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Expert consensus on endodontic therapy for patients withsystemic conditions

International Journal of Oral Science 2024年第3期16卷 390-397页

作者： Xin Xu Xin Zheng Fei Lin Qing Yu Benxiang Hou Zhi chen Xi Wei Lihong Qiu wenxia chen Jiyao Li Lili chen Zuomin Wang Hongkun Wu Zhiyue Lu Jizhi Zhao Yuhong Liang Jin Zhao Yihuai Pan Shuang Pan Xiaoyan Wang Deqin Yang Yanfang Ren Lin Yue Xuedong Zhou State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital StomatologyPeking UniversityBeijingChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of Oral DiseasesDepartment of Operative Dentistry&EndodonticsSchool of StomatologyThe Fourth Military Medical UniversityXi’anChina Center for Microscope Enhanced Dentistry Beijing Stomatological HospitalCapital Medical UniversityBeijingChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghua School of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina Department of Endodontics School of StomatologyChina Medical UniversityShenyangChina College&Hospital of Stomatology Guangxi Medical UniversityNanningChina Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Stomatology Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Geriatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina Beijing Hospital National Center of GerontologyBeijingChina Department of Stomatology Peking Union Medical College Hospit

The overall health condition of patients significantly affects the diagnosis, treatment, and prognosis of endodontic diseases. Asystemic consideration of the patient’s overall health along with oral conditions holds the utmost importance in determining thenecessity and feasibility of endodontic therapy, as well as selecting appropriate therapeutic approaches. This expert consensus is acollaborative effort by specialists from endodontics and clinical physicians across the nation based on the current clinical evidence,aiming to provide general guidance on clinical procedures, improve patient safety and enhance clinical outcomes of endodontictherapy in patients with compromised overall health.

关键词： patients diagnosis prognosis

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Expert consensus on irrigation and intracanal medication in root canal therapy

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International Journal of Oral Science 2024年第1期16卷 26-35页

作者： Xiaoying Zou Xin Zheng Yuhong Liang chengfei Zhang Bing Fan Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Zhi chen Xi Wei Lihong Qiu wenxia chen Wenxi He Xin Xu Liuyan Meng chen Zhang Liming chen Shuli Deng Yayan Lei Xiaoli Xie Xiaoyan Wang Jinhua Yu Jin Zhao Song Shen Xuedong Zhou Lin Yue Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Center of Stomatology Peking University HospitalBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Emergency Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Restorative Dental Sciences EndodonticsFaculty of DentistryThe University of Hong KongPok Fu LamHong Kong SARChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanChina Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Clinical Research Center for Oral DiseasesNational Center for StomatologyShanghai Key Laboratory of StomatologyShanghaiChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghua School of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina State Key Laboratory of Oral&Maxillofacial Reconstruction and R

Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes.

关键词： treatment irrigation Expert

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放射性龋的发病机制及诊疗要点

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中华口腔医学杂志 2024年第1期59卷 30-36页

作者：李贤玉陈文霞广西医科大学口腔医学院·附属口腔医院牙体牙髓科、广西壮族自治区卫生健康委员会口腔感染性疾病防治重点实验室南宁530021

放射性龋是头颈部肿瘤放疗后的常见并发症,是放疗后发生的一种快速进展性牙体硬组织疾病,严重影响放疗后患者的生活质量。本文阐述了放射性龋的致病机制、诊断及龋坏评价、治疗以及预防策略的研究进展,以期为放射性龋的临床防治提供参考。

关键词：龋齿放射性龋放射治疗诊断修复材料预防

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Expert consensus on difficulty assessment of endodontic therapy

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International Journal of Oral Science 2024年第1期16卷 15-25页

