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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal.and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Arbuscular mycorrhizal symbiosis facilitates apricot seedling(Prunus sibirica l.)growth and photosynthesis in northwest China

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International Journal of Coal Science & Technology 2021年第4期8卷 473-482页

作者： Yinli Bi linlin Xie Zhigang Wang Kun Wang wenwen liu Wenwu Xie State Key laboratory of Coal Resources and Safe Mining China University of Mining and Technology(Beijing)Beijing 100083China Institute of Ecological Environment Restoration in Mine Areas of West China Xi'an University of Science and TechnologyXi'an 710054ShaanxiChina

Arbuscular mycorrhizal(AM)fungi can successfully enhance photosynthesis(P_(n))and plants growth in agricultural or grassland ***,how the symbionts affect species restoration in sunlight-intensive areas remains largely ***,this study’s objective was to assess the effect of AM fungi on apricot seedling physiology,within a specific time period,in northwest *** 2010,an experimental field was established in Shaanxi Province,northwest *** experimental treatments included two AM fungi inoculation levels(0 or 100 g of AM fungal inoculum per seedling),three shade levels(1900,1100,and 550µmol m^(−2) s^(−1)),and three ages(1,3,and 5 years)of *** examined growth,Pn,and morphological indicators of apricot(Prunus sibirica l.)seedling performances in 2011,2013,and *** colonization rate in mycorrhizal seedlings with similar amounts of shade is higher than the corresponding *** mycorrhizal seedling biomass is significantly higher than the corresponding non-mycorrhizal seedling ***,P_(n),stomatal conductance(G_(s)),transpiration rate(T_(r)),and water use efficiency are also significantly higher in the mycorrhizal ***,mycorrhizal seedlings with light shade(lS)have the highest *** is increased in non-mycorrhizal seedlings because of the reduction in T_(r),while T_(r) is increased in mycorrhizal seedlings with *** is a significant increase in the N,P,and K fractions detected in roots compared with *** means that lS had apparent benefits for mycorrhizal *** results also indicate that AM fungi,combined with lS,exert a positive effect on apricot behavior.

关键词： Apricot seedlings Arbuscular mycorrhizal symbiosis Plant growth light shade Photosynthesis

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural.and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Environmental concentration of ammonia nitrogen induced marked changes in proteome of clam Ruditapes philippinarum in dose-and time-dependent manner

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Journal of Oceanology and limnology 2024年第5期42卷 1634-1650页

作者： Ming CONG Zhaoshun lI wenwen TIAN Yuanmei lI Jiasen lÜ School of Ocean Yantai UniversityYantai 264005China School of life Sciences Yantai UniversityYantai 264005China

Previous studies have revealed that ammonia nitrogen has several adverse effects on clam Ruditapes ***,knowledge is lacking regarding the related proteins involved in the toxicological responses,which is vital to elucidate the underlying mechanism of ammonia *** this study,clams *** were exposed to ammonia nitrogen for 21 d at two environmentally relevant *** tandem mass tags approach(TMT)was applied to assay the differentially expressed proteins(DEPs)in clam gill tissues on the 3 rd and 21 st ***,a total of 7263 proteins were *** analyses revealed that clam protein profiles changed in dose-and time dependent manner after ammonia nitrogen *** inferred that the clams may face heavy challenges after ammonia exposure,such as unbalanced gender ratio,lysosomal disease,energy lack,neurological disorders,altered glutamine metabolism,increased lipid synthesis,and impaired *** profiles of enzyme activities of glutaminase and glutamine synthase provided direct evidence to verify the related inference from proteome *** of the inferred toxic effects merit further *** study identified important proteins related to ammonia nitrogen toxicity in the clam and indicated the severe stress of marine ammonia pollution on the healthy development of mollusc aquaculture.

