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Effect of transcranial direct current stimulation on postoperative sleep disturbance in older patients undergoing lower limb major arthroplasty:a prospective,double-blind,pilot,randomised controlled trial

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General Psychiatry 2024年第2期37卷 224-233页

作者： Jie Yang Mingshu Tao Rongguang Liu Jiaxing Fang Chunyan Li Dexian Chen Qi Wei Xingyu Xiong wenxin zhao Wen Tan Yuan Han Hongxing Zhang He Liu Song Zhang Junli Cao Department of Anesthesiology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthesiology Hospital of Chengdu University of Traditional Chinese Medicine&Traditional Chinese Medicine Hospital of Sichuan ProvinceChengduSichuanChina NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs&Jiangsu Province Key Laboratory of Anesthesiology&Jiangsu Key Laboratory of Applied Technology of Anesthesia and Analgesia Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthesiology Eye&ENT Hospital of Fudan UniversityShanghaiChina Department of Anesthesiology&Clinical Research Center for Anesthesia and Perioperative Medicine&Huzhou Key Laboratory of Basic Research and Clinical Translation for Neuromodulation The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University||Huzhou Central Hospital||The Affiliated Huzhou HospitalZhejiang University School of Medicine||Affiliated Central Hospital Huzhou UniversityHuzhouZhejiangChina Department of Anesthesiology Renji Hospital School of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Postoperative sleep disturbance(PSD)is a common and serious postoperative complication and is associated with poor postoperative outcomes.Aims This study aimed to investigate the effect of transcranial direct current stimulation(tDCS)on PSD in older patients undergoing lower limb major arthroplasty.Methods In this prospective,double-blind,pilot,randomised,sham-controlled trial,patients 65 years and over undergoing lower limb major arthroplasty were randomly assigned to receive active tDCS(a-tDCS)or sham tDCS(s-tDCS).The primary outcomes were the objective sleep measures on postoperative nights(N)1 and N2.Results 116 inpatients were assessed for eligibility,and a total of 92 patients were enrolled;47 received a-tDCS and 45 received s-tDCS.tDCS improved PSD by altering the following sleep measures in the a-tDCS and s-tDCS groups;the respective comparisons were as follows:the promotion of rapid eye movement(REM)sleep time on N1(64.5(33.5-105.5)vs 19.0(0.0,45.0)min,F=20.10,p<0.001)and N2(75.0(36.0-120.8)vs 30.0(1.3-59.3)min,F=12.55,p<0.001);the total sleep time on N1(506.0(408.0-561.0)vs 392.0(243.0-483.5)min,F=14.13,p<0.001)and N2(488.5(455.5-548.5)vs 346.0(286.5-517.5)min,F=7.36,p=0.007);the deep sleep time on N1(130.0(103.3-177.0)vs 42.5(9.8-100.8)min,F=24.4,p<0.001)and N2(103.5(46.0-154.8)vs 57.5(23.3-106.5)min,F=8.4,p=0.004);and the percentages of light sleep and REM sleep on N1 and N2(p<0.05 for each).The postoperative depression and anxiety scores did not differ significantly between the two groups.No significant adverse events were reported.Conclusion In older patients undergoing lower limb major arthroplasty,a single session of anodal tDCS over the left dorsolateral prefrontal cortex showed a potentially prophylactic effect in improving postoperative short-term objective sleep measures.However,this benefit was temporary and was not maintained over time.

关键词： sleep stimulation postoperative

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Spatial distributions of soil nutrients affected by land use,topography and their interactions,in the Loess Plateau of China

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International Soil and Water Conservation Research 2024年第1期12卷 227-239页

作者： wenxin Zhou Changjia Li Wenwu zhao Lindsay C.Stringer Bojie Fu State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal UniversityBeijingChina Institute of Land Surface System and Sustainable Development Faculty of Geographical ScienceBeijing Normal UniversityBeijingChina Department of Environment and Geography University of YorkYorkUK York Environmental Sustainability Institute University of YorkYorkUK

