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基于穿透式模型的敏捷供应链管理

质量与可靠性 2024年第2期 55-61页

作者：高寒高文炜杨帆郭伟西安微电子技术研究所陕西西安710065 中国航天电子技术研究院北京100094

本文介绍了航天型号任务研制特点及供应链管理现状,论证了实施穿透式敏捷供应链管理的必要性。针对科研生产面临的多品种、多状态交织的新形势,构建了全级次穿透式供应链管理模型。结合单位实际,探索了适合本地化的供应链管理策略,以提... 详细信息

本文介绍了航天型号任务研制特点及供应链管理现状,论证了实施穿透式敏捷供应链管理的必要性。针对科研生产面临的多品种、多状态交织的新形势,构建了全级次穿透式供应链管理模型。结合单位实际,探索了适合本地化的供应链管理策略,以提升供应链管理水平,助力航天事业高质量、高效率、高效益发展。

关键词：供应链柔性穿透式敏捷管理

Wear behavior of Zn-38Al-3.5Cu-1.2Mg/SiC_(p) composite under different stabilization treatments

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International Journal of Minerals,Metallurgy and Materials 2022年第6期29卷 1270-1279页

作者： Sheng Liu Qing Yuan Yutong Sima Chenxi Liu Fang han wenwei Qiao The State Key Laboratory of Refractories and Metallurgy Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of EducationWuhan University of Science and TechnologyWuhan 430081China Wuhan Heavy Industry Casting&Forging Co.Ltd. China State Shipbuilding Corporation LimitedWuhan 430080China Jiangsu Huaneng Cable Company Limited Gaoyou 225613China

A Zn-38Al-3.5Cu-1.2Mg composite reinforced with nano-SiC_(p) was fabricated via stirring-assisted ultrasonic vibration.To improve the abrasive resistance of the Zn-38Al-3.5Cu-1.2Mg/SiC_(p) composite,several stabilization treatments with distinct solid solutions and aging temperatures were designed.The results indicated that the optimal stabilization treatment for the Zn-38Al-3.5Cu-1.2Mg/SiC_(p) composite comprised solution treatment at 380℃for 6 h and aging at 170℃for 48 h.The stabilization treatment led to the formation of dispersive and homogeneous nano-SiC_(p).During the friction wear condition,the nano-SiC_(p) limited the microstructure evolution from the hardα(Al,Zn)phase to the softβ(Al,Zn)phase.Moreover,the increased amount of nano-SiC_(p) improved the grain dimension and contributed to the composite abrasive resistance.Furthermore,the stabilization treatment suppressed the crack initiation and propagation in the friction wear process,thereby improving the abrasive resistance of the Zn-38Al-3.5Cu-1.2Mg/SiC_(p) composite.

关键词： composite ultrasonic vibration stabilization abrasive resistance microstructure evolution

Silica Nanoparticles with Virus-Mimetic Spikes Enable Efficient siRNA Delivery In Vitro and In Vivo

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Research 2023年第3期2022卷 281-294页

作者： Jianye Fu wenwei han Xue Zhang Yutong Sun Rajendra Bhadane Bo Wei Li Li Liangmin Yu Jinbo Yang Jessica MRosenholm Outi MHSalo-Ahen Taojian Fan Bin Zhang Wageh Swelm Ahmed AAl-Ghamdi Lin Xia han Zhang Meng Qiu Hongbo Zhang Xin Wang Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Collaborative Innovation Center for Optoelectronic Science&Technology International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationInstitute of Microscale OptoelectronicsCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Key Laboratory of Marine Chemistry Theory and Technology(Ocean University of China) Ministry of EducationQingdao 266100China College of Chemistry and Chemical Engineering China University of PetroleumQingdao 266555China. Pharmaceutical Sciences Laboratory Åbo Akademi University20520 TurkuFinland Structural Bioinformatics Laboratory BiochemistryÅbo Akademi University20520 TurkuFinland. Center for Innovation Marine Drug Screening&Evaluation Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Marine Biomedical Research Institute of Qingdao Qingdao 266100China Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia hangzhou No.14 High School Hangzhou 310000China Turku Bioscience Centre University of Turku andÅbo Akademi University20520 TurkuFinland

