检索结果-南通市图书馆

Neoadjuvant camrelizumab(an anti-PD-1 antibody)plus chemotherapy or apatinib(a VEGFR-2 inhibitor)for initially unresectable stage II–III non-small-cell lung cancer:a multicentre,two-arm,phase 2 exploratory study

引用

Signal Transduction and Targeted Therapy 2024年第7期9卷 3015-3023页

作者： Haoran Xia Han Zhang Zheng Ruan Huibiao Zhang Liangdong Sun hezhong Chen Yongxin Zhou Lele Zhang Dongliang Bian Xinsheng Zhu Jing Zhang Fenghuan Sun Huansha Yu Nan Song Xiaogang Liu Yuming Zhu Haiping Zhang wenxin he Jian Chen Jie Yang Guohan Chen Shiliang Xie Dongfang Tang Xiaomiao Zhang Liang Duan Deping Zhao Qinchuan Li Peng Zhang Gening Jiang Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Thoracic Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Thoracic Surgery Huadong Hospital Affiliated to Fudan UniversityShanghaiChina Department of Thoracic Surgery Changhai HospitalNaval Medical UniversityShanghaiChina Department of Thoracic-Cardiovascular Surgery Tongji HospitalTongji University School of MedicineShanghaiChina Central Laboratory Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Experimental Animal Center Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Oncology Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Thoracic Surgery Shanghai East HospitalTongji University School of MedicineShanghaiChina

This multicentre,two-arm,phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patients with initially unresectable stage II–III non-small-cell lung cancer(NSCLC).Eligible patients regardless of PD-L1 expression received neoadjuvant camrelizumab 200 mg and platinum-doublet chemotherapy every 3 weeks(arm A)or those with PD-L1-positive tumors received neoadjuvant camrelizumab and apatinib 250 mg once daily(arm B),for 2–4 cycles,followed by *** primary endpoint was major pathological response(MPR)*** patients in arm A and 21 in arm B were *** rates were 50.0%(15/30)in arm A and 42.9%(9/21)in arm B,with all patients achieving R0 *** these patients,the MPR and pathological complete response rates were both 20.0%(95%CI 4.3–48.1)in arm A and were 55.6%(95%CI 21.2–86.3)and 11.1%(95%CI 0.3–48.2)in arm B,*** corresponding objective response rates were 33.3%(95%CI 11.8–61.6)and 55.6%(95%CI 21.2–86.3).With a median follow-up of 22.4 months(95%CI 19.0–26.0),the median event-free survival was not reached(NR;95%CI 13.6-NR)in arm A and 16.8 months(95%CI 8.6-NR)in arm *** 3 or above treatment-related adverse events occurred in eight(26.7%)patients in arm A and three(14.3%)in arm *** analysis showed baseline TYROBP expression was predictive of treatment response in arm *** camrelizumab plus chemotherapy or apatinib exhibits preliminary efficacy and manageable toxicity in patients with initially unresectable stage II–III NSCLC.

关键词： Surgery chemotherapy treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death at a single Chinese center

引用

Frontiers of Medicine 2022年第5期16卷 760-765页

作者： Yuling Yang Xinnan Xu Ming Liu Yanfeng Zhao Yongmei Yu Xiaogang Liu Chang Chen Gening Jiang wenxin he Department of Thoracic Surgery Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200092China Department of Cardiothoracic Surgery Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhou 363000China

oluntary contribution has become the only source of donor lungs in China since *** elaborate the outcomes of patients awaiting lung transplantation(LTx)after the implementation of donation after brain death,we performed a retrospective study that encompassed 205 patients with end-stage lung disease who registered for LTx at Shanghai Pulmonary Hospital from January 1,2015 to January 1,2021.A total of 180 patients were enrolled in the *** median waiting time was 1.25 *** lung disease(ILD)(103/180,57.2%)and chronic obstructive pulmonary disease(COPD)(56/180,31.1%)were the most common diseases in our study *** mean pulmonary artery pressure(mPAP)of patients in the died-waiting group was higher than that of the survivors(53.29+21.71 mmHg vs.42.11+18.58 mmHg,P-0.002).The mortality of patients with ILD(34/103,33.00%)was nearly twice that of patients with COPD(10/56,17.86%)while awaiting LTx(P-0.041).In the died-waiting group,patients with ILD had a shorter median waiting time than patients with COPD after being listed(0.865 months vs.4.720 months,P-0.030).ILD as primary disease and mPAP>35 mmHg were two significant independent risk factors for waitlist mortality,with hazard ratios(HR)of 3.483(95%CI 1.311-9.111;P-0.011)and 3.500(95%CI 1.435-8.536;P=0.006).hence,LTx is more urgently needed in patients with ILD and pulmonary hypertension.

