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The First Detection of Echinococcus Granulosus DNA in Residents’Hands,Dogs’Hair,and Soil in Highly Endemic Region of Echinococcosis-Naqu City,Xizang Autonomous Region,China,2020

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China CDC weekly 2022年第44期4卷 982-985页

作者： Baixue Liu Chuizhao Xue Xu Wang wenting wu Shuai Han Weiping wu National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghaiChina Institute for Infectious Disease and Endemic Disease Control Beijing Center for Disease Prevention and ControlBeijingChina

Summary What is already known about this topic?Echinococcosis is a serious zoonotic parasitic disease that predominantly infects humans;domestic animals like cattle or sheep;as well as wild animals such as small rodents.To date,there is a lack of comprehensive information about all potential environmental transmission routes for Echinococcus.What is added by this report?This study assesses the importance of under-researched environmental factors for the transmission of Echinococcus.It concludes that hand hygiene is an important factor in the robust environmental transmission of Echinococcus granulosus.What are the implications for public health practice?This study suggests that residents are at risk of catching echinococcosis through hand-oral transmission routes.Health education given to local residents is thus a key intervention,as well as avoiding close contact with dogs and ensuring proper hand-washing practices are followed.

关键词： residents Highly education

Exploring visitors’visual perception along the spatial sequence in temple heritage spaces by quantitative GIS methods:a case study of the Daming Temple,Yangzhou City,China

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Built Heritage 2023年第4期7卷 91-109页

作者： Kai Zhou wenting wu Tianjie Li Xiaoling Dai School of Design and Architecture Zhejiang University of Technology288 Liuhe RdWest Lake DistrictHangzhou310023China

The Daming Temple,built during 457–464 C.E.,is one of the developing ancient temple heritage spaces located in Yangzhou city,P.R.China.Over the past 60 years,variation in visitors’spatial perception along the tour routes in the temple has occurred.This research attempts to reveal the changes in visitors’visual perception along the spatial sequences at 3 different times(i.e.,1962,1973 and 2022).A quantitative GIS-based method,which includes analysing the distribution of visitors’spatial preferences and spatial configuration,is proposed.Digital landscape tools and quantitative estimation methods are used,including mapping within Rhinoceros software,the kernel density estimation(KDE)method within ArcGIS software and spatial syntax analysis within DepthMap software.Extracted geodata from 500 photographs of the heritage space taken by volunteer visitors are analysed within the GIS environment.Values of the mean depth(MD)at both levels of visibility and accessibility are calculated within the visibility graph analysis(VGA)model.Comparisons between the visual preferences of the visitors and the spatial configuration along the spatial sequence are conducted.The results indicate that the spatial sequence has a significant impact on visitors’visual preferences and tour routes.The phenomenon of spatial sequence among dynamic temporal variations and the effects of narrative spaces along the spatial sequence are highlighted and explained,which reveal the relationship between visitors’geospatial preference and the spatial configuration of the temple.Some suggestions are put forwards for further studies on the revitalisation and management of East Asian ancient temple heritage spaces.

关键词： temple heritage space visual preference spatial sequence spatial configuration GIS

De novo Transcriptome Analysis in Leymus mollis to Unveil Genes Involved in Salt Stress Response

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Phyton-International Journal of Experimental Botany 2022年第8期91卷 1629-1642页

作者： wenting wu Yajing Zhang Yu Gao Kai Zhang Luying Zhu Hongxia Zhang College of Agriculture Ludong UniversityYantai264025China Engineering Research Institute of Agriculture and Forestry Ludong UniversityYantai264025China Key Laboratory of Molecular Module-Based Breeding of High Yield and Abiotic Resistant Plants in Universities of Shandong Ludong UniversityYantai264025China