Soil nutrient availability and their spatial distributions are strongly related to land use and landscape morphology.This study aims to address the knowledge gap regarding the interaction between these factors and the underlying mechanisms.We selected five land uses(grassland with Artemisia gmelinii,woodland with Robinia pseudoacacia,shrubland with Caragana korshinskii and Hippophae rhamnoides,and apple orchard with Malus pumila)and nine slope positions across hillslopes in the Loess Plateau,China,to investigate their combined effects on the contents and stocks of soil organic carbon(SOC),total nitrogen(TN)and total phosphorus(TP).Parametric and non-parametric statistical tests were conducted to determine the significant differences in the means or the medians of the soil nutrient variables.Results showed that the SOC and TN contents of shrubland with Caragana korshinskii were statistically significantly greater than those of the grassland(p<0.05).SOC and TN contents generally decreased from the upper slope to the middle slope,and to the foot slope for the grassland,woodland and shrublands,and on the contrary,an increasing trend from the upper slope,to the middle slope,and to the foot slope was identified for the apple orchard.This study highlights that land use,slope position and their interaction have significant effects on the spatial distributions of soil nutrients.It provides essential empirical evidence for the identification of the optimal vegetation type and slope positions in land management and vegetation restoration activities.

关键词： Soil organic carbon Total nitrogen Total phosphorus Slope position Vegetation restoration

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Fine-tuning the activation behaviors of ternary modular cabazitaxel prodrugs for efficient and on-target oral anti-cancer therapy

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 188-203页

作者： Mingyang Zhang Yifan Miao Can zhao Tong Liu Xiyan Wang Zixuan Wang wenxin Zhong Zhonggui He Chutong Tian Jin Sun Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province Hangzhou 310058China Joint International Research Laboratory of Intelligent Drug Delivery Systems Ministry of EducationShenyang 110016China Liaoning Provincial Institute of Drug Inspection and Testing Shenyang 110036China

The disulfide bond plays a crucial role in the design of anti-tumor prodrugs due to its exceptional tumor-specific redox responsiveness. However, premature breaking of disulfide bonds is triggered by small amounts of reducing substances (e.g., ascorbic acid, glutathione, uric acid and tea polyphenols) in the systemic circulation. This may lead to toxicity, particularly in oral prodrugs that require more frequent and high-dose treatments. Fine-tuning the activation kinetics of these prodrugs is a promising prospect for more efficient on-target cancer therapies. In this study, disulfide, steric disulfide, and ester bonds were used to bridge cabazitaxel (CTX) to an intestinal lymph vessel-directed triglyceride (TG) module. Then, synthetic prodrugs were efficiently incorporated into self-nanoemulsifying drug delivery system (corn oil and Maisine CC were used as the oil phase and Cremophor EL as the surfactant). All three prodrugs had excellent gastric stability and intestinal permeability. The oral bioavailability of the disulfide bond-based prodrugs (CTX-(C)S-(C)S-TG and CTX-S-S-TG) was 11.5- and 19.1-fold higher than that of the CTX solution, respectively, demonstrating good oral delivery efficiency. However, the excessive reduction sensitivity of the disulfide bond resulted in lower plasma stability and safety of CTX-S-S-TG than that of CTX-(C)S-(C)S-TG. Moreover, introducing steric hindrance into disulfide bonds could also modulate drug release and cytotoxicity, significantly improving the anti-tumor activity even compared to that of intravenous CTX solution at half dosage while minimizing off-target adverse effects. Our findings provide insights into the design and fine-tuning of different disulfide bond-based linkers, which may help identify oral prodrugs with more potent therapeutic efficacy and safety for cancer therapy.