关键词： lung transplantation donation after brain death waitlist

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bicarbonate used as a buffer for controlling nutrient solution pH value during the growth of hydroponic lettuce

引用

International Journal of Agricultural and Biological Engineering 2024年第3期17卷 59-67页

作者： Mengxue Zhang wenxin Wang Luming Zhong Fang Ji Dongxian he Key Laboratory of Agricultural Engineering in Structure and Environment of MARA College of Water Resources&Civil EngineeringChina Agricultural UniversityBeijing 100083China

Unstable pH of nutrient solution in hydroponic systems is a major obstacle to *** simplify the management of nutrient solution pH and attenuate negative effects of pH on plant growth,this study investigated the effect of different buffer salt additions on nutrient solution pH,ion uptake,growth and photosynthesis of Yamazaki lettuce,with the equivalent concentrations of macro-element *** results indicated that the pH of nutrient solution was buffered to varying degrees by the 2 mol/L HCO_(3)^(-),1 mol/L HCO_(3)^(-),and 0.33 mol/L HPO_(4)^(2-)The 0.33 mol/L HPO_(4)^(2-)treatment fluctuated most with a pH of 1.74 units,while the addition of HCO_(3)^(-)buffered nutrient solution pH was better,with higher pH values(7.2-7.7).The CK-pH control solution,1 mol/L HCO_(3)^(-)and 0.33 mol/L HPO_(4)^(2-)treatments all promoted the uptake of ion and then the growth of lettuce was better in comparison with the CK-pH no adjustment treatment,while the 2 mol/L HCO_(3)^(-)treatment inhibited K uptake and reduced the availability of Fe,the shoot and root fresh weight of lettuce decreased by 21.3%and 10.1%,*** addition,although the chlorophyll content and net photosynthetic rate under 1 mol/L HCO_(3)^(-)and 0.33 mol/L HPO_(4)^(2-)treatments were significantly lower than the CK-pH control solution treatment,there were no significant differences in leaf length and leaf number of lettuce among them,and shoot fresh weight per plant was 83.09,82.95,and 78.92 g,*** conclusion,adding 1 mol/L HCO_(3)^(-)to the nutrient solution in a single dosage not only buffered the pH of nutrient solution better but also promoted ion uptake,it had no negative effects on the growth,photosynthesis and ion uptake of hydroponic lettuce in comparison with the CK-pH control solution ***,1 mol/L HCO_(3)^(-)can be used as a buffer during the growth of hydroponic lettuce and reduce frequent addition of acids or alkalis,and then simplify the management of nut

关键词： pH buffer nutrient solution hydroponic lettuce growth ion uptake

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Flexible piezoelectret film sensor for noncontact mechanical signal capture by multiple transmission media

引用

Nano Research 2024年第8期17卷 7643-7657页

作者： Xingchen Ma Qianqian Hu Lian Zhou Xinhao Xiang Yi Qin Ke Zhang Pengfei he Ying Dai wenxin Niu Xiaoqing Zhang Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology School of Physics Science and EngineeringTongji UniversityShanghai 200092China Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) School of MedicineTongji UniversityShanghai 201619China Department of Rehabilitation Sciences Tongji University School of MedicineShanghai 200092China School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China

