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中国皮肤性病学杂志 2024年第1期38卷 94-96页

作者：喻光莲曹灿寸玥婷何盎然宋雯琦施东芳何黎刘彤云昆明医科大学第一附属医院皮肤科云南昆明650032

患者男,27岁,腋下、腹股沟区、耳颞部反复红斑、丘疹、脓疱伴痒2年。皮损组织病理示:角质层下海绵状脓疱形成,伴有棘层增厚,真皮浅层有中性粒细胞和淋巴细胞混合浸润。直接免疫荧光:阴性。诊断:皱褶部位无菌性脓疱病(APF)。

关键词：无菌性脓疱病皱褶部位嗜中性粒细胞皮病自身免疫性疾病

The Pathology of Primary Familial Brain Calcification:Implications for Treatment

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Neuroscience Bulletin 2023年第4期39卷 659-674页

作者： Xuan Xu Hao Sun Junyu Luo Xuewen Cheng wenqi Lv Wei Luo Wan-Jin Chen Zhi-Qi Xiong Jing-yu Liu Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China College of Life Science and Technology Huazhong University of Science and TechnologyWuhan430074China Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhou350005China Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou310009China

Primary familial brain calcification(PFBC)is an inherited neurodegenerative disorder mainly characterized by progressive calcium deposition bilaterally in the brain,accompanied by various symptoms,such as dystonia,ataxia,parkinsonism,dementia,depression,headaches,and epilepsy.Currently,the etiology of PFBC is largely unknown,and no specific prevention or treatment is available.During the past 10 years,six causative genes(SLC20A2,PDGFRB,PDGFB,XPR1,MYORG,and JAM2)have been identified in PFBC.In this review,considering mechanistic studies of these genes at the cellular level and in animals,we summarize the pathogenesis and potential preventive and therapeutic strategies for PFBC patients.Our systematic analysis suggests a classification for PFBC genetic etiology based on several characteristics,provides a summary of the known composition of brain calcification,and identifies some potential therapeutic targets for PFBC.

关键词： Primary familial brain calcification Causative gene Pathogenesis Preventive and therapeutic strategy

台湾海峡西侧海湾-岛屿系统影响下的流场年季变化——以南日水道为例

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应用海洋学学报 2024年第1期43卷 33-44页

作者：陈宇林于渟束芳芳蔡鸿泰李云海池文琦何佳陈智杰郑斌鑫中电投广西核电有限公司广西防城港538000 自然资源部第三海洋研究所福建厦门361005 福建省海洋物理与地质过程重点实验室福建厦门361005

台湾海峡地理位置独特,西侧海域海湾-岛屿系统普遍发育,显著影响了海域流场分布。同时,海峡西岸经济区的快速发展对区域海洋动力环境背景场及其变化的精细认识提出了更高的要求。福建莆田南日岛西侧南日水道是连通兴化湾与平海湾的主要... 详细信息

台湾海峡地理位置独特,西侧海域海湾-岛屿系统普遍发育,显著影响了海域流场分布。同时,海峡西岸经济区的快速发展对区域海洋动力环境背景场及其变化的精细认识提出了更高的要求。福建莆田南日岛西侧南日水道是连通兴化湾与平海湾的主要水道,是区域海洋动力环境的“咽喉”所在,在区域海洋环境保护与科学开发利用中居于至关重要的位置。为了全面认识台湾海峡西侧海湾-岛屿系统影响下区域海洋动力环境背景场的年季变化,本研究利用布放在南日水道的座底观测系统获得的周年海流资料,结合同期气象风场资料,通过数据统计分析、调和分析、滤波处理和小波变化等手段,研究了南日水道内海流的季节变化规律和驱动余流的动力要素,初步探讨了热带气旋等对海洋动力演化过程的影响。研究结果表明,研究海域潮流为不正规半日浅海潮流,并具有明显的半月周期,涨潮流大于落潮流,涨潮流主方向为WNW向,落潮流主方向为SE—ESE向。旋转谱结果表明,研究海域以半日潮为主,逆时针能量强于顺时针,惯性周期无明显的谱峰。潮流强度的季节变化特征为冬季最强,秋季、春季次之,夏季最弱。夏、秋季的余流流速较其他季节明显偏大,表层余流有明显的季节特征,底层余流全年为北向流。观测点余流主要由风引起,二者有很好的相关性,但频率统计结果显示二者方向不一致,表明余流在地形的作用下发生了转向,其中潮致余流对表层余流贡献较小。小波能量图表明,双台风(热带气旋)期间风和余流均存在1 d及6 d左右的周期信号,二者密切相关。本研究成果对于区域海洋环保以及海域科学开发与应用具有重要的现实意义。

