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肿瘤日间病房运行模式分析

新疆医科大学学报 2014年第9期37卷 1224-1225,1228页

作者：王文然古丽比也.沙比尔郭瑞肖蕾孙毅赵化荣刘云包永星新疆医科大学第一附属医院肿瘤中心乌鲁木齐830054 哈密地区中心医院肿瘤外科新疆哈密839000

目的探讨肿瘤日间病房的运行模式,解决患者住院难、住院贵的问题。方法 2012年6月—2013年9月新疆医科大学第一附属医院肿瘤中心日间病房经肿瘤专科医师评估后收治具有适应证的1 216人,均接受规范化治疗。结果平均住院天数为3.89d,放化... 详细信息

目的探讨肿瘤日间病房的运行模式,解决患者住院难、住院贵的问题。方法 2012年6月—2013年9月新疆医科大学第一附属医院肿瘤中心日间病房经肿瘤专科医师评估后收治具有适应证的1 216人,均接受规范化治疗。结果平均住院天数为3.89d,放化疗率为42.5%,患者得到及时治疗。其中发生急性并发症6例,经及时、积极地处理得到了有效控制。结论肿瘤日间病房可缩短住院时间,降低医疗费用,方便肿瘤患者就医,有望在新疆地区成为一种新型的、有效的医疗模式。

关键词：肿瘤日间病房肿瘤患者放化疗

Stress Granule Formation is One of the Early Antiviral Mechanisms for Host Cells Against Coxsackievirus B Infection

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Virologica Sinica 2018年第4期33卷 314-322页

作者： Xia Zhai Shuo Wu Lexun Lin Tianying wang Xiaoyan Zhong Yang Chen Weizhen Xu Lei Tong Yan wang wenran Zhao Zhaohua Zhong Department of Microbiology Harbin Medical University Harbin 150081 China Department of Cell Biology Harbin Medical University Harbin 150081 China

Stress granules(SGs) are intracellular granules formed when cellular translation is blocked and have been reported to be involved in a variety of viral infections. Our previous studies revealed that SGs are involved in the coxsackievirus B(CVB)infection process, but the role of SGs in CVB infection has not been fully explored. In this study, we found that CVB type 3(CVB3) could induce SG formation in the early phase of infection. Results showed that levels of CVB3 RNA and protein were significantly inhibited during the early stage of CVB3 infection by the elevated formation of SGs, while viral RNA and protein synthesis were significantly promoted when SG formation was blocked. Our findings suggest that SG formation is one of the early antiviral mechanisms for host cells against CVB infection.

关键词： Coxsackievirus B (CVB) Stress granule (SG) Viral replication

新疆某三甲医院肝癌住院患者的营养风险状况调查

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新疆医科大学学报 2014年第8期37卷 1059-1061,1065页

作者：马静肖蕾张华张瑞丽刘畅古丽比也.沙比尔王文然包永星新疆医科大学第一附属医院乌鲁木齐830054

目的掌握新疆某三甲医院肝癌住院患者的营养风险状况。方法选择2010年1-12月在新疆医科大学第一附属医院符合入选标准的286例肝癌患者,入院次日清晨采用营养风险筛查量表(NRS2002)进行营养风险状况调查。结果 286例肝癌患者有营养风险... 详细信息

目的掌握新疆某三甲医院肝癌住院患者的营养风险状况。方法选择2010年1-12月在新疆医科大学第一附属医院符合入选标准的286例肝癌患者,入院次日清晨采用营养风险筛查量表(NRS2002)进行营养风险状况调查。结果 286例肝癌患者有营养风险的发生率为60.84%(174/286),无营养风险发生率为39.16%(112/286)。营养风险与肿瘤分期无明显相关性(χ2=5.271,P=0.153)。有营养风险患者的住院天数和住院费用高于无营养风险患者。肝癌总体病死率为62.23%(178/286),有营养风险患者的病死率(68.02%)显著高于无营养风险患者病死率(53.57%)(χ2=5.883,P<0.05)。中位随访时间31个月,失访9例,随访率为96.85%。生存99例,死亡178例。结论肝癌患者中营养风险的发生率较高。

关键词：肝癌营养营养风险筛查 2002

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铁路自然语言大模型关键技术研究及应用展望

中国铁路 2024年第7期 7-14页

作者：史天运李新琴代明睿史维峰李国华杜文然中国铁道科学研究院集团有限公司北京100081 中国铁道科学研究院集团有限公司电子计算技术研究所北京100081

人工智能自然语言大模型的涌现为行业深度赋能带来了新的曙光,研究铁路自然语言大模型关键技术及应用,对促进和统筹铁路人工智能发展具有重要意义。根据铁路人工智能应用需求,提出铁路自然语言大模型应用场景;依托铁路人工智能平台,设... 详细信息

