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Direct interaction between CD155 and CD96 promotes immunosuppression in lung adenocarcinoma

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Cellular & Molecular Immunology 2021年第6期18卷 1575-1577页

作者： Hui Zhang Qianwen Liu Yiyan Lei Jianwen Zhou wenting jiang Yongmei Cui Qiong He Junfeng Zhu Zheng Zhu Yu Sun Zunfu Ke Institute of Precision Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China Department of Rheumatology The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China Department of Thoracic Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou510080China Department of Thoracic Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China Department of Pathology The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China Department of Pathology Longgang Central Hospital of ShenzhenAffiliated Longgang Hospital of Zunyi Medical UniversityShenzhen518116China

Despite the advance in targeted therapy,lung adenocarcinoma(LUAD)remains one of the leading causes of death in patients with ***155,a member of poliovirus receptor–related(PRR)family,has been identified as the ligand of the Ig-like receptors tactile(CD96)and DNAM-1(CD226)on T *** interaction of CD155 with CD96 transmits an inhibitory signal and suppresses immune *** interaction of CD155 with CD226 enhances the immune response.1,2,3 CD155 expression has been shown to be elevated in many types of cancers4,5 and is involved with immune suppression in melanoma.6 However,how CD155/CD96 is involved in immune response in the tumor microenvironment of LUAD remains unknown.

关键词： CD155 adenocarcinoma lung

Molecular simulation-based research on antifreeze peptides:advances and perspectives

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Journal of Future Foods 2022年第3期2卷 203-212页

作者： wenting jiang Fujia Yang Xu Chen Xixi Cai Jinhong Wu Ming Du Jianlian Huang Shaoyun Wang College of Biological Science and Engineering Fuzhou UniversityFuzhou 350108China School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240China School of Food Science and Technology Dalian Polytechnic UniversityDalian 116034China Key Laboratory of Refrigeration and Conditioning Aquatic Products Processing of Ministry of Agriculture and Rural Affairs Xiamen 361022China Fujian Anjoy Foods Co.Ltd. Xiamen 361022China

Antifreeze protein(AFP)can inhibit the growth of ice crystals to protect organisms from freezing damage,and demonstrates broad application prospects in food *** peptides(AFPP)are specifi c peptides with functional domains showing antifreeze activity in ***-based molecular simulation technology can more accurately explain the properties and mechanisms of biological ***,the binding stability of antifreeze peptides and antifreeze proteins(AFP(P))to ice and the molecular-scale growth kinetics of ice were analyzed by molecular simulation,which can make up for the limitations of experimental *** review concludes the molecular simulation-based research in the inhibition’s study of AFP(P)on ice growth,including sequence prediction,structure construction,molecular docking and molecular dynamics(MD)studies of AFP(P)on ice applications in growth ***,the review prospects the future direction of designing new antifreeze biomimetic materials through molecular simulation and machine *** information presented in this paper will help enrich our understanding of AFPP.

关键词： Antifreeze peptides Structure construction Sequence prediction Molecular docking Molecular dynamic

An Analytical Method to Detect the Coupling Damage Relationship of Concrete Subjected to Bending Fatigue and Temperature Actions

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Journal of Wuhan University of Technology(Materials Science) 2011年第3期26卷 573-577页

作者：李文婷 School of Materials Science and Engineering Southeast University

Based on the assumptions validated by the experiments,an analytical method to detect the coupling actions of bending fatigue and temperature on concrete was *** this purpose,a coefficient denoted by f D （T）with the strain distributions caused by these two actions was *** terms of the known parameters and the fitted functions of strain,the explicit expression for f D （T）which develops in the way same as the law of temperature change in the body of specimens was *** experimental results indicate that the weigh fraction of temperature stress decreases in the coupling damage field with the fading temperature gradient,and consequently disclose the mutual influence between these two types of actions in the loading history.

关键词： analytical method coupling damage concrete bending fatigue temperature

Tuning Fractional Order Proportional Integral Controllers Based on Vector in the Complex Plane for First Order Systems

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Tuning Fractional Order Proportional Integral Controllers Ba...

第26届中国控制与决策会议

作者： Chunyang Wang Nianchun Cai Lu Wang wenting jiang School of Electronic and Information Engineering Changchun University of Science and Technology

In this paper, an improved fractional order proportional integral controller parameter tuning method has been proposed. This method is to map the controller to get a set of vectors in the complex plane. Following the method of vector and geometric in the complex plane, the complicated derivation and calculation can be simplified in the process of the controller design. In addition, the established geometric relationship equations not only can still be used when the plant is different, but also can be programmed in MATLAB. Therefore, the repetitive process of formula derivation can be omitted. Because of the triangle constraints in the complex plane, we can solve the problem that using MATLAB to calculate the controller parameters has multiple solutions.

