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Schisandrin B exerts anticancer effects on human gastric cancer cells through ROS-mediated MAPK,STAT3,and NF-κB pathways

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BIOCELL 2023年第1期47卷 195-204页

作者： TIANZHU LI YU ZHANG TONG ZHANG YANNAN LI HUI XUE JINGLONG CAO wenshuang hou YINGHUA LUO CHENGHAO JIN Department of Molecular Biology College of Basic Medical ScienceChifeng UniversityChifeng024000China Department of Biochemistry and Molecular Biology College of Life Science and TechnologyHeilongjiang Bayi Agricultural UniversityDaqing163319China Department of Grass Science College of Animal Science and Veterinary MedicineHeilongjiang Bayi Agricultural UniversityDaqing163319China National Coarse Cereals Engineering Research Center Daqing163319China

Schisandrin B(Sch B)is a monomer with anti-cancer and anti-inflammatory effects,which are isolated from the plant Schisandra chinensis(Turcz)*** investigated the anti-gastric cancer(GC)effects of Sch B and its underlying molecular *** Cell Counting Kit-8 assay was used to determine the effects of Sch B on the viability of GC and normal cell ***/propidium iodide staining and flow cytometry were used to assess the apoptosis induction of Sch *** blotting was used to evaluate the effects of Sch B on downstream apoptotic *** DCFH-DA fluorescent probe was used to assess the regulatory effects of Sch B on reactive oxygen species(ROS)levels and related signaling pathways in GC *** results showed that Sch B could regulate the phosphorylation level of mitogen-activated protein kinase(MAPK)by upregulating ROS accumulation in gastric cancer cells,and then reduce the expression of nuclear factor kappa B(NF-κB)and phosphorylated transcription 3(p-STAT3).In addition,Sch B downregulated the cell cycle proteins cyclin-dependent kinase 2/4/6 and cyclin D1/E,and arrested cells in the G0/G1 ***,it also inhibited cell migration,which was reversed with Nacetylcysteine *** summary,Sch B has killing effects on GC cells by upregulating the production of intracellular ROS and regulating the MAPK/STAT3/NF-κB signaling pathway,leading to the migration arrest and apoptosis of GC cells.

关键词： Schisandrin B Gastric cancer Reactive oxygen species Apoptosis Migration Cell cycle

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Review on marine collagen peptides induce cancer cell apoptosis,necrosis,and autophagy by reducing oxidized free radicals

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BIOCELL 2023年第5期47卷 965-975页

作者： YINGHUA LUO YU ZHANG TONG ZHANG YANNAN LI HUI XUE JINGLONG CAO wenshuang hou JIAN LIU YUHE CUI TING XU CHENGHAO JIN Department of Grass Science College of Animal Science and Veterinary MedicineHeilongjiang Bayi Agricultural UniversityDaqing163319China Department of Biochemistry and Molecular Biology College of Life Science and TechnologyHeilongjiang Bayi Agricultural UniversityDaqing163319China National Coarse Cereals Engineering Research Center Daqing163319China

Marine collagen peptides(MCPs)are natural products prepared by hydrolyzing marine collagen protein through a variety of chemical methods or *** have a range of structures and biological activities and are widely present in marine *** also have a small molecular weight,are easily modified,and absorbed by the *** properties have attracted great interest from researchers studying antioxidant,anti-tumor,and anti-aging *** of specific molecular weights have significant anti-tumor activity and no toxic side ***,MCPs have the potential use as anti-cancer adjuvant *** radicals produced by oxidation are closely related to human aging,cancer,arteriosclerosis,and other diseases,but their relationship with cancer is not well *** this review,we focus on the antioxidant properties of MCPs in the treatment of cancer,highlighting their antioxidant molecular structure and potential for clinical practice.

关键词： Marine Collagen Peptides(MCPs) Antioxidant Anti-tumor Apoptosis Necrosis Autophagy

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Anti-inflammatory,Bacteriostatic and Anticancer Effects of Madecassoside

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Asian Agricultural Research 2023年第4期15卷 26-28,33页

作者： wenshuang hou Jinglong CAO Jian LIU Hui XUE Yannan LI Chenghao JIN College of Life Science and Biotechnology Heilongjiang Bayi Agricultural UniversityDaqing 163319China

Madecassoside is a natural active component extracted from Centella *** recent years,a large number of studies have reported that madecassoside has a variety of biological activities,such as anticancer,anti-inflammatory and antibacterial effects,prevention and treatment of cardiovascular diseases,nerve damage,visceral damage and arthritis,and other pharmacological *** this paper,the pharmacological action and mechanism of madecassoside were reviewed to provide a theoretical basis for further research of madecassoside and drug development.

