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Bioprinting and regeneration of auricular cartilage using a bioactive bioink based on microporous photocrosslinkable acellular cartilage matrix

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Bioactive Materials 2022年第10期7卷 66-81页

作者： Litao Jia Yujie Hua Jinshi Zeng wenshuai liu Di Wang Guangdong Zhou Xia liu Haiyue Jiang Research Center of Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100144PR China Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Key Laboratory of Tissue EngineeringShanghai Jiao Tong University School of MedicineShanghai200011PR China Research Institute of Plastic Surgery Weifang Medical UniversityWeifang261042PR China

Tissue engineering provides a promising strategy for auricular *** the first international clinical breakthrough of tissue-engineered auricular reconstruction has been realized based on polymer scaffolds,this approach has not been recognized as a clinically available treatment because of its unsatisfactory clinical *** is mainly since reconstruction constructs easily cause inflammation and *** this study,we present a novel strategy for the development of biological auricle equivalents with precise shapes,low immunogenicity,and excellent mechanics using auricular chondrocytes and a bioactive bioink based on biomimetic microporous methacrylate-modified acellular cartilage matrix(ACMMA)with the assistance of gelatin methacrylate(GelMA),poly(ethylene oxide)(PEO),and polycaprolactone(PCL)by integrating multi-nozzle bioprinting *** ACMMA is used to emulate the intricacy of the cartilage-specific microenvironment for active cellular behavior,while GelMA,PEO,and PCL are used to balance printability and physical properties for precise structural stability,form the microporous structure for unhindered nutrient exchange,and provide mechanical support for higher shape fidelity,***,mature auricular cartilage-like tissues with high morphological fidelity,excellent elasticity,abundant cartilage lacunae,and cartilage-specific ECM deposition are successfully regenerated in vivo,which provides new opportunities and novel strategies for the fabrication and regeneration of patient-specific auricular cartilage.

关键词： 3D bioprinting Photocrosslinkable acellular cartilage matrix Bioactive bioink Microporous Auricular cartilage regeneration

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An eikonal equation-based earthquake location method by inversion of multiple phase arrivals

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Science China Earth Sciences 2024年第6期67卷 1802-1817页

作者： Gaoyue LAO Dinghui YANG Shaolin liu Guiju DONG wenshuai WANG Kui liu National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China School of Earth Sciences Yunnan UniversityKunming 650091China Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China School of Mathematics and Statistics Ningxia UniversityYinchuan 750021China

The precise determination of earthquake location is the fundamental basis in seismological community,and is crucial for analyzing seismic activity and performing seismic *** arrivals are generally used to practically determine earthquake ***,first-arrival traveltimes are not sensitive to focal ***,they cannot accurately constrain focal *** improve the accuracy,researchers have analyzed the depth phases of earthquake *** traveltimes of depth phases are sensitive to focal depths,and the joint inversion of depth phases and direct phases can be implemented to potentially obtain accurate earthquake ***,researchers can determine earthquake locations in layered *** layered models can only represent the first-order feature of subsurface structures,the advantages of joint inversion are not fully explored if layered models are *** resolve the issue of current joint inversions,we use the traveltimes of three seismic phases to determine earthquake locations in heterogeneous *** three seismic phases used in this study are the first P-,sPg-and *** calculate the traveltimes of the three seismic phases by solving an eikonal equation with an upwind difference scheme and use the traveltimes to determine earthquake *** verify the accuracy of the earthquake location method by the inversion of three seismic phases,we take the 2021 M_(S)6.4 Yangbi,Yunnan earthquake as an example and locate this earthquake using synthetic and real seismic *** tests demonstrate that the eikonal equation-based earthquake location method,which involves the inversion of multiple phase arrivals,can effectively improve earthquake location accuracy.

