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Chinese Chemical Letters 2018年第8期29卷 1273-1276页

作者： Cong Duan Ling Ye wenqin xu Xinying Li Feng Chen Zhigang Zhao xuefeng Li College of Chemistry and Environment Protection Engineering Southwest Minzu University Chengdu 610041 China Faculty of Geosciences and Environmental Engineering Southwest Jiaotong University Chengdu 610031 China

A novel organocatalytic cascade process initiated by 1,6-conjugated addition has been successfully developed. A range of pharmaceutically active 2-amino-4-aryl-4H-chromenes were readily obtained in high yields（88%-99%） and excellent enantiopurities（86%-99% ee）. The functionalized para-Quinone methides（p-OMs） could be facilely obtained.

关键词： para-Quinone methides 2-Amino-4-aryl-4H-chromene Domino reaction 1,6-Conjugated addition Enantioselective

Synthesis, Biological Activity and 3D-QSAR Study of Novel Pyrrolidine-2,4-dione Derivatives Containing N-Substituted Phenylhydrazine Moiety

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Chemical Research in Chinese Universities 2015年第2期31卷 228-234页

作者： ZHANG Lizhi REN Zhengjiao LU Aimin ZHAO Zheng xu wenqin BAO Qianqian DING Weijie YANG Chunlong Jiangsu Key Laboratory of Pesticide Science Key Laboratory of Monitoring and Management of Crop Diseases and Pest lnsects Ministry of Agriculture College of Science Nanjing Agricultural University Nanjing 210095 P R. China

Twenty-seven novel pyrrolidine-2,4-dione derivatives containing N-substituted phenylhydrazine moiety were synthesized. Their structures were confirmed by IH NMR, 13C NMR and MS. The half effective concentration （ECs0） values of the title compounds against the phytopathogenic fungi Rhizoctonia cerealis were evaluated. Com- pounds 61 and 6q displayed good bioactivity with EC50 values of 1.626 and 2.043 μg/mL, respectively. The 3D quantitative structure activity relationship（3D-QSAR） model of CoMFA was established with reliable cross-validated correlation coefficient q2 value of 0.585 and Noncross-validated correlation coefficient r2 value of 0.971. This model provided a tool for guiding further design and synthesis of novel pyrrolidine-2,4-dione derivatives with high fungicidal activity.

关键词： Pyrrolidine-2,4-dione N-Substituted phenylhydrazine Antifungal activity 3D quantitative structure activity relationship(3 D-QSAR)

Identifying and Validating a Novel miRNA-mRNA Regulatory Network Associated with Prognosis in Lung Adenocarcinoma

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Chinese Medical Sciences Journal 2022年第1期37卷 31-43页

作者： wenqin xu Jingjing Ye Tianbing Chen Central Laboratory Yijishan Hospital of Wannan Medical CollegeWuhuAnhui 241002China Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution Wannan Medical CollegeWuhuAnhui 241002China

Objective Many studies have revealed the crucial roles of miRNA in multiple human cancers,including lung adenocarcinoma(LUAD).In this study,we sought to explore new miRNA-mRNA pairs that are associated with LUAD *** A novel miRNA-mRNA regulatory network associated with prognosis in LUAD was identified and validated using the bioinformatic tools including OncomiR database,StarBase,miRnet,GEPIA2,*** Twenty key miRNAs were compiled after the analysis of the expression and prognostic value in OncomiR and *** mRNAs of these key miRNAs were predicted in miRnet,and the resulting mRNAs were also analyzed for their prognostic values and expression patterns in GEPIA2 and UALCAN,*** expression correlation analysis was performed in ***,a new miRNA-mRNA network was built,of which each RNA pair showed negative expression correlation,opposite expression pattern,and prognostic ***-protein interaction network was under construction for the mRNAs,and 19 hub genes were *** analysis showed that“Cell Cycle,Mitotic”was the most significantly enriched ***,a miRNA-hub gene sub-network was *** selected and validated the regulatory relationship of some miRNA-hub pairs,including hsa-miR-1976/RFC2,hsa-let-7c-5p/RFC2,hsa-let-7c-5p/ESPL1,hsa-let-7c-5p/CDC25A,and hsa-miR-101-3p/***,over-expression of hsa-miR-1976 and hsa-let-7c-5p resulted in significant cell cycle *** Our results determined new prognosis-associated miRNA-mRNA pairs and might shed further light on the mechanism via which miRNA-mRNA network influences prognosis in LUAD.