人工智能自然语言大模型的涌现为行业深度赋能带来了新的曙光,研究铁路自然语言大模型关键技术及应用,对促进和统筹铁路人工智能发展具有重要意义。根据铁路人工智能应用需求,提出铁路自然语言大模型应用场景;依托铁路人工智能平台,设计铁路自然语言大模型的总体架构,研究自然语言大模型关键技术,构建面向智能问答的铁路行业大模型,并以实际数据进行模型验证;最后从铁路运输组织、铁路运营安全、旅客服务方面对铁路自然语言大模型的发展和应用进行展望。

关键词：智能高铁人工智能铁路自然语言大模型应用场景大模型架构大模型微调检索增强生成铁路知识问答

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Expression Profile and Function Analysis of Long Non-coding RNAs in the Infection of Coxsackievirus B3

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Virologica Sinica 2019年第6期34卷 618-630页

作者： Lei Tong Ye Qiu Hui wang Yunyue Qu Yuanbo Zhao Lexun Lin Yan wang Weizhen Xu wenran Zhao Hongyan He Guangze Zhao Mary HZhang Decheng Yang Xingyi Ge Zhaohua Zhong Department of Microbiology Harbin Medical UniversityHarbin 150081China College of Biology Hunan UniversityChangsha 410012China Department of Cell Biology Harbin Medical UniversityHarbin 150081China Department of Pathology and Laboratory Medicine University of British ColumbiaVancouverBC V6Z 1Y6Canada

The roles of lnc RNAs in the infection of enteroviruses have been barely demonstrated. In this study, we used coxsackievirus B3(CVB3), a typical enterovirus, as a model to investigate the expression profiles and functional roles of lnc RNAs in enterovirus infection. We profiled lnc RNAs and m RNA expression in CVB3-infected He La cells by lnc RNA-m RNA integrated microarrays. As a result, 700 differentially expressed lnc RNAs(431 up-regulated and 269 down-regulated) and665 differentially expressed m RNAs(299 up-regulated and 366 down-regulated) were identified in CVB3 infection. Then we performed lnc RNA-m RNA integrated pathway analysis to identify potential functional impacts of the differentially expressed m RNAs, in which lnc RNA-m RNA correlation network was built. According to lnc RNA-m RNA correlation, we found that XLOC-001188, an lnc RNA down-regulated in CVB3 infection, was negatively correlated with NFAT5 m RNA,an anti-CVB3 gene reported previously. This interaction was supported by q PCR detection following si RNA-mediated knockdown of XLOC-001188, which showed an increase of NFAT5 m RNA and a reduction of CVB3 genomic RNA. In addition, we observed that four most significantly altered lnc RNAs, SNHG11, RP11-145 F16.2, RP11-1023 L17.1 and RP11-1021 N1.2 share several common correlated genes critical for CVB3 infection, such as BRE and IRF2 BP1. In all, our studies reveal the alteration of lnc RNA expression in CVB3 infection and its potential influence on CVB3 replication,providing useful information for future studies of enterovirus infection.

关键词： Coxsackievirus B3(CVB3) lncRNA-mRNA correlation network Long non-coding RNA(lncRNA) XLOC-001188 NFAT5

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考虑区间型指标的电压暂降综合评估方法

电气技术 2024年第6期25卷 47-55页

作者：林洪洲粘凯昕郑峰刘闻然郑温剑国网福州市长乐区供电公司福州350200

为了充分准确地评估纺织行业的电压暂降水平,提出一种考虑区间型指标的综合评估方法。首先,根据各监测数据构建对应的多指标集合;其次,采用层次分析法与改进区间指标相关性赋权法(CRITIC)确定各指标的权重,再根据博弈论思想获取综合权重... 详细信息

为了充分准确地评估纺织行业的电压暂降水平,提出一种考虑区间型指标的综合评估方法。首先,根据各监测数据构建对应的多指标集合;其次,采用层次分析法与改进区间指标相关性赋权法(CRITIC)确定各指标的权重,再根据博弈论思想获取综合权重;接着,定义区间数差值关系,采用非整次秩和比法对各监测点电压暂降水平进行评估并分级;最后,采用8个纺织行业的监测数据进行实例分析,结果表明本文所提方法能够充分合理地评估监测点的电压暂降水平。

关键词：电压暂降区间型指标综合评估非整次秩和比

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长江大保护试点城市水环境治理模式及成效

环境工程学报 2024年第1期18卷 286-297页

作者：黄钰铃莫晶骆辉煌杨青瑞冯顺新惠二青陈文然中国水利水电科学研究院水生态环境研究所北京100038 中国长江三峡集团有限公司武汉430010 长江生态环保集团有限公司武汉430062

长江流域城市水环境治理取得阶段成果,全面评估其治理成效,总结城市水环境治理经验至关重要。以长江大保护4个试点城市水环境提质增效工程PPP项目为研究对象,评估城市水环境治理成效。结果表明:管网工程中,各试点城市生活污水集中收集... 详细信息

