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Computer Modeling in Engineering & Sciences 2022年第6期131卷 1635-1652页

作者： wenwen Zhou Mengyao Chen Yang Gao Ruilin Feng School of Economics and Management Beijing University of TechnologyBeijing100124China

To avoid the effects of systemic financial risks caused by extreme fluctuations in housing price,the Chinese government has been exploring the most effective policies for regulating the housing *** the effect of real estate regulation policies has been a challenge for present *** study innovatively employs big data technology to obtain Internet search data(ISD)and construct market concern index(MCI)of policy,and hedonic price theory to construct hedonic price index(HPI)based on building area,age,ring number,and other hedonic ***,the impact of market concerns for restrictive policy,monetary policy,fiscal policy,security policy,and administrative supervision policy on housing prices is ***,compared with the common housing price index,the hedonic price index considers the heterogeneity of houses and could better reflect the changes in housing prices caused by market supply and *** results indicate that(1)a long-term interaction relationship exists between housing prices and market concerns for policy(MCP);(2)market concerns for restrictive policy and administrative supervision policy effectively restrain rising housing prices while those for monetary and fiscal policy have the opposite *** results could serve as a useful reference for governments aiming to stabilize their real estate markets.

关键词： Real estate policy market concerns for policy hedonic price Internet search data housing prices

Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways

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Acta Pharmaceutica Sinica B 2015年第4期5卷 323-329页

作者： Chuanhong Wu wenwen Zhao Xuenong Zhang Xiuping Chen State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of Macao

Neocryptotanshinone(NCTS) is a natural product isolated from traditional Chinese herb Salvia miltiorrhiza Bunge. In this study, we investigated its anti-inflammatory effects in lipopolysaccharide(LPS)-stimulated mouse macrophage(RAW264.7) cells. MTT results showed that NCTS partly reversed LPS-induced cytotoxicity. Real-time PCR results showed that NCTS suppressed LPS-induced mRNA expression of inflammatory cytokines, including tumor necrosis factor α(TNFα), interleukin-6(IL-6) and interleukin-1β(IL-1β). Moreover, NCTS could decrease LPS-induced nitric oxide(NO)production. Western blotting results showed that NCTS could down-regulate LPS-induced expression of inducible nitric oxide synthase(iNOS), p-IκBα, p-IKKβ and p-NF-κB p65 without affecting cyclooxygenase-2(COX-2). In addition, NCTS inhibited LPS-induced p-NF-κB p65 nuclear *** conclusion, these data demonstrated that NCTS showed anti-inflammatory effect by suppression of NF-κB and iNOS signaling pathways.

关键词： Neocryptotanshinone Inflammation NF-κB Inducible nitric oxide synthase

富马酸丙酚替诺福韦治疗青岛地区60岁及以上慢性乙型肝炎患者的有效性和安全性

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临床肝胆病杂志 2023年第5期39卷 1061-1069页

作者：宋玉文陈立震金文文耿宁张旸杜水仙赵本田段建平周永毕春花马磊胡欣欣张吉宏孙建涛谭杰辛永宁青岛大学附属青岛市市立医院感染性疾病科山东青岛266000 青岛市第六人民医院感染性疾病科山东青岛266000 青岛大学附属医院感染性疾病科山东青岛266000 青岛市城阳区人民医院感染性疾病科山东青岛266000 青岛市即墨区人民医院感染性疾病科山东青岛266000

目的探讨富马酸丙酚替诺福韦(TAF)在老年慢性乙型肝炎(CHB)患者中的应用价值,明确其对骨骼和肾脏的影响。方法选取2021年6月—2022年10月在青岛市市立医院、青岛大学附属医院、青岛市第六人民医院、青岛市城阳人民医院、青岛市即墨人民... 详细信息