关键词：海洋水文学潮流余流年季变化海湾-岛屿系统热带气旋南日水道

百里香酚对犊牛源生物被膜阳性金黄色葡萄球菌耐药性的消除作用

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中国兽医杂志 2024年第1期60卷 66-71页

作者：赵红霞顾珂瑞宋晨李培锋孙月樊宏亮郭宇徐文琦内蒙古农业大学兽医学院内蒙古呼和浩特010010 内蒙古优然牧业有限责任公司内蒙古呼和浩特010010 内蒙古动物疾病预防控制中心内蒙古呼和浩特010010

为了了解内蒙古地区犊牛病料中生物被膜阳性金黄色葡萄球菌的流行情况、耐药情况及百里香酚对生物被膜阳性金黄色葡萄球菌耐药性的消除作用。本试验采用生化鉴定和PCR方法,对采集到的104份犊牛病料进行金黄色葡萄球菌的分离鉴定;采用K-... 详细信息

为了了解内蒙古地区犊牛病料中生物被膜阳性金黄色葡萄球菌的流行情况、耐药情况及百里香酚对生物被膜阳性金黄色葡萄球菌耐药性的消除作用。本试验采用生化鉴定和PCR方法,对采集到的104份犊牛病料进行金黄色葡萄球菌的分离鉴定;采用K-B法检测了金黄色葡萄球菌分离株对18种抗菌药物的敏感性;采用改良结晶紫染色法测定分离株的生物被膜形成能力;选取2株生物被膜强阳性菌株,采用微量肉汤稀释法测定百里香酚对分离株的最小抑菌浓度,并进行百里香酚耐药性消除试验。结果显示,在104份犊牛病料中共分离鉴定获得43株金黄色葡萄球菌。药敏试验结果显示,金黄色葡萄球菌分离株对氨苄西林、头孢西丁、卡那霉素、复方新诺明和红霉素5种抗菌药物的耐药率达到50.0%以上;74.4%(32/43)的分离株为多重耐药株。生物被膜形成能力强、中、弱和无生物被膜形成能力的分离株分别占比23.3%(10/43)、16.3%(7/43)、32.6%(14/43)和27.9%(12/43);生物被膜阳性株中83.9%(26/31)为多重耐药株。百里香酚对2株生物被膜强阳性株的最小抑菌浓度均为256 mg/mL,经百里香酚处理后均恢复了对头孢噻肟的敏感性。结果表明,百里香酚对生物被膜阳性金黄色葡萄球菌具有一定的耐药消除作用。

关键词：犊牛源金黄色葡萄球菌生物被膜多重耐药性百里香酚耐药消除

Research perspective and prospective of additive manufacturing of biodegradable magnesium-based materials

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Journal of Magnesium and Alloys 2023年第5期11卷 1485-1504页

作者： Qingyun Fu wenqi Liang Jiaxin Huang Weihong Jin Baisong Guo Ping Li Shulan Xu Paul K.Chu Zhentao yu Center of Oral Implantology Stomatological HospitalSouthern Medical UniversityGuangzhou 510280China Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou 510632China Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina

Biodegradable metals such as magnesium(Mg)and its alloys have attracted extensive attention in biomedical research due to their excellent mechanical properties and biodegradability.However,traditional casting,extrusion,and commercial processing have limitations in manufacturing components with a complex shape/structure,and these processes may produce defects such as cavities and gas pores which can degrade the properties and usefulness of the products.Compared to conventional techniques,additive manufacturing(AM)can be used to precisely control the geometry of workpieces made of different Mg-based materials with multiple geometric scales and produce desirable medical products for orthopedics,dentistry,and other fields.However,a detailed and thorough understanding of the raw materials,manufacturing processes,properties,and applications is required to foster the production of commercial Mg-based biomedical components by AM.This review summarizes recent advances and important issues pertaining to AM of Mg-based biomedical products and discusses future development and application trends.