长江流域城市水环境治理取得阶段成果,全面评估其治理成效,总结城市水环境治理经验至关重要。以长江大保护4个试点城市水环境提质增效工程PPP项目为研究对象,评估城市水环境治理成效。结果表明:管网工程中,各试点城市生活污水集中收集率达标,污水厂进厂生活污水化学需氧量(COD)达标率75%,九江和岳阳老旧小区改造后污水收集率为100%,改造后出口管网污水COD明显提升;污水处理工程中,试点城市污水厂处理率均达标,平均水力负荷达标率46.2%,平均COD负荷达标率30.8%,出水达标排放,九江白水湖、芳兰污水厂处理单位污水电耗较高;污泥处理处置工程中,各厂污泥含水率满足合同要求,处理吨水及单位污水COD去除的污泥产生量均较高;生态环境改善方面,试点城市水环境治理工程大幅削减污染物负荷,但工程影响范围内地表水质均未达标,超标因子为氨氮、总氮、总磷和COD;工程范围内黑臭水体治理达到合同要求,宜昌生态化岸线比例提高38.9%;社会文化贡献方面,试点城市水环境治理工程建设取得较好的社会贡献。评估结果对完善水环境治理项目,促进长江流域经济社会可持续发展有着重要意义。

关键词：长江大保护城市水环境治理成效评估管网污水处理

Curcumin inhibits the replication of enterovirus 71 in vitro

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Acta Pharmaceutica Sinica B 2014年第4期4卷 284-294页

作者： Ying Qin Lexun Lin Yang Chen Shuo Wu Xiaoning Si Heng Wu Xia Zhai Yan wang Lei Tong Bo Pan Xiaoyan Zhong Tianying wang wenran Zhao Zhaohua Zhong Department of Microbiology Harbin Medical UniversityHarbin 150086China Department of Cell Biology Harbin Medical UniversityHarbin 150086China

Human enterovirus 71(EV71)is the main causative pathogen of hand,foot,and mouth disease(HFMD)in *** epidemic of HFMD has been a public health problem in Asia-Pacific region for decades,and no vaccine and effective antiviral medicine are *** has been used as a traditional medicine for centuries to treat a diversity of disorders including viral *** this study,we demonstrated that curcumin showed potent antiviral effect again *** Vero cells infected with EV71,the addition of curcumin significantly suppressed the synthesis of viral RNA,the expression of viral protein,and the overall production of viral *** with the previous reports,curcumin reduced the production of ROS induced by viral ***,the antioxidant property of curcumin did not contribute to its antiviral activity,since N-acetyl-L-cysteine,the potent antioxidant failed to suppress viral *** study also showed that extracellular signal-regulated kinase(ERK)was activated by either viral infection or curcumin treatment,but the activated ERK did not interfere with the antiviral effect of curcumin,indicating ERK is not involved in the antiviral mechanism of *** the previous reports that curcumin inhibited protein degradation through ubiquitin–proteasome system(UPS),we found that curcumin had no impact on UPS in control ***,curcumin did reduce the activity of proteasomes which was increased by viral *** addition,the accumulation of the short-lived proteins,p53 and p21,was increased by the treatment of curcumin in EV71-infected *** further probed the antiviral mechanism of curcumin by examining the expression of GBF1 and PI4KB,both of which are required for the formation of viral replication *** found that curcumin significantly reduced the level of both ***,the decreased expression of either GBF1 or PI4KB by the application of siRNAs was sufficient to suppress viral *** also de

关键词： Curcumin Enterovirus 71 Viral replication GBF1 PI4KB Ubiquitin–proteasome system Apoptosis

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超滤-纳滤双膜工艺深度净化天然雨水试验

净水技术 2024年第1期43卷 74-80页

作者：郝文冉来存贤朱学武成小翔徐景涛武道吉山东建筑大学市政与环境工程学院山东济南250101 山东建筑大学资源与环境创新研究院山东济南250101

随着人口数量增长与城市工业化进程的不断加快,对水资源的需求日益剧增。为了缓解水资源压力同时减轻城市排水系统的负担,开展了超滤-纳滤双膜工艺深度净化天然雨水的试验,探究了双膜工艺对天然雨水的水质净化效果。结果表明,超滤-纳滤... 详细信息

随着人口数量增长与城市工业化进程的不断加快,对水资源的需求日益剧增。为了缓解水资源压力同时减轻城市排水系统的负担,开展了超滤-纳滤双膜工艺深度净化天然雨水的试验,探究了双膜工艺对天然雨水的水质净化效果。结果表明,超滤-纳滤双膜工艺可以有效降低雨水中污染物含量,对UV_(254)、总溶解性固体、总有机碳和电导率的平均去除率分别为87.5%、66.7%、32.0%和61.4%。双膜技术实现了对雨水中固体颗粒和溶解性有机物的高效去除,同时对荧光类有机物也显示出优异的截留效果。相比于常规的水处理工艺(混凝-沉淀-过滤工艺),双膜技术因具有出水水质优异、无二次污染、处理效率高等优势,在雨水的高效分离和资源化利用领域展现出较大的应用潜力。

关键词：超滤(UF) 纳滤(NF) 双膜工艺雨水水资源回用

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