Oligonucleotide-based therapy has experienced remarkable development in the past 2 decades,but its broad applications are severely hampered by delivery vectors.Widely used viral vectors and lipid nanovectors are suffering from immune clearance after repeating usage or requiring refrigerated transportation and storage,respectively.In this work,amino-modified virus-mimetic spike silica nanoparticles(NH_(2)-SSNs)were fabricated using a 1-pot surfactant-free approach with controlled spike lengths,which were demonstrated with excellent delivery performance and biosafety in nearly all cell types and mice.It indicated that NH2-SSNs entered cells by spike-dependent cell membrane docking and dynamin-dependent endocytosis.The positively charged spikes with proper length on the surface can facilitate the efficient encapsulation of RNAs,protect the loaded RNAs from degradation,and trigger an early endosome escape during intracellular trafficking,similarly to the cellular internalization mechanism of virions.Regarding the fantastic properties of NH_(2)-SSNs in nucleic acid delivery,it revealed that nanoparticles with solid spikes on the surface would be excellent vehicles for gene therapy,presenting self-evident advantages in storage,transportation,modification,and quality control in large-scale production compared to lipid nanovectors.

关键词： surfactant loaded transportation

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李贽民族观的四维向度探赜

黎明职业大学学报 2024年第1期 20-26页

作者：谢坤宏骆文伟华侨大学马克思主义学院福建厦门361021

李贽出任姚安知府时,力排边疆民族地区治理难题,以民计民生为念,通过多方面施政举措推动姚安政清民安。李贽为姚安留下治绩,同时也为历史留下李贽民族观这一文化遗产。“至人之治”是李贽民族观的主要内涵,“华夷无间”是李贽民族观形... 详细信息

李贽出任姚安知府时,力排边疆民族地区治理难题,以民计民生为念,通过多方面施政举措推动姚安政清民安。李贽为姚安留下治绩,同时也为历史留下李贽民族观这一文化遗产。“至人之治”是李贽民族观的主要内涵,“华夷无间”是李贽民族观形成的重要逻辑。李贽民族观体现“和合共生”这一中华优秀传统文化重要基因,具有丰富的当代价值。当下要从形成时代背景、主要内涵、逻辑意蕴、当代价值等4个维度把握李贽民族观,古为今用,守正创新,推动中华民族共同体建设。

关键词：李贽民族观 “至人之治” 和合共生姚安府

基于超声影像的肱骨外上髁炎分型及其中医临床应用

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中医正骨 2024年第5期36卷 69-71页

作者：李言杰韩铭明王艳春王文伟河南省人民医院河南郑州450003

肱骨外上髁炎的主要病理改变是前臂伸肌总腱因慢性劳损而出现撕裂、钙化和退变。超声检查能清晰显示前臂伸肌总腱内部不同病变的回声状态,且能精准定位而引导侵入性治疗。本文基于前臂伸肌总腱的超声影像将肱骨外上髁炎分为钙化型、低... 详细信息

肱骨外上髁炎的主要病理改变是前臂伸肌总腱因慢性劳损而出现撕裂、钙化和退变。超声检查能清晰显示前臂伸肌总腱内部不同病变的回声状态,且能精准定位而引导侵入性治疗。本文基于前臂伸肌总腱的超声影像将肱骨外上髁炎分为钙化型、低回声型、混合回声型3型,并对这种分型在中医治疗该病疗法选择方面的临床应用进行了探讨,为实现肱骨外上髁炎的精准治疗提供参考。

