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Revalidation of a prognostic score model based on complete blood count for nasopharyngeal carcinoma through a prospective study

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Chinese Journal of Cancer Research 2016年第5期28卷 467-477页

作者： Xiaohui Li Hui Chang Yalan Tao Xiaohui Wang jin Gao wenwen Zhang Chen Chen Yunfei Xia Department of Radiation Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine Guangzhou 510060 China Department of Oncology the 421 Hospital of Chinese People's Liberation Army Guangzhou 510318 China Department of Radiation Oncology Anhui Provincial Hospital Affiliated to Anhui Medical University Hefei 230001 China

Objective： In our previous work, we incorporated complete blood count （CBC） into TNM stage to develop a new prognostic score model, which was validated to improve prediction efficiency of TNM stage for nasopharyngeal carcinoma （NPC）. The purpose of this study was to revalidate the accuracy of the model, and its superiority to TNM stage, through data from a prospective ***： CBC of 249 eligible patients from the 863 Program No. 2006AA02Z4B4 was evaluated. Prognostic index （PI） of each patient was calculated according to the score model. Then they were divided by the PI into three categories： the low-, intermediate-and high-risk patients. The 5-year disease-specific survival （DSS） of the three categories was compared by a log-rank test. The model and TNM stage （Tth edition） were compared on efficiency for predicting the 5-year DSS, through comparison of the area under curve （AUC） of their receiver-operating characteristic ***： The 5-year DSS of the low-, intermediate- and high-risk patients were 96.0%, 79.1% and 62.2%, respectively. The low- and intermediate-risk patients had better DSS than the high-risk patients （P〈0.001 and P〈0.005, respectively）. And there was a trend of better DSS in the low-risk patients, compared with the intermediate-risk patients （P=0.049）. The AUC of the model was larger than that of TNM stage （0.726 vs. 0.661, P：0.023）. Conclusions： A CBC-based prognostic score model was revalidated to be accurate and superior to TNM stage on predicting 5-year DSS of NPC.

关键词： Complete blood count score model revalidadon disease-specific survival nasopharyngeal carcinoma

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Recent Progress on Engineering Highly Efficient Porous Semiconductor Photocatalysts Derived from Metal–Organic Frameworks

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Nano-Micro Letters 2019年第1期11卷 5-32页

作者： wenwen Zhan Liming Sun Xiguang Han Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Department of ChemistrySchool of Chemistry and Chemical Engineering Jiangsu Normal University

Porous structures o er highly accessible surfaces and rich pores, which facilitate the exposure of numerous active sites for photocatalytic reactions, leading to excellent performances. Recently, metal–organic frameworks(MOFs) have been considered ideal precursors for well-designed semiconductors with porous structures and/or heterostructures, which have shown enhanced photocatalytic activities. In this review, we summarize the recent development of porous structures, such as metal oxides and metal sulfides, and their heterostructures, derived from MOF-based materials as catalysts for various light-driven energy-/environment-related reactions, including water splitting, CO_2 reduction, organic redox reaction, and pollution degradation. A summary and outlook section is also included.

关键词： Metal–organic frameworks Derivatives Porous structure Photocatalysis

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Preparation of Ce3+doped Bi2O3 hollow needle-shape with enhanced visible-light photocatalytic activity

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Journal of Rare Earths 2019年第7期37卷 726-731页

作者： wenwen Zhang Shaomin Gao Donghui Chen College of Environmental Science and Engineering Donghua UniversityShanghai 201620China College of Chemical and Environmental Engineering Shanghai Institute of TechnologyShanghai 201418China

Ce3+ doped Bi2O3 hollow needle-shape with enhanced visible-light photocatalytic activity was successfully prepared via the method of chemical precipitation using Bi(NO3)·5H2O and Ce(NO3)3·6H2O as the source of bismuth and cerium, HNO3 as solvent and NaOH as precipitants, respectively and after calcination at 500 ℃ for 2 h. The morphology and elemental composition,crystal form,purity and specific surface area of the hollow needle Bi2O3 were characterized by SEM-EDS, XRD, BET and FT-IR. The photocatalytic properties of the as-obtained samples were measured by UV-vis diffuse reflection spectroscopy and photochemical reactor. As a result, the obtained Bi2O3 hollow needle-shape doped with 5 wt% Ce shows good morphology, α-phase, stronger absorbent for visible light and good photocatalytic property. Under the simulated visible light of 300 W, the photodegradation rate of tetracycline over HNBCe can reach to 89.1%,which is higher than that of commercial Bi2O3 nanoparticles and Bi2O3 hollow needle-shape.

