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基于Logistic回归分析影响高压氧联合地塞米松治疗突发性耳聋疗效的因素

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中国医药指南 2025年第1期23卷 49-52页

作者：蔡振省晋江市东石中心卫生院耳鼻喉科福建晋江362271

目的基于Logistic回归分析探讨影响高压氧联合地塞米松治疗突发性耳聋疗效的因素。方法选取2021年1月至2024年1月本院收治的81例接受高压氧联合地塞米松治疗的突发性耳聋患者作为研究对象。结合临床疗效将研究对象分为疗效优良组、疗效... 详细信息

目的基于Logistic回归分析探讨影响高压氧联合地塞米松治疗突发性耳聋疗效的因素。方法选取2021年1月至2024年1月本院收治的81例接受高压氧联合地塞米松治疗的突发性耳聋患者作为研究对象。结合临床疗效将研究对象分为疗效优良组、疗效不佳组。收集研究对象的基线信息,选择Logistic回归分析两组基线信息中差异项,分析影响高压氧联合地塞米松疗效的影响因素。结果本次纳入的81例突发性耳聋患者中,治疗痊愈、显效、有效共66例,占比81.48%,归为疗效优良组,无效15例,占比18.52%,归为疗效不佳组。两组年龄、病程、听力损失程度、耳聋类型、是否合并高血压、是否合并血管粥样硬化狭窄对比均存在差异(P1。结论高压氧联合地塞米松对突发性耳聋疗效优良,但小部分患者疗效不显著,影响其疗效的危险因素包括年龄>50岁、病程≥7 d、重度及极重度听力损失、高频下降或全聋型耳聋、合并高血压、合并血管粥样硬化狭窄。

关键词： Logistic回归分析高压氧地塞米松突发性耳聋

Long noncoding RNA LINC01106 promotes lung adenocarcinoma progression via upregulation of autophagy

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Oncology research 2025年第1期33卷 171-184页

作者： Gengyun Sun Yiping Zheng Jianfeng cai Jie Gao Lie Dong Xiangbin Zhang Yinghui Huang Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Anhui Medical University Hefei 230022 China. Department of Respiratory and Critical Care Medicine Nanping First Hospital Affiliated to Fujian Medical University Nanping 353006 China.

Background:Long noncoding RNA, LINC01106 exhibits high expression in lung adenocarcinoma (LUAD) tumor tissues, but its functional role and regulatory mechanism in LUAD cells remain unclear.Methods:LINC01106 expression was analyzed in LUAD tissues and its functional impact on LUAD cells was assessed. LUAD cells were silenced with sh-LINC01106 and injected into nude mice to investigate tumor growth. The downstream transcription factors and molecular mechanism were determined using the Human transcription factor database (TFDB) database and Gene Expression Profiling Interactive Analysis (GEPIA) database. Additionally, the impact of linc01106 on autophagy was analyzed by determining the expression of autophagy-related genes (ATGs) in LUAD cells.Results:Our results showed that LINC01106 exhibited upregulation in both LUAD tissues and cell lines. The silencing of LINC01106 demonstrated a suppressive effect on tumorigenesis in a xenograft mouse model of LUAD. Additionally, LINC01106 was found to recruit TATA-binding protein-associated factor 15 (TAF15), an RNA-binding protein, thereby enhancing the mRNA stability of TEA domain transcription factor 4 (TEAD4). In turn, TEAD4 served as a transcription factor that bound to the LINC01106 promoter and regulated its expression. Further assays indicated that LINC01106 promoted autophagy in LUAD cells by upregulating the expression of autophagy-related genes (ATGs). The silencing of LINC01106 in LUAD cells inhibited autophagy, and cell proliferation, and promoted apoptosis, which all were effectively reversed by ATG5 overexpression.Conclusions:Overall, LINC01106, transcriptionally activated by TEAD4, interacts with TAF15 to promote the stability of TEAD4 and upregulates the expression of ATGs, promoting malignancy of LUAD cells.