关键词：网球肘超声检查中医药疗法

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金盆水库上游降雨径流二维泥沙输移沉积模拟

水力发电 2024年第5期50卷 21-26页

作者：樊文薇韩森王琦岩黄廷林高爱平马旭西安建筑科技大学环境与市政工程学院西北水资源与环境生态教育部重点实验室陕西西安710055 西安建筑科技大学环境与市政工程学院陕西省环境工程重点实验室陕西西安710055

为了探究降雨径流在不同流量、含沙量下对西安市金盆水库水体的影响规律,基于湍流流动模型,对2022年10月降雨径流时期西安市金盆水库上游的泥沙输移和沉积进行了数值模拟,并对所建立模型的可靠性进行了验证。通过对不同流量、含沙量下... 详细信息

为了探究降雨径流在不同流量、含沙量下对西安市金盆水库水体的影响规律,基于湍流流动模型,对2022年10月降雨径流时期西安市金盆水库上游的泥沙输移和沉积进行了数值模拟,并对所建立模型的可靠性进行了验证。通过对不同流量、含沙量下的径流进行模拟计算,表明在沿程前部断面处,流速越大底部含沙量越小;在沿程后部断面处,流速越大断面含沙量越高;径流含沙量越大,断面含沙量越大,泥沙分布厚度越大。因此,可以根据降雨径流时期来水的流量及含沙量分析泥沙输移沉积的过程,为水库的运行维护提供参考。

关键词：湍流模型数值模拟降雨径流泥沙输移沉积金盆水库

Dynamic tensile behavior of AZ31B magnesium alloy at ultra-high strain rates

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Chinese Journal of Aeronautics 2015年第2期28卷 593-599页

作者： Geng Changjian Wu Baolin Liu Fang Tong wenwei han Zhenyu Aviation Industry Corporation of China Engine Design and Research Institute School of Materials Science and Engineering Shenyang Aerospace University

The samples having {0001 } parallel to extruding direction （ED） present a typical true stress-true strain curve with concave-down shape under tension at low strain rate. Ultra-rapid ten- sile tests were conducted at room temperature on a textured AZ31B magnesium alloy. The dynamic tensile behavior was investigated. The results show that at ultra-high strain rates of 1.93 × 10^2 s^-1 and 1.70 × 10^3 s^-1, the alloy behaves with a linear stress-strain response in most strain range and exhibits a brittle fracture. In this case, {10-12} 〈 10-11 〉 extension twinning is basic deformation mode. The brittleness is due to the macroscopic viscosity at ultra-high strain rate, for which the external critical shear stress rapidly gets high to result in a cleavage fracture before large amounts of dislocations are activated. Because { 10-12} tension twinning, { 10-11 } compressive twinning, basal 〈 a 〉 slip, prismatic 〈 a 〉 slip and pyramidal 〈 c ＋ a 〉 slip have different critical shear stresses （CRSS）, their contributions to the degree of deformation are very differential. In addition, Schmid factor plays an important role in the activity of various deformation modes and it is the key factor for the samples with different strain rates exhibit various mechanical behavior under dynamic tensile loading.

关键词： AZ31B magnesium alloy Schmid factor Slip Texture Twinning

Genomic prediction of yield performance among single-cross maize hybrids using a partial diallel cross design

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The Crop Journal 2023年第6期11卷 1884-1892页

作者： Ping Luo Houwen Wang Zhiyong Ni Ruisi Yang Fei Wang Hongjun Yong Lin Zhang Zhiqiang Zhou Wei Song Mingshun Li Jie Yang Jianfeng Weng Zhaodong Meng Degui Zhang Jienan han Yong Chen Runze Zhang Liwei Wang Meng Zhao wenwei Gao Xiaoyu Chen Wenjie Li Zhuanfang Hao Junjie Fu Xuecai Zhang Xinhai Li State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China International Maize and Wheat Improvement Center(CIMMYT) Texcoco 56237Mexico College of Agronomy Xinjiang Agricultural UniversityUrumqi 830091XinjiangChina College of Agronomy Northeast Agricultural UniversityHarbin 150030HeilongjiangChina Institute of Cereal and Oil Crops Hebei Academy of Agriculture and Forestry SciencesShijiazhuang 050035HebeiChina Food Crops Research Institute Xinjiang Academy of Agricultural ScienceUrumqi 830091XinjiangChina Maize Research Institute of Shandong Academy of Agricultural Sciences Jinan 250100ShandongChina

