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Genomic analysis provides insights into the westward expansion of domesticated peaches in China

Horticultural Plant Journal 2024年第2期10卷 367-375页

作者： wenqing Li Yong Li Xinwei Wang Guoqing Zhao Gengrui Zhu Ke Cao Weichao Fang Jinlong Wu Kai Ma Changwen Chen Lirong Wang Zhengzhou Fruit Research Institute CAASZhengzhouHennan 450009China Xinjiang Academy of Agricultural Sciences UrumqiXinjiang 830091China Western Research Institute CAASChangjiXinjiang 831100China

Peach, an economically important model plant of the Rosaceae family, has been domesticated and cultivated in China for approximately5 000 years. The Hexi Corridor, an important corridor connecting east-central China and the Tarim Basin, is the starting point of the Silk Road that links China and the Eurasian region. As a globally distributed fruit tree, the spread of peach was accomplished through historical trade routes in the Hexi Corridor and the Tarim Basin. However, knowledge of peach genetic diversity in these regions remains limited. In this study,we examined the relationships and the spread history of domesticated peaches through sequencing and genomic analysis of 161 peach accessions collected from Northwest China, including 43.from the Hexi Corridor and 104 from the Tarim Basin. The results indicate that peach landraces in the Hexi Corridor and the Tarim Basin are derivatives of peaches from the east and south of China (ESC). Notably, the genetic diversity of accessions from both the Hexi Corridor and the Tarim Basin was lower than that of ESC accessions. Reduction of diversity (ROD) and linkage disequilibrium (LD) analyses detected a genetic bottleneck in peaches from these regions. Additionally, these peaches have undergone varying degrees of selection from natural environment. Moreover, genes responsive to biotic and abiotic stresses were under selection, which could be the result of the climate change of Northwest China after the Last Glacial Maximum (LGM). Our findings provide a better understanding of the genetic basis of peach migration in Northwest China. Furthermore, this study expands the available genomic data for peaches and provides critical information for future peach breeding programs.

关键词： Peach Hexi corridor Tarim Basin Genetic diversity Gene flow

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Genesis of the Nuri Cu-W-Mo Deposit,Tibet,China:Constraints from in situ Trace Elements and Sr Isotopic Analysis of Scheelite

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 117-131页

作者： WANG Yiyun WU Zhishan CHEN wenqing DU Qing’an TANG Liwei SHI Hongzhao MA Guotao ZHANG Zhi LIANG Wei WU Bo MIAO Hengyi Chengdu Center China Geological Survey(Geoscience Innovation Center of Southwest China)Chengdu 610081China The Second Geological Institute of China’s Metallurgical Geology Bureau Fuzhou 351111China

The Nuri deposit is the only Cu-W-Mo polymetallic deposit with large-scale WO3.resources in the eastern section of the Gangdese metallogenic belt,Tibet,***,the genetic type of this deposit has been controversial since its *** on a study of the geological characteristics of the deposit,this study presents mineralization stages,focusing on the oxide stage and the quartz-sulfide stage where scheelite is mainly formed,referred to as Sch-A and Sch-B,*** LA-ICP-MS trace element and Sr isotope analyses,the origin,evolutionary process of the oreforming fluid and genesis of the ore deposit are *** Electron Microscope-Cathodoluminescence(SEMCL)observations reveal that Sch-A consists of three generations,with dark gray homogenous Sch-A1 being replaced by relatively lighter and homogeneous Sch-A2 and Sch-A3.with Sch-A2 displaying a gray CL image color with vague and uneven growth bands and Sch-A3.has a light gray CL image color with hardly any growth *** contrast,Sch-B exhibits a‘core-rim’structure,with the core part(Sch-B1)being dark gray and displaying a uniform growth band,while the rim part(Sch-B2)is light gray and *** normalized distribution pattern of rare earth elements in scheelite and Sr isotope data suggest that the early ore-forming fluid in the Nuri deposit originated from granodiorite porphyry and,later on,some country rock material was mixed in,due to strong water-rock *** the O-H isotope data further indicates that the ore-forming fluid in the Nuri deposit originated from magmatic-hydrothermal sources,with contributions from metamorphic water caused by water-rock interaction during the mineralization process,as well as later meteoric *** intense water-rock interaction likely played a crucial role in the precipitation of scheelite,leading to varying Eu anomalies in different generations of scheelite from the oxide stage to the quartz-sulfide stage,while also causing a

关键词： trace elements in situ Sr isotopes tungsten mineralization Gangdese metallogenic belt Tibet

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A Trade-off between Solvation and Collision Activation in Steering Competing E2 and S_(N)2 Dynamics

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Precision Chemistry 2024年第1期2卷 40-48页