作者： Dingming Huang Xiaoyan Wang Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Xinmei chen Jiyao Li Ling Ye Lei cheng Xin Xu Tao Hu Hongkun Wu Bin Guo Qin Su Zhi chen Lihong Qiu wenxia chen Xi Wei Zhengwei Huang Jinhua Yu Zhengmei Lin Qi Zhang Deqin Yang Jin Zhao Shuang Pan Jian Yang Jiayuan Wu Yihuai Pan Xiaoli Xie Shuli Deng Xiaojing Huang Lan Zhang Lin Yue Xuedong Zhou State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Operative Dentistry and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Clinical Research Center for Oral DiseasesNational Center for StomatologyShanghai Key Laboratory of StomatologyShanghaiChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghuaSchool of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhanChina Department of Operative Dentistry&Endodontics School of StomatologyThe Fourth Military Medical UniversityXi’anChina Department of Endodontics Beijing Stomatological HospitalSchool of StomatologyCapital Medical UniversityBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Preventive Dentistry West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Geriatric dentistry West China Hospital of Stomatology

Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy(RCT). Recent research, encompassing bacterial etiology and advanced imaging techniques, contributes to our understanding of the root canal system’s anatomy intricacies and the technique sensitivity of RCT. Success in RCT hinges on factors like patients, infection severity, root canal anatomy, and treatment techniques. Therefore, improving disease management is a key issue to combat endodontic diseases and cure periapical lesions. The clinical difficulty assessment system of RCT is established based on patient conditions, tooth conditions, root canal configuration, and root canal needing retreatment, and emphasizes pre-treatment risk assessment for optimal outcomes. The findings suggest that the presence of risk factors may correlate with the challenge of achieving the high standard required for RCT. These insights contribute not only to improve education but also aid practitioners in treatment planning and referral decision-making within the field of endodontics.

关键词： anatomy difficulty treatment

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从金水相生理论认识儿童闭塞性细支气管炎

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世界中医药 2024年第14期19卷 2148-2151页

作者：杨犇陈文霞郑晓华王敏河南中医药大学儿科医学院郑州450000 河南中医药大学第一附属医院郑州450000

儿童闭塞性细支气管炎(BO)是一种慢性阻塞性肺系疾病,该病具有病因复杂,病情迁延难愈,死亡率高等特点,且目前尚无行之有效的治疗手段。近年来发现,中医对该病的治疗有一定的优势。现基于中医五行学说,认为肺金与肾水本为同源,相互滋养... 详细信息

儿童闭塞性细支气管炎(BO)是一种慢性阻塞性肺系疾病,该病具有病因复杂,病情迁延难愈,死亡率高等特点,且目前尚无行之有效的治疗手段。近年来发现,中医对该病的治疗有一定的优势。现基于中医五行学说,认为肺金与肾水本为同源,相互滋养。故提出从金水相生角度认识儿童BO,研究其内在联系以及演变过程。治疗上则根据“治未病”思想,补肺益肾,增强正气,为中医药防治儿童BO从肺肾论治提供理论依据。

关键词：闭塞性细支气管炎儿童中医金水相生肺肾同治

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共情护理联合心理护理对老年帕金森病患者负面情绪及生活质量的影响

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中外医学研究 2024年第9期22卷 84-87页

作者：陈文霞张媛翟倩南京医科大学附属南京医院(南京市第一医院) 江苏南京210001

目的:探讨共情护理联合心理护理对老年帕金森病患者负面情绪、生活质量及护理满意度的影响。方法:选择2021年4月—2022年12月南京市第一医院收治的80例帕金森病患者,按随机数表法分成两组,各40例。对照组实施常规护理,观察组在对照组基... 详细信息

目的:探讨共情护理联合心理护理对老年帕金森病患者负面情绪、生活质量及护理满意度的影响。方法:选择2021年4月—2022年12月南京市第一医院收治的80例帕金森病患者,按随机数表法分成两组,各40例。对照组实施常规护理,观察组在对照组基础上实施共情护理联合心理护理。比较两组护理前后汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分、帕金森病患者生活质量问卷(PDQ-39)评分及护理总满意度。结果:护理后,观察组HAMA评分、HAMD评分、PDQ-39评分均低于对照组,差异有统计学意义(P<0.05)。观察组护理总满意度为97.50%,高于对照组的85.00%,差异有统计学意义(P<0.05)。结论:共情护理联合心理护理用于老年帕金森病患者中能改善其负面情绪,提高生活质量和护理满意度。