关键词： Needle-shape Bi2O3 Precipitation method Tetracycline Rare earths

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Sparse Weighted Canonical Correlation Analysis

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Chinese Journal of Electronics 2018年第3期27卷 459-466页

作者： MIN wenwen LIU Juan ZHANG Shihua State Key Laboratory of Software Engineering School of Computer Wuhan University National Center for Mathematics and Interdisciplinary Sciences Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematics Sciences University of Chinese Academy of Sciences

Given two data matrices X and Y, Sparse canonical correlation analysis（SCCA） is to seek two sparse canonical vectors u and v to maximize the correlation between Xu and Yv. Classical and sparse Canonical correlation analysis（CCA） models consider the contribution of all the samples of data matrices and thus cannot identify an underlying specific subset of samples. We propose a novel Sparse weighted canonical correlation analysis（SWCCA）,where weights are used for regularizing different *** solve the L;-regularized SWCCA（L;-SWCCA） using an alternating iterative algorithm. We apply L;-SWCCA to synthetic data and real-world data to demonstrate its effectiveness and superiority compared to related methods. We consider also SWCCA with different penalties like Least absolute shrinkage and selection operator（LASSO）and Group LASSO, and extend it for integrating more than three data matrices.

关键词： Canonical correlation analysis(CCA) Sparse canonical correlation analysis(SCCA) Sparse weighted CCA(SWCCA) Group LASSO regularized SWCCA Multi-view SWCCA

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Control of Strain Hardening Behavior in High-Mn Austenitic Steels

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Acta Metallurgica Sinica(English Letters) 2014年第3期27卷 546-556页

作者： wenwen Song Tobias Ingendahl Wolfgang Bleck Steel Institute RWTH Aachen University Intzestr.1 52072 AachenGermany

Austenitic high-Mn steels with Mn contents between approximately 15 and 30 wt% gain much interest because of their excellent mechanical properties and the option for adjusting strain hardening behavior due to different deformation mechanisms. 2D and 3D composition-dependent stacking fault energy （SFE） maps indicate the effect of chemical composition and temperature on SFE and consequently on the deformation mechanisms. Three steels with different chemical compositions and the same or different SFE are characterized in quasi-static tensile tests. The control parameters of strain hardening behavior in the high-Mn austenitic steels are described, and consequences for future developments are discussed.

关键词： High-Mn austenitic steels Stacking fault energy Strain hardening

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Agricultural Non-point Source Pollution in China:Evaluation,Convergence Characteristics and Spatial Effects

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Chinese Geographical Science 2021年第3期31卷 571-584页

作者： QIU wenwen ZHONG Zhangbao LI Zhaoliang School of Literature Law and EconomicsWuhan University of Science and TechnologyWuhan 430081China Research Center for Rural Social Construction and Management Huazhong Agricultural UniversityWuhan 430070China College of Law and Business Wuhan Institute of TechnologyWuhan 430205China

In this study,an inventory analysis approach was used to investigate the intensity of agricultural non-point source pollution(ANSP)and its spatial convergence at national and provincial levels in China from 1999 to *** this basis,spatial factors affecting ANSP were explored by constructing a spatial econometric *** results indicate that:1)The intensity of China's ANSP emission showed an overall upward trend and an obvious spatial difference,with the values being high in the eastern and central regions and relatively low in the western region.2)Significant spatial agglomeration was shown in China's ANSP intensity,and the agglomeration effect was increasing gradually.3)In the convergence analysis,a spatial lag model was found applicable for interpretation of the ANSP intensity,with the convergence rate being accelerated after considering the spatial factors but slower than that of regional economic growth.4)The spatial factors affecting the ANSP intensity are shown to be reduced by improving agricultural infrastructure investment,labor-force quality,and crop production ratio,while the expansion of agricultural economy scale and precipitation and runoff have positive impact on ANSP in the study ***,agricultural research and development(R&D)investment showed no direct significant effect on the ANSP ***,improving the quality of the labor force would significantly reduce the ANSP intensity in the surrounding areas,while the precipitation and runoff would significantly increase the pollution of neighboring *** research has laid a theoretical basis for formulation and optimization of ANSP prevention strategies in China and related regions.

