·h·g^(-1)after 100 cycles at 0.5 A·g^(-1).

关键词： Tungsten diselenide Transition metal dichalcogenides Hydrothermal Sodium-ion batteries Layered structure

Torque Limit-based Inertial Control Method Based on Delayed Support for Primary Frequency Control of Wind Turbines

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 561-570页

作者： Wei Gu Zaiyu Chen Qun Li Minghui Yin Qiang Li Yun zou School of Automation Nanjing University of Science and TechnologyNanjing 210094China State Grid Jiangsu Electric Power Co. Ltd.Research InstituteNanjing 211103China

To avoid the secondary frequency dip caused by the steep drop of the electrical power of wind turbines(WTs)at the end of frequency support stage,the torque limit-based iner-tial control(TLIC)method sets the power reference as a linear function of rotor speed,rather than the step form for the step-wise inertial ***,the compensation effect on the frequency nadir(FN)caused by the load surge is weakened as the TLIC power is no longer in the step ***,the maximum point of the frequency response component(FRC)contributed by TLIC occurs earlier than the minimum point of FRC corresponding to the load surge,so that the FN cannot be adequately ***,this paper first investigates the relation between the peak and nadir times of FRCs stimulated by the TLIC and load *** this basis,with the compensation principle of matching the peak and nadir times of FRCs,the improved TLIC method based on delayed support is ***,the effectiveness of the proposed method is validated via the experiments on the test bench of wind-integrated power system.

关键词： Wind turbine frequency response component torque limit inertial control delayed support