关键词：帕金森病共情护理心理护理负面情绪生活质量

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考虑结电容和跨导非线性的辐射频段EMI分析模型

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电源学报 2024年第5期22卷 19-27页

作者：陈雯霞陈文洁程睿王红彭霍永琪吴恢斌西安交通大学电气工程学院西安710000

宽禁带WBG(wide band gap)半导体电力电子器件由于其开关频率高、开关速度快、寄生参数大等特点从噪声源头引发了越来越严峻的电磁干扰问题。然而,传统的噪声源研究主要集中在30 MHz传导频段以内,如何评估噪声源在30~300 MHz较高频率范... 详细信息

宽禁带WBG(wide band gap)半导体电力电子器件由于其开关频率高、开关速度快、寄生参数大等特点从噪声源头引发了越来越严峻的电磁干扰问题。然而,传统的噪声源研究主要集中在30 MHz传导频段以内,如何评估噪声源在30~300 MHz较高频率范围内的辐射频段产生的影响仍存在不确定性,因此提出1种改进的WBG器件电磁干扰分析模型,与传统的非对称梯形波电磁干扰模型相比,首次详细考虑了WBG器件的结电容和跨导体的非线性特性,评估了非线性参数对辐射频段噪声的影响,并进一步提出该模型在辐射频段噪声源抑制中的应用。仿真结果验证了所提计算方法的准确性,基于SiC器件的硬件测试结果与理论分析相吻合。

关键词：结电容跨导电磁干扰开关模型

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安徽池州道地黄精中总黄酮的提取工艺优化和含量测定研究

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当代化工研究 2024年第16期 40-42页

作者：陈文霞胡双艺陈纭杨芮安徽医科大学药学院安徽230032

利用超声提取法对池州黄精中总黄酮进行提取,并对提取条件进行优化,基于硝酸铝-亚硝酸钠比色原理,采用紫外-可见分光光度法测定总黄酮含量。最优乙醇体积分数、料液比、超声时间和超声温度分别为80%、1:10、25 min和30℃,该条件下测得... 详细信息

利用超声提取法对池州黄精中总黄酮进行提取,并对提取条件进行优化,基于硝酸铝-亚硝酸钠比色原理,采用紫外-可见分光光度法测定总黄酮含量。最优乙醇体积分数、料液比、超声时间和超声温度分别为80%、1:10、25 min和30℃,该条件下测得黄精样品中总黄酮含量为0.735 mg/g。结果表明优化后的总黄酮提取效率高,建立的紫外-可见分光光度含量测定法精密度高、重复性好,可为池州黄精资源开发提供可行性依据。

关键词：池州黄精总黄酮超声提取法紫外-可见分光光度法

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基质细胞衍生因子1通过PI3K/AKT1信号通路对巨噬细胞极化的影响

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中华口腔医学研究杂志（电子版） 2024年第2期18卷 89-95页

作者：狄静陈禹江陈欣欣陈文霞广西医科大学口腔医学院/附属口腔医院广西口腔感染性疾病防治重点实验室南宁5530021 广西医科大学附属口腔医院牙体牙髓科南宁530021

目的研究基质细胞衍生因子1(SDF-1)对小鼠RAW264.7巨噬细胞迁移和极化的影响及机制。方法对体外培养对数生长期小鼠RAW264.7巨噬细胞采用SDF-1和(或)磷脂酰肌醇3-激酶(PI3K)抑制剂LY294002处理,Transwell检测细胞的迁移情况;反转录聚合... 详细信息