关键词： ATG5 LINC01106 Lung adenocarcinoma (LUAD) Non-small cell lung cancer (NSCLC) TAF15 TEAD4

Accuracy analysis of a single-fault Markov model for FADEC system

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Journal of Systems Engineering and Electronics 2019年第5期30卷 1044-1052页

作者： cai Jing HU Wei cai Kunye College of Civil Aviation Nanjing University of Aeronautics and Astronautics

Time-limited dispatching(TLD)analysis of the full authority digital engine control(FADEC)systems is an important part of the aircraft system safety analysis and a necessary task for the certification of commercial aircraft and *** the time limited dispatch guidance document ARP5107B,a single-fault Markov model(MM)approach is proposed for TLD ***,ARP5107B also requires that the loss of thrust control(LOTC)rate error calculated by applying the single-fault MM must be less than 5%when performing airworthiness ***,the sources of accuracy errors in three kinds of MM are analyzed and specified through a case study of the general FADEC system,and secondly a two-fault MM considering maintenance policy is established through analyzing and calculating the expected repair time when two related faults ***,a specific FADEC system is given to study on the influence factors of accuracy error in the single-fault MM,and the results show that the accuracy error of the single-fault MM decreases with the increase of short or long prescribed dispatch time,and the range values of short time(ST)and long time(LT)are determined to satisfy the requirement of accuracy error within 5%.

关键词： full authority digital engine control(FADEC)system Markov model(MM) accuracy analysis loss of thrust control(LOTC)

基于海陆生态安全格局的生态修复关键区域识别——以辽西地区为例

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水土保持研究 2025年第1期32卷 285-293页

作者：蔡雨池李红刘兆顺吉林大学地球科学学院

[目的]识别出生态敏感性极高的辽西地区生态修复关键区域，为该地区国土空间生态修复工作提供科学参考。[方法]综合运用MSPA分析、景观连通性评价和电路理论等研究方法，尝试将陆域生态安全格局与海域生态安全格局相连接，识别辽西地区... 详细信息

[目的]识别出生态敏感性极高的辽西地区生态修复关键区域，为该地区国土空间生态修复工作提供科学参考。[方法]综合运用MSPA分析、景观连通性评价和电路理论等研究方法，尝试将陆域生态安全格局与海域生态安全格局相连接，识别辽西地区国土空间生态修复关键区域。[结果]（1）辽西地区共识别生态源地42个，面积为11 619.75 km2,生态源地多呈东北至西南的条带状分布，以林地及草地等土地利用类型为主。（2）生态廊道95条，其中一级廊道9条，二级廊道26条，三级廊道60条，全长778.30 km。（3）国土空间生态修复关键区域196处，其中生态夹点93处，生态障碍点103处。[结论]生态修复关键区识别是国土空间生态修复的重要基础与依据。在综合分析生态修复关键区域空间分布和土地利用现状特征基础上，提出了辽西地区针对性的国土空间生态修复策略。

关键词：生态修复关键区生态安全格局国土空间生态修复 MSPA 电路理论

Numerical simulations of high enthalpy flows around entry bodies

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Chinese Journal of Aeronautics 2016年第2期29卷 326-334页

作者： cai Chunpei Department of Mechanical Engineering-Engineering Mechanics Michigan Technological University

Ablation flows around entry bodies are at highly nonequilibrium states. This paper pre- sents comprehensive computational fluid dynamics simulations of such hypersonic flow examples. The computational scheme adopted in this study is based on the Navie-Stokes equations, and it is capable of simulating multiple-dimensional, non-equilibrium, chemically reacting gas flows with multiple species. Finite rate chemical reactions, multiple temperature relaxation processes, and ion- izations phenomena with electrons are modeled. Simulation results of several hypersonic gas flows over axisymmetric bodies are presented and compared with results in the literature. It confirms that some past treatment of adopting less species for hypersonic flows is acceptable, and the differences from more species and more chemical reactions are not significant.

关键词： Chemical reactions Compressible flows Fluid dynamics Finite volume methods Hypersonic flow Navier-Stokes equations Numerical method

Autothermal reforming of methane over Ni catalysts supported over ZrO2-CeO2-Al2O3

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Journal of Natural Gas Chemistry 2008年第2期17卷 201-207页

作者： Xiulan cai Yuanxing cai Weiming Lin Guangdong Pharmaceutical University Guangzhou 510006 Guangdong China Shandong Architecture Institute Jinan 250101 Shandong China South China University of Technology Guangzhou 510640 Guangdong China

