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Protein tyrosine phosphatases in skeletal development and diseases

Bone Research 2022年第1期10卷 1-19页

作者： Huiliang yang Lijun Wang Christian Shigley wentian yang Department of Orthopaedic Surgery and Orthopaedic Research Institute West China Hospital of Sichuan UniversityChengdu 610041SichuanChina Department of Orthopaedic Surgery Rhode Island Hospital and Brown University Alpert Medical SchoolProvidenceRI 02903USA

Skeletal development and homeostasis in mammals are modulated by finely coordinated processes of migration, proliferation,differentiation, and death of skeletogenic cells originating from the mesoderm and neural crest. Numerous molecular mechanisms are involved in these regulatory processes, one of which is protein posttranslational modifications, particularly protein tyrosine phosphorylation(PYP). PYP occurs mainly through the action of protein tyrosine kinases(PTKs), modifying protein enzymatic activity, changing its cellular localization, and aiding in the assembly or disassembly of protein signaling complexes. Under physiological conditions, PYP is balanced by the coordinated action of PTKs and protein tyrosine phosphatases(PTPs).Dysregulation of PYP can cause genetic, metabolic, developmental, and oncogenic skeletal diseases. Although PYP is a reversible biochemical process, in contrast to PTKs, little is known about how this equilibrium is modulated by PTPs in the skeletal ***-genome sequencing has revealed a large and diverse superfamily of PTP genes(over 100 members) in humans, which can be further divided into cysteine(Cys)-, aspartic acid(Asp)-, and histidine(His)-based PTPs. Here, we review current knowledge about the functions and regulatory mechanisms of 28 PTPs involved in skeletal development and diseases;27 of them belong to class Ⅰ and Ⅱ Cys-based PTPs, and the other is an Asp-based PTP. Recent progress in analyzing animal models that harbor various mutations in these PTPs and future research directions are also discussed. Our literature review indicates that PTPs are as crucial as PTKs in supporting skeletal development and homeostasis.

关键词： harbor supporting Whole

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Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis

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Bone Research 2021年第1期9卷 75-85页

作者： Lijun Wang Huiliang yang Jiahui Huang Shaopeng Pei Liyun Wang Jian Q.Feng Dian Jing Hu Zhao Henry M.Kronenberg Douglas C.Moore wentian yang Department of Orthopedic Surgery Brown University Alpert Medical School and Rhode Island HospitalProvidenceRI 02903USA Department of Mechanical Engineering University of DelawareNewarkDE DE19716USA Department of Biomedical Sciences Texas A&M College of Dentistry3302 Gaston AveDallasTX 75246USA Department of Comprehensive Dentistry Texas A&M College of Dentistry3302 Gaston AveDallasTX 75246USA Endocrine Unit Massachusetts General Hospital and Harvard Medical SchoolBostonMA 02114USA

The maturation and function of osteoblasts(OBs)rely heavily on the reversible phosphorylation of signaling *** date,most of the work in OBs has focused on phosphorylation by tyrosyl kinases,but little has been revealed about dephosphorylation by protein tyrosine phosphatases(PTPases).SHP2(encoded by PTPN11)is a ubiquitously expressed ***11 mutations are associated with both bone and cartilage manifestations in patients with Noonan syndrome(NS)and metachondromatosis(MC),although the underlying mechanisms remain ***,we report that SHP2 deletion in bone gamma-carboxyglutamate protein-expressing(Bglap+)bone cells leads to massive osteopenia in both trabecular and cortical bones due to the failure of bone cell maturation and enhanced osteoclast activity,and its deletion in Bglap+chondrocytes results in the onset of enchondroma and osteochondroma in aged mice with increased tubular bone ***,SHP2 was found to be required for osteoblastic differentiation by promoting RUNX2/OSTERIX signaling and for the suppression of osteoclastogenesis by inhibiting STAT3-mediated RANKL production by osteoblasts and *** findings are likely to explain the compromised skeletal system in NS and MC patients and to inform the development of novel therapeutics to combat skeletal disorders.

关键词： skeletal homeostasis SHP2

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SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity

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Bone Research 2018年第2期6卷 132-144页

作者： Chunlin Zuo Lijun Wang Raghavendra M.Kamalesh Margot E.Bowen Douglas C.Moore Mark S.Dooner Anthony M.Reginato Qian Wu Christoph Schorl Yueming Song Matthew L.Warman Benjamin G.Neel Michael G.Ehrlich wentian yang Department of Orthopaedics Brown University Alpert Medical School and Rhode Island HospitalProvidenceRI 02903USA Orthopaedic Research Laboratories and Howard Hughes Medical Institute Boston Children's Hospital and Department of GeneticsHarvard Medical SchoolBostonMA 02115USA Division of Hematology and Oncology Brown University Alpert Medical School and Rhode Island HospitalProvidenceRI 02903USA Division of Rheumatology Brown University Alpert Medical School and Rhode Island HospitalProvidenceRI 02903USA Department of Pathology and Laboratory Medicine University of Connecticut Health CenterFarmingtonCT 06030USA Department of Molecular and Cell Biology and Biochemistry Brown University70 Ship StreetProvidenceRI 02912USA Department of Orthopedic Surgery West China Hospital of Sichuan UniversityChengdu 610041 Laura and Issac Perlmutter Cancer Center NYU Langone Medical CenterNew YourkNY 10016USA Department of Endocrinology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China

