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Succinylation modification:a potential therapeutic target in stroke

Neural Regeneration Research 2024年第4期19卷 781-787页

作者： Jie Lian wenwu liu Qin Hu Xiaohua Zhang Department of Neurosurgery Ren Ji HospitalShanghai Jiao Tong University School of Medicine Department of Diving and Hyperbaric Medicine Naval Medical CenterNaval Medical University

Stroke is a leading cause of mortality and disability worldwide.Ischemic cell death triggered by the compromised supply of blood oxygen and glucose is one of the major pathophysiology of strokeinduced brain injury.Impaired mitochondrial energy metabolism is observed minutes after stroke and is closely associated with the progression of neuropathology.Recently,a new type of posttranslational modification,known as lysine succinylation,has been recognized to play a significant role in mitochondrial energy metabolism after ischemia.However,the role of succinylation modification in cell metabolism after stroke and its regulation are not well understood.We aimed to review the effects of succinylation on energy metabolism,reactive oxygen species generation,and neuroinflammation,as well as Sirtuin 5 mediated desuccinylation after stroke.We also highlight the potential of targeting succinylation/desuccinylation as a promising strategy for the treatment of stroke.The succinylation level is dynamically regulated by the nonenzymatic or enzymatic transfer of a succinyl group to a protein on lysine residues and the removal of succinyl catalyzed by desuccinylases.Mounting evidence has suggested that succinylation can regulate the metabolic pathway through modulating the activity or stability of metabolic enzymes.Sirtuins,especially Sirtuin 5,are characterized for their desuccinylation activity and have been recognized as a critical regulator of metabolism through desuccinylating numerous metabolic enzymes.Imbalance between succinylation and desuccinylation has been implicated in the pathophysiology of stroke.Pharmacological agents that enhance the activity of Sirtuin 5 have been employed to promote desuccinylation and improve mitochondrial metabolism,and neuroprotective effects of these agents have been observed in experimental stroke studies.However,their therapeutic efficacy in stroke patients should be validated.

关键词： mitochondria metabolism neuroprotection sirtuin 5 stroke succinylation modification

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Selenium-doped cathode materials with polyaniline skeleton for lithium-organosulfur batteries

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Journal of Energy Chemistry 2023年第4期79卷 148-157页

作者： Rong Zou wenwu liu Fen Ran State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals School of Materials Science and EngineeringLanzhou University of TechnologyLanzhou 730050GansuChina

Sulfur-containing polymer(SCP)is considered as an outstanding cathode material for lithium-sulfur batteries.However,undesirable soluble polysulfides may shuttle in electrolyte,concluding long-chain Li_(2)S_(n)(n>4)and short-chain Li2Sn(n≤4),as well as the sluggish conversion kinetics are yet to be solved to enhance the performance of lithium-sulfur batteries.Here Se-doped sulfurized polyaniline with adjusted sulfur-chain-S_(x)-(x≤6)contribute to ensure the absence of long-chain polysulfides,and the skeleton with quinoid imine can endow strongly adsorption towards short-chain polysulfides by the reversible transition between deprotonated/protonated imine(-NH^(+)=and-N=),which offer double insurance against suppressing“shuttle effect”.Furthermore,Se atoms are doped into sulfurized polysulfides to accelerate the redox conversion and take a frontier orbital theory-oriented view into catalytic mechanism.Se-doped sulfurized polyaniline as active materials for lithium-organosulfur batteries delivers good electrochemical performance,including high rate,reversible specific capacity(680 mA h g^(-1)at 0.1 A g^(-1)),and lower capacity decay rate only of 0.15%with near 100%coulomb efficiency during long-term cycle.This work provides a valuable guiding ideology and promising solution for the chemistry-oriented structure design and practical application for lithium-organosulfur batteries.