关键词： Steric disulfide bond Triglyceride-like pr odrugs Cabazitaxel Lymphatic transport Oral chemotherapy

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The appearance of cytoplasmic cytochrome C precedes apoptosis during Drosophila salivary gland degradation

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Insect Science 2024年第1期31卷 157-172页

作者： Shihui Long wenxin Cao Yongyu Qiu Ruohan Deng Jiali Liu Lidan Zhang Renke Dong Fengxin Liu Sheng Li Haigang zhao Na Li Kang Li Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhouChina Guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouGuangdong ProvinceChina School of Food Science and Engineering South China University of TechnologyGuangzhouChina ChemPartner PharmaTech Co. LtdJiangmenGuangdong ProvinceChina

Apoptosis is an important process for organism development that functions to eliminate cell damage,maintain homeostasis,and remove obsolete tissues during morphogenesis.In mammals,apoptosis is accompanied by the release of cytochrome C(Cyt-c)from mitochondria to the cytoplasm.However,whether this process is conserved in the fruit fly,Drosophila melanogaster,remains controversial.In this study,we discovered that during the degradation of Drosophila salivary gland,the transcription of mitochondria apoptosis factors(MAPFs),Cyt-c,and death-associated APAF1-related killer(Dark)encoding genes are all upregulated antecedent to initiator and effector caspases encoding genes.The proteins Cyt-c and the active caspase 3 appear gradually in the cytoplasm during salivary gland degradation.Meanwhile,the Cyt-c protein colocates with mito-GFP,the marker indicating cytoplasmic mitochondria,and the change in mitochondrial membrane potential coincides with the appearance of Cyt-c in the cytoplasm.Moreover,impeding or promoting 20E-induced transcription factor E93 suppresses or enhances the staining of Cyt-c and the active caspase 3 in the cytoplasm of salivary gland,and accordingly decreases or increases the mitochondrial membrane potential,respectively.Our research provides evidence that cytoplasmic Cyt-c appears before apoptosis during Drosophila salivary gland degradation,shedding light on partial conserved mechanism in apoptosis between insects and mammals.

关键词： active caspase 3 apoptosis Cyt-c Drosophila salivary gland

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An Equivalent Substitute Strategy for Constructing 3D Ordered Porous Carbon Foams and Their Electromagnetic Attenuation Mechanism

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Nano-Micro Letters 2022年第10期14卷 15-35页

作者： Meng Zhang Hailong Ling Ting Wang Yingjing Jiang Guanying Song Wen zhao Laibin zhao Tingting Cheng Yuxin Xie Yuying Guo wenxin zhao Liying Yuan Alan Meng Zhenjiang Li College of Materials Science and Engineering College of Electromechanical EngineeringQingdao University of Science and TechnologyQingdao 266061People’s Republic of China State Key Laboratory Base of Eco-Chemical Engineering College of Chemistry and Molecular EngineeringCollege of Chemical Engineering in Gaomi CampusQingdao University of Science and TechnologyQingdao 266042People’s Republic of China

Three-dimensional(3D)ordered porous carbon is generally believed to be a promising electromagnetic wave(EMW)absorbing material.However,most research works targeted performance improvement of 3D ordered porous carbon,and the specific attenuation mechanism is still ambiguous.Therefore,in this work,a novel ultra-light egg-derived porous carbon foam(EDCF)structure has been successfully constructed by a simple carbonization combined with the silica microsphere template-etching process.Based on an equivalent substitute strategy,the influence of pore volume and specific surface area on the electromagnetic parameters and EMW absorption properties of the EDCF products was confirmed respectively by adjusting the addition content and diameter of silica microspheres.As a primary attenuation mode,the dielectric loss originates from the comprehensive effect of conduction loss and polarization loss in S-band and C band,and the value is dominated by polarization loss in X band and Ku band,which is obviously greater than that of conduction loss.Furthermore,in all samples,the largest effective absorption bandwidth of EDCF-3 is 7.12 GHz under the thickness of 2.13 mm with the filling content of approximately 5 wt%,covering the whole Ku band.Meanwhile,the EDCF-7 sample with optimized pore volume and specific surface area achieves minimum reflection loss(RL_(min))of−58.08 dB at 16.86 GHz while the thickness is 1.27 mm.The outstanding research results not only provide a novel insight into enhancement of EMW absorption properties but also clarify the dominant dissipation mechanism for the porous carbon-based absorber from the perspective of objective experiments.

