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巨噬细胞极化在草酸钙肾结石形成中作用及其影响因素的研究进展

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中国病理生理杂志 2024年第1期40卷 180-186页

作者：李卫胜张传国李杨东何文强河南中医药大学河南郑州450003 新乡医学院第一附属医院泌尿外科河南郑州450003 河南中医药大学第一附属医院泌尿外科河南卫辉453100

肾结石是泌尿外科多发性疾病,可造成肾功不全、肾萎缩和脓胸等并发症,给患者带来严重的经济负担[1-2]。草酸钙(calcium oxalate,Ca Ox)肾结石的形成涉及活性氧(reactive oxygen species,ROS)产生增多、免疫炎症反应和肾小管上皮损伤等... 详细信息

肾结石是泌尿外科多发性疾病,可造成肾功不全、肾萎缩和脓胸等并发症,给患者带来严重的经济负担[1-2]。草酸钙(calcium oxalate,Ca Ox)肾结石的形成涉及活性氧(reactive oxygen species,ROS)产生增多、免疫炎症反应和肾小管上皮损伤等病理过程[3]。既往研究证实,巨噬细胞的不同极化状态能够影响Ca Ox肾结石形成[4]。

关键词：肾结石炎症巨噬细胞极化草酸钙

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水分和氮磷钾胁迫处理苗期水稻对褐飞虱抗性的影响

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华南农业大学学报 2024年第2期45卷 247-255页

作者：黄福钢程玲何文强李发活邱永福广西大学农学院/亚热带农业生物资源保护与利用国家重点实验室广西南宁530004 长江大学农学院湖北荆州434025 粮食作物种质创新与遗传改良湖北省重点实验室湖北武汉430064

【目的】探究水源和食物对褐飞虱死亡速率的影响,探究不同浓度养分处理下的水稻幼苗对褐飞虱的抗性和趋避性,为综合应用田间水肥管理防治褐飞虱提供理论依据。【方法】以感虫水稻品系‘9311’和抗性品系‘BPHR96’为供试材料,观察不同... 详细信息

【目的】探究水源和食物对褐飞虱死亡速率的影响,探究不同浓度养分处理下的水稻幼苗对褐飞虱的抗性和趋避性,为综合应用田间水肥管理防治褐飞虱提供理论依据。【方法】以感虫水稻品系‘9311’和抗性品系‘BPHR96’为供试材料,观察不同的水源和食物处理(取食‘9311’茎段,取食‘BPHR96’茎段,有水源的饥饿胁迫以及无水源的饥饿胁迫)对褐飞虱死亡率的影响。在玻璃温室内开展水培试验,设置不同浓度营养液培养水稻幼苗,测定幼苗分蘖数、株高、根长、地上部鲜质量和根鲜质量5个表型性状;并观察侵染后褐飞虱的存活数量、增质量率、蜜露排泄量以及寄主选择数量。【结果】无食物的情况下,褐飞虱死亡率上升迅速;无水源饥饿胁迫处理的褐飞虱在接虫后48 h全部死亡;接虫216 h时,有水源饥饿胁迫处理的死亡率达到96.8%,取食‘BPHR96’的死亡率达到85.0%,而取食‘9311’的死亡率也始终维持较低水平(44.3%)。营养液水培试验发现,与对照和高浓度氮磷钾营养液处理相比,低浓度氮磷钾营养液虽然对水稻幼苗的生长有所抑制,但能显著降低褐飞虱的存活数量、增质量率、蜜露排泄量以及寄主选择数量,且抗性水稻品系的效应更为明显。相比于低浓度钾营养液处理,对照和高浓度钾营养液处理能显著促进水稻幼苗的生长,但未发现钾浓度对褐飞虱的取食响应有显著影响。【结论】充足的水分是保证褐飞虱维持生命活动的首要因素,其次才是食物的适口性。低浓度氮磷钾处理能够降低褐飞虱对水稻的危害,高浓度氮磷钾处理则利于褐飞虱的侵害,水稻大田生产过程中可通过水肥管理对褐飞虱进行综合防治。