目的研究基质细胞衍生因子1(SDF-1)对小鼠RAW264.7巨噬细胞迁移和极化的影响及机制。方法对体外培养对数生长期小鼠RAW264.7巨噬细胞采用SDF-1和(或)磷脂酰肌醇3-激酶(PI3K)抑制剂LY294002处理,Transwell检测细胞的迁移情况;反转录聚合酶链反应(RT-PCR)检测各组细胞相关基因的表达;流式细胞术检测M1、M2巨噬细胞特异性表面标志物;ELISA测定细胞因子;Western blot检测PI3K/蛋白激酶B1(AKT1)蛋白磷酸化水平。使用SPSS 21.0软件进行统计学分析。结果SDF-1可以促进巨噬细胞的迁移,SDF-1组的细胞迁移数从(90±16)上升至(199±9),差异有统计学意义(t=12.010,P<0.001),并显著提高巨噬细胞M2向极化诱导过程中抗炎相关基因白细胞介素10(IL-10)、转化生长因子β(TGF-β)的表达水平,IL-10表达量从(1.015±0.111)上升至(3.686±0.268),差异有统计学意义(t=15.960,P<0.001);CD206+M2样巨噬细胞占比增加11.5%;PI3K/AKT1蛋白磷酸化水平显著增加,p-AKT1表达从(1.02±0.09)增长至(1.47±0.12),差异有统计学意义(t=5.082,P=0.007),促进巨噬细胞向M2极化。LY294002抑制了PI3K/AKT1蛋白磷酸化,P-AKT1表达从(1.02±0.09)减少至(0.41±0.13),差异有统计学意义(t=6.503,P=0.002)。并使SDF-1诱导巨噬细胞迁移的能力下降,细胞迁移数从(90±16)下降至(60±11),差异有统计学意义(t=3.133,P=0.02),同时下调了M2巨噬细胞极化诱导过程中抗炎相关因子IL-10、TGF-β的表达水平,IL-10表达量从(1.015±0.111)下降至(0.608±0.034),差异有统计学意义(t=6.075,P<0.001);CD206+M2样巨噬细胞占比减少10.3%。与SDF-1处理组相比,SDF-1和LY294002联合处理组M2巨噬细胞极化诱导过程中抗炎相关因子IL-10、TGF-β的表达下降(t_(IL-10)=14.730,P_(IL-10)<0.001,t_(TGF-β)=31.180,P_(TGF-β)<0.001),M1巨噬细胞极化过程中促炎因子IL-6、肿瘤坏死因子α(TNF-α)表达无明显变化。结论SDF-1可显著促进巨噬细胞向M2型极化,其机制可能与激活PI3K/AKT1信号通路相关。

关键词：基质细胞衍生因子1 巨噬细胞巨噬细胞极化 PI3K/AKT1信号通路

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SDF-1对骨髓间充质干细胞迁移和细胞外基质形成的影响

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右江民族医学院学报 2024年第3期46卷 289-294页

作者：陈禹江陈欣欣狄静怿陈文霞广西医科大学口腔医学院/附属口腔医院广西口腔颌面修复与重建研究重点实验室广西壮族自治区卫生健康委员会口腔感染性疾病防治重点实验室广西南宁530021 广西医科大学附属口腔医院牙体牙髓科广西南宁530021

目的探讨基质细胞衍生因子(stromal cell-derived factor-1,SDF-1)对大鼠骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)迁移、胶原RNA表达及细胞膜片细胞外基质表达的影响。方法CCK-8和Transwell细胞迁移实验观察SDF-1对BMSCs增殖和迁移的影响;实时荧光定量PCR检测BMSCs胶原RNA的表达水平;蛋白质印迹法检测BMSCs细胞膜片胶原蛋白的表达水平;酶联免疫吸附试验检测BMSCs细胞膜片培养基上清透明质酸(HA)的表达水平。结果SDF-1趋化BMSCs迁移作用的强度与浓度相关,对细胞的增殖无明显影响;SDF-1降低BMSCsⅠ型胶原与Ⅲ型胶原RNA和蛋白相对表达量的比值,并显著升高BMSCs细胞膜片透明质酸表达水平(P<0.05)。结论SDF-1在适宜的浓度范围内,可显著促进BMSCs的迁移,降低Ⅰ型胶原与Ⅲ型胶原RNA和蛋白相对表达量的比值,并可提高透明质酸的表达水平。

关键词：基质细胞衍生因子骨髓间充质干细胞细胞归巢胶原透明质酸

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