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Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2025年第1期 249-262页

作者： Jinliang wang Wenyong Zhou Yu Xu Jianchun Duan Qiaoxia Zhou Guoqiang wang Leo Li Chunwei Xu wenxian.wang Shangli Cai Zhijie wang Jie wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteraction<0.001).Multiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqNSCLCs（P=0.040） and sqNSCLCs（P=0.014）,*** the POPLAR/OAK cohort,nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel(hazard ratio（HR）=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del（HR=1.05,P=0.64）.Conversely,sqNSCLCs without LRP1B-del benefited more from atezolizumab（HR=0.60,P=0.002） than those with LRP1B-del（HR=1.30,P=0.31）.Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1B-del in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

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Unique Duplex Microstructure and Porosity Effect on Mechanical Properties of AlCoCrFeNi_(2.1) Eutectic High-Entropy Alloys Processed by Selective Laser Melting

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Acta Metallurgica Sinica(English Letters) 2023年第9期36卷 1465-1481页

作者： Liwei Lan wenxian.wang Zeqin Cui Xiaohu Hao College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Taiyuan University of TechnologyMinistry of EducationTaiyuan030024China Shanxi–Zhejiang University New Materials and Chemical Research Institute Taiyuan030032China

Selective laser melting(SLM)was performed on AlCoCrFeNi_(2.1) eutectic high-entropy alloys(EHEAs),and the unique duplex microstructure and porosity were investigated as well as the negative effect on mechanical *** printed AlCoCrFeNi_(2.1) EHEAs is composed of face-centered cubic and BCC/B2 phases,and the surface texture of samples perpendicular to and parallel to the building direction is *** the bottom of the molten pool to the inside,the structure changes from dendrites to columnar crystals and then to cellular crystals,the distribution of elements in and around the molten pool is uniform,and there is no element *** surface hardness of as-printed AlCoCrFeNi_(2.1) EHEAs is higher than that of as-cast ones due to the grain refinement strengthening,and there is anisotropy in different surface hardness,the highest hardness is 580 HV(X–Y plane)and 560 HV(X–Z plane).The reduction of bearing area and tip stress concentration caused by pores have adverse effects on the tensile strength and elongation of the alloy,the ultimate tensile strength increased from 1060 to 1289 MPa.

关键词： Selective laser melting Eutectic high-entropy alloys Metallurgical porosity Microstructure evolution Grains and interfaces

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Interfacial Morphology and Bonding Mechanism of Explosive Weld Joints

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Chinese Journal of Mechanical Engineering 2021年第2期34卷 201-212页

作者： Tingting Zhang wenxian.wang Zhifeng Yan Jie Zhang Advanced Forming and Intelligent Equipment Research Institute Taiyuan University of TechnologyTaiyuan 030024China College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan 030024China College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China

Interfacial structure greatly affects the mechanical properties of laminated ***,the critical material properties that impact the interfacial morphology,appearance,and associated bonding mechanism of explosive welded plates are still *** this paper,the same base plate(AZ31B alloy)and different flyer metals(aluminum alloy,copper,and stainless steel)were used to investigate interfacial morphology and *** and TEM results showed that typical sine wave,wave-like,and half-wave-like interfaces were found at the bonding interfaces of Al/Mg,Cu/Mg and SS/Mg clad plates,*** different interfacial morphologies were mainly due to the differences in hardness and yield strength between the flyer and base *** results of the microstructural distribution at the bonding interface indicated metallurgical bonding,instead of the commonly believed solid-state bonding,in the explosive welded clad *** addition,the shear strength of the bonding interface of the explosive welded Al/Mg,Cu/Mg and SS/Mg clad plates can reach up to 201.2 MPa,147.8 MPa,and 128.4 MPa,*** proposed research provides the design basis for laminated composite metal plates fabrication by explosive welding technology.

关键词： Interfacial structure Bonding mechanism Explosive welding Metallurgical bonding Magnesium alloy

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Interfacial bonding characteristics and mechanical properties of H68/AZ31B clad plate

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International Journal of Minerals,Metallurgy and Materials 2022年第6期29卷 1237-1248页

作者： Tingting Zhang wenxian.wang Jie Zhang Zhifeng Yan Advanced Forming and Intelligent Equipment Research Institute Taiyuan University of TechnologyTaiyuan 030024China College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan 030024China College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of EducationTaiyuan 030024China Shanxi Key Laboratory of Advanced Magnesium-based Materials Taiyuan 030024China

Interfacial bonding,microstructures,and mechanical properties of an explosively-welded H68/AZ31B clad plate were systematically *** to the results,the bonding interface demonstrated a“wavy-like”structure containing three typical zones/layers:(1)diffusion layer adjacent to the H68 brass plate;(2)solidification layer of melted metals at the interface;(3)a layer at the side of AZ31B alloy that experienced severe *** copper,CuZn_(2),andα-Mg phases were observed in the melted-solidification *** polygonal grains with twins were found at the H68 alloy side,while fine equiaxed grains were found at the AZ31B alloy side near the interface due to *** results revealed the formation of brittle intermetallic CuZn_(2) phases at the bonding *** interface was bonded well through metallurgical reactions due to diffusion of Cu,Zn,and Mg atoms across the interface and metallurgic reaction of partially melted H68 and AZ31B alloys.