关键词： Porous carbon foam Electromagnetic wave absorption Adjustable pore structure Polarization loss Attenuation mechanism

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Boosted electromagnetic wave absorption performance from synergistic induced polarization of SiC_(NWs)@MnO_(2)@PPy heterostructures

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Nano Research 2023年第2期16卷 3558-3569页

作者： Meng Zhang Laibin zhao wenxin zhao Ting Wang Liying Yuan Yuying Guo Yuxin Xie Tingting Cheng Alan Meng Zhenjiang Li College of Electromechanical Engineering Key Laboratory of Polymer Material Advanced Manufacturing’s Technology of Shandong provinceCollege of Materials Science and EngineeringQingdao University of Science and TechnologyQingdao 266061China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science MOEShandong Key Laboratory of Biochemical AnalysisCollege of Gaomi CampusCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China

In the last decade,electromagnetic pollution has caused people’s considerable attention.Developing absorbing material with low cost,lightweight,simple preparation,and high electromagnetic attenuation efficiency has become a feasible means to deal with this problem.In this work,core–shell SiC_(NWs)@MnO_(2)@PPy(NWs:nanowires,PPy:polypyrrole)heterostructures composed of SiC nanowires core,MnO_(2)nanosheets inter-layer,and PPy coating were successfully prepared through chemical vapor deposition and two-step electrodeposition process.Taking advantage of the interfacial polarization and dipole polarization,the obtained product displays excellent electromagnetic wave absorption performances with the minimum reflection loss(RLmin)of−50.59 dB when the matching thickness is 2.41 mm,and the optimal effective absorption bandwidth(EAB)value reaches to 6.64 GHz at a matching thickness of 2.46 mm,revealing that the SiC_(NWs)@MnO_(2)@PPy nanocomposite could be served as a promising electromagnetic wave absorbing material.On the basis of systematic analysis concerning the electromagnetic parameters,the dissipation process of the incident electromagnetic wave was demonstrated reasonably,which may provide a referable preparation strategy for novel heterostructures,especially nonmagnetic lightweight absorbing material.

关键词： SiC nanowires heterostructure polarization loss electromagnetic wave absorption attenuation mechanism

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Enhancing electromagnetic wave absorption in carbon fiber using FeS_(2)nanoparticles

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Nano Research 2023年第7期16卷 9591-9601页

作者： Yuying Guo Meng Zhang Tingting Cheng Yuxin Xie Laibin zhao Liang Jiang wenxin zhao Liying Yuan Alan Meng Jian Zhang Ting Wang Zhenjiang Li College of Electromechanical Engineering Key Laboratory of Polymer Material Advanced Manufacturing’s Technology of Shandong provinceCollege of Materials Science and EngineeringQingdao University of Science and TechnologyQingdao 266061China College of Chemical Engineering Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life ScienceMOEShandong Key Laboratory of Biochemical AnalysisCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China College of Textiles and Clothing Qingdao UniversityQingdao 266071China

Carbon-based electromagnetic wave absorbing materials(absorbers)adhered with metallic sulfide nanoparticles of good electrical conductivity attract increasing researchers’attention.In this study,on the basis of carbon fiber(C_(f))@Fe_(3)O_(4) nanocomposites obtained by the electrostatic spinning and reflow method,C_(f)@FeS_(2)nanocomposite was successfully prepared during a further hydrothermal process.The products exhibit excellent electromagnetic wave absorption performances with a minimum reflection loss(RLmin)of-54.11 dB at 2.13 mm matching thickness.At the same time,the optimal effective absorption bandwidth(EAB)value of 6.04 GHz at a thickness of 1.98 mm covers the whole Ku band,suggesting its excellent electromagnetic wave absorption performances.In addition,the interlaced network structure constructed by carbon fiber,outstanding conductivity of FeS_(2)nanoparticles,and interfacial polarization from hetero-structure play significant parts in enhancing the electromagnetic parameters and absorption performances.All these results suggest that the C_(f)@FeS_(2)nanocomposites can be taken as a new electromagnetic wave-absorbing material under their low density,simple craft,and strong absorption characteristics.