关键词： Magnesium-based materials Additive manufacturing Wires and powders Biomedical metallic materials Medical devices

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爬岩红提取物对化学性肝损伤小鼠的保护作用

龙岩学院学报 2024年第2期42卷 44-52页

作者：谭烨敏李嘉嘉余雯琦王雪魏雨萱陈彤龙岩学院福建省家畜疫病防治与生物技术重点实验室福建龙岩364000

分别用体积分数0.5%CCl_(4)、50%乙醇溶液建立小鼠急性肝损伤模型,研究爬岩红水提物、醇提物对CCl_(4)和酒精所致的肝损伤小鼠的保护作用。结果显示,爬岩红水提物、醇提物均能降低CCl_(4)肝损伤小鼠血清ALT活性、肝组织MDA水平,升高肝组... 详细信息

分别用体积分数0.5%CCl_(4)、50%乙醇溶液建立小鼠急性肝损伤模型,研究爬岩红水提物、醇提物对CCl_(4)和酒精所致的肝损伤小鼠的保护作用。结果显示,爬岩红水提物、醇提物均能降低CCl_(4)肝损伤小鼠血清ALT活性、肝组织MDA水平,升高肝组织GSH-PX、T-SOD、CAT、白蛋白水平,减轻CCl4肝损伤小鼠肝组织的病理变化程度,且二者的保肝作用无显著差异(P>0.05);爬岩红水提物、醇提物均能降低酒精性肝损伤小鼠血清ALT活性、肝组织MDA和TG水平,升高肝组织GSH、T-SOD水平,减轻酒精性肝损伤小鼠肝组织的病理变化程度,且水提物的效果更为显著(P<0.05)。爬岩红水提取物、醇提取物对CCl_(4)和酒精所致的肝损伤小鼠均有保护作用,水提物对酒精性肝损伤的保护作用更好。

关键词：爬岩红提取物小鼠肝损伤保护作用

Lynch syndrome pre-screening and comprehensive characterization in a multi-center large cohort of Chinese patients with colorectal cancer

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Cancer Biology & Medicine 2022年第8期19卷 1235-1248页

作者： Yan Li Lihong Fan Jianming Zheng Xiu Nie yu Sun Qin Feng Shenyi Lian wenqi Bai Weijing Cai Yanan Yang Bo Su Yanfeng Xi Dongmei Lin Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Respiration Medicine Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Pathology Changhai Hospital of ShanghaiShanghai 200433China Department of Pathology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital&InstituteBeijing 100142China Department of Colorectal Surgery Shanxi Cancer HospitalTaiyuan 030013China Shanghai Tongshu Biotechnology Co. LtdShanghai 200120China Department of Biochemistry and Molecular Biology Mayo ClinicRochesterMN 55905USA Central Laboratory Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China Department of Pathology Shanxi Cancer HospitalTaiyuan 030013China

Objective:Lynch syndrome(LS)pre-screening methods remain under-investigated in colorectal cancers(CRCs)in Asia.Here,we aimed to systematically investigate LS pre-screening and comprehensively characterize LS CRCs.Methods:Microsatellite instability(MSI)and germline variants of DNA mismatch repair(MMR)genes were examined in 406 deficient MMR(dMMR)and 250 proficient MMR CRCs.The genetic differences between LS and sporadic CRCs were studied with whole exome sequencing analysis.Results:The incidence of dMMR in Chinese patients with CRCs was 13.8%.Consistency analysis between MMR immunohistochemistry(IHC)and MSI testing showed the kappa value was 0.758.With next-generation sequencing(NGS),germline variants were detected in 154 CRCs.Finally,88 patients with CRC were identified as having LS by Sanger sequencing.Among them,we discovered 21 previously unreported pathogenic germline variants of MMR genes.Chinese patients with LS,compared with sporadic CRCs,tended to be early-onset,right-sided,early-stage and mucinous.Overall,the performance of MMR IHC and MSI testing for LS pre-screening was comparable:the area under the ROC curve for dMMR,MSI-H,and MSI-H/L was 0.725,0.750,and 0.745,respectively.dMMR_MSI-H LS and sporadic CRCs showed substantial differences in somatic genetic characteristics,including different variant frequencies of APC,CREBBP,and KRAS,as well as different enriched pathways of VEGF,Notch,TGFβR,mTOR,ErbB,and Rac protein signal transduction.Conclusions:MMR IHC and MSI testing were effective methods for LS pre-screening.The revealed clinical and somatic genetic characteristics in LS CRCs may have the potential to improve the performance of LS pre-screening in combination with dMMR/MSI.