关键词： Lithium-organosulfur batteries Selenium-doped Cathode materials Sulfur-containing polymer Frontier orbital theory

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Sulfur-containing polymer cathode materials: From energy storage mechanism to energy density

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InfoMat 2022年第8期4卷 1-24页

作者： Rong Zou wenwu liu Fen Ran State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals School of Material Science and EngineeringLanzhou University of TechnologyLanzhouP.R.China

Besides lithium-ion batteries, it is imperative to develop new battery energystorage system with high energy density. In conjunction with the developmentof Li-S batteries, emerging sulfur-containing polymers with tunable sulfur-chain length and organic groups gradually attract much attention as cathodematerials. This can avoid the problems that are impeding the development ofthe typical Li-S batteries, such as volume expansion, active material dissolu-tion, shuttle effect, and so on. This review aims to generalize the type ofsulfur-containing polymers and the working principles in Li-S batteries. Thesulfur-containing polymers (R-Sn-R) with different sulfur-chain length (n > 6,n ≤ 2, and 3 ≤ n ≤ 6) are summarized. It also discusses several organic groupssuch as phenyl rings, N-heterocycles, and unique structure with cross-linkednetworks and multi-micropores skeleton. This review also explores other strat-egies of sulfur-containing polymers in the rest of Li-S batteries, providing asummary of the advantages of sulfur-containing polymers, recent develop-ment, in-depth discussion of the mechanism in Li-S batteries, and organicgroup-structure-performance relationship. This review would have guidelinesfor future development of sulfur-containing polymers in Li-S batteries.

关键词： cathode materials energy density energy storage mechanism Li-S batteries sulfur-containing polymer

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论武术套路技术的“技击性”

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体育学研究 2024年第1期38卷 63-69,81页

作者：刘文武华东师范大学体育与健康学院上海200241

技击性需要在具体情境中才能得以彰显,而具体情境中技击性的彰显包含了多种因素。它们所起作用虽然有大有小,但各司其职,能够从不同方面对武术的技击做出贡献。以此反观武术套路技术,主要包括了由内而外的4个层次:核心层一攻一防的单个... 详细信息

技击性需要在具体情境中才能得以彰显,而具体情境中技击性的彰显包含了多种因素。它们所起作用虽然有大有小,但各司其职,能够从不同方面对武术的技击做出贡献。以此反观武术套路技术,主要包括了由内而外的4个层次:核心层一攻一防的单个动作、第二层攻防兼具的组合技术、第三层奋己惊人的抡拍技术和最外层显示功巧的花式技术。4个层次技术在各种武术套路中都不同程度地存在,构成了武术套路技术技击性的复合特征。由此得出研究启示:①用于提升传统武术技击性的技术载体须依托于武术套路核心层的一攻一防的单个动作;②用于学校武术教育的技术载体应选择以攻防兼具的组合技术为主体构成的武术套路;③用于竞技和表演的武术套路应在奋己惊人的抡拍技术和显示功巧的花式技术基础上,适当增加表现攻防的技术的比重。

关键词：传统武术武术套路武术技术技击性武术教育武术竞技武术表演

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Kinematic Characteristics Analysis and Parametric Solving of Snow Melting Agent Throwing Mechanism with Variable Crank Length

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Journal of Harbin Institute of Technology(New Series) 2021年第4期28卷 60-66页

作者： wenwu liu Nianli Lu Hongxin liu Engineering College Northeast Agriculture UniversityHarbin 150030China School of Electro-Mechanical Engineering Harbin Institute of TechnologyHarbin 150001China

Variable crank length cam⁃linkage mechanism has attracted much attention due to its compact overall structure when realizing complex motion laws.According to the special trajectory requirements,the kinematic characteristics and parameters of the mechanism have been analyzed and solved,which lays foundation for the implementation of the variable crank length snow melting agent throwing mechanism designed in this paper.Based on the trajectory equation of the point,the mathematical model of the throwing mechanism was established,and the theoretical trajectory of the end point of the throwing mechanism was obtained by programming.The parametric modeling and trajectory drawing were carried out by computer aided three⁃dimensional interactive application(CATIA),and the correctness of the mathematical model was verified by comparison.The regional trajectory distribution characteristics of the end points of the throwing mechanism were studied by using the trajectory region location method,and the influence of various parameters on the trajectory was investigated by using the numerical cycle comparison method.The human⁃computer interaction system of snow melting agent throwing mechanism with variable crank length was constructed by using Microsoft Visual Basic(VB)software.Based on the restriction conditions,the optimum combination of structural adjustment parameters and operational parameters suitable for Harbin first⁃class roads was obtained by using orthogonal test table,which provides an effective method to solve the parameters of the variable crank length cam mechanism with smooth impulse trajectory.

