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Rational design of new in situ reduction of Ni(II)catalytic system for low-cost and large-scale preparation of porous aromatic frameworks

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Carbon Energy 2024年第5期6卷 105-113页

作者： Shanshan Wang Yue Wu wenxiang Zhang Hao Ren Guangshan Zhu Heping ma School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'anChina State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchunChina College of Chemistry Northeast Normal UniversityChangchunChina

Porous aromatic framework 1(PAF-1)is an extremely representative nanoporous organic framework owing to its high stability and exceptionally high surface ***,the synthesis of PAF-1 is catalyzed by the Ni(COD)2/COD/bpy system,suffering from great instability and high ***,we developed an in situ reduction of the Ni(II)catalytic system to synthesize PAF-1 in low cost and high *** active Ni(0)species produced from the NiCl_(2)/bpy/NaI/mg catalyst system can effectively catalyze homocoupling of tetrakis(4-bromophenyl)methane at the room temperature to form PAF-1 with high Brunauer-Emmett-Teller(BET)-specific surface area up to 4948 m^(2) g^(−1)(Langmuir surface area,6785 m2 g−1).The possible halogen exchange and dehalogenation coupling mechanisms for this new catalytic process in PAF's synthesis are discussed in *** efficiency and universality of this innovative catalyst system have also been demonstrated in other PAFs'*** work provides a cheap,facile,and efficient method for scalable synthesis of PAFs and explores their application for high-pressure storage of Xe and Kr.

关键词： adsorption carbon material nickel catalysis porous aromatic framework porous organic polymer

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa m.G.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Highly dispersed metal incorporated hexagonal mesoporous silicates for catalytic cyclohexanone oxidation to adipic acid

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Chinese Journal of Chemical Engineering 2020年第10期28卷 2542-2548页

作者： Wenjuan Yan wenxiang Zhang Qi Xia Shuaishuai Wang Shuxia Zhang Jian Shen Xin Jin State Key Laboratory of Heavy Oil Processing Center for Chemical Engineering Experimental TeachingChina University of PetroleumQingdao 266580China College of Environment and Resources Xiangtan UniversityXiangtan 411105China

Adipic acid is a dicarboxylic acid of great industrial importance,mainly used in the production of nylon-6,6 and *** use of nitric acid as an oxidant in the industrial production of adipic acid poses significant carbon footprint to the *** adipic acid synthesis methods using a heterogeneous catalyst with H2O2 as oxidant and water as solvent have potential advantages of low catalyst cost,easy synthesis and recovery,cleanness and environmental *** this work,hexagonal mesoporous silicate materials were synthesized by a sol–gel method and evaluated for cyclohexanol/cyclohexanone oxidation to adipic *** physical and chemical properties of Fe-HmS were characterized by XRD,HR-TEm,BET and UV–*** experimental results showed that Fe-HmS materials show pore sizes ranging from 2–3 nm.W-and mo-based polyoxometalates were also evaluated and compared to the Fe-based HmS *** improve the adipic acid yield,the influence of the transition metal as well as the effect of metal loading,reaction temperature and catalyst amount on the catalytic performances of Fe-HmS have been investigated in *** Si/Fe atomic ratio=100,Fe-HmS catalyst shows the highest activity,with a cyclohexanone conversion of 92.3%and adipic acid selectivity of 29.4%.The reaction pathway of cyclohexanone oxidation was further proposed based on experimental data.

关键词： Oxidation Adipic acid Hexagonal mesoporous silicates hydrogen peroxide

Arctic sea-ice extent: No record minimum in 2023 or recent years

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 52-55页

作者： Ola m.Johannessen Tor I.Olaussen Nansen Scientific Society BergenNorway Nansen Environmental and Remote Sensing Center BergenNorway

Arctic sea-ice extent reaches its minimum each year in September. On 11 September 2023 the minimum was 4.969 million square kilometers(***^(2)). This was not a record low, which occurred in 2012, when the minimum was 4.175 ***^(2), 0.794 ***^(2) less than the minimum in 2023. However, the ice extent had decreased by 0.432 ***^(2) compared with 2022. Nevertheless, the summer melting in 2023 was remarkably less than expected when considering the strong heat waves in the atmosphere and ocean, with record temperatures set around the world. In general, there is a high correlation between the long-term decrease in sea-ice extent and the increasing CO_(2) in the atmosphere, where the increase of CO_(2) in recent decades explains about 80% of the decrease in sea ice in September, while the remainder is caused by natural variability.

关键词： Sea ice Arctic minimum ice Climate

Insights from an academic endeavor into central nervous system drug discovery

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Neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： Lieve van Veggel An m.Voets Tim Vanmierlo Rudy Schreiber BIOmED Biomedical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium Department of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharmacology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University mS Center(UmSC) Hasselt-PeltBelgium

Historically,"big pharma"did most central nervous system drug discovery R&D ***,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(mazzucato,2013).