关键词：氮磷钾胁迫褐飞虱水稻水分胁迫

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贺兰山东坡不同植被类型凋落物层水文效应

生态学杂志 2024年第4期43卷 1047-1056页

作者：何文强陈林庞丹波曹萌豪张雅琪李学斌宁夏大学生态环境学院西北退化生态系统恢复与重建教育部重点实验室银川750021

以宁夏贺兰山东坡7种植被为对象,采用野外调查和室内实验的方法研究凋落物水文效应,以期探讨不同植被类型和分解层凋落物水源涵养能力的差异。结果表明:(1)不同植被类型,凋落物蓄积量为1.56~60.78 t·hm^(-2),凋落物最大持水量为6.34~10... 详细信息

以宁夏贺兰山东坡7种植被为对象,采用野外调查和室内实验的方法研究凋落物水文效应,以期探讨不同植被类型和分解层凋落物水源涵养能力的差异。结果表明:(1)不同植被类型,凋落物蓄积量为1.56~60.78 t·hm^(-2),凋落物最大持水量为6.34~10.91 t·hm^(-2);最大持水率为126.8%~199.1%,最大拦蓄率为125.0%~190.4%;有效拦蓄率为105.9%~160.6%;有效拦蓄量为2.59~15.22 t·hm^(-2);对不同分解层而言,凋落物蓄积量为12.19~71.60 t·hm^(-2),凋落物最大持水量为4.91~10.16 t·hm^(-2),最大持水率为112.5%~207.3%,最大拦蓄率为104.0%~193.8%,有效拦蓄率为87.1%~162.7%,最大拦蓄量为2.41~53.14 t·hm^(-2),有效拦蓄量为2.00~44.65 t·hm^(-2)。(2)不同植被类型凋落物蓄积量、最大拦蓄量以及有效拦蓄量表现出了相对一致的规律,均表现出青海云杉林(Picea crassifolia)、油松林(Pinus tabuliformis)以及混交林最大;而在不同分解层均表现出已分解层和半分解层最大。(3)不同植被类型不同分解层凋落物的持水量、失水量分别与浸水时间和失水时间呈显著的对数函数关系(P<0.01),吸水速率、失水速率分别与浸水时间和失水时间呈显著的幂函数关系(P<0.01)。综合比较7种植被类型不同分解层凋落物的持水、拦蓄能力,发现青海云杉林、油松林、混交林等3种乔木针叶林的凋落物水源涵养能力最强,不同分解层之间以已分解层和半分解层水源涵养能力最强。可见,该地区凋落物的水源涵养能力在不同植被类型和分解层间有明显分异特征。

关键词：贺兰山东坡植被分解层凋落物水文效应

PI3K/Akt/mTOR信号通路与自噬调控及相关疾病关系

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重庆医学 2024年第13期53卷 2047-2052页

作者：李卫胜王婷婷何文强河南中医药大学郑州450003 河南中医药大学第一附属医院泌尿外科郑州450003

磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路是细胞内重要的代谢、增殖和存活调节途径,对维持细胞的稳态具有关键作用。该信号通路可以通过介导细胞自噬参与多种疾病的发生和发展过程,如肿瘤、神经退... 详细信息

磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路是细胞内重要的代谢、增殖和存活调节途径,对维持细胞的稳态具有关键作用。该信号通路可以通过介导细胞自噬参与多种疾病的发生和发展过程,如肿瘤、神经退行性疾病(ND)和代谢性疾病等。该文就PI3K/Akt/mTOR信号通路在自噬调控中的作用进行综述,以期更好地理解细胞代谢和存活的调节机制,并探究该信号通路在多种疾病中的作用及未来研究方向,为探索新的疾病治疗方法提供参考资料。

关键词： PI3K/Akt/mTOR信号通路自噬疾病综述

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三金化石汤辅助输尿管软镜术治疗肾结石的效果

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河南医学研究 2024年第5期33卷 905-909页

作者：屈颖伟何文强郑聪崔勇河南中医药大学第一附属医院泌尿外科河南郑州450000

目的研究三金化石汤辅助输尿管软镜术(RIRS)治疗肾结石的临床效果,并分析其作用机制。方法选择2016年1月至2022年11月在河南中医药大学第一附属医院接受治疗的110例肾结石患者,按照随机数表法进行分组,对照组55例接受RIRS治疗,研究组55... 详细信息