关键词： throwing mechanism variable crank length cam mechanism mathematical model kinematic characteristics parametric solving

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连续采煤机液驱行走稳定性研究

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煤矿机械 2024年第2期45卷 52-55页

作者：刘文武山西天地煤机装备有限公司太原030006 中国煤炭科工集团太原研究院有限公司太原030006

基于连续采煤机液驱行走的需求,设计了液驱行走负载敏感液压系统,分析了负载敏感液压系统压力脉动作用机理,研究了负载反馈回路2种滤波方法,设计了变阻尼阀,并在连续采煤机液驱行走负载敏感液压系统进行了试验,试验结果表明,通过调节变... 详细信息

基于连续采煤机液驱行走的需求,设计了液驱行走负载敏感液压系统,分析了负载敏感液压系统压力脉动作用机理,研究了负载反馈回路2种滤波方法,设计了变阻尼阀,并在连续采煤机液驱行走负载敏感液压系统进行了试验,试验结果表明,通过调节变阻尼阀可达到预期的稳定性。

关键词：负载敏感液压系统载荷波动变阻尼阀稳定性

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The predictive role of the neutrophil-lymphocyte ratio in the prognosis of adult patients with stroke

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Chinese Neurosurgical Journal 2020年第3期6卷 161-170页

作者： Jinzhao Wan Xiaoxiong Wang Yunbo Zhen Xin Chen Penglei Yao wenwu liu Enzhou Lu Yiming Du Huailei liu Shiguang Zhao Department of Neurosurgery The First Affiliated Hospital of Harbin Medical UniversityNo.23 Youzheng StreetNangang DistrictHarbin 150001Heilongjiang ProvincePeople’s Republic of China Institute of Brain Science Harbin Medical UniversityNo.23 Youzheng StreetNangang DistrictHarbin 150001Heilongjiang ProvincePeople’s Republic of China Institute of Neuroscience Sino-Russian Medical Research CenterHarbin Medical UniversityNo.23 Youzheng StreetNangang DistrictHarbin 150001Heilongjiang ProvincePeople’s Republic of China

Our study aimed to determine the effect of the neutrophil-lymphocyte ratio on the prognosis of adult patients with acute stroke.We searched the Web of Science,PubMed,Embase,Cochrane Library,and China National Knowledge Infrastructure databases and selected all of the potentially eligible studies.From the included studies,we extracted characteristics such as the stroke type and acquisition time until routine blood collection and the odds ratios across studies.The 95%confidence intervals and odds ratios were pooled to calculate the effect size for the neutrophil-lymphocyte ratio in acute stroke patients.We defined poor function outcomes according to the modified Rankin Scale≥3 or Glasgow Outcome Scale<3.Thirteen studies with 4443 patients were included in our analysis,including 7 ischemic and 6 hemorrhagic stroke studies.The pooled odds ratios for poor functional outcome at 3 months with a higher neutrophil-lymphocyte ratio in acute ischemic and hemorrhagic patients were 1.689(95%CI=1.184-2.409,p<0.001)and 1.125(95%CI=1.022-1.239,p<0.001),respectively,and the overall pooled odds ratio for poor functional outcome following stroke was 1.257(95%CI=1.146-1.379,p<0.001).At the same time,the overall combined odds ratio for death at 3 months was 1.632(95%CI=1.155-2.306,p<0.001).The neutrophil-lymphocyte ratio,an easily calculated marker,plays a predictive role in the short-term outcomes of adult patients(mean age≥50 years)following acute ischemic and hemorrhagic stroke.

关键词： Prognosis of stroke adult patients with stroke Neutrophil-lymphocyte ratio Acute stroke Predictive role

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矿用梭车卷缆延时阀的设计

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煤矿机械 2024年第1期45卷 19-20页

作者：刘文武山西天地煤机装备有限公司太原030006 中国煤炭科工集团太原研究院有限公司太原030006

基于矿用梭车启动时产生的甩电缆现象,设计了一种卷缆延时阀,可将电缆瞬时绷紧过程改为缓慢的绷紧,消除了电缆瞬时甩动,避免了甩电缆伤人;卷缆延时阀还可以通过变换不同孔径的节流孔,根据电缆粗细和实际甩动情况,改变延时时长。

关键词：矿用梭车卷缆控制卷缆延时阀甩电缆

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新型冠状病毒感染后潜水员适潜性评估

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海军军医大学学报 2024年第3期45卷 352-357页