关键词： lung adenocarcinoma bioinformatic analysis miRNA prognosis cell cycle

Synthesis and Characterization of Ti-ZSM-5 in a Non-alkaline Medium in the Presence of Fluoride Ions

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Chemical Research in Chinese Universities 1989年第1期5卷 8-17页

作者： Qiu Shilun , Pang wenqin and xu Ruren(Institute of Synthetic and Catalytic Chemistry, Jilin University,Changchun)

Ti-ZSM-5 was synthesized by hydro thermal crystallization in the presence of fluoride via using a non-alkaline medium. pH values were 5;. SEM showed perfect Ti-ZSM-5 crystals and a large single crystal growing from the favourable medium. Substitution of titanium for silicon in the ZSM-5 framework led to a decrease of crystal size and of the length/width ratio. Electron microprobe analysis indicated a homogeneous distribution of titanium in the ZSM-5 framework. The unit cell parameters of the Ti-ZSM-5 determined by XRD increased with an increase in titanium content in the framework. TiO4tetrahedron vibrations were found in the IR spectrum. Si（1Ti） peakwas seen in the 29Si MAS NMR spectrum at -1O1ppm（from TMS） and 13CMAS NMR analysis verified the effect of （C3H7）4N+F- occluded in thechannels. XPS study on the precursors, calcined and H2O2 adsorbed Ti-ZSM-5 was performed and some interesting results were observed.

关键词： Ti-ZSM-5 Non-alkaline Synthesis

Synthesis and Structure of Large Single Crystal of TPAF-AlPO_4-5 Molecular Sieve

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Chemical Research in Chinese Universities 1989年第2期5卷 120-124页

作者： Qiu Shilun, Pang wenqin and xu Ruren (Institute of Synthetic and Catalytic Chemistry, Jilin University, Changchun)

A large single crystal of TPAF-AlPO4-5 molecular sieve was synthesized by hydrothermal crystallization in the presence of ammonium fluoride. Starting material composition was · 1 P2O5 · 1 Al2O3 · 2. 2 TPAOH · 1. 7 NH4F ·318 H2O. The crystal size has a hexagonal prism with 80μm across and 500μm *** structure of tetrapropylarnmonium fluoride - aluminium phosphate type-5 was investigated with X-ray diffraction. The unit cell composition is 12AlPO4 · TPAF, space group P6cc (a= 13. 740(5), c= 8. 474(4) A ). Average bond distances are: P-O 1. 564A and Al-O 1. 640A ,which may be due to the partial disorder of the arrangement of P, Al in the framework. The angles of O-T-O and T-O-T (T?P, Al) are 102-116° and 148-176°, respectively. Residue electron density was not well enough defined to give a precise position for tetrapropylammonium fluoride (TPAF). The template agent, TPA+ cations, situate in the 12-ring channels and F- anions locate in double 4-rings near the 12-ring channels. Fixing atomic positions for the TPAF reduced the unweighted and weighted R, R, from 0. 063 and 0. 082 to 0. 046 and 0. 042,respectively.

关键词： AlPO_4-5 molecular sieve single crystal

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多阶段传感器-武器联合任务管理方法

国防科技大学学报 2020年第4期42卷 98-106页

作者：陈晨胥文钦张明阳北京理工大学自动化学院北京100081 复杂系统智能控制与决策国家重点实验室北京100081

针对动态环境下的传感器-武器联合任务管理问题展开研究。根据在动态作战过程中出现的有效新目标、有效空闲传感器和武器数量设定阶段门限,以决定进入下一阶段的时机,从而构建多阶段的作战过程。从打击方案质量及系统响应时间的角度出发... 详细信息

针对动态环境下的传感器-武器联合任务管理问题展开研究。根据在动态作战过程中出现的有效新目标、有效空闲传感器和武器数量设定阶段门限,以决定进入下一阶段的时机,从而构建多阶段的作战过程。从打击方案质量及系统响应时间的角度出发,分析构建分布式作战体系对系统作战效能的影响,使系统在每个任务管理阶段可以决定响应流程。通过仿真实验验证了所构建的分布式作战体系与设定的阶段门限可以明显提升系统的作战效能。

关键词：动态任务管理多阶段分布式作战体系传感器武器联合管理

网络文学“出海”的演进脉络、现实图景与突围策略

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出版与印刷 2023年第3期 50-60页

作者：洪长晖徐雯琴上海大学新闻传播学院

研究中国网络文学成功“出海”的实践和经验,促进中华文化“走出去”,提升国家文化软实力。文章立足于网络文学新发展阶段,指出网络文学“出海”的成功得益于技术驱动、现实土壤、海外因素与原生优势,网络文学“出海”历经了线下版权出... 详细信息

研究中国网络文学成功“出海”的实践和经验,促进中华文化“走出去”,提升国家文化软实力。文章立足于网络文学新发展阶段,指出网络文学“出海”的成功得益于技术驱动、现实土壤、海外因素与原生优势,网络文学“出海”历经了线下版权出售、线上翻译连载、自主平台主导传播、资源联动集群“出海”四个阶段,形成了扩大化的传播体量、多样化的传播形态和全球化的传播规模,依靠国内生态、发挥科技力量、深耕传统文化、注重通力合作、坚持受众导向是其显著特点。指出网络文学“出海”存在阅读体验有待提升、题材需要平衡、国际影响仍需扩大、知识产权亟待保护等发展问题,需要各方从长远出发,不断在实践中探索解决。

