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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang wenwu zhang Gang Li Xing Cheng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord injury.Microglia and astrocytes play key roles in the spinal cord injury micro-environment and share a close interaction.However,the mechanisms involved remain unclear.In this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming phenotypes.The expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord injury.In vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between them.We further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling pathway.This,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling pathways.In vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function recovery.Overall,Gas6 may play a role in the treatment of spinal cord injury.It can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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Succinylation modification:a potential therapeutic target in stroke

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Neural Regeneration Research 2024年第4期19卷 781-787页

作者： Jie Lian wenwu Liu Qin Hu Xiaohua zhang Department of Neurosurgery Ren Ji HospitalShanghai Jiao Tong University School of Medicine Department of Diving and Hyperbaric Medicine Naval Medical CenterNaval Medical University

Stroke is a leading cause of mortality and disability worldwide.Ischemic cell death triggered by the compromised supply of blood oxygen and glucose is one of the major pathophysiology of strokeinduced brain injury.Impaired mitochondrial energy metabolism is observed minutes after stroke and is closely associated with the progression of neuropathology.Recently,a new type of posttranslational modification,known as lysine succinylation,has been recognized to play a significant role in mitochondrial energy metabolism after ischemia.However,the role of succinylation modification in cell metabolism after stroke and its regulation are not well understood.We aimed to review the effects of succinylation on energy metabolism,reactive oxygen species generation,and neuroinflammation,as well as Sirtuin 5 mediated desuccinylation after stroke.We also highlight the potential of targeting succinylation/desuccinylation as a promising strategy for the treatment of stroke.The succinylation level is dynamically regulated by the nonenzymatic or enzymatic transfer of a succinyl group to a protein on lysine residues and the removal of succinyl catalyzed by desuccinylases.Mounting evidence has suggested that succinylation can regulate the metabolic pathway through modulating the activity or stability of metabolic enzymes.Sirtuins,especially Sirtuin 5,are characterized for their desuccinylation activity and have been recognized as a critical regulator of metabolism through desuccinylating numerous metabolic enzymes.Imbalance between succinylation and desuccinylation has been implicated in the pathophysiology of stroke.Pharmacological agents that enhance the activity of Sirtuin 5 have been employed to promote desuccinylation and improve mitochondrial metabolism,and neuroprotective effects of these agents have been observed in experimental stroke studies.However,their therapeutic efficacy in stroke patients should be validated.

关键词： mitochondria metabolism neuroprotection sirtuin 5 stroke succinylation modification

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Novel CoP/CoMoP_(2) heterojunction with nanoporous structure as an efficient electrocatalyst for hydrogen evolution

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Nano Research 2024年第5期17卷 3693-3699页

作者： Lili zhang Xinxing Shi Aijiao Xu wenwu Zhong Jitang zhang Shijie Shen Zhejiang Provincial Key Laboratory for Cutting Tools Taizhou UniversityJiaojiang 318000China

The exploration of new heterojunction materials is of great significance in reducing the cost of existing noble metal catalysts and thus realizing the large-scale application of electrocatalytic hydrolysis technology.Herein,a novel CoP/CoMoP_(2) heterojunction was synthesized and served as a hydrogen evolution reaction(HER)electrocatalyst.The heterojunction has morphology of nanoporous structure,which is conducive to exposing more active sites and facilitating bubbles transport.The charge distribution is optimized by a strong interface interaction between CoP and CoMoP_(2).The catalyst’s conductivity and the adsorption properties of the intermediates have both been enhanced.CoP/CoMoP_(2) demonstrates excellent HER activity with an overpotential of 93.6 mV at 10 mA∙cm^(-2),which is competitive with the reported performance of analogous electrocatalysts.This work provides insights into the development of innovative phosphide-based heterojunction electrocatalysts.