关键词： Microsatellite instability mismatch repair sequencing Lynch syndrome somatic genetic characteristics

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船舶结构边界条件下多气泡脉动特性

山东交通学院学报 2024年第2期32卷 116-122页

作者：龚月滢于福临苏超郭文琦李战全阮雨李庆海山东交通学院船舶与港口工程学院山东威海264200 威海市流固耦合动力学重点实验室山东威海264200

为研究多气泡在船舶壁面结构附近的脉动特性,采用400 V水下低压放电生成气泡技术,通过超高速摄像机记录水下气泡的脉动过程。在气泡距壁面适当距离下,在水平壁面下方水平布置或垂向布置2个气泡,在V型结构壁面两侧对称水平布置2个气泡,... 详细信息

为研究多气泡在船舶壁面结构附近的脉动特性,采用400 V水下低压放电生成气泡技术,通过超高速摄像机记录水下气泡的脉动过程。在气泡距壁面适当距离下,在水平壁面下方水平布置或垂向布置2个气泡,在V型结构壁面两侧对称水平布置2个气泡,在不同的气泡与壁面距离、2个气泡间距下分析多气泡耦合脉动特性。试验结果表明:不同边界条件下2个气泡的耦合特性不同;水平壁面下方垂向布置的2个气泡融合后出现颈缩现象,产生的射流穿透气泡后冲击到壁面,壁面承受冲击力;水平壁面下方水平布置的2个气泡融合后产生斜向上的射流,射流相撞,最终冲击到壁面上,对壁面造成损伤;V型结构壁面下水平布置2个气泡,耦合后产生指向对方和V型结构的射流,射流在气泡中间相撞,气泡断裂,射流对V型结构的冲击较小。

关键词：水下爆炸多气泡 V型结构气泡脉动

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对位甲基取代苯基吡唑啉酮缩芳胺类席夫碱的合成与表征

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山东化工 2024年第8期53卷 11-13,17页

作者：徐宁尚宇辉霍文琪于兰芳张恒强吴琼河北民族师范学院河北承德067000

利用1-对甲苯基-3-甲基-4-呋喃甲酰基吡唑啉酮-5(HPMFP)为本体分别与对甲苯胺、对碘苯胺进行缩合反应得到的HPMFP缩对甲苯胺、HPMFP缩对碘苯胺两种席夫碱新物质,并利用元素分析法、红外分光光度分析法和X-射线单晶法对实验最终得到的产... 详细信息

利用1-对甲苯基-3-甲基-4-呋喃甲酰基吡唑啉酮-5(HPMFP)为本体分别与对甲苯胺、对碘苯胺进行缩合反应得到的HPMFP缩对甲苯胺、HPMFP缩对碘苯胺两种席夫碱新物质,并利用元素分析法、红外分光光度分析法和X-射线单晶法对实验最终得到的产物进行表征,进一步确定了实验所得最终产物的结构。

关键词：取代苯基吡唑啉酮席夫碱合成表征晶体结构

Co-firing of coal and biomass in oxy-fuel fluidized bed for CO2 capture: A review of recent advances

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Chinese Journal of Chemical Engineering 2019年第10期27卷 2261-2272页

作者： Qinwen Liu Yan Shi wenqi Zhong Aibing yu Key Laboratory of Energy Thermal Conversion and Control of the Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China Center for Simulation and Modelling of Particulate Systems Southeast University-Monash University Joint Research InstituteSuzhou 215000China 3 ARC Research Hub for Computational Particle TechnologyDepartment of Chemical EngineeringMonash UniversityClaytonVIC 3800Australia

The co-firing of coal and biomass in oxy-fuel fluidized beds is one of the most promising technologies for capturing CO2.This technology has attracted wide attention from academia and industry in recent years as a negative emission method to capture CO2 produced by carbon contained in biomass.In the past decades,many studies have been carried out regarding experiments and numerical simulations under oxy-fuel combustion conditions.This paper firstly briefly discusses the techno-economic viability of the biomass and coal co-firing with oxycombustion and then presents a review of recent advancements involving experimental research and computational fluid dynamics(CFD)simulations in this field.Experimental studies on mechanism research,such as thermogravimetric analysis and tube furnace experiments,and fluidized bed experiments based on oxy-fuel fluidized beds with different sizes as well as the main findings,are summarized as a part of this review.It has been recognized that CFD is a useful approach for understanding the behaviors of the co-firing of coal and biomass in oxyfuel fluidized beds.We summarize a recent survey of published CFD research on oxy-fuel fluidized bed combustion,which categorized into Eulerian and Lagrangian methods.Finally,we discuss the challenges and interests for future research.

关键词： Oxy-fuel combustion Co-firing of coal and biomass Oxy-fuel fluidized bed CFD simulation