作者：官振标董宇超徐佳骏俞旭华文宇坤刘霞刘文武海军军医大学(第二军医大学)第一附属医院呼吸与危重症医学科上海200433 海军军医大学(第二军医大学)海军特色医学中心潜水与高气压医学研究室上海200433

新型冠状病毒感染(COVID-19)对全身几乎所有器官都会产生影响,其中最主要的受累器官为肺和心脏。随着COVID-19康复患者数量不断增加,越来越多的证据表明,因COVID-19住院治疗获得康复的患者中有相当大比例的人群存在后遗症,主要表现为呼... 详细信息

新型冠状病毒感染(COVID-19)对全身几乎所有器官都会产生影响,其中最主要的受累器官为肺和心脏。随着COVID-19康复患者数量不断增加,越来越多的证据表明,因COVID-19住院治疗获得康复的患者中有相当大比例的人群存在后遗症,主要表现为呼吸系统和心血管系统的症状。对于潜水员,COVID-19后的运动耐受、心肺功能的恢复对其适潜性具有重要影响。一些组织和机构发布了潜水员COVID-19后的适潜性评估指南。本文对COVID-19后的呼吸和心血管系统后遗症及相关的适潜性评估方案进行简要介绍,并基于已有的相关要求和我国实际,初步提出我国潜水员COVID-19后的适潜性评估要求。

关键词：新型冠状病毒感染适潜性评估肺功能运动耐受心功能

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Long- versus short-interval follow-up after resection of hepatocellular carcinoma: a retrospective cohort study

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Cancer Communications 2018年第1期38卷 280-290页

作者： Wei He Yun Zheng Ruhai Zou Jingxian Shen Junping Yang Jiliang Qiu Qiang Tao wenwu liu Zhiwen Yang Yuanping Zhang Binkui Li Yunfei Yuan State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060China Department of Hepatobiliary Oncology Sun Yat-Sen University Cancer CenterGuangzhou 510060China Department of Ultrasound Sun Yat-Sen University Cancer CenterGuangzhou 510060China Department of Medical Imaging Sun Yat-Sen University Cancer CenterGuangzhou 510060China

Background:Average postoperative follow-up intervals vary in patients undergoing hepatocellular carcinoma(HCC)resection because of limited evidence regarding the optimal interval.We aimed to compare the associations of long-versus short-interval follow-up with survival and recurrence in risk-stratified HCC patients.Methods:We performed a retrospective cohort study between 2007 and 2014.In total,1227 patients treated by curative resection of Barcelona Clinic Liver Cancer stage A or B HCC were stratified as having a low(n=865)or high(n=362)risk of early recurrence(within the first 2 years after resection)based on prognostic factors identified by the least absolute shrinkage and selection operation algorithm.Patients were further classified into long-interval(every 4-6 months)and short-interval(every 2-4 months)follow-up subgroups based on follow-up within 2 years after resection(low risk,long vs.short:n=390 vs.n=475;high-risk,long vs.short:n=149 vs.n=213).Results:The short-interval follow-up did not prolong overall survival in either the low-risk(hazard ratio[HR]=1.152;95%confidence interval[CI]0.720-1.843)or high-risk(HR=1.213;95%CI 0.702-2.094)patients.Early recurrence occurred in 401 patients.For high-risk patients,the short-interval follow-up subgroup exhibited smaller intrahepatic recurrence than did the long-interval group(2.6 vs.3.5 cm,respectively,P=0.045).However,no significant difference in the rate of Barcelona Clinic Liver Cancer stage 0/A recurrence was found between the long-and short-interval follow-up groups in either low-or high-risk patients(63.1%vs.68.2%,respectively,P=0.580;31.3%vs.41.5%,respec-tively,P=0.280).The rate of curative intent treatment for recurrence(34.5%vs.39.7%,respectively,P=0.430;14.6%vs.20.3%,respectively,P=0.388)was also similar between the follow-up groups for low-and high-risk patients.Conclusions:Shortening the postoperative follow-up interval from every 4-6 months to every 2-4 months within the first 2 years after resection did not increase the rate of curative intent trea

关键词： Hepatocellular carcinoma Hepatectomy Prognosis Surveillance Recurrence

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