关键词： academic approval consequences

Neurocircuit regeneration by extracellular matrix reprogramm.ng

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Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su Ian N.Levasseur Kimberly m.Alonge Department of medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECm),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECm regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(miyata et al.,2012),cation buffering(moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECm indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programm.ng

Co-substitution of zirconium and neodymium on hyperfine interactions and AC susceptibility of SrFe12O19 nanohexaferrites

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Journal of Rare Earths 2020年第3期38卷 265-273页

作者： m.A.Almessere Y.Slimani H.Güngünes A.Baykal Department of Physics College of ScienceImam Abdulrahman Bin Faisal UniversityP.O.Box 198231441DammamSaudi Arabia Department of Biophysics Institute for Research&Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityP.O.Box 198231441DammamSaudi Arabia Department of Physics Hitit University19030Cevre Yolu Bulvan-CorumTurkey Department of Nano-medicine Research Institute for Research&Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityP.O.Box 198231441DammamSaudi Arabia

This study presents the influence of Zn and Nd co-substitution on structure,morphology,AC susceptibility and ZFC-FC magnetizations of Sr nanohexaferrites(NHFs),SrFe12-x(Zn,Nd)xO19(0.0≤x≤1.0),which was produced by sol-gel *** powder patterns,scanning electron microscopy(SEm) and high-resolution transmission electron spectroscopy(HR-TEm) approve the synthesis of Sr m-type *** spectra show that Zn^2+ions occupy 2 b and 4f1 sites while Nd3+ions locate at 2 a,4f2 and 12 k *** magnetic properties of the produced Sr-NHFs were investigated also by ZFC-FC magnetizations and AC *** to the mFC-mZFC results(between 2 and 400 K),no blocking temperature was detected which indicates the ferromagnetic(Fm) behavior of *** lower temperatures,a super-spin glass like behavior is *** AC susceptibility indicates that the magnetic interactions are improved due to the inclusion of low content(x=0.1) of Nd^3+and Zn^2+ions into the ***,with further increasing the Nd^3+and Zn^2+contents(x=0.9),the magnetic interactions are weakened.

关键词： Sr hexaferrites Rare earths mossbauer spectroscopy AC susceptibility ZFC-FC

Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 177-192页

作者： m.NAVEED m.ImRAN T.ASGHAR Z.ABBAS Department of mathematics Division of Science and TechnologyUniversity of Education Department of mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAm).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词： hybrid nanofluid oscillating curved stretchable sheet gyrotactic microorganism Cattaneo-Christov heat and mass flux chemical reaction analytical solution O368

用模型和模拟方法设计氨氯地平的群体药动学研究方案

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药学学报 2012年第7期47卷 941-946页

作者：左笑丛袁洪张毕奎 Chee m.ng Jeff S.BARRETT 阳国平黄志军裴奇郭韧周亚男荆宁宁 DI Wu 中南大学湘雅三医院湖南长沙410013 美国费城儿童医院临床药物治疗系应用药动学/药效学研究室 PA19104

合理的采样设计是建立可靠群体药动学模型的重要基础。应用非线性混合效应模型的群体药动学研究,是一种有效利用稀疏血样数据估算群体药动学参数的方法。本研究根据D最优化设计和贝叶斯法设计采样方案。以已报道的氨氯地平群体药动学模... 详细信息

合理的采样设计是建立可靠群体药动学模型的重要基础。应用非线性混合效应模型的群体药动学研究,是一种有效利用稀疏血样数据估算群体药动学参数的方法。本研究根据D最优化设计和贝叶斯法设计采样方案。以已报道的氨氯地平群体药动学模型为基础,根据临床研究的目的、给药方案和随访时间等设计几套采样方案,采用WinPOPT软件计算优化采样方案,用蒙特卡罗法(monte Carlo)对各优化的采样方案分别建立一套含400个患者的NONmEm数据文件,用NONmEm7.2软件模拟氨氯地平的浓度数据,然后估算其重要药动学参数(CL/F,V/F和Ka),并计算其平均预测误差(mPE)和平均绝对预测误差(mAPE)。在6个采样方案中,以方案6和3对CL/F估算的准确度和精密度较优,mPE分别为0.1%和0.6%,mAPE均为0.7%。对V的估算,各采样方案间无明显差异。因此,选用氨氯地平拟合药动学参数的准确度和精密度较优,且采样点个数较少的方案3为最佳临床研究方案。本研究旨在为开展氨氯地平在肾功能损害合并高血压患者的群体药动学研究提供科学、有效的采样方法,为群体PK/PD研究提供一种优化设计临床研究方案的科学方法。

关键词：氨氯地平群体药动学模型和模拟方案设计