关键词： Earthquake location Eikonal equation Fast marching method Heterogeneous model

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Bone-derived MSCs encapsulated in alginate hydrogel prevent collagen-induced arthritis in mice through the activation of adenosine A_(2A/2B)receptors in tolerogenic dendritic cells

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药学学报:英文版 2023年第6期13卷 2778-2794页

作者： Gaona Shi Yu Zhou wenshuai liu Chengjuan Chen Yazi Wei Xinlong Yan Lei Wu Weiwei Wang Lan Sun Tiantai Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China Faculty of Environmental and Life Sciences Beijing University of TechnologyBeijing 100124China

Tolerogenic dendritic cells(tol DCs)facilitate the suppression of autoimmune responses by differentiating regulatory T cells(Treg).The dysfunction of immunotolerance results in the development of autoimmune diseases,such as rheumatoid arthritis(RA).As multipotent progenitor cells,mesenchymal stem cells(MSCs),can regulate dendritic cells(DCs)to restore their immunosuppressive function and prevent disease ***,the underlying mechanisms of MSCs in regulating DCs still need to be better ***,the delivery system for MSCs also influences their ***,MSCs are encapsulated in alginate hydrogel to improve cell survival and retention in situ,maximizing efficacy in *** three-dimensional co-culture of encapsulated MSCs with DCs demonstrates that MSCs can inhibit the maturation of DCs and the secretion of pro-inflammatory *** the collagen-induced arthritis(CIA)mice model,alginate hydrogel encapsulated MSCs induce a significantly higher expression of CD39^(+)CD73^(+)on *** enzymes hydrolyze ATP to adenosine and activate A_(2A/2B)receptors on immature DCs,further promoting the phenotypic transformation of DCs to tol DCs and regulating naive T cells to ***,encapsulated MSCs obviously alleviate the inflammatory response and prevent CIA *** finding clarifies the mechanism of MSCs-DCs crosstalk in eliciting the immunosuppression effect and provides insights into hydrogel-promoted stem cell therapy for autoimmune diseases.

关键词： Mesenchymal stem cells Alginate hydrogel Tolerogenic dendritic cells Immunotolerance Adenosine A_(2A/2B)receptor CD39/CD73 Treg Rheumatoid arthritis

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Phosphotungstic acid ionic liquid for efficient photocatalytic desulfurization:Synthesis,application and mechanism

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Chinese Journal of Chemical Engineering 2024年第5期69卷 101-111页

作者： Chenchao Hu Suhang Xun Desheng liu Junjie Zhang Minqiang He Wei Jiang Huaming Li wenshuai Zhu Institute of Environmental Health and Ecological Security School of Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China School of Chemistry and Chemical Engineering Institute for Energy ResearchJiangsu UniversityZhenjiang 212013China Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment Suzhou University of Science and TechnologySuzhou 215009China

An efficient mass transfer process is a critical factor for regulating catalytic activity in a photocatalytic desulfurization ***,a phosphotungstic acid(HPW)active center is successfully composited with a quaternary ammonium phosphotungstate-based hexadecyltrimethylammonium chloride ionic liquid(CTAC-HPW)by the ion exchange method for the photocatalytic oxidative desulfurization of dibenzothiophene *** keggin structure of HPW and highly mass transfer performance of organic cations synergistically enhanced the photocatalytic activity towards the effective convertion of dibenzothiophene(DBT)with the excitation of visible *** deep desulfurization(<10 mg·kg^(-1))is attained within 30 min,and well stability is demonstrated within 25 ***,the CTAC-HPW photocatalyst projects well selectivity to interference from coexisting compounds such as olefins and aromatic hydrocarbons and universality of dibenzothiophenes,for example,4-methyldibenzothiophene(4-MDBT)and 4,6-dimethyldibenzothiophene(4,6-DMDBT).Ultimately,a possible photocatalytic desulfurization mechanism is proposed according to the Gaschromatography-mass spectrometry(GC-MS),proving that the final product is the corresponding *** trapping experiment and electron spin resonance(ESR)analysis confirmed that h^(+)and,COOH played critical roles in the oxidation *** work offers a practicable strategy for efficiently converting DBT to DBTO_(2) with added value.