目的研究三金化石汤辅助输尿管软镜术(RIRS)治疗肾结石的临床效果,并分析其作用机制。方法选择2016年1月至2022年11月在河南中医药大学第一附属医院接受治疗的110例肾结石患者,按照随机数表法进行分组,对照组55例接受RIRS治疗,研究组55例接受RIRS、三金化石汤辅助治疗。比较两组结石清除率、肾功能[血肌酐(SCr)、胱抑素C(Cys-C)、尿素氮(BUN)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)]、炎症反应[肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、白介素-6(IL-6)及C反应蛋白(CRP)]、生活质量及并发症。结果研究组治疗2周后结石清除率(98.18%)较对照组(85.45%)高(P0.05)。结论三金化石汤辅助RIRS治疗肾结石效果确切,可有效提升结石清除率,促进肾功能恢复,改善生活质量,未增加并发症。

关键词：肾结石三金化石汤输尿管软镜术肾功能炎症反应生活质量

Response of soil respiration to short-term changes in precipitation and nitrogen addition in a desert steppe

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Journal of Arid Land 2023年第9期15卷 1084-1106页

作者： MA Jinpeng PANG Danbo he wenqiang ZHANG Yaqi WU Mengyao LI Xuebin CheN Lin College of Forestry and Prataculture Ningxia UniversityYinchuan 750021China College of Ecological Environment Ningxia UniversityYinchuan 750021China Breeding Base for State Key Laboratory of Land Degradation and Ecological Restoration in Northwest China Ningxia UniversityYinchuan 750021China

Changes in precipitation and nitrogen(N)addition may significantly affect the processes of soil carbon(C)cycle in terrestrial ecosystems,such as soil ***,relatively few studies have investigated the effects of changes in precipitation and N addition on soil respiration in the upper soil layer in desert *** this study,we conducted a control experiment that involved a field simulation from July 2020 to December 2021 in a desert steppe in Yanchi County,***,we measured soil parameters including soil temperature,soil moisture,total nitrogen(TN),soil organic carbon(SOC),soil microbial biomass carbon(SMBC),soil microbial biomass nitrogen(SMBN),and contents of soil microorganisms including bacteria,fungi,actinomyces,and protozoa,and determined the components of soil respiration including soil respiration with litter(RS+L),soil respiration without litter(RS),and litter respiration(RL)under short-term changes in precipitation(control,increased precipitation by 30%,and decreased precipitation by 30%)and N addition(0.0 and 10.0 g/(m^(2)·a))*** results indicated that short-term changes in precipitation and N addition had substantial positive effects on the contents of TN,SOC,and SMBC,as well as the contents of soil actinomyces and *** addition,N addition significantly enhanced the rates of RS+L and RS by 4.8%and 8.0%(Phe rates of RS+L and RS by 2.3%(Phe rates of RS+L and RS by 12.9%(P0.05).The mean RL/RS+L value observed under all treatments was 27.63%,which suggested that RL is an important component of soil respiration in the desert steppe *** results also showed that short-term changes in precipitation and N add

关键词： soil respiration litter respiration nitrogen deposition soil carbon soil microorganisms climate change desert steppe ecosystems

Insights on evolution of virulence and resistance from the whole-genome analysis of a predominant methicillin-resistant Staphylococcus aureus clone sequence type 239 in China

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Chinese Science Bulletin 2014年第11期59卷 1104-1112页

作者： Hongbin Chen Xi Yang Qi Wang Chunjiang Zhao henan Li wenqiang he Xiaojuan Wang Feifei Zhang Zhanwei Wang Minjun Chen Baoli Zhu Hui Wang Department of Clinical Laboratory Peking University People’s Hospital Key Laboratory of Pathogenic Microbiology & Immunology Institute of MicrobiologyChinese Academy of Sciences Department of Clinical Laboratory Peking Union Medical College Hospital