关键词： intensity of agricultural non-point source pollution spatial effects inventory analysis spatial econometric model βconvergence

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The role of CALYPSO in the discovery of high-T_c hydrogen-rich superconductors

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Chinese Physics B 2019年第10期28卷 56-61页

作者： wenwen Cui Yinwei Li Laboratory of Quantum Materials Design and Application School of Physics and Electronic EngineeringJiangsu Normal University

Hydrogen-rich compounds are promising candidates for high-Tc or even room-temperature superconductors. The search for high-Tc hydrides poses a major experimental challenge because there are many known hydrides and even more unknown hydrides with unusual stoichiometries under high pressure. The combination of crystal structure prediction and first-principles calculations has played an important role in the search for high-Tc hydrides, especially in guiding experimental synthesis. Crystal structure AnaLYsis by Particle Swarm Optimization(CALYPSO) is one of the most efficient methods for predicting stable or metastable structures from the chemical composition alone. This review summarizes the superconducting hydrides predicted using CALYPSO. We focus on two breakthroughs toward room-temperature superconductors initiated by CALYPSO: the prediction of high-Tc superconductivity in compressed hydrogen sulfide and lanthanum hydrides, both of which have been confirmed experimentally and have set new record Tc values. We also address the challenges and outlook in this field.

关键词： CALYPSO structure prediction hydrogen-rich superconductors

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Robust U-type test for high dimensional regression coefficients using refitted cross-validation variance estimation

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Science China Mathematics 2016年第12期59卷 2319-2334页

作者： GUO wenwen CHEN YongShuai CUI HengJian School of Mathematical Sciences Capital Normal University

This paper aims to develop a new robust U-type test for high dimensional regression coefficients using the estimated U-statistic of order two and refitted cross-validation error variance estimation. It is proved that the limiting null distribution of the proposed new test is normal under two kinds of ordinary *** further study the local power of the proposed test and compare with other competitive tests for high dimensional data. The idea of refitted cross-validation approach is utilized to reduce the bias of sample variance in the estimation of the test statistic. Our theoretical results indicate that the proposed test can have even more substantial power gain than the test by Zhong and Chen(2011) when testing a hypothesis with outlying observations and heavy tailed distributions. We assess the finite-sample performance of the proposed test by examining its size and power via Monte Carlo studies. We also illustrate the application of the proposed test by an empirical analysis of a real data example.

关键词： high dimension regression large p small n refitted cross-validation variance estimation U-type test robust

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Language clusters based on linguistic complex networks

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Chinese Science Bulletin 2010年第30期55卷 3458-3465页

作者： LIU HaiTao LI wenwen School of International Studies Zhejiang University Hangzhou 310058 China Institute of Applied Linguistics Communication University of China Beijing 100024 China

To investigate the feasibility of using complex networks in the study of linguistic typology,this paper builds and explores 15 linguistic complex networks based on the dependency syntactic treebanks of 15 languages. The results show that it is possible to classify human languages by means of the following main parameters of complex networks:(a) average degree of the node,(b) cluster coefficients,(c) average path length,(d) network centralization,(e) diameter,(f) power exponent of degree distribution,and (g) the determination coefficient of power law distributions. The precision of this method is similar to the results achieved by means of modern word order typology. This paper tries to solve two problems of current linguistic typology. First,the language sample of a typological study is not real text; second,typological studies pay too much attention to local language structures in the course of choosing typological parameters. This study performs better in global typological features of language and not only enhances typological methods,but it is also valuable for developing the applications of complex networks in the humanities,social,and life sciences.

关键词：人类语言复杂网络集群类型学发展中国家路径长度指数分布分布系数

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Preparation of ZIF-8@PEBAX/PVDF nanocomposite membrane by the combination of self-assembly and in-situ growth for removing thiophene from the model gasoline

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Chinese Journal of Chemical Engineering 2023年第12期64卷 177-187页

作者： Zhesai Zhao Qingwen Han wenwen He Xiaolong Han School of Chemical Engineering Northwest UniversityXi’an 710069China Hubei Three Gorges Laboratory Yichang 443007China School of Chemistry and Life Science Advanced Institute of Materials ScienceChangchun University of TechnologyChangchun 130012China

Metal-organic frameworks(MOFs)have gained attention in the development of MOFs/polymer hybrid membranes for ***,the agglomeration of MOFs particles and interfacial defects limit its further *** this study,we present a novel approach to fabricate a ZIF-8@PEBAX/PVDF nanocomposite membrane for removing thiophene from the model gasoline by combination of selfassembly and in-situ ***,a PVDF supporting membrane was modified to have a negative ***,positively charged zinc ions were attracted onto the negatively charged PVDF supporting membrane through electrostatic ***,the Zinc ions deposited PVDF membrane was immersed into dimethylimidazole solution to form a uniform ZIF-8 ***,the ZIF-8 layer was coated with poly(ether-block-amide)(PEBAX)using the pouring *** results showed that the separating efficiency of the ZIF-8@PEBAX/PVDF nanocomposite membrane was improved significantly compared to that of pristine PEBAX *** optimal permeation flux and enrichment factor of membrane were 27.80 kg(m^(2)h)^(-1)and 6.9,respectively.

关键词： Nanocomposite membrane ZIF-8 nanoparticles PEBAX Thiophene

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