关键词： nanoporous CoP CoMoP_(2) heterojunction hydrogen evolution reaction

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Comprehensive optimization of piezoelectric coefficient and depolarization temperature in Mn-doped Bi_(0.5)Na_(0.5)TiO_(3)-Bi_(0.5)K_(0.5)TiO_(3)-BaTiO_(3)lead-free piezoceramics

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Journal of Materials Science & Technology 2024年第5期172卷 255-263页

作者： Huashan Zheng Enwei Sun Huajie Luo Xiaoyu zhang Yixiao Yang Bin Yang Rui zhang Shantao zhang wenwu Cao Condensed Matter Science and Technology Institute School of Instrumentation Science and EngineeringHarbin Institute of TechnologyHarbin150080China Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing100083China National Laboratory of Solid State Microstructures Department of Materials Science and EngineeringCollege of Engineering and Applied Science&Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China Department of Mathematics and Materials Research Institute The Pennsylvania State UniversityUniversity ParkPennsylvania16802United States of America

Lead-free Bi_(_(0.5))Na_(_(0.5))TiO_(3)(BNT)piezoelectric ceramics have the advantages of large coercive fields and high Curie temperatures.But the improvement of piezoelectric coefficient(d 33)is usually accompanied by a huge sacrifice of depolarization temperature(T d).In this work,a well-balanced performance of d 33 and T d is achieved in MnO_(2)-doped 0.79(Bi_(_(0.5))Na_(_(0.5))TiO_(3))-0.14(Bi_(0.5)K_(0.5)TiO_(3))-0.07BaTiO_(3)ternary ceramics.The in-corporation of 0.25 mol%MnO_(2)enhances the d 33 by more than 40%,while T d remains almost unchanged(i.e.,d 33=181 pC/N,T d=184℃).X-ray diffraction(XRD)shows that an appropriate fraction of the small axis-ratio ferroelectric phase(pseudo-cubic,P c)coexists with the long-range ferroelectric phase(tetrag-onal,T)under this MnO_(2)doping.Piezoelectric force microscopy(PFM)has revealed a special domain configuration,namely large striped and layered macro domains embedded with small nanodomains.This study provides a distinctive avenue to design BNT-based piezoelectric ceramics with high piezoelectric performance and temperature stability.

关键词： BNT-BKT-BT ceramics Mn doping Piezoelectric Depolarization temperature Phase structure

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Spectral Index Distribution of Various Scale Components in Supernova Remnant Cassiopeia A

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Research in Astronomy and Astrophysics 2024年第5期24卷 211-217页

作者： Xianhuan Lei Hui Zhu Zongyao Yin Haiyan zhang wenwu Tian Xianchuan Yu Key Laboratory of Radio Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China School of Artiﬁcial Intelligence Beijing Normal UniversityBeijing 100875China

Cassiopeia A(Cas A) is a well-known candidate for studying cosmic-ray acceleration, in which compact features of various scales have attracted much attention. Based on observations by the Very Large Array of Cas A at 6 cm and 21 cm, we measure the spectral index distribution of various scale components using the observation of the 1998 epoch. We decompose its total density image into nine scale components, and map the temperature spectral index distribution of each component, which ranges from-2.48 ± 0.01 to-2.91 ± 0.05. We find that the spectral indices increase from the small scale to large scale components. A damped post-shock magnetic field model with a strength larger than ~200 μG and a damping length scale less than ~10% of the remnant radius can account for the spectral index variation naturally.

关键词： ISM supernova remnants-(ISM:)cosmic rays-radio continuum ISM

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A supersaturated Cu-Ag nanoalloy joint with ultrahigh shear strength and ultrafine nanoprecipitates for power electronic packaging

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Journal of Materials Science & Technology 2023年第14期145卷 56-65页

作者： wenwu zhang Penghao zhang Dashi Lu Hao Pan Xiangli Liu Chengyan Xu Jun Wei Mingyu Li Hongjun Ji The State Key Laboratory of Advanced Welding and Joining School of Materials Science and EngineeringHarbin Institute of Technology at ShenzhenShenzhen 518055China Sauvage Laboratory for Smart Materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Shenzhen Key Laboratory of Flexible Printed Electronics Technology Harbin Institute of Technology(Shenzhen)Shenzhen 518055China

Ag-Cu bimetallic nanoalloy,integrating the advantages of reducing migration and cost of nano-Ag and alleviating oxidation of nano-Cu,is a prospective bonding material for power electronic packaging.The Ag-coated Cu nanoparticles(Cu@Ag NPs)paste can execute bonding with high quality at 250℃,and the achieved supersaturated Ag-Cu nanoalloy joint with ultrahigh shear strength(152 MPa)dramatically exceeds most nano-paste joints.The interstitial solid solutions with atomic-level metallurgical bonds at the interface dominantly promoted the shear strength.Besides,the numerous ultrafine nanograin,high proportion of low angle grain boundaries(7.44%)without deformation,and the Cu nanoprecipitates in the joint would improve subordinately.Furthermore,the high content(16.8%)of∑3 twin boundaries would contribute to the electrical and thermal conductivity.Thus,the multiple strengthening mechanisms with the solid solution,the second precipitated phase,and ultrafine nanograin can dramatically enhance shear strength and electro-thermal conductivity of joints for high-temperature device packaging.