关键词： Photocatalytic desulfurization Extraction Ionic liquid CTAC-HPW

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垂直结构WS_(2)@C复合材料的制备及其储能性能研究

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合肥学院学报（综合版） 2024年第2期41卷 67-74页

作者：张朔方泽中尹宗贵黄灿刘文帅王黎丽邓崇海合肥学院能源材料与化工学院合肥230601

使用一种简便的水热合成方法,将废弃的甘蔗渣作为碳源,成功合成了具有垂直结构的WS_(2)@C复合材料。WS_(2)纳米片均匀地垂直锚定在甘蔗渣碳片上,提供了开放的孔道结构,作为碳基底的甘蔗渣碳片有效改善了WS_(2)材料的本征导电率,实现了... 详细信息

使用一种简便的水热合成方法,将废弃的甘蔗渣作为碳源,成功合成了具有垂直结构的WS_(2)@C复合材料。WS_(2)纳米片均匀地垂直锚定在甘蔗渣碳片上,提供了开放的孔道结构,作为碳基底的甘蔗渣碳片有效改善了WS_(2)材料的本征导电率,实现了良好的电接触,并有效地缓解了循环过程中的体积膨胀效应,因此在作为钠离子电池负极材料时,实现了高稳定性和高容量的电化学性能。这项工作为寻求新型高性能储能材料的设计和合成提供了有益的参考。

关键词：甘蔗渣 WS_(2) 复合材料钠离子电池负极材料

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Unraveling the Rheology of Nanocellulose Aqueous Suspensions:A Comprehensive Study on Biomass-Derived Nanofibrillated Cellulose

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Journal of Renewable Materials 2024年第3期12卷 443-455页

作者： Mingyue Miao Fei Wang Qing Li Longchen Tao Chenchen Dai Yu liu Shujuan Han wenshuai Chen Ping Lu Key Laboratory of Bio-Based Material Science and Technology Ministry of EducationNortheast Forestry UniversityHarbin150040China Department of Chemistry and Biochemistry Rowan UniversityGlassboroNew Jersey08028USA

The rheological properties of nanocellulose aqueous suspensions play a critical role in the development of nanocellulose-based bulk ***-crystalline,high-aspect ratio,and slender nanofibrillated cellulose(NFC)were extracted from four biomass *** cellulose nanofibrils and nanofibril bundles formed inter-connected networks in the NFC aqueous *** storage moduli of the suspensions with different concentrations were higher than their corresponding loss *** the concentration increased,the storage and loss modulus of NFC dispersion *** the shear rate increased to a certain value,there were differences in the changing trend of the rheological behavior of NFC aqueous suspensions derived from different biomass resources and the suspensions with different solid *** dispersion’s storage and loss modulus increased when the temperature rose to nearly 80℃.We hope this study can deepen the understanding of the rheological properties of NFC colloids derived from different biomass resources.

关键词： Biomass resources nanofibrillated cellulose high-pressure homogenizer suspension rheology properties

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面向空天地异构网络的边缘计算部分任务卸载策略

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电子与信息学报 2022年第9期44卷 3091-3098页

作者：李斌刘文帅费泽松南京信息工程大学计算机与软件学院南京210044 北京理工大学信息与电子学院北京100081

空天地异构网络作为一种新型网络构架,是未来6G实现泛在连接的关键支撑。该文提出一种面向空天地异构网络(SAGIN)的移动边缘计算部分任务卸载方案。首先,分析了低轨(LEO)卫星的覆盖时间。其次,联合考虑用户与无人机(UAV)匹配关联因子、... 详细信息

空天地异构网络作为一种新型网络构架,是未来6G实现泛在连接的关键支撑。该文提出一种面向空天地异构网络(SAGIN)的移动边缘计算部分任务卸载方案。首先,分析了低轨(LEO)卫星的覆盖时间。其次,联合考虑用户与无人机(UAV)匹配关联因子、任务分配、带宽分配、无人机计算资源分配以及无人机轨迹,旨在建立一个能耗最小化问题。最后,采用交替迭代优化算法,将原非凸问题分解为3个子问题,并利用变量替换和连续凸逼近方法将问题转化为凸问题进行求解。仿真结果表明,所提算法具有良好的收敛性能,并有效地降低系统能耗。

关键词：空天地一体化网络移动边缘计算计算卸载无人机

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宁夏农药经营现状及存在问题浅析

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农药科学与管理 2024年第4期45卷 12-17页

作者：于丽杨金娟李华姬宇翔周兴隆王彦琪张文丽张力李喜红刘宏何春花刘文帅宁夏农业技术推广总站宁夏银川750001 石嘴山市农业执法大队宁夏石嘴山753000 利通区农业技术推广服务中心宁夏吴忠751100