Leymus mollis,a wild relative of wheat,is very tolerant to salt stress,and has been considered as a valuable genetic resource for wheat breeding.However,the genetic basis for salt tolerance of this species is still largely unknown.In this study,de novo sequencing,assembly and analysis of L.mollis transcriptome in response to salt stress was performed.A total of 110,323 and 112,846 unigenes were generated for the NaCl-free(CK)and 180 mM NaCl-treated(CT)library,respectively.For the two libraries,73,414 unigenes were successfully annotated in five common protein databases,and 7521 differentially expressed genes(DEGs)between CK and CT libraries were identified.GO enrichment analysis of the DEGs showed that the significantly enriched GO terms were predominantly involved in environmental adaptation(including“response to abiotic stimulus”,“response to water deprivation”),regulation of signaling pathway(such as“regulation of abscisic acid mediated signaling pathway”,“regulation of cell communication”),and photosynthesis(including“response to light stimulus”,“photosynthesis,light harvesting”and“chlorophyll metabolic process”).KEGG pathway enrichment analysis showed that“mRNA surveillance pathway”,“RNA transport”and“plant hormone signal transduction”were predominantly enriched pathways,followed by several secondary metabolic pathways,photosynthesis,carbohydrate metabolism and lipid metabolism.In addition,DEGs related to osmotic stress,ion homeostasis and oxidative stress,including four dehydrins,five aquaporins,an LmNHX2 and several antioxidant enzymes or proteins genes,were found to be up-regulated in response to salt stress.These results will be helpful for further studies on the molecular mechanisms of salt responses in L.mollis.

关键词： Leymus mollis transcriptome salt stress

A neuropsin-based optogenetic tool for precise control of Gq signaling

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Science China(Life Sciences) 2022年第7期65卷 1271-1284页

作者： Ruicheng Dai Tao Yu Danwei Weng Heng Li Yuting Cui Zhaofa wu Qingchun Guo Haiyue Zou wenting wu Xinwei Gao Zhongyang Qi Yuqi Ren Shu Wang Yulong Li Minmin Luo National Institute of Biological Sciences(NIBS) Beijing 102206China School of Life Sciences Tsinghua UniversityBeijing 100084China School of Life Sciences Peking UniversityBeijing 100871China Graduate School of Peking Union Medical College Beijing 100730China Chinese Institute for Brain Research Beijing 102206China Tsinghua Institute of Multidisciplinary Biomedical Research(TIMBR) Beijing 102206China Peking University-Tsinghua University-NIBS Joint Graduate Program NIBSBeijing 102206China State Key Laboratory of Membrane Biology Peking University School of Life SciencesBeijing 100871China PKU-McGovern Institute for Brain Research Beijing 100871China Capital Medical University Beijing 102206China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China

G_(q)-coupled receptors regulate numerous physiological processes by activating enzymes and inducing intracellular Ca^(2+)signals.There is a strong need for an optogenetic tool that enables powerful experimental control over G_(q) signaling.Here,we present chicken opsin 5(cOpn5)as the long sought-after,single-component optogenetic tool that mediates ultra-sensitive optical control of intracellular G_(q) signaling with high temporal and spatial resolution.Expressing cOpn5 in HEK 293T cells and primary mouse astrocytes enables blue light-triggered,G_(q)-dependent Ca^(2+) release from intracellular stores and protein kinase C activation.Strong Ca^(2+) transients were evoked by brief light pulses of merely 10 ms duration and at 3 orders lower light intensity of that for common optogenetic tools.Photostimulation of cOpn5-expressing cells at the subcellular and single-cell levels generated fast intracellular Ca^(2+)transition,thus demonstrating the high spatial precision of cOpn5 optogenetics.The cOpn5-mediated optogenetics could also be applied to activate neurons and control animal behavior in a circuit-dependent manner.cOpn5 optogenetics may find broad applications in studying the mechanisms and functional relevance of G_(q) signaling in both non-excitable cells and excitable cells in all major organ systems.

