检索结果-南通市图书馆

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

我国小奥德蘑属食用菌研究现状与展望

食药用菌 2021年第2期29卷 116-122页

作者：崔玉进荣成博秦文韬宋忠娟刘宇王守现北京市农林科学院植物保护环境保护研究所北京100081 北京市食用菌工程技术研究中心北京100081 农业农村部华北都市农业重点实验室北京100081 京科智宝(北京)农业科技有限公司北京100097

小奥德蘑属(Oudemansiella)真菌是一类极具开发潜力的真菌。通过阅览文献评介卵孢小奥德蘑、丝球小奥德蘑、拟粘小奥德蘑、厚褶小奥德蘑、褐褶边小奥德蘑和毛柄长奥德蘑的人工驯化栽培现状,以及在育种、多糖和功能活性等方面的研究进展。

关键词：小奥德蘑属栽培驯化育种多糖抗氧化活性

在线全文

学校读者我要写书评

暂无评论

应用于装配式桥梁的微膨胀UHPC研究

粘接 2022年第11期49卷 156-160页

作者：蔡莉莉孙明书郭小坤秦文涛洪碧武西南交通建设集团股份有限公司云南昆明650000

通过制备自密实微膨胀UHPC的原材料入手,分析多种因素对自密实微膨胀UHPC的性能影响,结果显示当减水剂掺量由0.3%提高到0.45%时,自密实微膨胀UHPC的抗压强度由68 MPa增加至最高抗压强度90.2 MPa;当减水剂掺量超过0.45%时,自密实微膨胀U... 详细信息

通过制备自密实微膨胀UHPC的原材料入手,分析多种因素对自密实微膨胀UHPC的性能影响,结果显示当减水剂掺量由0.3%提高到0.45%时,自密实微膨胀UHPC的抗压强度由68 MPa增加至最高抗压强度90.2 MPa;当减水剂掺量超过0.45%时,自密实微膨胀UHPC的抗压强度出现降低;在钢纤维体积掺量不超过2.5%的前提下,随着钢纤维体积掺量的增加,自密实微膨胀UHPC的抗压强度、抗折强度、抗拉强度均有所增加。结果说明应用于装配式桥梁的自密实微膨胀UHPC的结构性能受到减水剂、钢纤维体积、膨胀剂、粉煤灰微珠掺量等多种因素的共同影响。

关键词： UHPC 自密实减水剂粉煤灰微珠

Targeting STAT3 with SH-4-54 suppresses stemness and chemoresistance in cancer stem-like cells derived from colorectal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2025年第2期16卷 63-75页

作者： Xu-Fan Zhang Qian Chen qin Jiang Qiong-Ying Hu Department of Nuclear Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina Department of Laboratory Medicine Hospital of Mianyang Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Department of Laboratory Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Over the years,the numbers of treatment options for colorectal cancer(CRC)have increased,leading to notable improvements in the overall survival of CRC *** therapy may initially yield positive results,the development of drug resistance can result in treatment failure and cancer *** resistance is often attributed to the presence of cancer stem cells(CSCs).These CSCs not only contribute to therapeutic resistance but also play crucial roles in the initiation and development of tumor *** To investigate the antitumor effects of SH-4-54,which are mediated by targeting CSCs relative to treatment *** CSCs were enriched by culturing CRC cells in serum-free *** of stemness and IL-6/JAK2/STAT3 signaling were detected by Western *** of CSC malignancy,including proliferation,invasion,and tumor formation,were *** In this study,we employed SH-4-54,which exhibits anticancer activity in solid tumors through targeting the SH2 domain of both the signal transducer and activator of transcription(STAT)3 and the STAT5,and evaluated its effects on stemness and chemoresistance in colorectal *** expected,SH-4-54 treatment inhibited the phosphorylation of STAT3(p-STAT3)and decreased the percentage of ALDH1A1-positive CRC *** addition of SH-4-54 dissociated colorectal spheroids and decreased the expression of stemness markers,including ALDH1A1,CD44 and ***-4-54 treatment decreased IL-6/JAK2/STAT3 signaling by inhibiting p-STAT3 and thus inhibited spheroid formation by SW480 and LoVo ***,SH-4-54 treatment inhibited indicators of malignancy,including cell proliferation,invasion,and tumor formation,in CSCs in vitro and in ***,SH-4-54 treatment significantly increased chemosensitivity to *** Taken together,these results indicate that SH-4-54 is a promising molecule that exerts antitumor effects on colorectal CSCs by inhibiting STAT3 signaling.