作者： Hongyi Wang Xu Liu Siwei Zhao Gang Fu wenqing Zhen Li Yang Jiaxu Zhang State Key Laboratory of Urban Water Resource and Environment MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and StorageSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001P.R.China College of Chemistry Liaoning UniversityShenyang 110036P.R.China

The prototypical E2 elimination and SN2 sub-stitution reactions between microsolvated fluoride and ethyl bromide show unexpected dynamic behaviors in mechanistic evolution driven by solvation and collision *** the steric effects,the gas-phase selectivity favors an E2 pathway barely dependent on collision ***,base solvation steers the reaction in an effective way toward substitution at a near-thermal energy,whereas the governing high-energy events retain *** dynamics simulations reproduce exper-imental findings and uncover a crucial solute-solvent coupling in determining such competing ***,collision activation can tune the underlying atomistic dynamics essentially in the reactant entrance channel and cause a mechanism *** features for the ubiquitous competing E2/SN2 dynamics remain quite unknown,providing unique insight into reaction selectivity for complex chemical networks.

关键词： E2/S_(N)2 Competition Atomistic Dynamics Reaction Mechanisms Microsolvation Collision Activation

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circPVT1 promotes silica-induced epithelial-mesenchymal transition by modulating the miR-497-5p/TCF3.axis

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Journal of Biomedical Research 2024年第2期38卷 163-174,I0011-I0015页

作者： Siyun Zhou Yan Li wenqing Sun Dongyu Ma Yi Liu Demin Cheng Guanru Li Chunhui Ni Department of Occupational Medical and Environmental Health Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Biomedical Publications Center Nanjing Medical UniversityNanjingJiangsu 211166China Gusu School Nanjing Medical UniversityNanjingJiangsu 211166China

Epithelial-mesenchymal transition(EMT)is a vital pathological feature of silica-induced pulmonary ***,whether circRNA is involved in the process remains *** present study aimed to investigate the role of circPVT1 in the silica-induced EMT and the underlying *** found that an elevated expression of circPVT1 promoted EMT and enhanced the migratory capacity of silica-treated epithelial *** isolation of cytoplasmic and nuclear separation assay showed that circPVT1 was predominantly expressed in the *** immunoprecipitation assay and RNA pull-down experiment indicated that cytoplasmic-localized circPVT1 was capable of binding to ***,we found that miR-497-5p attenuated the silica-induced EMT process by targeting transcription factor 3.TCF3.,an E-cadherin transcriptional repressor,in the silica-treated epithelial ***,these results reveal a novel role of the circPVT1/miR-497-5p/TCF3.axis in the silica-induced EMT process in lung epithelial *** validated,this finding may provide a potential theoretical basis for the development of interventions and treatments for pulmonary fibrosis.

关键词： silicosis epithelial-mesenchymal transition circPVT1 miR-497-5p TCF3

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Pharmacological effects of bioactive agents in earthworm extract: A comprehensive review

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Animal Models and Experimental Medicine 2024年第05期 653-672页

作者： Zihan Zhu Xinyi Deng wenqing Xie Hengzhen Li Yusheng Li Zhenhan Deng Department of Orthopedics Xiangya Hospital Central South University Xiangya School of Medicine Central South University National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Department of Orthopaedic Surgery The First Affiliated Hospital of Wenzhou Medical University

This review compiles information from the literature on the chemical composition,pharmacological effects, and molecular mechanisms of earthworm extract(EE) and suggests possibilities for clinical translation of EE. We also consider future trends and concerns in this domain. We summarize the bioactive components of EE, including G-90, lysenin, lumbrokinase, antimicrobial peptides, earthworm serine protease(ESP),and polyphenols, and detail the antitumor, antithrombotic, antiviral, antibacterial,anti-i nflammatory, analgesic, antioxidant, wound-healing, antifibrotic, and hypoglycemic activities and mechanisms of action of EE based on existing in vitro and in vivo studies. We further propose the potential of EE for clinical translation in anticancer and lipid-modifying therapies, and its promise as source of a novel agent for wound healing and resistance to antibiotic tolerance. The earthworm enzyme lumbrokinase embodies highly effective anticoagulant and thrombolytic properties and has the advantage of not causing bleeding phenomena due to hyperfibrinolysis. Its antifibrotic properties can reduce the excessive accumulation of extracellular matrix. The glycolipoprotein extract G-90 can effectively scavenge reactive oxygen groups and protect cellular tissues from oxidative damage. Earthworms have evolved a well-developed defense mechanism to fight against microbial infections, and the bioactive agents in EE have shown good antibacterial, fungal, and viral properties in in vitro and in vivo experiments and can alleviate inflammatory responses caused by infections, effectively reducing pain. Recent studies have also highlighted the role of EE in lowering blood glucose. EE shows high medicinal value and is expected to be a source of many bioactive compounds.