目的探讨富马酸丙酚替诺福韦(TAF)在老年慢性乙型肝炎(CHB)患者中的应用价值,明确其对骨骼和肾脏的影响。方法选取2021年6月—2022年10月在青岛市市立医院、青岛大学附属医院、青岛市第六人民医院、青岛市城阳人民医院、青岛市即墨人民医院接受TAF抗病毒治疗的60岁及以上CHB患者36例。所有患者接受TAF(25 mg/d)抗病毒治疗。收集患者基线期、48周病毒学指标、生化指标、尿蛋白电泳指标以及甲胎蛋白(AFP)、肝脏超声瞬时弹性成像测定(FibroScan)、骨密度测定数据。收集24周病毒学指标,生化指标,尿蛋白电泳指标。正态分布计量资料治疗前后进行配对t检验,非正态分布计量资料治疗前后比较采用Wilcoxon符号秩和检验。计数资料的比较采用χ^(2)检验或Fisher确切概率法。结果36例CHB患者完成了24周随访。TAF治疗24周后,完全病毒学应答率为83.3%(30/36),与基线期77.8%(28/36)比较,差异无统计学意义(χ^(2)=0.36,P=0.55)。24周DBil(t=-2.42,P=0.02)、Cys C(t=-4.34,P0.05)。结论TAF在60岁及以上CHB患者中有良好的抗病毒效果,使更多CHB患者达到完全病毒学应答,未发现对肾脏造成损害,能够改善骨密度及肝纤维化程度。

关键词：乙型肝炎,慢性富马酸丙酚替诺福韦治疗结果老年人

Assouad dimensions of Moran sets and Cantor-like sets

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Frontiers of Mathematics in China 2016年第3期11卷 705-722页

作者： wenwen LI Wenxia LI Junjie MIAO Lifeng XI Department of Mathematics Ningbo University Ningbo 315211 China School of MathematiCs and Statistics Fuyang Normal University Fuyang 236037 China Department of Mathematics East China Normal University Shanghai 200241 China Shanghai Key Lab of PMMP East China Normal University Shanghai 200241 China

We obtain the Assouad dimensions of Moran sets under suitable condition. Using the homogeneous set introduced in [J. Math. Anal. Appl., 2015, 432：888 917], we also study the Assouad dimensions of Cantor-like sets.

关键词： Fractal Assouad dimension Moran set Cantor-like set

A general-purpose framework for parallel processing of large-scale LiDAR data

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International Journal of Digital Earth 2018年第1期11卷 26-47页

作者： Zhenlong Li Michael E.Hodgson wenwen Li Department of Geography University of South CarolinaColumbiaSCUSA School of Geographical Sciences and Urban Planning Arizona State UniversityTempeAZUSA

Light detection and ranging(LiDAR)data are essential for scientific discoveries such as Earth and ecological sciences,environmental applications,and responding to natural *** collecting LiDAR data over large areas is quite possible the subsequent processing steps typically involve large computational *** storing,managing,and processing LiDAR data are the prerequisite steps for enabling these LiDAR-based ***,handling LiDAR data poses grand geoprocessing challenges due to data and computational *** tackle such challenges,we developed a general-purpose scalable framework coupled with a sophisticated data decomposition and parallelization strategy to efficiently handle‘big’LiDAR data *** contributions of this research were(1)a tile-based spatial index to manage big LiDAR data in the scalable and fault-tolerable Hadoop distributed file system,(2)two spatial decomposition techniques to enable efficient parallelization of different types of LiDAR processing tasks,and(3)by coupling existing LiDAR processing tools with Hadoop,a variety of LiDAR data processing tasks can be conducted in parallel in a highly scalable distributed computing environment using an online geoprocessing application.A proof-of-concept prototype is presented here to demonstrate the feasibility,performance,and scalability of the proposed framework.

关键词： Big data online geoprocessing Hadoop MapReduce spatial decomposition LAStools parallel

Molecular simulation of oligomer inhibitors for calcite scale

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Particuology 2012年第3期10卷 266-275页

作者： Qiuyu Zhang Hua Ren wenwen Wang Junping Zhang Hepeng Zhang School of Science Northwestern Polytechnical UniversityXi'an 710072China

Molecular simulation was performed to study the interaction between CaCO3 crystal and several oligomer inhibitors, by using the equilibrium morphology method to calculate the growth morphology of CaCO3 without inhibitors. The calculated morphology agreed well with SEM photographs. Then, a double-layer model was built to investigate the interaction between calcite crystal and oligomer inhibitors containing maleic anhydride （MA） and acrylic acid （AA）. Interaction energy per gram of an oligomer inhibitor was introduced as a scale of inhibition efficiency of different monomers. The results indicated that, for calcite scale inhibition, acrylamide （AM） and vinyl phosphonic acid （VPA） were the most efficient monomers, while allylsulfonic acid （AS） was the poorest. Increasing proportion of AM in dimer inhibitor molecule would improve the inhibition efficiency of MA, though, for a trimer, such as MA-AA-AM, certain sequence of monomers in the inhibitor molecule was necessary besides higher proportion of AM.