Ni catalysts supported on Al2O3, ZrO2-Al2O3, CeO2-Al2O3 and ZrO2-CeO2-Al2O3 were prepared by coprecipitation method, and their catalytic performances for autothermal reforming of methane to hydrogen were investigated. The Ni-supported catalysts were characterized by XRD, TPR and XPS. The relationship between the structures and catalytic activities of the catalysts was discussed. The results showed that the catalytic activity and stability of the Ni/ZrO2-CeO2-Al2O3 catalyst was better than those of other catalysts with the highest CH4 conversion, H2/CO and H2/COx ratio at 750 ℃. The catalyst showed a little deactivation along the reaction time during its 72 h on stream with the mean deactivation rate of 0.08%/h. The catalytic performance of the Ni/ZrO2-CeO2-Al2O3 catalyst was also affected by reaction temperature, no2 ： nCH4 molar ratio and nH2O ： nCH4 molar ratio. TPR, XRD and XPS measurements indicated that the formation of ZrO2-CeO2 solid solution could improve the dispersion of NiO, and inhibit the formation of NiAl2O3, and thus significantly promoted the catalytic activity of the Ni/ZrO2-CeO2-Al2O3 catalyst.

关键词： methane autothermal reforming hydrogen Ni/ZrO2-CeO2-Al2O3

Quantum biology: explore quantum dynamics in biological systems

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Science China(Information Sciences) 2016年第8期59卷 110-116页

作者： Jianming cai School of Physics Huazhong University of Science and Technology Center of Quantum Optics Science Huazhong University of Science and Technology

In recent years, people have been extending the concepts developed in quantum information science to explore quantum dynamics in biological systems. The existence of quantum coherence in certain biological processes has been identified in a number of experiments. The role of quantum coherence and quantum entanglement has been carefully investigated, which suggests that quantum effect is important in these processes although in a more complicated way. In the mean time, these findings urge the development of new experiment methodology to reveal more biological scenarios in which quantum effect exists and plays a non-trivial *** this article, we review the latest progress in the field of quantum biology and discuss the key challenges in further development of quantum biology.

关键词： quantum information quantum biology quantum optics quantum coherence quantum physics

Fault processing policy based on dual-redundant control law for aero-engine control sensors

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航空动力学报 2014年第8期29卷 1974-1980页

作者： JIANG cai-hong Shenyang Engine Design and Research Institute Aviation Industry Corporation of China Shenyang 110015 China

A fault processing policy was proposed for the circumstance under which all the dual-redundant closed-loop feedback control sensors went *** policy was based on dual-redundant control law and may maintain the performance of turbofan *** pair of controlling sensors went wrong and the primary control law was unable to implement,control system performs the backup control law instead of the primary one so that the fault sensors were isolated from the closed control *** fault processing policy may not only avoid increasing engine weight and cost with the additional sensors hardware,but also avoid the error of analytical sensor *** can improve the engine mission reliability and control quality.

关键词：法律控制传感器健康管理数字化控制

Experimental Research on a Feasible Building Insulation Material Based Reed in China

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Journal of Thermal Science 2025年第1期 176-187页

作者： LIU Tiantian PENG Yizhe LIU Lifang cai Chenghan WANG Shuang LI Hongqiang College of Civil Engineering Hunan University College of Civil Engineering Hunan University of Science and Technology School of Energy and Power Jiangsu University of Science and Technology National Center for International Research Collaboration in Building Safety and Environment (NCIRCBSE) Hunan University Key Laboratory of Building Safety and Energy Efficiency of the Ministry of Education Hunan University

The seemingly useless reeds are prepared as thermal insulation materials,which not only meet the requirements of environmental sustainability but also enhance the added value of reeds,creating new economic *** hydrophobicity of raw biomass surfaces leads to problems such as weak bonding strength and non-dense structure in the formed materials,as well as issues related to the residual insect infestations on the *** this study,reed straw was used as the raw material,and foamed geopolymer was used as the binder to prepare building insulation materials based *** improve the interfacial adhesion performance between reed straw and foamed geopolymer,a thermochemical modification method-thermal carbonization,was *** this study,the mechanical properties and hydraulic properties of the studied materials with different degrees of surface thermal modification were tested,especially the fire resistance performance,and weathering resistance performance rarely found in published *** the surface thermal modification condition of reed straw was 250℃（30 min）,the comprehensive performance of reed-based building insulation materials was the best,when the studied material density was 321.3 kg/m3;the compressive strength was 0.59 MPa;the thermal conductivity was 0.101 W/（m·K）;the pH was 11.27;the moisture absorption rate was 25.1%,and the compressive strength loss rate in wet-dry cycles was 18.5%.In addition,it had excellent fire resistance performance and weathering resistance *** new material can be widely used to improve the thermal insulation of traditional buildings and as sandwich filler in prefabricated buildings,such as preparing insulating walls.

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