关键词： constructed network structure carbon fiber(C_(f))@FeS_(2)nanocomposite enhanced dielectric loss microwave attenuation mechanism

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数据挖掘算法在作业车间调度问题中的应用

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计算机集成制造系统 2024年第2期30卷 520-536页

作者：王艳红赵也践刘文鑫沈阳工业大学人工智能学院辽宁沈阳110870

为了从与日俱增的车间生产数据中提取调度规则来指导生产调度任务,提出一种基于数据挖掘的调度算法。将最小化最大完工时间设置为性能指标,从作业车间的离线生产数据中建立合适的调度样本集;将建立的调度样本集按合适的比例分为训练集... 详细信息

为了从与日俱增的车间生产数据中提取调度规则来指导生产调度任务,提出一种基于数据挖掘的调度算法。将最小化最大完工时间设置为性能指标,从作业车间的离线生产数据中建立合适的调度样本集;将建立的调度样本集按合适的比例分为训练集和测试集;用数据挖掘算法中的分类回归树(CART)从训练集中获取有效的调度知识,形成CART树状调度规则库;为了验证所得调度规则的有效性,将调度规则与遗传算法结合,设计了一种基于数据挖掘和调度规则的遗传算法作为调度算法来求解作业车间调度问题。通过对不同作业车间经典算例进行仿真与测试,验证了所提调度规则和调度算法的有效性与优越性。

关键词：数据挖掘作业车间调度分类回归树调度规则

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长波长发射碳点合成、调控及应用研究进展

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发光学报 2024年第4期45卷 534-556页

作者：陈劲良曲丹赵雯辛安丽孙再成北京工业大学化学与生命科学学院环境科学与工程学院绿色催化与分离北京市重点实验室环境安全与生物效应中心北京100124

近年来,随着碳点在合成路线、反应机理、光学性质等方面的发展,大量的工作聚焦于红光或近红外光等长波长发射的碳点。长波长是指发射范围在600~1800 nm的红色或近红外光谱区,相比短波长碳点,其具有深组织穿透、较小自荧光、长荧光寿命... 详细信息

近年来,随着碳点在合成路线、反应机理、光学性质等方面的发展,大量的工作聚焦于红光或近红外光等长波长发射的碳点。长波长是指发射范围在600~1800 nm的红色或近红外光谱区,相比短波长碳点,其具有深组织穿透、较小自荧光、长荧光寿命以及光损伤小等特点,能够进一步应用在生物医学治疗、光电子以及光学器件制备等领域。因此,深入探究长波长发射碳点的设计和合成对于其发展和广泛应用具有重要意义。本文综述了近年来长波长发射碳点的研究进展,从碳源选择和光学性质调控两个方面介绍了长波长发射碳点的设计与制备。选择氨基较多的脂肪族化合物和具有共轭结构的芳香化合物,以及通过调控有效共轭长度、表面修饰和杂原子掺杂等方法来调控其光学性质。最后,阐述了长波长碳点在生物医学、LED光学器件和加密防伪等一些领域的最新研究和未来的挑战。

关键词：长波长发射碳点光学性质应用

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红外焦平面探测器复合条件工作点闪元标定方法

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光子学报 2024年第2期53卷 13-25页

作者：赵雯昕赖雪峰夏昱成李素钧周金梅中国科学院光电技术研究所成都610209 中国科学院大学电子电气与通信工程学院北京100049

针对闪元传统标定方法的不足,提出一种结合灰度域图像和能量域图像进行复合条件工作点闪元标定的方法。该方法解决了单一工作点对闪元激发条件不够充分和探测器非均匀性所造成的闪元漏检等问题。实验验证表明,单一工作点上闪元检测率平... 详细信息

针对闪元传统标定方法的不足,提出一种结合灰度域图像和能量域图像进行复合条件工作点闪元标定的方法。该方法解决了单一工作点对闪元激发条件不够充分和探测器非均匀性所造成的闪元漏检等问题。实验验证表明,单一工作点上闪元检测率平均提高了12.49%,与传统方法相比,整体闪元检测率提高了9.41%。本文所提方法有效提高了闪元的检出率。

关键词：红外焦平面探测器闪元检测闪元标定复合条件工作点能量域图像

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