Chondrocytes and osteoblasts differentiate from a common mesenchymal precursor, the osteochondroprogenitor（OCP）, and help build the vertebrate skeleton. The signaling pathways that control lineage commitment for OCPs are incompletely understood. We asked whether the ubiquitously expressed protein-tyrosine phosphatase SHP2（encoded by Ptpn11） affects skeletal lineage commitment by conditionally deleting Ptpn11 in mouse limb and head mesenchyme using ＂Cre-lox P＂-mediated gene ***2-deficient mice have increased cartilage mass and deficient ossification, suggesting that SHP2-deficient OCPs become chondrocytes and not osteoblasts. Consistent with these observations, the expression of the master chondrogenic transcription factor SOX9 and its target genes Acan, Col2a1, and Col10a1 were increased in SHP2-deficient chondrocytes, as revealed by gene expression arrays, q RT-PCR, in situ hybridization, and immunostaining. Mechanistic studies demonstrate that SHP2 regulates OCP fate determination via the phosphorylation and SUMOylation of SOX9, mediated at least in part via the PKA signaling pathway. Our data indicate that SHP2 is critical for skeletal cell lineage differentiation and could thus be a pharmacologic target for bone and cartilage regeneration.

关键词： SHP2 regulates skeletal cell modifying SOX9 expression transcriptional activity SOX

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股权性质与企业社会责任偏好:基于利益相关者视角的研究

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科学学与科学技术管理 2022年第8期43卷 137-155页

作者：车密江旭许珊杨天文西安交通大学管理学院西安710049 西安交通大学过程控制与效率工程教育部重点实验室西安710049

基于利益相关者视角,对不同股权性质的企业是否存在社会责任偏好差异进行探究,同时探讨了股权性质影响企业社会责任偏好的边界条件。采用2009—2017年沪深两市A股上市公司面板数据集的研究结果表明,由于股权性质的差异,国有企业和民营... 详细信息

基于利益相关者视角,对不同股权性质的企业是否存在社会责任偏好差异进行探究,同时探讨了股权性质影响企业社会责任偏好的边界条件。采用2009—2017年沪深两市A股上市公司面板数据集的研究结果表明,由于股权性质的差异,国有企业和民营企业在履行社会责任时均具有一定程度的偏好性:与民营企业相比,国有企业更偏好与内部利益相关者相关的社会责任;而民营企业更加关注外部利益相关者的社会责任诉求。此外,制度的健全性和行业的竞争性都会对企业的社会责任偏好产生影响:随着制度的不断发展,国有企业对内部社会责任的偏好受到了一定程度的抑制,而激烈的行业竞争则促进了民营企业对外部社会责任的偏好。

关键词：企业社会责任国有企业民营企业制度发展行业竞争

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有机胂化合物的研究——ⅩⅢ.胂业立德及其反应产物的质谱

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武汉大学学报（自然科学版） 1990年第2期36卷 86-88页

作者：陶文田杨庭贤武汉大学化学系

我们曾报道了α-噻吩甲酰基次甲基三苯肺、Ⅰ)的合成及其质谱裂解的主要特征碎片峰。本文报道(Ⅰ)裂解途径及其反应产物的质谱。其质谱测试条件:质谱仪为 VG-ZAB-HF-3F 型。电子撞击电离电压70eV,离子源温度为200℃,直接进样杆的探头温... 详细信息

我们曾报道了α-噻吩甲酰基次甲基三苯肺、Ⅰ)的合成及其质谱裂解的主要特征碎片峰。本文报道(Ⅰ)裂解途径及其反应产物的质谱。其质谱测试条件:质谱仪为 VG-ZAB-HF-3F 型。电子撞击电离电压70eV,离子源温度为200℃,直接进样杆的探头温度不加热。视样品的不同分辩本领在1800～5000范围。它的质谱除了分子离子峰(M_(·^+)m/e 430以外,还有 m/e 347(M-83)^+,m/e 306(M-124)^+,m/e 229(M-124-77)^+,m/e 227(M-124-77-2)^+,m/e 152(M-124-77-2-75)等特征峰,其结构式和裂解途径见图1.