本文通过对宁夏农药市场经营现状进行调研,找出目前经营中存在的问题,并针对问题提出相关建议,以期为切实加强全区农药经营市场监督管理,推动农药行业高质量发展提供依据。

关键词：农药经营现状问题建议

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智能反射面赋能无人机边缘网络计算卸载方案

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通信学报 2022年第10期43卷 223-233页

作者：李斌刘文帅谢万城费泽松南京信息工程大学计算机与软件学院江苏南京210044 北京理工大学信息与电子学院北京100081

针对无人机辅助边缘计算城市场景,因无人机与地面用户之间的任务卸载链路易受障碍物遮挡而造成卸载速率低的问题,提出了一种智能反射面赋能的无人机边缘计算部分任务卸载方案。联合考虑任务分配、用户发射功率、智能反射面相移矩阵、无... 详细信息

针对无人机辅助边缘计算城市场景,因无人机与地面用户之间的任务卸载链路易受障碍物遮挡而造成卸载速率低的问题,提出了一种智能反射面赋能的无人机边缘计算部分任务卸载方案。联合考虑任务分配、用户发射功率、智能反射面相移矩阵、无人机计算资源分配以及无人机轨迹,建立了一个用户最小平均数据吞吐量最大化问题。由于该问题是一个随机优化问题,且优化变量之间密切耦合,难以直接求解。因此,首先通过利用数学期望的性质,将随机优化问题转换为确定性优化问题;其次,利用块坐标下降算法将确定性优化问题分解为3个子问题,并通过引入辅助变量、利用连续凸近似和半定松弛技术将非凸问题转换为凸优化问题,进而得到问题的近似次优解。仿真结果表明,所提方案具有良好的收敛性能,并有效地提高了地面用户的平均数据吞吐量。

关键词：无人机通信移动边缘计算智能反射面计算卸载资源分配

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Titanium alloy composited with dual-cytokine releasing polysaccharide hydrogel to enhance osseointegration via osteogenic and macrophage polarization signaling pathways

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Regenerative Biomaterials 2022年第1期9卷 372-388页

作者： Yaping Wang Zujian Feng Xiang liu Chunfang Yang Rui Gao wenshuai liu Wenbin Ou-Yang Anjie Dong Chuangnian Zhang Pingsheng Huang Weiwei Wang Department of Polymer Science and Engineering Key Laboratory of Systems Bioengineering(Ministry of Education)School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Key Laboratory of Innovative Cardiovascular Devices Chinese Academy of Medical SciencesBeijing 100037China Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300192China Structural Heart Disease Center National Center for Cardiovascular DiseaseChina and Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

Titanium alloy has been widely used in orthopedic surgeries as bone defect ***,the regeneration of high-quality new bones is limited due to the pro-inflammatory microenvironment around implants,resulting in a high occurrence rate of implant loosening or failure in osteological *** this study,extracellular matrix-mimetic polysaccharide hydrogel co-delivering BMP-2 and interleukin(IL)-4 was composited with 3D printed titanium alloy to promote the osseointegration and regulate macrophage response to create a pro-healing microenvironment in bone ***,it is discovered from the bioinformatics data that IL-4 and BMP-2 could affect each other through multiple signal pathways to achieve a synergistic effect toward *** composite scaffold significantly promoted the osteoblast differentiation and proliferation of human bone marrow mesenchyme stem cells(hBMSCs).The repair of large-scale femur defect in rat indicated that the dual-cytokinedelivered composite scaffold could manipulate a lower inflammatory level in situ by polarizing macrophages to M2 phenotype,resulting in superior efficacy of mature new bone regeneration over the treatment of native titanium alloy or that with an individual ***,this work highlights the importance of M2-type macrophages-enriched immune-environment in bone *** biomimetic hydrogel–metal implant composite is a versatile and advanced scaffold for accelerating in vivo bone regeneration,holding great promise in treating orthopedic diseases.

关键词： hydrogel composite scaffold bone regeneration cytokine delivery macrophage polarization

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