关键词： Molecular simulationCrystal morphology Interaction energy Scale inhibitorScale inhibition efficiency

Initial identification of heavy metals contamination in Taihu Lake, a eutrophic lake in China

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Journal of Environmental Sciences 2012年第9期24卷 1539-1548页

作者： Xia Jiang wenwen Wang Shuhang Wang Bo Zhang Jiachen Hu Key Laboratory of Environmental Protection of Lake Pollution Control Chinese Research Academy of Environmental Science Beijing 100012 China School of Forestry Northeast Forestry University Harbin 150040 China

A detailed investigation of seven heavy metals （Cu, Cd, Cr, As, Pb, Zn, Ni） in the water column, interstitial water and surface sediment was conducted to quantify the extent of their contamination in Taihu Lake. Results showed the average total concentrations ranged from 0.93μg/L for Cd to 47.03 μg/L for Zn. The dissolved concentrations in the overlying water ranged from 0.06μg/L for Cd to 15.86 μg/L for Zn. The metals in the Taihu Lake surface water were primarily in the particulate phase, especially for Cd, whose particulate concentration represented 94.3% of the total. In the surface sediment, the mean concentrations for Cr, Ni, Cu, Zn, As, Cd and Pb were 41.50, 28.72, 27.82, 65.46, 5.94, 0.82 and 41.17 mg/kg, respectively. The metals in the water column and sediments of Taihu Lake displayed significant spatial variations, and the higher metal concentrations mainly occurred in the north and west of Taihu Lake, especially in Zhushan Bay and West Taihu Lake. A quality assessment indicated that most of the metals in the surface water of Taihu Lake had no or low adverse health effects on organisms, except for Pb and Cu, which may cause chronic toxicity. Compared with the ＂Consensus-Based Sediment Quality Guidelines＂, the polluting metals were Cr, Ni and Cd, and the polluted regions were confined to Zhnshan Bay, Meiliang Bay and the west of Taihu Lake, especially for north of Zhushan Bay. The polluted areas for Cr, Ni and Cd were 14.36, 34.70 and 13.24 km2, respectively. We suggest that Cr, Ni, and Cd in the polluted areas should be addressed and that tissue chemistry and sediment toxicity assessments be performed as soon as possible.

关键词： Taihu Lake water sediment heavy metal assessment

Vegard’s law deviating Ti_(2)(Sn_(x)Al_(1−x))C solid solution with enhanced properties

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Journal of Advanced Ceramics 2023年第8期12卷 1655-1669页

作者： Zhihua Tian Peigen Zhang wenwen Sun Bingzhen Yan Zhengming Sun School of Materials Science and Engineering Southeast UniversityNanjing 211189China

The achievement of chemical diversity and performance regulation of MAX phases primarily relies on solid solution ***,the reported A-site solid solution is undervalued due to their expected chemical disorder and compliance with Vegard’s law,as well as discontinuous composition and poor ***,we synthesized high-purity Ti_(2)(Sn_(x)Al_(1−x))C(x=0–1)solid solution by the feasible pressureless sintering,enabling us to investigate their property evolution upon the A-site *** formation mechanism of Ti_(2)(Sn_(x)Al_(1−x))C was revealed by thermal analysis,and crystal parameters were determined by Rietveld refinement of X-ray diffraction(XRD).The lattice constant(a)adheres to Vegard’s law,while the lattice constant(c)and internal free parameter(zM)have noticeable deviations from the law,which is caused by the significant nonlinear distortion of Ti_(6)C octahedron as Al atoms are substituted by Sn ***,the deviation also results in nonlinear changes in their physicochemical properties,which means that the solid solution often exhibits better performance than end members,such as hardness,electrical conductivity,and corrosion *** work offers insights into the deviation from Vegard’s law observed in the A-site solid solution and indicates that the solid solution with enhanced performance may be obtained by tuning the A-site composition.