Earlier, we reported that ST239 was the15-year predominant methicillin-resistant Staphylococcus aureus(MRSA) clone in China. In this study, MRSA strain CN79 belonging to ST239 and isolated from blood was used to determine the whole genome sequence. Comparative genomics analysis was done between MRSA CN79and 25 sequenced S. aureus in the NCBI GenBank database. A total of 2,734 protein-encoding genes were identified in the MRSA CN79 genome, which carries 11antibiotic resistance genes and 65 virulence genes. Two prophages phiCN79A and phiNM3-like were found on the MRSA CN79 genome. MRSA CN79 carries 30 specific genes that are absent from the 25 sequenced S. aureus genomes. Most of them were prophage-related *** antibiotic resistance genes, such as b-lactamase and ABC-type multidrug transport system gene, were located on the genomic island mSab. The antibiotic resistance genes, such as tet(M), ermA1, and blaZ, were also located on different transposons. The virulence genes sea,map, hlb, and sak are located on phiNM3-like prophage and the exotoxin genes are carried on the genomic island mSaa. These results suggest that ST239 MRSA strains are widespread owing to horizontal acquisition of the mobile genetic elements harbored antibiotic resistance genes and virulence genes in response to environmental selective pressures, such as antibiotics and the human immune system during evolution.

关键词：金黄色葡萄球菌基因组分析毒力基因进化过程序列类型中国克隆 GenBank

Plasma spray coating on interconnector toward promoted solid oxide fuel cells and solid oxide electrolysis cells

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Frontiers in Energy 2024年第3期18卷 390-398页

作者： Junwen CAO Yun ZheNG wenqiang ZHANG Bo YU Institute of Nuclear and New Energy Technology(INET) Collaborative Innovation Center of Advanced Nuclear Energy TechnologyTsinghua UniversityBeijing 100084China Department of Chemical Engineering University of WaterlooWaterlooOntario N2L 3G1Canada Institute of New Energy Materials and Engineering School of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China

Interconnector is a critical component to construct solid oxide cells (SOCs) stack. Oxidation of metallic interconnectors and Cr poisoning caused by oxidation are important factors that lead to long-term performance degradation of SOCs. Coating on the interconnector surface is an important approach to inhibit the oxidation and Cr migration of the interconnector. herein, (La0.75Sr0.25)0.95MnO3–δ (LSM) and Mn1.5Co1.5O4 (MCO) are used to fabricate the coatings of interconnector. Two advanced thermal spray technology, atmospheric plasma spraying (APS) and low-pressure plasma spray (LPPS), are adopted for the coating preparation. The electrochemical performance, rising and cooling cycle stability, and Cr diffusion inhibition performance of the coatings are tested and evaluated. The result indicates that MCO can generate more uniform and denser coatings than LSM. In addition, MCO coatings prepared by LPPS shows the best electrochemical performance, rising and cooling cycle stability, and Cr diffusion inhibition. The initial area specific resistance (ASR) is 0.0027 Ω·cm2 at 800 °C. After 4 cooling cycle tests, the ASR increases to 0.0032 Ω·cm2 but lower than other samples. Meanwhile, the relative intense of Cr at the interface of SUS430 with MCO coatings fabricated by LPPS is lower than that of MCO fabricated by APS after 4 rising and cooling cycle operations, showing more favorable Cr diffusion inhibition performance.

关键词： interconnector coating plasma spray electrochemical performance Cr diffusion inhibition solid oxide cells(SOCs)

An unexpected stereochemical effect of thio-substituted Asp in native chemical ligation

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Chinese Chemical Letters 2024年第8期35卷 278-281页

作者： Min Fu Pan he Sen Zhou wenqiang Liu Bo Ma Shiying Shang Yaohao Li Ruihan Wang Zhongping Tan State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Center of Pharmaceutical Technology School of Pharmaceutical SciencesTsinghua UniversityBeijing 100084China Chemical Engineering College Hebei Normal University of Science and TechnologyQinhuangdao 066600China

This study presents an unexpected finding that the cis isomer ofβ-thio-Asp exhibits higher ligation ac-tivity than the trans *** discovery sheds light on the intricate nature of native chemical ligation and highlight... 详细信息

关键词： Native chemical ligation Stereochemistry Ligation activity β-Thio-Asp Intramolecular hydrogen bond