关键词： ammonia nitrogen Ruditapes philippinarum proteomic analysis toxicity

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong l.ang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

Association of TCF7l2 rs7903146 Gene Polymorphism with the Risk of NAFlD and CAD in the Chinese Han Population

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Journal of Clinical.and Translational Hepatology 2020年第4期8卷 371-376页

作者： Xin Yan wenwen Jin Jie Zhang Mengke Wang Shousheng liu Yongning Xin Department of Infectious Disease Qingdao Municipal HospitalQingdaoShandongChina Clinical Research Center Qingdao Municipal HospitalQingdaoShandongChina Digestive Disease Key laboratory of Qingdao QingdaoShandongChina Dal.an Medical University DalianLiaoningChina

Background and Aims:Coronary artery disease (CAD) is a major cause of morbidity and mortality in patients with non-alcoholic fatty liver disease (NAFlD). Previous studies have suggested that TCF7l2 rs7903146 was related to the risk of developing NAFlD but the conclusions are not consistent and no related study has been conducted in Chinese populations. The aim of this study was to investigate the association be-tween TCF7l2 rs7903146 and the risk of developing NAFlD and CAD in a Chinese Han population. Methods: TCF7l2 rs7903146 genotypes were measured by the MAlDI-TOF-MS from 143 NAFlD patients, 159 CAD patients, 131 NAFlD+ CAD patients, and 212 healthy controls. The demographic data and serum lipid profiles of all subjects were collected. The distributions of genotype and allele frequency in each group were also tested. logistic regression was used to inves-tigate the risk of TCF7l2 rs7903146 with NAFlD and CAD. All statistical.analyses were conducted using SPSS 23.0. Results: There were no significant differences in the distri-butions of TCF7l2 rs7903146 genotype and allele frequency in each of the two groups, and the TCF7l2 rs7903146 CT+TT genotype did not increase the risk of developing NAFlD, CAD, and NAFlD+CAD. Except for body mass index in the control group, the differences of clinical parameters between the TCF7l2 rs7903146 T allele carriers and non-carriers in each group were not significant. In the non-obese group, the TCF7l2 rs7903146 CT+TT genotype was a protective factor for the development of NAFlD in the non-obese subjects (odds ratio=0.359, 95% confidence interval: 0.134-0.961, p = 0.041). Conclusions: TCF7l2 rs7903146 was not associated with the risk of developing NAFlD, CAD, and NAFlD + CAD in the Chinese Han population. In the non-obese population, the TCF7l2 rs7903146 CT + TT genotype was a protective factor against the development of NAFlD.

关键词： Nonalcoholic fatty liver disease Coronary artery disease TCF7l2 Single nucleotide polymorphism

激光结合螺旋藻增强FeSO_(4)诱导鼠伤寒沙门氏菌和单核细胞增生李斯特菌铁死亡的发生机制

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食品科学 2025年第2期46卷 8-19页

作者：孙晋跃潘佳能陈奕颖刘人诚周文文浙江大学生物系统工程与食品科学学院浙江杭州310058

为探究激光(laser,l)结合螺旋藻(Spirulina platensis,SP)增强FeSO_(4)(Fe)诱导鼠伤寒沙门氏菌(Salmonella enterica serovar Typhimurium,ST)和单核细胞增生李斯特氏菌(listeria monocytogenes,lM)铁死亡发生的机制,研究不同处理后菌体细胞脂质过氧化、活性氧、谷胱甘肽变化,形态特征、细胞膜损伤和关键基因的表达等。结果表明,经l结合SP处理后FeSO4的杀菌效果显著增强,且4 mmol/l Fe+SP+l处理后ST和lM的菌数均降低至lg(CFU/ml))。此外,Fe+SP+l处理使得微生物细胞的脂质过氧化水平和活性氧升高,谷胱甘肽的比例降低,菌体细胞膜完整性受到破坏,细胞膜的通透性增加,膜电位降低,进而导致菌体的核酸和蛋白泄漏增加,最终导致菌体死亡。此外,抑制生物被膜实验和生物被膜杀菌实验表明4 mmol/l Fe+SP+l处理对2种菌生物被膜的形成具有很好的控制作用。最后,4 mmol/l Fe+SP+l处理可使得生菜上ST和lM的数量分别显著降低至4.63(lg(CFU/g))和4.60(lg(CFU/g))。综上,Fe+SP+l处理可以显著降低游离状态和生物膜状态下ST和lM的数量,具有较好的控制生菜等食品表面食源性致病菌的潜力。

关键词：激光螺旋藻铁死亡脂质过氧化生物被膜