关键词： chicken opsin 5 astrocytes photostimulation Ca^(2+)imaging IP3 protein kinase C neural circuit

Boosting Transport Kinetics of Ions and Electrons Simultaneously by Ti3C2Tx(MXene)Addition for Enhanced Electrochromic Performance

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Nano-Micro Letters 2021年第1期13卷 381-393页

作者： wenting wu Huajing Fang Hailong Ma Liangliang wu Wenqing Zhang Hong Wang State Key Laboratory for Mechanical Behavior of Materials School of Material Science and EngineeringXi’an Jiaotong UniversityXi’an 710049People’s Republic of China School of Electronic and Information Engineering and State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China Department of Physics Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Shenzhen Engineering Research Center for Novel Electronic Information Materials and Devices Southern University of Science and TechnologyShenzhen 518055People’s Republic of China

Electrochromic technology plays a significant role in energy conservation,while its performance is greatly limited by the transport behavior of ions and electrons.Hence,an electrochromic system with overall excellent performances still need to be explored.Initially motivated by the high ionic and electronic conductivity of transition metal carbide or nitride(MXene),we design a feasible procedure to synthesize the MXene/WO3−x composite electrochromic film.The consequently boosted electrochromic performances prove that the addition of MXene is an effective strategy for simultaneously enhancing electrons and ions transport behavior in electrochromic layer.The MXene/WO3−x electrochromic device exhibits enhanced transmittance modulation and coloration efficiency(60.4%,69.1 cm^2 C^−1),higher diffusion coefficient of Li+and excellent cycling stability(200 cycles)over the pure WO3−x device.Meanwhile,numerical stimulation theoretically explores the mechanism and kinetics of the lithium ion diffusion,and proves the spatial and time distributions of higher Li+concentration in MXene/WO3−x composite electrochromic layer.Both experiments and theoretical data reveal that the addition of MXene is effective to promote the transport kinetics of ions and electrons simultaneously and thus realizing a high-performance electrochromic device.This work opens new avenues for electrochromic materials design and deepens the study of kinetics mechanism of ion diffusion in electrochromic devices.

关键词： Electrochromic Mxene Transport kinetics Ionic conductivity Tungsten oxide

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流行服装图案设计中生态印染技术的应用探析

纺织报告 2024年第1期43卷 49-51页

作者：毋文婷河池学院广西河池546300

随着社会和经济的快速发展,生态理念开始融入各个行业,为行业发展提供了全新的思路。为了解决服装行业以往的污染等问题,实现环保目标,生态印染技术应运而生并且被广泛应用于实践中,展现出较好的应用效果。因此,为了进一步促进生态印染... 详细信息

随着社会和经济的快速发展,生态理念开始融入各个行业,为行业发展提供了全新的思路。为了解决服装行业以往的污染等问题,实现环保目标,生态印染技术应运而生并且被广泛应用于实践中,展现出较好的应用效果。因此,为了进一步促进生态印染技术的应用,文章在明确技术相关内容、具体应用的基础上明确技术的应用价值,并且提出有效应用措施,在不断创新流行服装图案设计的同时,开辟出全新的行业发展道路,为服装行业的进一步发展提供支持。

关键词：流行服装图案设计生态印染技术

Intramolecular Charge Transfer-Enhanced BODIPY Photosensitizer in Photoinduced Electron Transfer and Its Application to Photoxidation under Mild Condition

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Chinese Journal of Chemistry 2015年第11期33卷 1251-1258页

作者： Ruiqin Wang Ying Geng Lili Zhang wenting wu Weiyu Fan Zhongtao Li Lizhuo Wang Liying Zhan Xueyan wu Mingbo wu State Key Laboratory of Heavy Oil Processing School of Chemical Engineering China University of Petroleum Qingdao Shandong 266580 China ~cience and Techology Bureau of Huangdao Qingdao Shandong 266400 China

Photoinduced electron transfer process is a crucial step in photooxidation to obtain synthetic chemicals. How- ever, the driving forces of electron transfer as priority in all have been rarely studied in stepwise detail. Herein, we report a series of BODIPY derivatives with an emphasis on the intramolecular charge transfer, enhancing the key step of photoinduced electron transfer process and photooxidation performances. A series of novel BODIPY photosensitizers （B-1--B-5） were prepared, wherein diethylamine amino of B-3 as charge injection group was conjugated to the 2,6-diiodo-styryl-BODIPY, and the electron transfer impetus was enhanced 1.6 times due to its more negative redox potentials. These results were also confirmed by the DFT/TDDFT calculation. Without pure oxygen, B-3 still can exhibit an exceptional performance in photoxidative aromatization of 1,4-DHP under mild condition. After irradiation for 28 rain, the conversion rate came to 98.2%.