关键词： Fractional order proportional integral controller The complex plane Vectors Tuning

来源： cnki会议评论

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空气分级燃烧炉内壁面硫化物分布的数值模拟

动力工程学报 2016年第2期36卷 91-98页

作者：秦明姜文婷吴少华哈尔滨工业大学能源科学与工程学院哈尔滨150001

以某600 MW超超临界锅炉为研究对象,采用数值模拟方法研究了硫化物气体在炉内还原区水冷壁壁面区域的分布特性.结果表明:SO_2主要分布在主燃烧器壁面区域,而H_2S主要分布在分离燃尽风(SOFA)与主燃烧器之间的壁面区域,且该区域的氧量极低... 详细信息

以某600 MW超超临界锅炉为研究对象,采用数值模拟方法研究了硫化物气体在炉内还原区水冷壁壁面区域的分布特性.结果表明:SO_2主要分布在主燃烧器壁面区域,而H_2S主要分布在分离燃尽风(SOFA)与主燃烧器之间的壁面区域,且该区域的氧量极低,温度又较高,发生高温腐蚀的可能性更大;随着燃料中含硫量的增大,壁面区域的硫化物气体质量分数有所提高,但并不显著,而高质量分数硫化物气体所占区域面积却明显增大,在主燃烧器的局部区域,壁面也出现了H_2S质量分数较高的区域.

关键词：空气分级燃烧高温腐蚀硫化物数值模拟

Nitrogen-doping assisted local chemical heterogeneity and mechanical properties in CoCrMoW alloys manufactured via laser powder bed fusion

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Advanced Powder Materials

Advanced Powder Materials 2024年第5期3卷 46-57页

作者： wenting jiang Ruidi Li Junyang He Song Ni Li Wang Zibin Chen Yi Huang Caiju Li Jianhong Yi Min Song State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China College of Materials and Advanced Manufacturing Hunan University of TechnologyZhuzhou 412007China Research Institute for Advanced Manufacturing Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHong KongChina Department of Design and Engineering Faculty of Science and TechnologyBournemouth UniversityPooleDorsetBH125BBUK Materials Research Group Department of Mechanical EngineeringUniversity of SouthamptonSouthamptonSO171BJUK Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China

CoCrMoW alloys with different nitrogen(N)additions(0,0.05,0.1,and 0.2 wt%)were prepared via laser powder bed fusion(LPBF).The effects of N content on the microstructure and mechanical properties were *** results indicate that the LPBFed CoCrMoW alloy with 0.1 wt%N addition(0.1 N alloy)shows the best combination of mechanical properties with a yield strength of~983 MPa and an elongation of~19%.Both the LPBF process and the N addition impose great effects on suppressing theγtoεmartensitic transformation,resulting in a decrease in the width and amount ofεlaths/stacking ***,the N addition promotes the segregation of elements Mo,W,and Si along the cellular sub-grain boundaries(CBs),forming fine and discontinuous precipitates rich in Mo,W and Si along the CBs in the 0.1 N alloy,but dense and continuous(Mo,W)5Si_(3)precipitates along the CBs in the 0.2 N ***(Mo,W)5Si_(3)precipitates with a tetragonal structure were observed and characterized for the first time in the Co-Cr based *** negative mixing enthalpy between the non-metallic elements N,Si and the metallic elements Mo,W,Cr,and the rapid solidification induced segregation of high melting point elements such as Mo and W along CBs during LPBF process,synergistically contribute to the chemical heterogeneity in the *** pure FCC matrix,the slightly increased segregation of Mo,W,Si elements and fine precipitates along the CBs contribute to the good combination of strength and elongation of the 0.1 N ***,though pure FCC phase was present in the 0.2 N alloy,the dense and continuous(Mo,W)5Si_(3)precipitates along CBs acted as nucleation sites for cracks,deteriorating the elongation of the ***,it is possible to tune the mechanical properties of the LPBFed CoCrMoW alloy by adjusting the local chemical heterogeneity.

关键词： CoCrMoW alloy Laser powder bed fusion Nitrogen addition Mechanical properties Precipitation behaviors

日本落叶松谷胱甘肽过氧化物酶(GPX)酶学特性与抗逆性研究

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北京林业大学学报 2023年第2期45卷 78-86页

作者：张萌姜文婷王雪纯蒋湘宁盖颖北京林业大学生物科学与技术学院树木花卉育种生物工程国家林业和草原局重点实验室林木育种国家工程实验室北京100083

【目的】植物谷胱甘肽过氧化物酶(GPX)是酶促活性氧清除机制中的关键酶之一,对日本落叶松GPX开展酶学特性与抗逆性研究,可以补充和完善林木改良基因资源,也为探究谷胱甘肽过氧化物酶抗逆的分子机制提供理论依据。【方法】本研究以日本... 详细信息