关键词： MAX phase Ti_(2)(Sn_(x)Al_(1−x))C Vegard’s law high purity properties

Stress corrosion cracking failure of X80 carbon steel U-b end cause d by Desulfovibrio vulgaris biocorrosion

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Journal of Materials Science & Technology 2024年第7期174卷 95-105页

作者： Zhong Li Jike Yang Shihang Lu wenwen Dou Tingyue Gu Corrosion&Protection Center University of Science&Technology BeijingBeijing 100083China Institute of Marine Science and Technology Shandong UniversityQingdao 266237China Department of Chemical and Biomolecular Engineering Institute for Corrosion and Multiphase TechnologyOhio UniversityAthensOH 45701USA

Sulfate reducing bacteria(SRB)are widely present in oil and gas industry,causing pitting corrosion on pipeline *** corrosion cracking(SCC)often occurs in the presence of mechanical stress before pit-ting perforation failure,leading to economic losses and even catastrophic *** this study,stress distribution simulation using the finite element method(FEM),corrosion analysis techniques and elec-trochemical corrosion measurements were employed to investigate the SCC mechanism of X80 pipeline steel caused by Desulfovibrio vulgaris,which is a common SRB strain used in microbiologically influenced corrosion(MIC)*** was found that *** MIC caused sharp microcracks on an X80 U-bend coupon after only 2 weeks of immersion at 37℃in the deoxygenated ATCC 1249 culture medium inocu-lated with *** X80 U-bend coupon’s weight loss-based uniform corrosion rate for the 12 cm^(2)surface was 60%of that for the unstressed flat square coupon(2.3 mg cm^(−2)vs.3.8 mg cm^(−2)).This was likely because the square coupon had wide MIC pits,providing a larger effective surface area for more sessile cells(4.2×10^(8)cells cm^(−2)on square coupon vs.2.4×10^(8)cells cm^(−2)on U-bend coupon)to attach and harvest more *** SCC failure occurred on an X80 U-bend pre-cracked at the outer bottom after a 6-week immersion in the *** *** from MIC damage,this could also be because *** metabolism increased the availability hydrogen atoms on the steel surface,and promoted the diffusion of hydrogen atoms into the metal lattice,thus increasing the brittleness of the steel.

关键词： Stress corrosion cracking Microbiologically influenced corrosion Sulfate reducing bacteria X80 U-bend steel Tensile stress

Wave effect of gravitational waves intersected with a microlens field:A new algorithm and supplementary study

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Science China(Physics,Mechanics & Astronomy) 2023年第3期66卷 156-168页

作者： Xikai Shan Guoliang Li Xuechun Chen wenwen Zheng Wen Zhao Department of Astronomy Beijing Normal UniversityBeijing 100875China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaChinese Academy of SciencesHefei 230026China

The increase in gravitational wave(GW) events has allowed receiving strong lensing image pairs of GWs. However, the wave effect(diffraction and interference) due to the microlens field contaminates the parameter estimation of the image pair, which may lead to a misjudgment of strong lensing signals. To quantify the influence of the microlens field, researchers need a large sample of statistical research. Nevertheless, due to the oscillation characteristic, the Fresnel-Kirchhoff diffraction integral’s computational time hinders this aspect’s study. Although many algorithms are available, most cannot be well applied to the case where the microlens field is embedded in galaxy/galaxy clusters. This work proposes a faster and more accurate algorithm for studying the wave optics effect of microlenses embedded in different types of strong lensing images. Additionally, we provide a quantitative estimation criterion for the lens plane boundary for the Fresnel-Kirchhoff diffraction integral. This algorithm can significantly facilitate the study of wave optics, particularly in the case of microlens fields embedded in galaxy/galaxy clusters.

关键词： gravitational waves gravitational micro lensing Fresnel-Kirchhoff diffraction integral