Mechanical signal capture without physical contact has emerged as a highly promising research field and attracted tremendous attention due to its prosperous applications in household medical care,lifestyle monitoring and remote operation,offering users high level of safety,convenience and ***,noncontact sensing is ideal to maximize the immersive user experience in the human–machine interaction(HMI),eliminating interference to human activities and mechanical fatigue to the sensor,***,we report a self-powered flexible sensor integrated with irradiation cross-linked polypropylene(IXPP)piezoelectret film for noncontact sensing,featuring multi-functions to detect mechanical signals transmitted through solid,liquid and gaseous media and would facilitate their versatile practical *** folded-structure configuration of the sensor facilitates the improvement of the noncontact sensing *** solid media,such as the rectangular wooden stick used in this study,the sensor can detect mechanical stimulus exerted at a distance of 100 cm.A system detection sensitivity up to 57 pC/kPa with a low detection limit of 0.6 kPa is achieved at a noncontact distance of 10 *** when partly or completely immersed in water,the sensor effectively traces movement signals of human bodies underwater,demonstrating great advantages for non-inductive aquatic fitness training ***,due to the low acoustic impedance of piezoelectret film,speech recognition through gaseous medium is also *** further introduce application demonstrations of the developed film sensors to monitor exercise postures and physiological signals without direct contact between human body and the sensor,displaying great potential to be incorporated into future smart *** study commendably expands the application scope of piezoelectret materials,which will have profound implications for exploring novel intelligent human–machine interactions.

关键词： noncontact sensing piezoelectret multiple transmission media mechanical signal capture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Functional micro/nanobubbles for ultrasound medicine and visualizable guidance

引用

Science China Chemistry 2021年第6期64卷 899-914页

作者： Chen Zhang Yihong Li Xinyong Ma wenxin he Chenxi Liu Zhe Liu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjin 300072China Division of Academic&Cultural Activities Academic Divisions of the Chinese Academy of SciencesBeijing 100190China

Chemically functionalized gas-filled bubbles with a versatile micro/nano-sized scale have witnessed a long history of developments and emerging applications in disease diagnosis and *** combination with ultrasound and image-guidance,micro/nanobubbles have been endowed with the capabilities of biomedical imaging,drug delivery,gene transfection and diseaseoriented *** an external stimulus,ultrasound(US)-mediated targeting treatments have been achieving unprecedented ***,US is playing a crucial role in visualizing biological/pathological changes in lives as a reliable imaging technique and a powerful therapeutic *** review retrospects the history of ultrasound,the chemistry of functionalized agents and summarizes recent advancements of functional micro/nanobubbles as US contrast agents in preclinical and transclinical *** ultrasound-based treatment modalities in association with functional micro/nanobubbles have been highlighted as their great potentials for disease precision *** is believed that these state-of-the-art micro/nanobubbles will become a booster for ultrasound medicine and visualizable guidance to serve future human healthcare in a more comprehensive and practical manner.

关键词： ultrasound functional biomaterials image guidance visualizable medicine drug delivery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Artificial optical microfingerprints for advanced anticounterfeiting

引用

Nano Research 2024年第5期17卷 4371-4378页

作者： Xueke Pang Qiang Zhang Jingyang Wang Xin Jiang Menglin Wu Mingyue Cui Zhixia Feng wenxin Xu Bin Song Yao he Suzhou Key Laboratory of Nanotechnology and Biomedicine Institute of Functional Nano&Soft Materials&Collaborative Innovation Center of Suzhou Nano Science and Technology(NANO-CIC)Soochow UniversitySuzhou 215123China School of Sensing Science and Engineering Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Artificial optical microfingerprints,known as physically unclonable functions(PUFs)offer a groundbreaking approach for ***,these PUFs artificial optical microfingerprints suffer from a limited number of challenge-response pairs,making them vulnerable to machine learning(ML)attacks when additional error-correcting units are *** study presents a pioneering demonstration of artificial optical microfingerprints that combine the advantages of PUFs,a large encoding capacity algorithm,and reliable deep learning authentication against ML *** approach utilizes the triple-mode PUFs,incorporating bright-field,multicolor fluorescence wrinkles,and the topography of surface enhanced Raman scattering in the mechanical and optical ***,the quaternary encoding of these PUFs artificial microfingerprints allows for an encoding capacity of 6.43×10^(24082) and achieves 100%deep learning recognition ***,the PUFs artificial optical microfingerprints exhibit high resilience against ML attacks,facilitated by generative adversarial networks(GAN)(with mean prediction accuracy of~85.0%).The results of this study highlight the potential of utilizing up to three PUFs in conjunction with a GAN training system,paving the way for achieving encoded information that remains resilient to ML attacks.