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Nootkatone suppresses TLR4/NF-κB/NLRP3.pathway to alleviate non-alcoholic fatty liver disease via modulating gut microbiota

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Food Science and Human Wellness 2024年

作者： Rongrong Fu Lechen Wang wenqing Xue Jingjie Liang Jing Meng Min Zhang State Key Laboratory of Food Nutrition and Safety， College of Food Science and Engineering， Tianjin University of Science and Technology Tianjin International Joint Academy of Biomedicine China-Russia Agricultural Processing Joint Laboratory， Tianjin Agricultural University

Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Gut microbiota and its metabolites alteration are closely related to NAFLD. Nootkatone is an edible flavorants derived from grapefruit which has a variety of biological activities. However， the precise mechanisms of nootkatone on NAFLD remains to be defined. Our results showed that nootkatone prevented body weight gain and decreased serum lipid level， hepatic lipogenesis， hepatic proinflammatory cytokines secretion in NAFLD mice. Also， nootkatone attenuated inflammatory response via inhibiting TLR4/NF-κB/NLRP3.pathway. Moreover， nootkatone restored intestinal barrier damage through increasing tight junction proteins and SCFAs contents. Further 16S rRNA sequencing of colonic content suggested that nootkatone recovered the disturbed gut microbiota to improve NAFLD. Spearman correlation analysis between gut microbiota and NAFLD related parameters indicated that nootkatone regulated lipid metabolism and immunity via altering the gut microbiota. In conclusion， these findings revealed that nootkatone alleviated hepatic lipid homeostasis and inflammatory response in NAFLD mice， which associated with intestinal barrier integrity and the regulation of gut microbiota. This study provides new perspectives that nootkatone has efficacy on NAFLD via “gut-liver axis”， and nootkatone is expected to be developed as a functional food additive.

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Response Mechanisms to Flooding Stress in Mulberry Revealed by Multi-Omics Analysis

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Phyton-International Journal of Experimental Botany 2024年第2期93卷 227-245页

作者： Jingtao Hu Wenjing Chen Yanyan Duan Yingjing Ru wenqing Cao Pingwei Xiang Chengzhi Huang Li Zhang Jingsheng Chen Liping Gan College of Biology and Food Engineering Chongqing Three Gorges UniversityChongqing404100China Chongqing Three Gorges Academy of Agricultural Sciences Chongqing Three Gorges UniversityChongqing404155China

Abiotic stress,including flooding,seriously affects the normal growth and development of ***(Morus alba),a species known for its flood resistance,is cultivated worldwide for economic *** transcriptomic analysis has identified numerous differentially expressed genes(DEGs)involved in submergence tolerance in mulberry ***,a comprehensive analyses of metabolite types and changes under flooding stress in mulberry remain unreported.A non-targeted metabolomic analysis utilizing liquid chromatographytandem mass spectrometry(LC-MS/MS)was conducted to further investigate the effects of flooding stress on mulberry.A total of 1,169 metabolites were identified,with 3.1 differentially accumulated metabolites(DAMs)exhibiting up-regulation in response to flooding stress and 3.4 displaying *** enrichment analysis identified significant modifications in many metabolic pathways due to flooding stress,including amino acid biosynthesis and metabolism and flavonoid *** and DEGs are significantly enriched in the Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways for amino acid,phenylpropanoid and flavonoid ***,metabolites such as methyl jasmonate,sucrose,and D-mannose 6-phosphate accumulated in mulberry leaves post-flooding ***,genes and metabolites associated with these KEGG pathways are likely to exert a significant influence on mulberry flood *** study makes a substantial contribution to the comprehension of the underlying mechanisms implicated in the adaptation of mulberry plants to submergence.

关键词： Mulberry flooding stress flavonoid biosynthesis phenylpropanoid biosynthesis

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承插式管片拼装误差仿真分析研究

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隧道建设（中英文） 2024年第4期44卷 682-688页

作者：武文清中铁十四局集团大盾构工程有限公司江苏南京210000

为解决承插式管片在拼装过程中出现的误差累积问题,提出一种基于管片装配尺寸链的仿真方法,通过建立MATLAB仿真模型并采用蒙特卡罗法对管片拼装过程进行模拟分析。研究结果表明:1)管片纵缝接触面张角是管片成环拼装可靠度的主要影响因素... 详细信息

为解决承插式管片在拼装过程中出现的误差累积问题,提出一种基于管片装配尺寸链的仿真方法,通过建立MATLAB仿真模型并采用蒙特卡罗法对管片拼装过程进行模拟分析。研究结果表明:1)管片纵缝接触面张角是管片成环拼装可靠度的主要影响因素,实际管片拼装中应严格控制纵缝接触面张角的偏差;2)多环管片拼装分析中,在相同管片拼装公差控制条件下,错缝拼装方式对应的管片环内拼装可靠度较通缝拼装方式高;3.对南京江心洲隧道工程采用的承插式管片拼装公差进行优化设计,拼装可靠度得到有效提升,管片拼装质量更高。