关键词： Madecassoside Pharmacological effect Anti-inflammatory effect Bacteriostasis Anticancer effect Arthritis

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Biological Activity and Molecular Mechanism of Bullatine G

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Medicinal Plant 2023年第2期14卷 90-92,96页

作者： Jian LIU Jinglong CAO Hui XUE Yannan LI wenshuang hou Chenghao JIN College of Life Science and Biotechnology Heilongjiang Bayi Agricultural UniversityDaqing 163319China

Bullatine G has many biological effects such as anti-inflammatory,anti-anxiety,anti-tumor,anti-arrhythmia and anti-heart failure *** order to provide a theoretical basis for the further study and clinical application ... 详细信息

关键词： Bullatine G Diterpene alkaloids Anti-inflammatory effect Anticancer effect Pharmacological effects

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Anticancer,Anti-inflammatory and Antibacterial Effects of Aloin and Its Molecular Mechanism

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Medicinal Plant 2023年第6期14卷 81-83,87页

作者： Ting XU wenshuang hou Yuhe CUI Anqi WANG Jiazhu LI Chenghao JIN College of Life Science and Biotechnology Heilongjiang Bayi Agricultural UniversityDaqing 163319China

Aloin is the main medicinal component extracted from Aloe *** is a natural anthraquinone compound,with anticancer,anti-inflammatory and antibacterial and other biological *** paper reviews the pharmacological action and related mechanisms of aloin,in order to provide a theoretical basis for the development and utilization of aloin.

关键词： Aloin Anticancer Anti-inflammatory Antibacterial

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Purification Process,Content Determination,Pharmacological Activity and Molecular Mechanism of Neogambogic Acid

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Plant Diseases and Pests 2023年第2期14卷 32-35页

作者： Tong ZHANG Jinglong CAO wenshuang hou Anqi WANG Yinghua LUO Chenghao JIN College of Life Science and Biotechnology Heilongjiang Bayi Agricultural UniversityDaqing 163319China College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural UniversityDaqing 163319China

Neogambogic acid is characterized by broad antitumor spectrum,good antitumor effect and low toxicity and side *** paper reviews the purification process,content determination and pharmacologic activity of neogambogic ... 详细信息

关键词： Neogambogic acid Purification process Content determination Pharmacological activity

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Research Progress on Purification Process Optimization and Content Determination of Zeaxanthin

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Asian Agricultural Research 2023年第3期15卷 37-39,46页

作者： Jian LIU Jinglong CAO Hui XUE Yannan LI wenshuang hou Chenghao JIN College of Life Science and Technology Heilongjiang Bayi Agricultural UniversityDaqing 163319China

At present,the purification process of zeaxanthin mainly includes organic solvent extraction,ultrasonic-assisted extraction and enzyme extraction,and the content determination technology mainly includes ultraviolet-spectrophotometry and high performance liquid *** this paper,the purification process and content determination technology of zeaxanthin in recent years are reviewed in order to provide ideas and theoretical basis for further research and application of zeaxanthin.

关键词： Zeaxanthin Carotenoid Purification process Content determination

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Pharmacological Effects and Molecular Mechanism of Osthole

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Medicinal Plant 2023年第2期14卷 93-96页

作者： Yannan LI wenshuang hou Jinglong CAO Anqi WANG Yinghua LUO Chenghao JIN College of Life Science and Biotechnology Heilongjiang Bayi Agricultural UniversityDaqing 163319China College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural UniversityDaqing 163319China

Osthole has various pharmacological effects such as anti-cancer,anti-inflammation,prevention and treatment of cardiovascular diseases and *** paper reviews the advances in the research of the pharmacological effects and molecular mechanisms of osthole,in order to provide new ideas for further research and clinical application of osthole.

关键词： Osthole Pharmacological effects Anti-cancer Anti-inflammation Prevention and treatment of cardiovascular diseases Neuroprotection

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Research on Purification Process and Pharmacological Action of Andrographolide

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Medicinal Plant 2024年第5期15卷 13-16页

作者： Changtao CAI wenshuang hou Quan QUAN Jingchao WANG Mingxinzhi WANG Chenghao JIN College of Life Science and Technology Heilongjiang Bayi Agricultural UniversityDaqing 163319China

This paper reviews the purification process,content determination methods and pharmacological action of Andrographolide,aiming to provide new ideas for the subsequent study of Andrographolide and its related drug deve... 详细信息

关键词： Andrographolide Purification process Content determination Pharmacological action

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Anticancer,Anti-inflammatory,Analgesic,and Anxiolytic Effects of Koumine and Their Molecular Mechanisms

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Asian Agricultural Research 2024年第9期16卷 28-31页

作者： Anqi WANG wenshuang hou Quan QUAN Jingchao WANG Mingxinzhi WANG Chenghao JIN College of Life Science and Biotechnology Heilongjiang Bayi Agricultural UniversityDaqing 163319China

Koumine is an indole alkaloid monomer extracted from the Chinese herb Gelsemium elegans,which has a variety of pharmacological *** paper provides a comprehensive summary of the pharmacological effects and molecular mechanisms of koumine,with a particular emphasis on its mechanisms of action in the context of anticancer,anti-inflammatory,analgesic,and anxiolytic *** aim is to provide a theoretical foundation for further research and the application of koumine in clinical practice.

关键词： Koumine Anticancer Anti-inflammatory Analgesic Anxiolytic

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