关键词： artificial microfingerprints physically unclonable functions deep learning anti-counterfeiting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of helmet-wearing regulation on electric-bike riders:a case study of two cities in China

引用

Transportation Safety and Environment 2024年第3期6卷 62-70页

作者： wenxin Ma Zhiyong Liu Ruimin Li Department of Civil Engineering Tsinghua UniversityBeijing 100084China School of Traffic and Transportation Beijing Jiaotong UniversityBeijing 100044China

Objectives:Electric bikes(e-bikes)are widely used for commuting and delivery in *** the rapid increase in e-bikes on the road,related accidents have become crucial issues threatening the *** research aims to explore the protective effect of helmet-wearing regulation and to investigate some factors influencing head injury with reference to two case cities in China,obtaining information to protect e-bike ***:The traffic police-reported crash data cover the periods before and after the implementation of helmet-wearing regulations in Taizhou(with data from 2017 to 2019)and Nanning(with data in 2020)of *** statistical analysis,logistic regression and chi-square test with a Bonferroni correction were applied in the ***:A lack of helmets was common among victims in the context of a high helmet-wearing rate among general e-bike riders in Taizhou,indicating that fatality could be avoided to some extent by wearing ***,helmet wearing could reduce the probability of suffering fatal head injury by 6.4%.After the regulation implementation in Taizhou,the proportion of fatal head injuries decreased from 89%to 79%,remaining at a high level,which indicates that other measures in addition to helmet-wearing regulations should be *** to the results from Nanning,mandatory regulation worked more effectively than encouraged regulation in terms of reducing head ***:Mandatory helmet-wearing regulations are highly recommended to policymakers to reduce head injury among e-bike *** in addition to helmet-wearing regulation,*** law-abiding awareness and improving road infrastructure,should be considered to further protect e-bike riders.

关键词： e-bike safety accident analysis helmet-wearing regulation head injury

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fine-tuning the activation behaviors of ternary modular cabazitaxel prodrugs for efficient and on-target oral anti-cancer therapy

引用

Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 188-203页

作者： Mingyang Zhang Yifan Miao Can Zhao Tong Liu Xiyan Wang Zixuan Wang wenxin Zhong Zhonggui he Chutong Tian Jin Sun Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province Hangzhou 310058China Joint International Research Laboratory of Intelligent Drug Delivery Systems Ministry of EducationShenyang 110016China Liaoning Provincial Institute of Drug Inspection and Testing Shenyang 110036China

The disulfide bond plays a crucial role in the design of anti-tumor prodrugs due to its exceptional tumor-specific redox responsiveness. However, premature breaking of disulfide bonds is triggered by small amounts of reducing substances (e.g., ascorbic acid, glutathione, uric acid and tea polyphenols) in the systemic circulation. This may lead to toxicity, particularly in oral prodrugs that require more frequent and high-dose treatments. Fine-tuning the activation kinetics of these prodrugs is a promising prospect for more efficient on-target cancer therapies. In this study, disulfide, steric disulfide, and ester bonds were used to bridge cabazitaxel (CTX) to an intestinal lymph vessel-directed triglyceride (TG) module. Then, synthetic prodrugs were efficiently incorporated into self-nanoemulsifying drug delivery system (corn oil and Maisine CC were used as the oil phase and Cremophor EL as the surfactant). All three prodrugs had excellent gastric stability and intestinal permeability. The oral bioavailability of the disulfide bond-based prodrugs (CTX-(C)S-(C)S-TG and CTX-S-S-TG) was 11.5- and 19.1-fold higher than that of the CTX solution, respectively, demonstrating good oral delivery efficiency. However, the excessive reduction sensitivity of the disulfide bond resulted in lower plasma stability and safety of CTX-S-S-TG than that of CTX-(C)S-(C)S-TG. Moreover, introducing steric hindrance into disulfide bonds could also modulate drug release and cytotoxicity, significantly improving the anti-tumor activity even compared to that of intravenous CTX solution at half dosage while minimizing off-target adverse effects. Our findings provide insights into the design and fine-tuning of different disulfide bond-based linkers, which may help identify oral prodrugs with more potent therapeutic efficacy and safety for cancer therapy.