关键词： intramolecular charge transfer photoinduced electron transfer BODIPY photosensitizers photoxidation

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水压驱动两级提拉式水下发射装置内弹道建模

兵工学报 2024年第2期45卷 594-605页

作者：丁彦超王宝寿吴文婷刘新辉童心中国船舶科学研究中心深海技术科学太湖实验室江苏无锡214082

针对大深度环境水下发射技术需求,提出一种利用水压驱动两级提拉式水下新型发射方案。利用大深度环境高压水驱动两级活塞实现武器快速发射。建立武器出管过程动力学模型,开展高压水驱动方案原理验证试验,并与高压气体驱动方案进行了对... 详细信息

针对大深度环境水下发射技术需求,提出一种利用水压驱动两级提拉式水下新型发射方案。利用大深度环境高压水驱动两级活塞实现武器快速发射。建立武器出管过程动力学模型,开展高压水驱动方案原理验证试验,并与高压气体驱动方案进行了对比分析。研究结果表明:水压驱动与气体驱动方案的内弹道结果基本一致,高压水发射方案在大深度环境具有显著优势;加速度峰值出现在发射瞬时和级间转换过程,级间转换过程武器加速度存在显著的陡变现象;水下发射武器出管过程弹道预报结果得出,在发射水深100~500 m条件下,武器出管过程最大速度范围为7.4~15.3 m/s,最大加速度小于100 m/s 2;研究结果验证了水压驱动两级活塞式发射方案的可行性,为装置的进一步研制开发提供了设计依据。

关键词：大深度水下发射水压驱动两级活塞缸内弹道建模

表皮生长因子受体突变的肺腺癌转化为肉瘤的临床分析

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中华结核和呼吸杂志 2024年第1期47卷 24-30页

作者：祝清清杜明占吴文婷郭凌川黄建安沈旦苏州大学附属第一医院呼吸与危重症医学科苏州215006 苏州大学附属第一医院病理科苏州215006

目的组织学转化是非小细胞肺癌(non-small cell lung cancer,NSCLC)表皮生长因子受体(epidermal growth factor receptor,EGFR)-酪氨酸激酶抑制剂(tyrosine kinase inhibitor,TKI)耐药的一种形式,其中以小细胞癌转化多见,肉瘤转化鲜有报道。本文报道1例肺腺癌EGFR-TKI耐药后转化为肉瘤的临床资料,并复习文献,以提高对该耐药机制的认识。方法收集该例肺腺癌EGFR-TKI耐药后肉瘤转化患者的诊治过程、病理特征、临床转归等资料,并检索文献,对腺癌耐药后肉瘤样癌/肉瘤转化的发生机制、患者的临床特点以及治疗方案等进行分析。结果本例患者接受埃克替尼一线治疗后出现EGFR-T790M突变,二线使用阿美替尼治疗后出现肉瘤转化,随后行化疗、放射性粒子植入、抗血管生成治疗及免疫治疗等,效果均不理想。检索文献未见EGFR-TKI耐药肺腺癌转化为肉瘤的相关报道,14例腺癌转化为肉瘤样癌的相关报道中,8例伴EGFR突变,3例伴ALK突变,2例ROS1突变,1例未见相关敏感突变;14例患者转为肉瘤样癌后中位存活时间仅为3个月。结论肉瘤组织转化可为肺腺癌患者EGFR-TKI治疗后耐药的形式之一,腺癌患者肉瘤样转化后预后较差。

关键词：肺腺癌 EGFR-TKI耐药肉瘤转化