【目的】植物谷胱甘肽过氧化物酶(GPX)是酶促活性氧清除机制中的关键酶之一,对日本落叶松GPX开展酶学特性与抗逆性研究,可以补充和完善林木改良基因资源,也为探究谷胱甘肽过氧化物酶抗逆的分子机制提供理论依据。【方法】本研究以日本落叶松茎部组织为材料克隆谷胱甘肽过氧化物酶基因,进行生物信息学分析和亚细胞定位研究。诱导、纯化目的蛋白进行体外酶学活性测定,通过点斑试验、生长曲线试验验证GPX抗逆性。【结果】从日本落叶松茎中克隆得到了2个GPX基因,分别命名为LkGPX2、LkGPX3,二者都含有完整的特征保守基序。构建系统进化树发现,LkGPXs和具有抗逆功能的PmGPX与PeGPX聚为一支。亚细胞定位显示,LkGPX2和LkGPX3蛋白在细胞核和细胞质中均有表达。以硫氧还蛋白(Trx)为电子供体进行体外酶学活性测定,LkGPX2与LkGPX3对过氧化氢(H2O2)、过氧化氢叔丁醇(t-BHP)和有机氢过氧化物(Cum-OOH)都具有催化活性,LkGPX2对于3种底物的催化活性分别为(0.402±0.037)、(0.424±0.018)、(0.425±0.009)U/mg,LkGPX3对于3种底物的催化活性分别为(0.397±0.027)、(0.449±0.028)、(0.407±0.021)U/mg。大肠杆菌体外逆境处理试验表明,LkGPX2、LkGPX3能够提高大肠杆菌对模拟干旱胁迫和盐胁迫的耐受性。【结论】日本落叶松谷胱甘肽过氧化物酶(GPX)既能起到活性氧清除作用,同时具备一定应对非生物胁迫的能力。

关键词：日本落叶松谷胱甘肽过氧化物酶亚细胞定位酶学性质抗逆

城市道路隧道附属设施(地下设备用房)布置研究

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隧道建设（中英文） 2019年第S02期39卷 242-252页

作者：冯励凡姜文婷单浩然上海市政工程设计研究总院(集团)有限公司上海200092

为解决城市道路隧道设计中附属设施布置的难题,将城市道路隧道附属设施(地下设备用房)作为研究对象,对其类型进行分类,归纳其功能和特点,并以此为基础从前期选址、设计过程中需要重点考虑的因素和出地面建(构)筑物的景观设计3个方面结... 详细信息

为解决城市道路隧道设计中附属设施布置的难题,将城市道路隧道附属设施(地下设备用房)作为研究对象,对其类型进行分类,归纳其功能和特点,并以此为基础从前期选址、设计过程中需要重点考虑的因素和出地面建(构)筑物的景观设计3个方面结合实际案例进行归纳和总结。最后提出城市道路隧道附属设施的布置方法,即通过前期策划、多方案比选、着重解决附属设施的主要矛盾、在满足功能的基础上减小对周边的影响,最终实现城市道路附属设施与周边环境的和谐统一。

关键词：城市隧道附属设施布置方案

乳腺癌病人乳腺癌相关淋巴水肿发生风险及其与发病情况的关联效应分析

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护理研究 2022年第18期36卷 3338-3343页

作者：蒋文婷陈丽君广西医科大学附属肿瘤医院广西530021

目的:分析乳腺癌病人乳腺癌相关淋巴水肿(BCRL)发生风险、发病情况及两者之间的关联效应。方法:选取2019年1月—2020年12月广西医科大学附属肿瘤医院因乳腺癌住院治疗的1441例病人为研究对象,采用一般资料调查表、Additive风险评分系统... 详细信息

目的:分析乳腺癌病人乳腺癌相关淋巴水肿(BCRL)发生风险、发病情况及两者之间的关联效应。方法:选取2019年1月—2020年12月广西医科大学附属肿瘤医院因乳腺癌住院治疗的1441例病人为研究对象,采用一般资料调查表、Additive风险评分系统、Norman电话问卷对病人进行调查。结果:1441例乳腺癌术后病人中,BCRL高风险病人751例(52.12%),BCRL低风险病人690例(47.88%)。BCRL高风险病人年龄≥60岁、体质指数(BMI)≥25 kg/m^(2)、居住地为城市、行化疗或放疗、术后发生感染的比例均高于BCRL低风险病人,且BCRL高风险病人和BCRL低风险病人婚姻状况、医疗付费方式、临床分期、肿瘤部位、放疗区域、腋窝淋巴结清扫级别、手术方式、手术切口类型、治疗方式、腋窝淋巴结清扫类型、术后时长比较,差异均有统计学意义(P<0.05)。751例BCRL高风险病人中,283例(37.68%)患BCRL,468例(62.32%)未患BCRL;690例BCRL低风险病人中,85例(12.32%)患BCRL,605例(87.68%)未患BCRL。与患BCRL的低风险病人相比,高风险病人采用腋窝淋巴结清扫术者较多、接受放疗或化疗者比例较高、重度水肿比例较高、BCRL发生时间较早、接受治疗次数较多、坚持自我照护者较多、自我照护时间较长。BCRL风险暴露和BCRL发病情况的关联效应结果显示,BCRL高风险暴露因素与BCRL发病情况为强关联,BCRL低风险暴露因素与BCRL发病情况为弱关联,关联具有统计学意义(P<0.05)。结论:乳腺癌病人中BCRL高风险者较多且与BCRL发生的关联强度较大。需关注BCRL高风险病人,尽早采取有效的预防和管理措施进行干预,减少或避免BCRL发生。

关键词：乳腺癌淋巴水肿风险关联效应护理