关键词：中国网络文学网文“出海” 中华文化“走出去” 海外传播

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径向柱塞泵柱塞副泄漏流量的计算

润滑与密封 2006年第11期31卷 184-185,189页

作者：徐文琴浙江工业职业技术学院浙江绍兴312000

考虑到流体的粘度随压力及温度变化,柱塞内油液压力随吸油压力和排油压力交变,密封长度也随柱塞在缸孔中的位置而变化,及柱塞运动引起的剪切流量等因素,通过积分方法,对新型径向柱塞泵中柱塞副的环形间隙泄漏流量计算公式进行修正,得到... 详细信息

考虑到流体的粘度随压力及温度变化,柱塞内油液压力随吸油压力和排油压力交变,密封长度也随柱塞在缸孔中的位置而变化,及柱塞运动引起的剪切流量等因素,通过积分方法,对新型径向柱塞泵中柱塞副的环形间隙泄漏流量计算公式进行修正,得到了柱塞副泄漏流量修正系数。

关键词：径向柱塞泵环形间隙泄漏流量

视网膜小胶质细胞中Toll样受体在炎症性和缺血性视网膜疾病中的作用

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中华实验眼科杂志 2016年第1期34卷 92-96页

作者：徐文芹王雨生西安第四军医大学西京医院眼科全军眼科研究所 710032

Toll样受体家族（TLRs）是天然免疫模式识别系统中的重要组成部分，可以识别多种病原微生物和自身细胞损伤后释放的分子。TLRs可在视网膜的多种细胞中表达，包括小胶质细胞、Miiller细胞、星形胶质细胞、视网膜色素上皮细胞和感光细胞... 详细信息

Toll样受体家族（TLRs）是天然免疫模式识别系统中的重要组成部分，可以识别多种病原微生物和自身细胞损伤后释放的分子。TLRs可在视网膜的多种细胞中表达，包括小胶质细胞、Miiller细胞、星形胶质细胞、视网膜色素上皮细胞和感光细胞等，与相关配体结合后启动细胞内信号转导通路，诱导特异性基因表达，上调共刺激分子表达水平并促进炎性因子的分泌，发挥抗感染作用。此外，这些激活的炎性因子还可以通过调节相关血管生长因子的水平，影响视网膜的病理性新生血管生成。在复杂的视网膜细胞系统中，小胶质细胞是重要的天然免疫细胞，能够发挥免疫监视及修复等作用。TLRs是小胶质细胞识别受体系统中的重要一类，在调节小胶质细胞参与视网膜感染和炎症反应以及视网膜缺血性疾病等中发挥作用。本文就小胶质细胞中TLRs的作用进行综述。

关键词： T0u样受体视网膜小胶质细胞炎症新生血管

EyeHealer:A large-scale anterior eye segment dataset with eye structure and lesion annotations

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Precision Clinical Medicine 2021年第2期4卷 85-92页

作者： Wenjia Cai Jie xu Ke Wang Xiaohong Liu wenqin xu Huimin Cai Yuanxu Gao Yuandong Su Meixia Zhang Jie Zhu Charlotte L.Zhang Edward E.Zhang Fangfei Wang Yun Yin Iat Fan Lai Guangyu Wang Kang Zhang Yingfeng Zheng State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Beijing Institute of Ophthalmology Capital Medical UniversityBeijing Tongren HospitalBeijing 100730China Department of Computer Science and Technology&BNRist Tsinghua UniversityBeijing 100084China Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and Technology and University HospitalMacao 999078China Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhou 510623China Center for Translational Innovations West China Hospital and Sichuan UniversityChengdu 610041China Bioland Laboratory Guangzhou 510005China School of Business Macao University of Science and TechnologyMacao 999078China Ophthalmic Center Kiang Wu HospitalMacaoChina School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

Anterior segment eye diseases account for a significant proportion of presentations to eye clinics worldwide,including diseases associated with corneal pathologies,anterior chamber abnormalities(*** or inflammation),and lens *** construction of an automatic tool for segmentation of anterior segment eye lesions would greatly improve the efficiency of clinical *** research on artificial intelligence progressing in recent years,deep learning models have shown their superiority in image classification and *** training and evaluation of deep learning models should be based on a large amount of data annotated with expertise;however,such data are relatively scarce in the domain of ***,the authors developed a new medical image annotation system,called *** is a large-scale anterior eye segment dataset with both eye structures and lesions annotated at the pixel *** experiments were conducted to verify its performance in disease classification and eye lesion *** results showed that semantic segmentation models outperformed medical segmentation *** paper describes the establishment of the system for automated classification and segmentation *** dataset will be made publicly available to encourage future research in this area.

关键词： anterior segment eye diseases artificial intelligence annotation