关键词： Steric disulfide bond Triglyceride-like pr odrugs Cabazitaxel Lymphatic transport Oral chemotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation

引用

Acta Pharmaceutica Sinica B 2022年第9期12卷 3602-3617页

作者： Jian Sun Tongzhu Jin Zhihui Niu Jiayu Guo Yingying Guo Ruoxuan Yang Qianqian Wang Huiying Gao Yuhan Zhang Tianyu Li wenxin he Zhixin Li Wenchao Ma Wei Su Liangliang Li Xingxing Fan Hongli Shan Haihai Liang Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China Northern Translational Medicine Research and Cooperation Center Heilongjiang Academy of Medical SciencesHarbin Medical UniversityHarbin 150081China Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji UniversityShanghai 200433China State Key Laboratory of Quality Research in Chinese Medicine/Macao Institute for Applied Research in Medicine and health Macao University of Science and TechnologyMacao(SAR)China Research Unit of Noninfectious Chronic Diseases in Frigid Zone(2019RU070) Chinese Academy of Medical SciencesHarbin 150081China Zhuhai People's Hospital Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and TreatmentZhuhai Hospital Affiliated with Jinan UniversityJinan UniversityZhuhai 519000China

Idiopathic pulmonary fibrosis(IPF)is a progressive disease with unknown etiology and limited therapeutic *** of fibroblasts is a prominent feature of pulmonary *** we report that lncRNA DACH1(dachshund homolog 1)is downregulated in the lungs of IPF patients and in an experimental mouse model of lung ***1 knockout mice develop spontaneous pulmonary fibrosis,whereas overexpression of LncDACH1 attenuated TGF-β1-induced aberrant activation,collagen deposition and differentiation of mouse lung ***,forced expression of LncDACH1 not only prevented bleomycin(BLM)-induced lung fibrosis,but also reversed established lung fibrosis in a BLM ***,LncDACH1 binding to the serine/arginine-rich splicing factor 1(SRSF1)protein decreases its activity and inhibits the accumulation of *** expression of SRSF1 blocked the anti-fibrotic effect of LncDACH1 in lung ***,loss of LncDACH1 promoted proliferation,differentiation,and extracellular matrix(ECM)deposition in mouse lung fibroblasts,whereas such effects were abolished by silencing of *** addition,a conserved fragment of LncDACH1 alleviated hyperproliferation,ECM deposition and differentiation of MRC-5 cells driven by TGF-β***,LncDACH1 inhibits lung fibrosis by interacting with SRSF1 to suppress CTNNB1 accumulation,suggesting that LncDACH1 might be a potential therapeutic target for pulmonary fibrosis.

关键词： Idiopathic pulmonary fibrosis LncRNA DACH1 SRSF1 CTNNB1 Fibroblast Myofibroblast Extracellular matrix Proliferation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inactivated H9N2 vaccines developed with early strains do not protect against recent H9N2 viruses:Call for a change in H9N2 control policy

引用

Journal of Integrative Agriculture 2024年第6期23卷 2144-2148页

作者： Yanjing Liu Qingqing Yu Xiangyu Zhou wenxin Li Xinwen he Yan Wang Guohua Deng Jianzhong Shi Guobin Tian Xianying Zeng Hualan Chen College of Veterinary Medicine Gansu Agricultural UniversityLanzhou 730070China State Key Laboratory for Animal Disease Control and Prevention Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry DiseasesMinistry of Agriculture and Rural Affairs/Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150009China National Poultry Laboratory Animal Resource Center Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150009China Harbin Weike Biotechnology Co. Ltd.Harbin 150009China

H9N2 virus has been widely distributed in wild birds and poultry around the world since its first emergence in the United States of America in 1966(Gu et al.2017;Carnaccini and Perez 2020).The virus appeared in chickens in China in the early 1990s,and over the last two decades has gradually become the dominant epidemic subtype(Sun and Liu 2015;Bi et al.2020).Although H9N2 virus infection alone cannot cause severe disease or death in poultry,H9N2 virus-infected birds experience a degree of egg production drop and can be easily infected by other pathogens,thus causing economic losses for poultry industry.

关键词： H9N2 poultry policy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：