关键词： Supersaturated Ag-Cu solid solution Cu nanoparticle precipitates Ultrafine nanograin Strengthening mechanism Electronic packaging

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Improving superficial microstructure and properties of the laser-processed ultrathin kerf in Ti-6Al-4V alloy by water-jet guiding

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Journal of Materials Science & Technology 2023年第25期156卷 32-53页

作者： Yang Chao Yuezhuan Liu Zifa Xu Weixin Xie Li zhang Wentai Ouyang Haichen Wu Zebin Pan Junke Jiao Shujun Li Guangyi zhang wenwu zhang Liyuan Sheng Ningbo Institute of Materials Technology and Engineering Key Laboratory of Aero Engine Extreme Manufacturing Technology of Zhejiang ProvinceCASNingbo 315201China School of Mechanical Engineering Ningbo University of TechnologyNingbo 315336China Huizhou Port Customs Huizhou 516084China School of Mechanical Engineering Yangzhou UniversityYangzhouJiangsu 225127China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China Shenzhen Institute Peking UniversityShenzhen 518057China PKU-HKUST ShenZhen-HongKong Institution Shenzhen 518057China

In the present research,the gas-assisted laser(GAL)and water-jet guided laser(WGL)processing technologies were applied to machine the ultrathin kerf in the wrought Ti-6Al-4V alloy.The microstructure,microhardness,and wear properties of the superficial layer were investigated.The results reveal that the GAL processing could machine the kerf with a high depth-to-width ratio of 12–15,but the increased processing times enhance the depth little.Due to the oxygen entrainment and relatively low heat and mass transferring efficiency,the assisted gas promotes the formation of a scaled recast layer containingβ-Ti phase and oxides,which increases the roughness to 20μm.The WGL processed kerf has a low depth-to-width ratio with a value of 1.9–2.5 and the depth could be increased by increasing the WGL processing times.With the assistance of the water jet,the remelted debris and heat could be eliminated immediately,which restrains the formation of the recast layer and heat-affected zone.The ultrathin oxide outer layer with hundreds of nanometers and ultrafineα-Ti grain inner layer are formed on the surface,which decreases the roughness to 12μm.Compared with the as-received Ti-6Al-4V alloy,the microhardness of GAL processed kerf surface is increased to 382.8 HV accompanied by residual tensile stress,while the microhardness of WGL processed kerf surface is increased to 481.6 HV accompanying with residual compressive stress.In addition,the GAL processing increases the wear rate at room temperature but decreases the wear rate at high temperatures.Comparatively,the WGL processing decreases the wear rate at room and high temperatures,simultaneously.Such wear behaviors could be ascribed to their different superficial microstructures and phase constituents.

关键词： Ti-6Al-4V alloy Water-jet guided laser processing Superficial layer Microstructure Wear properties

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民营经济促进共同富裕:理论澄清、逻辑机制与现实路径

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社会科学研究 2024年第3期 69-75页

作者：张文武南京林业大学经济管理学院江苏南京210037

党的二十大报告开创性地阐释了中国式现代化的内涵,全体人民共同富裕是最重要的特征之一,民营经济是促进共同富裕的内在要素。马克思主义中国化时代化的经验表明,要用发展的眼光辩证地解析共同富裕,特别是理解共同富裕的所有制形式不能... 详细信息

党的二十大报告开创性地阐释了中国式现代化的内涵,全体人民共同富裕是最重要的特征之一,民营经济是促进共同富裕的内在要素。马克思主义中国化时代化的经验表明,要用发展的眼光辩证地解析共同富裕,特别是理解共同富裕的所有制形式不能简单地一分为二、固执其一,应该是兼容并蓄、动态包纳地促进多种所有制共生共存。民营经济是优化社会主义所有制体系的重要组成、实现社会财富增长的重要来源、共同富裕三次分配的重要途径。新时代新征程,实现全体人民共同富裕的中国式现代化离不开民营经济,应肥沃民营经济发展之壤、培育劳动资本利益共享之根,不断夯实共同富裕的制度保障,为实现中华民族伟大复兴提供坚定支撑。