关键词： explosive welding interfacial bonding numerical simulation nanoindentation dissimilar metal composite

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Almost automorphically-forced flows on S^(1) or R in one-dimensional almost periodic semilinear heat equations

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Science China Mathematics 2022年第9期65卷 1875-1894页

作者： wenxian Shen Yi wang Dun Zhou Department of Mathematics and Statistics Auburn UniversityAuburnAL 36849USA School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China School of Mathematics and Statistics Nanjing University of Science and TechnologyNanjing 210094China

In this paper,we consider the asymptotic dynamics of the skew-product semiflow generated by the following time almost periodically-forced scalar reaction-diffusion equation:u_(t)=u_(xx)+f(t,u,u_(x)),t>0,0 详细信息

关键词： non-autonomous parabolic equation almost automorphically-forced circle flow function of the number of zeros minimal set ω-limit set

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Microstructure evolution and corrosion resistance of AZ31 magnesium alloy tube by stagger spinning

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International Journal of Minerals,Metallurgy and Materials 2022年第7期29卷 1361-1372页

作者： Fanlin Zheng Hongsheng Chen Yuanqi Zhang wenxian.wang Huihui Nie College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of Advanced Magnesium-Based Materials Taiyuan 030024China College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China

This study fabricates an AZ31 magnesium alloy tube by spinning technology-power stagger forward *** microstructure evolution of the tube is investigated by combining electron backscatter diffraction and transmission electron microscopy analysis,and the corrosion resistance is measured by an electrochemical corrosion *** show that the grains are obviously more uniform and finer along the wall thickness’s direction of the AZ31 alloy tube after the third spinning *** number of twins ascends first and then descends,while the varying trend of low-angle grain boundaries(LAGBs)is opposite to that of the twins as the spinning pass *** the increase of the total spinning deformation,the deformation texture initially increases and the c-axis of the{0001}crystal plane gradually rotates to the axial direction of the tube;the deformation texture then decreases and the orientation of grains becomes more *** main mechanism of grain refinement is dynamic recrystallization by the twin-induced way and bowing out of the nucleation at grain boundaries during the first and second ***,the dominant mechanism of the refined grain is the high-temperature dynamic recovery in the third pass,and the microstructure mainly consists of substructured *** the spinning deformation,the corrosion resistance of the AZ31 alloy tube decreases due to the combined effect of twins and high density-dislocations.

关键词： AZ31 magnesium alloy power stagger forward spinning microstructure evolution corrosion resistance

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FeS2@C nanorods embedded in three-dimensional graphene as high-performance anode for sodium-ion batteries

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Frontiers of Materials Science 2020年第3期14卷 255-265页

作者： Zhenxiao Lu wenxian.wang Jun Zhou Zhongchao Bai College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024China Department of Mechanical Engineering Pennsylvania State University ErieThe Behrend CollegeEriePA16563USA

FeS2 has drawn tremendous attention as electrode material for sodium-ion batteries(SIBs)due to its high theoretical capacity and abundant ***,it suffers from severe volume expansion and dull reaction kinetics during the cycling process,leading to poor rate capacity and short ***,a well-designed FeS2@C/G composite constructed by FeS2 nanoparticles embedded in porous carbon nanorods(FeS2@C)and covered by three-dimensional(3D)graphene is ***2 nanoparticles can shorten the Na+diffusion distance during the sodiation-desodiation *** carbon nanorods and 3D graphene not only improve conductivity but also provide double protection to alleviate the volume variation of FeS2 during ***,FeS2@C/G exhibits excellent cyclability(83.3%capacity retention after 300 cycles at 0.5A·g−1 with a capacity of 615.1 mA·h·g−1)and high rate capacity(475.1 mA·h·g−1 at 5A·g−1 after 2000 cycles).The pseudocapacitive process is evaluated and confirmed to significantly contribute to the high rate capacity of FeS2@C/G.