关键词：承插式管片拼装误差 MATLAB仿真模型蒙特卡洛法仿真分析

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Recent advances,challenges,and perspectives on carbon capture

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 75-104页

作者： Shihan Zhang Yao Shen Chenghang Zheng Qianqian Xu Yifang Sun Min Huang Lu Li Xiongwei Yang Hao Zhou Heliang Ma Zhendong Li Yuanhang Zhang wenqing Liu Xiang Gao Institute of Energy and Sustainable Development Zhejiang University of TechnologyHangzhou 310014China College of Environment Zhejiang University of TechnologyHangzhou 310014China Baima Lake Laboratory Hangzhou 310051China Institute of Carbon Neutrality College of Energy EngineeringZhejiang UniversityHangzhou 310027China State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Key Laboratory of Environmental Optics and Technology Anhui Institute of Optics and Fine MechanicsHFIPSChinese Academy of SciencesHefei 230031China

Carbon capture,utilization and storage(CCUS)technologies play an essential role in achieving Net Zero Emissions *** the lack of timely reviews on the recent advancements in promising CCUS technologies,it is crucial to provide a prompt review of the CCUS advances to understand the current research gaps pertained to its industrial *** that end,this review first summarized the developmental history of CCUS technologies and the current large-scale ***,based on a visually bibliometric analysis,the carbon capture remains a hotspot in the CCUS *** that the materials applied in the carbon capture process determines its *** a result,the state-of-the-art carbon capture materials and emerging capture technologies were comprehensively summarized and *** between state-of-art carbon capture process and its ideal counterpart are analyzed,and insights into the research needs such as material design,process optimization,environmental impact,and technical and economic assessments are provided.

关键词： Carbon capture,utilization and storage Visualization analysis Research hotspots and trends CO_(2)capture technology

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Small moleculeα-methylene-γ-butyrolactone,an evolutionarily conserved moiety in sesquiterpene lactones,ameliorates arthritic phenotype via interference DNA binding activity of NF-κB

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3561-3575页

作者： Kegang Linghu wenqing Cui Taiqin Li Yueting Tuo Dasong Wang Huiqi Pan Tian Zhang Ligen Lin Hua Yu Xiaoxia Hu Haiyang Li Xiangchun Shen Department of Surgery the Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001China The Key Laboratory of Optimal Utilization of Natural Medicine Resources School of Pharmaceutical SciencesGuizhou Medical UniversityGuian New DistrictGuizhou 561113China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China Guizhou Institute of Precision Medicine Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001China

Rheumatoid arthritis(RA)is an inflammatory disease accompanied by abnormal synovial microenvironment(SM).Sesquiterpene lactones(SLs)are the main anti-inflammatory ingredients of many traditional herbs utilized in RA treatment.α-Methylene-γ-butyrolactone(α-M-γ-B)is a core moiety that widely exists in natural *** study was designed to investigate the anti-arthritic potential ofα-M-γ-B as an independent small molecule in vitro and in vivo.α-M-γ-B exhibited stronger electrophilicity and anti-inflammatory effects than the other six analogs.α-M-γ-B inhibited the production of pro-inflammatory mediators via repolarizing M1 macrophages into M2 *** transcriptome sequencing suggested thatα-M-γ-B regulated the immune system ***,α-M-γ-B attenuated collagen type II-induced arthritic(CIA)phenotype,restored the balance of Tregs-macrophages and remodeled SM via repolarizing the synovial-associated macrophages in CIA ***,althoughα-M-γ-B did not prevent the trans-nucleus of NF-κB it interfered with the DNA binding activity of NF-κB via direct interaction with the sulfhydryl in cysteine residue of NF-κB p65,which blocked the activation of NF-κ*** of NF-κB reduced the M1 polarization of macrophage and suppressed the synovial hyperplasia and angiogenesis.α-M-γ-B failed to ameliorate CIA in the presence of N-acetylcysteine or when the mice were subjected to the macrophage-specific deficiency of *** conclusion,α-M-γ-B significantly attenuated the CIA phenotype by directly targeting NF-κB p65 and inhibiting its DNA binding *** results suggest thatα-M-γ-B has the potential to serve as an alternative candidate for treating *** greater electrophilicity ofα-M-γ-B,the basis for triggering strong anti-inflammatory activity,accounts for the reason whyα-M-γ-B is evolutionarily conserved in the SLs by medical plants.

关键词： a-Methylene-gbutyrolactone Rheumatoid arthritis NF-κB p65 Synovial microenvironment Sesquiterpene lactones

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