Genomic prediction(GP)in plant breeding has the potential to predict and identify the best-performing hybrids based on the genotypes of their parental lines.In a GP experiment,34 elite inbred lines were selected to make 285 single-cross hybrids in a partial-diallel cross design.These lines represented a mini-core collection of Chinese maize germplasm and comprised 18 inbred lines from the Stiff Stalk heterotic group and 16 inbred lines from the Non-Stiff Stalk heterotic group.The parents were genotyped by sequencing and the 285 hybrids were phenotyped for nine yield and yield-related traits at two locations in the summer sowing area(SUS)and three locations in the spring sowing area(SPS)in the main maizeproducing regions of China.Multiple GP models were employed to assess the accuracy of trait prediction in the hybrids.By ten-fold cross-validation,the prediction accuracies of yield performance of the hybrids estimated by the genomic best linear unbiased prediction(GBLUP)model in SUS and SPS were 0.51 and 0.46,respectively.The prediction accuracies of the remaining yield-related traits estimated with GBLUP ranged from 0.49 to 0.86 and from 0.53 to 0.89 in SUS and SPS,respectively.When additive,dominance,epistasis effects,genotype-by-environment interaction,and multi-trait effects were incorporated into the prediction model,the prediction accuracy of hybrid yield performance was improved.The ratio of training to testing population and size of training population optimal for yield prediction were determined.Multiple prediction models can improve prediction accuracy in hybrid breeding.

关键词： Maize Genomic prediction Prediction model Genetic effects Hybrid performance

黄土高原人口变化对县域经济系统脆弱性的影响研究

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地理科学 2022年第11期42卷 2006-2018页

作者：袁倩文陈佳韩文维杨新军西北大学城市与环境学院陕西西安710127

以黄土高原地区县域为例,利用敏感性-应对能力模型评估了黄土高原地区2000年以来县域经济脆弱性特征及其时空变化,并结合ArcGIS空间技术与灰色关联分析探究人口变化对县域经济脆弱性的影响作用。研究发现:(1) 2000年黄土高原县域经济脆... 详细信息

以黄土高原地区县域为例,利用敏感性-应对能力模型评估了黄土高原地区2000年以来县域经济脆弱性特征及其时空变化,并结合ArcGIS空间技术与灰色关联分析探究人口变化对县域经济脆弱性的影响作用。研究发现:(1) 2000年黄土高原县域经济脆弱性等级以低和较低脆弱性等级为主导,而2010年低脆弱度区域面积开始出现减少,中、高脆弱度区域面积显著增加,2017年低和较低脆弱性等级的区域占土地面积比例增加,中、高脆弱度区域面积下降。总体来说,2000—2017年黄土高原地区县域经济脆弱性整体呈现出“先升高再降低”的趋势。(2)黄土高原县域经济脆弱性整体呈现“南高北低”的空间格局,处于高和较高水平的县区主要集中在甘肃东部部分县域和山西西部县域;中等水平的县区集中分布于甘肃省庆阳、平凉市东部县域、山西省大同、忻州市部分县域以及山西西部部分县域;省会城市所辖县区、地市周边地区的脆弱性水平最低。(3)表征人口变化的人口外流率、性别比和老年人口比重是影响黄土高原县域经济脆弱性关键因素,且不同时期人口变化对经济脆弱性的影响因素存在分异。

关键词：经济脆弱性人口变化县域黄土高原地区