关键词： FeS2 electrode material sodium-ion battery nanoparticles graphene

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MICROSTRUCTURES AND MECHANICAL PROPERTIES OF RAPIDLY SOLIDIFIED Al-Fe-Cr-Zr-V-Si ALLOY AND THEIR THERMAL STABILITY

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中国有色金属学会会刊：英文版 1998年第3期8卷 122-125页

作者： Xiao, Yude Li, Songrui Li, wenxian.wang, Richu Central South Univ of Technology Changsha China

１ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｍｅｃｈａｎｉｃａｌｐｒｏｐｅｒｔｉｅｓｏｆｔｈｅｃｏｎｖｅｎｔｉｏｎａｌａｅｒｏｎａｕｔｉｃａｌｈｉｇｈｓｔｒｅｎｇｔｈａｌｕｍｉｎｉｕｍａｌｌｏｙｓｄｅｇｅｎｅｒａｔｅｒａｐ... 详细信息

１ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｍｅｃｈａｎｉｃａｌｐｒｏｐｅｒｔｉｅｓｏｆｔｈｅｃｏｎｖｅｎｔｉｏｎａｌａｅｒｏｎａｕｔｉｃａｌｈｉｇｈｓｔｒｅｎｇｔｈａｌｕｍｉｎｉｕｍａｌｌｏｙｓｄｅｇｅｎｅｒａｔｅｒａｐｉｄｌｙｗｈｅｎｔｈｅｔｅｍｐｅｒ...

关键词： rapid solidification powder metallurgy heat resistant aluminium alloy Al Fe Cr Zr V Si

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Anisotropy study of the microstructure and properties of AlCoCrFeNi2.1 eutectic high entropy alloy additively manufactured by selective laser melting

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Journal of Materials Science & Technology 2022年第34期129卷 228-239页

作者： Liwei Lan wenxian.wang Zeqin Cui Xiaohu Hao Dong Qiu College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Taiyuan University of TechnologyMinistry of EducationTaiyuan 030024China Shanxi-Zhejiang University New Materials and Chemical Research Institute Taiyuan 030024China Centre for Additive Manufacturing School of EngineeringRMIT UniversityMelbourneVictoria 3001Australia

The AlCoCrFeNi2.1 eutectic high-entropy alloy(EHEA) was prepared by selective laser melting(SLM), focusing on the anisotropy of microstructure and mechanical performance. The AlCoCrFeNi2.1 EHEA printed by SLM has face-centered cubic(FCC) and body-centered cubic(BCC)/B2 phases, and the FCC phase accumulates at the boundary of the molten pool. With the increase in volumetric energy density(VED), the content of the FCC phase parallel to the surface in the direction of the building increases from 30.9% to 41%. The X–Z plane mainly produces columnar crystals along the temperature gradient, while a large number of equiaxed crystals are produced in the X–Y direction. When the volume energy density is 157 k J/mol(VED 157), the average grain size is 1.33 μm for BCC and 1.14 μm for FCC, which is significantly smaller than other preparation methods. Due to defect distribution and size, the microhardness of the X–Y plane is generally higher than that of the X–Z plane, with maximum hardnesses of 660 HV and 655 HV, respectively, which is much higher than those of traditionally manufactured *** compression performance of SLM process AlCoCrFeNi2.1 EHEAs shows maximum yield strength of 1567 MPa, and the ultimate compressive strength can reach 3276 MPa.

关键词： Selective laser melting High-entropy alloys Anisotropy Metallurgical defects Microstructure evolution

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Effect of natural prolongation with geological features on maritime delimitation

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Acta Oceanologica Sinica 2017年第2期36卷 35-42页

作者： QIU wenxian JIN Xianglong FANG Yinxia wang Kui Guanghua Law School Zhejiang University Hangzhou 310008 China Key Laboratory of Submarine Geosciences Second Institute of Oceanography State Oceanic Administration Hangzhou 310012 China Key Laboratory of Marine Ecosystem and Biogeochemistry Second Institute of Oceanography State Oceanic Administration Hangzhou 310012 China

The United Nations Convention on the Law of the Sea entitled the coastal States to naturally extend the continental shelf, which has caused more drastic disputes of maritime delimitation. This paper devotes to clarifying the significant concept of natural prolongation through an effect method combing the legal principles and technical analysis. Firstly, the classic samples with respect of the development of geological features are traced. Based on these samples, the classification with a model is proposed in order to affirm the concept＇s significance under certain geomorphologic situations. Lastly, scientific analysis is used to present two potential prolongation situations and emphasize that all the technical analysis on maritime delimitation should be complied with international law and protect the common interest of all the mankind.

关键词： natural prolongation geological feature the continental shelf maritime delimitation

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