关键词：民营经济共同富裕中国式现代化 “两个健康”

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Ring finger protein 157 is a prognostic biomarker and is associated with immune infiltrates in human breast cancer

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BIOCELL 2023年第10期47卷 2265-2281页

作者： XIN ZHU BIN XIAO wenwu zhang XIAOYU SONG WEI GONG LINHAI LI XINPING CHEN School of Life Sciences Hainan UniversityHaikou570228China Department of Medical Laboratory Hainan Cancer HospitalAffiliated Cancer Hospital of Hainan Medical UniversityHainan Tropical Cancer Research InstituteHaikou570312China Department of Laboratory Medicine The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan511518China Graduate School Guangzhou University of Chinese MedicineGuangzhou510006China School of Pharmaceutical Sciences Hainan UniversityHaikou570228China

Background: The protein encoded by ring finger protein 157 (RNF157) is known to function as an E3 ubiquitinligase. However, whether the level of RNF157 expression in breast cancer correlates with prognosis and immune cellinfiltration among breast cancer patients remains to be further explored. Methods: In this study, publicly availabledatasets were used for evaluating RNF157 expression in different tumors compared with normal samples. Severalindependent datasets were screened for investigating the relationship between RNF157 and breast cancer survival,different mutation profiles, and tumor immune cell infiltration. We conducted a pathway enrichment analysis toidentify signaling pathways associated with RNF157. Results: Analysis of public and online databases revealed thatRNF157 expression markedly decreased in breast cancer tissue samples compared to non-carcinoma counterparts.Consistently, immunohistochemistry assays also demonstrated this RNF157 down-regulation in breast cancer samples.RNF157 up-regulation could predict the improved survival of breast cancer cases. Further, different RNF157expression level groups exhibited different mutational profiles. Pathway enrichment profiling of RNF157-related genessuggested its possible involvement in regulating breast cancer via the mitogen-activated protein kinase (MAPK)pathway. RNA sequencing (RNA-seq) data and genomic enrichment analysis showed that RNF157 downregulatedseveral genes positively associated with the MAPK signaling pathway. We also explored RNF157 expression andimmune cell infiltration in breast cancer and found that RNF157 mRNA levels were negatively related to non-Timmune cell infiltration. Conclusion: According to our work, RNF157 may be a promising diagnostic biomarker andtherapeutic target for breast cancer.

关键词： RNF157 Prognosis Immune infiltrate MAPK signal pathway Breast cancer

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A peak enhancement of frequency response of waveguide integrated silicon-based germanium avalanche photodetector

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Journal of Semiconductors 2024年第7期45卷 61-68页

作者： Linkai Yi Daoqun Liu Wenzheng Cheng Daimo Li Guoqi Zhou Peng zhang Bo Tang Bin Li wenwu Wang Yan Yang Zhihua Li Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China School of Electronic Electrical and Communication Engineering University of Chinese Academy of SciencesBeijing 100049China

Avalanche photodetectors(APDs) featuring an avalanche multiplication region are vital for reaching high sensitivity and responsivity in optical transceivers. Waveguide-coupled Ge-on-Si separate absorption, charge, and multiplication(SACM)APDs are popular due to their straightforward fabrication process, low optical propagation loss, and high detection sensitivity in optical communications. This paper introduces a lateral SACM Ge-on-Si APD on a silicon-on-insulator(SOI) wafer, featuring a 10 μm-long, 0.5 μm-wide Ge layer at 1310 nm on a standard 8-inch silicon photonics platform. The dark current measures approximately 38.6 μA at-21 V, indicating a breakdown voltage greater than-21 V for the device. The APDs exhibit a unitgain responsivity of 0.5 A/W at-10 V. At-15 V, their responsivity reaches 2.98 and 2.91 A/W with input powers of-10 and-25 dBm, respectively. The device's 3-dB bandwidth is 15 GHz with an input power of-15 dBm and a gain is 11.68. Experimental results show a peak in impedance at high bias voltages, attributed to inductor and capacitor(LC) circuit resonance, enhancing frequency response. Furthermore, 20 Gbps eye diagrams at-21 V and-9 dBm input power reveal signal to noise ratio(SNRs) of 5.30. This lateral SACM APD, compatible with the stand complementary metal oxide semiconductor(CMOS) process,shows that utilizing the peaking effect at low optical power increases bandwidth.

关键词： photodetectors optical communications responsivity 3-dB bandwidth

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