关键词：三苯胂裂解质谱胂业立德胂

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基于企业人员活动特征与需求的交通规划方法研究

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交通与运输 2024年第S1期40卷 41-45,55页

作者：杨文添张利帆贺杰深圳市综合交通与市政工程设计研究总院有限公司深圳518001 深圳市城市交通规划设计研究中心股份有限公司深圳518000

在交通基础设施建设放缓的新形势下,交通规划方案不应将落脚点过多的放在交通设施供给和布局上,应转变为以提升企业人群出行服务体验感为目标。首先,通过深入挖掘手机GPS定位大数据的潜在价值,将数据分析内容和交通规划方案紧密结合,衔... 详细信息

在交通基础设施建设放缓的新形势下,交通规划方案不应将落脚点过多的放在交通设施供给和布局上,应转变为以提升企业人群出行服务体验感为目标。首先,通过深入挖掘手机GPS定位大数据的潜在价值,将数据分析内容和交通规划方案紧密结合,衔接融合,研究高新园区企业人员不同类型的人才出行活动特征和服务需求;其次,在此基础上将传统的交通规划思路进行优化,提出目标圈层和出行体验感的出行服务导向,构建出行服务全链条评估体系,从而制定出行服务方案;最后,为新形势下交通规划思路与方法提供借鉴和指导性意见。

关键词：企业人员活动特征出行需求交通规划方法

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PCR扩增利什曼原虫kDNA动物实验研究对内脏利什曼病早期诊断的价值

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寄生虫与医学昆虫学报 1995年第4期2卷 193-197页

作者：杨文天胡孝素华西医科大学寄生虫学研究室

本文报道了用ＰＣＲ扩增Ｌ．ｄｏｎｏｖａｎｌ种特异性ｋＤＮＡ片段来检测不同时间采集的感染金地鼠组织样品，结果表明在腹腔接种感染后第４天就可以从金地鼠外周血和脾组织内检测到病原体ｋＤＮＡ的存在，感染后第４８天，５只金地鼠... 详细信息

本文报道了用ＰＣＲ扩增Ｌ．ｄｏｎｏｖａｎｌ种特异性ｋＤＮＡ片段来检测不同时间采集的感染金地鼠组织样品，结果表明在腹腔接种感染后第４天就可以从金地鼠外周血和脾组织内检测到病原体ｋＤＮＡ的存在，感染后第４８天，５只金地鼠的外周血和脾组织样品ＰＣＲ检测结果都为阳性，扩增产物经与地高辛标记的重组质粒ｐＬＫ２探针斑点杂交得到进一步证实。由此可见，用ＰＣＲ技术检测外周血或肝、脾组织进行内胜利什曼病的早期诊断是可行的。

关键词：内脏利什曼病诊断聚合酶链反应利什曼原虫

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Increase in the variability of terrestrial carbon uptake in response to enhanced future ENSO modulation

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 32-38页

作者： Younong Li Li Dan Jing Peng Qidong yang Fuqiang yang Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Key Laboratory of Atmospheric Environment and Processes in the Boundary Layer over the Low-Latitude Plateau Region Department of Atmospheric ScienceYunnan UniversityKunmingChina

El Niño-Southern Oscillation(ENSO)is a major driver of climate change in middle and low latitudes and thus strongly influences the terrestrial carbon cycle through land-air *** the ENSO modulation and carbon flux variability are projected to increase in the future,but their connection still needs further *** investigate the impact of future ENSO modulation on carbon flux variability,this study used 10 CMIP6 earth system models to analyze ENSO modulation and carbon flux variability in middle and low latitudes,and their relationship,under different scenarios simulated by CMIP6 *** results show a high consistency in the simulations,with both ENSO modulation and carbon flux variability showing an increasing trend in the *** higher the emissions scenario,especially SSP5-8.5 compared to SSP2-4.5,the greater the increase in *** flux variability in the middle and low latitudes under SSP2-4.5 increases by 30.9%compared to historical levels during 1951-2000,while under SSP5-8.5 it increases by 58.2%.Further analysis suggests that ENSO influences mid-and low-latitude carbon flux variability primarily through *** occurrence may potentially be attributed to the increased responsiveness of gross primary productivity towards regional temperature fluctuations,combined with the intensified influence of ENSO on land surface temperatures.

关键词： Carbon variability ENSO modulation CMIP6 models

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High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

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Journal of Energy Chemistry 2025年第1期100卷 426-457页

作者： Chong Peng Xinyi Huang Mingwei Zhao Shuling Liao Quanhong yang Nianjun yang Siyu Yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Flexible supercapacitors High-temperature tolerance Gel polymer electrolytes Electrode materials

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Role of the Greenland Sea ice anomaly in the late-spring drought over Northwest China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 1-5页

作者： yang Liu Huopo Chen Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University for Information Science and TechnologyNanjingChina

Drought across Northwest China in late spring has exerted a vital effect on the local climate and agricultural production,and has been alleviated during the past *** study explored the influence of the preceding Arctic sea ice on the May drought in Northwest China caused by the precipitation *** analysis indicated that when the Greenland Sea ice concentration is abnormally high during February to April,the dry conditions in Northwest China tend to be *** increase of sea ice in the Greenland Sea can excite a meridional circulation,which causes sea surface temperature(SST)anomalies in the North Atlantic via the sea-air interaction,manifested as significant warm SST anomalies over the south of Greenland and the subtropical North Atlantic,but negative SST anomalies over the west of the *** abnormal SST pattern maintains to May and triggers a zonal wave train from the North Atlantic through Scandinavia and Central Asia to Northwest China,leading to abnormal cyclones in Northwest ***,Northwest China experiences a more humid climate than usual.

关键词： Arctic sea ice Greenland Sea North Atlantic SST Drought Northwest China

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