关键词： SH-4-54 Colorectal cancer Cancer stem-like cells Stemness Chemosensitivity

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

塑钢纤维对高性能喷射混凝土的性能优化研究

粘接 2022年第3期49卷 139-143页

作者：孙明书蔡莉莉秦文涛郭小坤郭军峰西南交通建设集团股份有限公司云南昆明650000

为提高隧道支护系统的稳定性,研究在普通喷射混凝土内掺杂塑钢纤维材料,以提高其抗压、抗渗和力学支撑性能。塑钢纤维提升喷射混凝土性能的研究依托复合材料、纤维间距理论,试验结果显示:塑钢纤维混凝土的最大承受荷载为17.2 kN;最大平... 详细信息

为提高隧道支护系统的稳定性,研究在普通喷射混凝土内掺杂塑钢纤维材料,以提高其抗压、抗渗和力学支撑性能。塑钢纤维提升喷射混凝土性能的研究依托复合材料、纤维间距理论,试验结果显示:塑钢纤维混凝土的最大承受荷载为17.2 kN;最大平均渗透高度5.4 cm,为普通喷射混凝土的40.6%;最大渗透系数0.506×10^(-9) cm/s,为普通喷射混凝土的16.5%;塑钢纤维喷射混凝土的抗压性、抗渗性和韧性均优于普通喷射混凝土。

关键词：塑钢纤维喷射混凝土高性能性能优化复合材料渗透高度

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

Effects of fiber orientation on tool wear evolution and wear mechanism when cutting carbon fiber reinforced plastics

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2023年第5期36卷 549-565页

作者： Weizhou WU Shipeng LI Xuda qin wentao LIU Xin CUI Hao LI Mengrui SHI Haibao LIU Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education Tianjin UniversityTianjin 300350China Tianjin Aerospace Long March Launch Vehicle Manufacturing Co.Ltd Tianjin 30000China Centre for Aeronautics School of AerospaceTransport and ManufacturingCranfield UniversityCranfield MK430ALUK

The aim of the present paper is to reveal the influence of different fiber orientations on the tool wear evolution and wear mechanism. Side-milling experiments with large-diameter milling tools are conducted. A finite element(FE) cutting model of carbon fiber reinforced plastics(CFRP)is established to get insight into the cutting stress status at different wear stages. The results show that different fiber orientations bring about distinct differences in the extent, profile and mechanism of tool wear. Severer wear occurs when cutting 45° and 90° plies, followed by 0°, correspondingly,the least wear is obtained when θ = 135°(θ represents the orientation of fibers). Moreover, the worn profiles of cutting tools when θ = 0° and 45° are waterfall edge, while round edge occurs whenθ = 135° and a combined shape of waterfall and round edge is obtained when θ = 90°. The wear mechanisms under different fiber orientations are strongly dependent on the cutting stress distributions. The evolution of tool wear profile is basically consistent with the stress distribution on the tool surface at different wear stages, and the extent of tool wear is determined by the magnitude of stress on the tool surface. Besides, the worn edges produce an actual negative clearance angle,which decreases the actual cutting thickness and leads to compressing and bending failure of fibers beneath the cutting region as well as low surface qualities.

关键词： Carbon fiber reinforced plastics(CFRP) Fiber orientation Finite element method(FEM) Tool wear Wear mechanism

Changes of glacier area in the Xiying River Basin, East Qilian Mountain, China

在线全文

学校读者我要写书评

暂无评论

Research in Cold and Arid Regions 2017年第5期9卷 432-437页

作者： YuShuo Liu Xiang qin wentao Du State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Lanzhou Gansu 730000 China Qilian Shan Station of Glaciology and Ecologic Environment Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Lanzhou Gansu 730000 China

The Xiying River,one of eight tributaries of the Shiyang River,located at Lenglongling,east Qilian Mountain,is formed by the confluence of Luotuo,qingyang,Ningchan,and Shuiguan *** the Xiying River Basin,where have 42 glaciers which toward NE in the *** this study,three Landsat images and two topographic maps were used to extract boundaries by artificial vector *** show that glacier area in Xiying Basin increased slightly around 1987,since then,has been reduced *** 1956/1972 to 2008,glacier area in Xiying River Basin was reduced by20.76%,nine glaciers have disappeared,and below 4,100 m a.s.l.,there is no ice *** tendency of glacier retreat was obviously controlled by *** increase especially after 1987 is the main reason of glacier shrinkage,where glaciers in the Xiying River Basin are more sensitive to climate change.

关键词： glacier shrink Qilian Mountain Xiying River remote sense

Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia qin Lingyan Liang Yichen Wei qingping Zhang Xiaocheng Li Haixia qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang Jian-qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis