检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

新技术趋势下的智慧城市发展解读

信息通信技术 2019年第S1期13卷 49-56页

作者：张瑾冯伟斌杨锦洲吕文琪邸青玥中国联通研究院

智慧城市的发展进入了一个新阶段,城市管理者逐步意识到制定智慧城市战略的出发点在于人,而非科技,智慧城市建设的核心内涵是“以人为本”,提高居民生活质量和获得感。文章总结国内外智慧城市发展现状,分析智慧城市当前建设中存在的问... 详细信息

智慧城市的发展进入了一个新阶段,城市管理者逐步意识到制定智慧城市战略的出发点在于人,而非科技,智慧城市建设的核心内涵是“以人为本”,提高居民生活质量和获得感。文章总结国内外智慧城市发展现状,分析智慧城市当前建设中存在的问题及痛点,指出运营商一体化的ICT服务能力和渠道资源使得其非常适合“智慧城市运营方”的角色定位,通过为智慧城市提供顶层设计、平台建设、应用集成等服务,构建智慧城市合作生态,最后介绍新型智慧城市建设的新技术要素如5G、人工智能、物联网、无人机等,提出智慧城市建设的新架构,并对城市治理、惠民服务、绿色生态、产业发展等典型应用场景的重塑进行阐述。

关键词：新型智慧城市数字城市 5G

在线全文

学校读者我要写书评

暂无评论

桑叶发酵前后提取液降血糖作用的研究

广东化工 2019年第13期46卷 19-20页

作者：陈妍言李德贤吕文琪姜涛吉林大学珠海学院药学与食品科学学院

目的:研究对比桑叶发酵前后提取液对四氧嘧啶糖尿病模型小鼠的降血糖作用。方法:用啤酒酵母对桑叶进行发酵;用四氧嘧啶诱导建立糖尿病小鼠模型,将40只建模成功的KM小鼠随机分为模型对照组、未发酵低剂量组(2g/kg)、未发酵高剂量组(8g/kg... 详细信息

目的:研究对比桑叶发酵前后提取液对四氧嘧啶糖尿病模型小鼠的降血糖作用。方法:用啤酒酵母对桑叶进行发酵;用四氧嘧啶诱导建立糖尿病小鼠模型,将40只建模成功的KM小鼠随机分为模型对照组、未发酵低剂量组(2g/kg)、未发酵高剂量组(8g/kg)、发酵低剂量组(2g/kg)和发酵高剂量组(8g/kg),每组8只,另取8只健康KM小鼠作为正常对照组。连续灌胃给药15d,每天1次,每两天记录一次各组小鼠的体重,分别于给药的第0、5、10、15天用血糖仪测定各组小鼠禁食12h后的空腹血糖,研究对比桑叶发酵前后提取液对糖尿病小鼠的降血糖作用。结果:给药15天后,桑叶未发酵低剂量组与发酵低剂量组以2g/kg的给药量灌胃不能降低糖尿病小鼠的血糖值,而未发酵高剂量组和发酵高剂量组均能明显降低糖尿病小鼠的血糖值。给药第10天,发酵高剂量组与未发酵高剂量组之间血糖值有显著差异(P0.05)。同时,5组模型组之间糖尿病小鼠的体重无显著差异(P>0.05)。结论:连续给药15天,桑叶未发酵提取液与发酵提取液均不能缓解糖尿病小鼠体重的降低。采用啤酒酵母发酵法,未经发酵与经发酵的高剂量桑叶提取液均对糖尿病小鼠有良好的降血糖作用,短期内发酵高剂量组降糖作用优于未发酵高剂量组,长期两者的降糖效果相近。

关键词：桑叶发酵降血糖糖尿病小鼠

应用于电推进系统的宽输入电压范围高压电源研究

在线全文

学校读者我要写书评

暂无评论

电子技术应用 2021年第3期47卷 91-96页

作者：施凯敏张东来王子才张华吕文琪哈尔滨工业大学航天学院黑龙江哈尔滨150001 深圳航天科技创新研究院电力电子所广东深圳518057 哈尔滨工业大学(深圳)机电工程与自动化学院广东深圳518055

电推进电源(Power Processing Unit,PPU)是电推进系统的核心单机,其体积、重量及关键技术难度往往超过推力器本身。屏栅电源及阳极电源这类大功率高压电源是电推进电源系统的核心部件。针对多模式切换电推进系统的需求,提出了一种适用... 详细信息

电推进电源(Power Processing Unit,PPU)是电推进系统的核心单机,其体积、重量及关键技术难度往往超过推力器本身。屏栅电源及阳极电源这类大功率高压电源是电推进电源系统的核心部件。针对多模式切换电推进系统的需求,提出了一种适用于宽输入电压范围屏栅电源的两级式功率拓扑架构,前级为两相交错并联Boost拓扑以实现宽范围调压,后级为工作于最优频率点的不控谐振拓扑以实现高变比隔离升压。研究该功率拓扑架构的控制方式及磁性器件的设计原则并最终给出了相应的实验结果。

关键词： PPU 屏栅电源交错并联Boost 谐振

Temperature acclimation in hot-spring snakes and the convergence of cold response

在线全文

学校读者我要写书评

暂无评论

The Innovation 2022年第5期3卷 97-106页

作者： Chaochao Yan Wei Wu wenqi Dong Bicheng Zhu Jiang Chang Yunyun lv Shilong Yang Jia-Tang Li CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China College of Wildlife and Protected Area Northeast Forestry UniversityHarbin 660223China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100085China College of Life Science Neijiang Normal UniversityNeijiangSichuan 641100China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China

Animals have evolved sophisticated temperature-sensing systems and mechanisms to detect and respond to ambient temperature changes.As a relict species endemic to the Qinghai-Tibet Plateau,hot-spring snake(Thermophis baileyi)survived the dramatic changes in climate that occurred during plateau uplift and ice ages,providing an excellent opportunity to explore the evolution of temperature sensation in ectotherms.Based on distributional information and behavioral experiments,we found that T.baileyi prefer hotspring habitats and respond more quickly to warmth than other two snakes,suggesting that T.baileyi may evolve an efficient thermal-sensing system.Using high-quality chromosome-level assembly and comparative genomic analysis,we identified cold acclimation genes experiencing convergent acceleration in high-altitude lineages.We also discovered significant evolutionary changes in thermosensation-and thermoregulation-related genes,including the transient receptor potential(TRP)channels.Among these genes,TRPA1 exhibited three species-specific amino acid replacements,which differed from those found in infrared imaging snakes,implying different temperature-sensing molecular strategies.

关键词： habitat spring snake

炙马钱子胶囊治疗硼替佐米致周围神经病变的临床研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华中医药学刊 2017年第6期35卷 1405-1409页

作者：戴铁颖陈楚楚裴君王亚格吕文琪杨薛洪莉莉蒋艳沈建平裘昌林胡致平浙江中医药大学附属第一医院浙江杭州310006

目的:观察炙马钱子胶囊治疗硼替佐米致周围神经病(bortezomib-induced peripheral neuropathy,BIPN)的临床疗效。方法:收集19例经弥可保等药物治疗无效的患者,采用自身前后对照方法,予炙马钱子胶囊口服治疗,观察治疗前后神经毒性评分、... 详细信息

目的:观察炙马钱子胶囊治疗硼替佐米致周围神经病(bortezomib-induced peripheral neuropathy,BIPN)的临床疗效。方法:收集19例经弥可保等药物治疗无效的患者,采用自身前后对照方法,予炙马钱子胶囊口服治疗,观察治疗前后神经毒性评分、神经痛分级、中医症候积分及肌电图神经传导速度,评价中药有效率。结果:治疗后神经毒性评分、神经痛分级、中医症候积分降低(P<0.05),神经传导速度增加(P<0.05),疗效肯定,无明显毒副反应。结论:马钱子治疗BIPN安全有效,可改善骨髓瘤患者预后;采用非侵入性、精准、中西医结合的评估体系,可更早诊断BIPN,更好提供中药治疗有效的科学依据。

关键词：硼替佐米致周围神经病变炙马钱子胶囊中医症候神经传导

A systems biology approach identifies a regulator,BplERF1,of cold tolerance in Betula platyphylla

在线全文

学校读者我要写书评

暂无评论

Forestry Research 2021年第1期1卷 96-105页

作者： Kaiwen lv wenqi Wu Hairong Wei Guifeng Liu State Key Laboratory of Tree Genetics and Breeding Northeast Forestry UniversityHarbin 150040China Beijing Advanced Innovation Center for Tree Breeding by Molecular Design Beijing Forestry UniversityBeijing 100083China College of Forest Resources and Environmental Science Michigan Technological UniversityHoughtonMI 49931United States of America

Cold is an abiotic stress that can greatly affect the growth and survival of plants.Here,we reported that an AP2/ERF family gene,BplERF1,isolated from Betula platyphylla played a contributing role in cold stress tolerance.Overexpression of BplERF1 in B.platyphylla transgenic lines enhanced cold stress tolerance by increasing the scavenging capability and reducing H_(2)O_(2) and malondialdehyde(MDA)content in transgenic plants.Construction of BplERF-mediated multilayered hierarchical gene regulatory network(ML-hGRN),using Top-down GGM algorithm and the transcriptomic data of BplERF1 overexpression lines,led to the identification of five candidate target genes of BplERF1 which include MPK20,ERF9,WRKY53,WRKY70,and GIA1.All of them were then verified to be the true target genes of BplERF1 by chromatin-immunoprecipitation PCR(ChIP-PCR)assay.Our results indicate that BplERF1 is a positive regulator of cold tolerance and is capable of exerting regulation on the expression of cold signaling and regulatory genes,causing mitigation of reactive oxygen species.

关键词： tolerance platyphylla verified

A novel mutation in ROR2 led to the loss of function of ROR2 and inhibited the osteogenic differentiation capability of bone marrow mesenchymal stem cells(BMSCs)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2023年第7期47卷 1561-1569页

作者： wenqi CHEN XIAOYANG CHU YANG ZENG YOUSHENG YAN YIPENG WANG DONGLAN SUN DONGLIANG ZHANG JING ZHANG KAI YANG Prenatal Diagnosis Center Shijiazhuang Obstetrics and Gynecology HospitalKey Laboratory of Maternal and Fetal Medicine of Hebei ProvinceShijiazhuang050011China Department of Stomatology Fifth Medical Center of Chinese PLA General HospitalBeijing100039China Institute of Hematology Fifth Medical Center of Chinese PLA General HospitalBeijing100039China Prenatal Diagnosis Center Beijing Obstetrics and Gynecology HospitalBeijing Maternal and Child Health Care HospitalCapital Medical UniversityBeijing100026China Department of Orthodontics Beijing Stomatological HospitalCapital Medical University School of StomatologyCapital Medical UniversityBeijing100050China

Receptor tyrosine kinase-like orphan receptor 2(ROR2)has a vital role in osteogenesis.However,the mechanism underlying the regulation of ROR2 in osteogenic differentiation is still poorly comprehended.A previous study by our research group showed that a novel compound heterozygous ROR2 variation accounted for the autosomal recessive Robinow syndrome(ARRS).This study attempted to explore the impact of the ROR2:c.904C>T variant specifically on the osteogenic differentiation of BMSCs.Methods:Coimmunoprecipitation(CoIP)-western blotting was carried out to identify the interaction between ROR2 and Wnt5a.Double-immunofluorescence staining was used for determining the expressions and co-localization of ROR2 and Wnt5a in bone marrow mesenchymal stem cells(BMSCs).Western blot(WB)analysis and quantitative reverse transcription polymerase chain reaction(RT-qPCR)were conducted to identify the expression levels of ROR2 in the BMSCs transfected with lv-shROR2 or lv-ROR2-c.904C>T.The alkaline phosphatase(ALP)activity was detected,and Alizarin Red S staining was done for evaluating the osteogenic differentiation of BMSCs.RT-qPCR was employed to identify the expression of the sphingomyelin synthase 1(SMS1)mRNA in the BMSCs transfected with lv-shROR2 or lv-ROR2-c.904C>T and the mRNA expression levels of Runt-related transcription factor 2(RUNX2),osteocalcin(OCN),and osteopontin(OPN).WB was performed to confirm the protein expressions of extracellular regulated protein kinases1(ERK),P-ERK,Smad family member1/5/8(Smad1/5/8),P-Smad1/5/8,P-P38,P38,RUNX2,OCN,and OPN in the BMSCs transfected with lv-shROR2/lv-ROR2-c.904C>T and sphingomyelin(SM).Results:The ROR2:c.904C>T mutant altered the subcellular localization of the ROR2 protein,which caused an impaired interaction between ROR2 and Wnt5a.The depletion of ROR2 restricted the osteogenic differentiation capability of BMSCs and downregulated the expression of SMS1.SM treatment could reverse the inhibition of osteoblastic differentiation in ROR2-depleted BMSCs.Conclusion:The findings of

关键词： Bone marrow mesenchymal stem cells ROR2 Wnt5a Osteogenic differentiation Sphingomyelin

Grain Yield Predict Based on GRA-AdaBoost-SVR Model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal on Big Data 2021年第2期3卷 65-76页

作者： Diantao Hu Cong Zhang wenqi Cao Xintao lv Songwu Xie Wuhan Polytechnic University Wuhan430023China

Grain yield security is a basic national policy of China,and changes in grain yield are influenced by a variety of factors,which often have a complex,non-linear relationship with each other.Therefore,this paper proposes a Grey Relational Analysis-Adaptive Boosting-Support Vector Regression(GRA-AdaBoost-SVR)model,which can ensure the prediction accuracy of the model under small sample,improve the generalization ability,and enhance the prediction accuracy.SVR allows mapping to high-dimensional spaces using kernel functions,good for solving nonlinear problems.Grain yield datasets generally have small sample sizes and many features,making SVR a promising application for grain yield datasets.However,the SVR algorithm’s own problems with the selection of parameters and kernel functions make the model less generalizable.Therefore,the Adaptive Boosting(AdaBoost)algorithm can be used.Using the SVR algorithm as a training method for base learners in the AdaBoost algorithm.Effectively address the generalization capability problem in SVR algorithms.In addition,to address the problem of sensitivity to anomalous samples in the AdaBoost algorithm,the GRA method is used to extract influence factors with higher correlation and reduce the number of anomalous samples.Finally,applying the GRA-AdaBoost-SVR model to grain yield forecasting in China.Experiments were conducted to verify the correctness of the model and to compare the effectiveness of several traditional models applied to the grain yield data.The results show that the GRA-AdaBoost-SVR algorithm improves the prediction accuracy,the model is smoother,and confirms that the model possesses better prediction performance and better generalization ability.

关键词： Grey Relational Analysis(GRA) Support Vector Regression(SVR) Adaptive Boosting algorithm(AdaBoost) grain yield prediction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

椎神经节麻醉的应用解剖学研究

中国临床解剖学杂志 2023年第6期41卷 640-646页

作者：吴文斌胡雨田代琳曦吕旺轩吕丰均尹袁杰杨红梦畅君达李文奇郭义威新乡医学院大体形态学实验室新乡医学院新乡医学院国际教育学院新乡医学院人体解剖与组织胚胎学系河南新乡453003

目的观测椎神经节的解剖特征,为临床颈部交感干神经节麻醉提供解剖学依据。方法对30具(60侧)成人大体标本进行解剖,根据出现的形式区分颈中神经节与椎神经节,观测椎神经节的形态、位置、大小及其与周围结构的毗邻关系。结果椎神经节出... 详细信息

目的观测椎神经节的解剖特征,为临床颈部交感干神经节麻醉提供解剖学依据。方法对30具(60侧)成人大体标本进行解剖,根据出现的形式区分颈中神经节与椎神经节,观测椎神经节的形态、位置、大小及其与周围结构的毗邻关系。结果椎神经节出现率为83.33%,测得椎神经节长,右侧:男(5.06±2.64)mm,女(4.72±2.56)mm,左侧:男(4.43±2.76)mm,女(4.28±2.43)mm;宽,右侧:男(3.31±1.57)mm,女(2.86±1.96)mm,左侧:男(3.14±0.93)mm,女(3.08±1.56)mm;厚,右侧:男(1.52±1.07)mm,女(1.88±1.56)mm,左侧:男(1.57±0.98)mm,女(2.14±1.21)mm,左右侧椎神经节的长、宽、厚未见统计学差异(P>0.05)。椎神经节的形态多为椭圆形(50%),其主要位于椎动脉起始部稍上方,发出分支与颈胸神经节的节后纤维共同分布于相应部位。两侧椎神经节至颈前正中线的距离及至皮肤的深度相近,无统计学差异(P>0.05)。结论椎神经节为颈部交感神经节的一部分,可能为低位颈中神经节,是颈胸神经节的辅助神经节,与其共同发出节后纤维至靶器官,颈胸神经节阻滞时的不完全阻滞和副反应可能与椎神经节的纤维联系有关。

关键词：交感神经麻醉椎神经节应用解剖