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Constraints on the late Mesozoic regional angular unconformity in West Liaoning-North Hebei by LA-ICP-MS dating

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Progress in Natural Science:Materials International 2008年第11期18卷 1395-1402页

作者： Hong Zhang~(a,b,*) wenmin Guo~a Xiaoming liu~b a College of Mechanical and Energy Engineering,Jiangsu Polytechnic University,Changzhou 213016,China b Key Laboratory of Continental Dynamics,Department of Geology,Northwest University,Xi’an 710069,China College of Mechanical and Energy Engineering Jiangsu Polytechnic University Changzhou 213016 China Key Laboratory of Continental Dynamics Department of Geology Northwest University Xi’an 710069 China

The angular unconformity between the Tuchengzi Formation and the Zhangjiakou Formation in the Chengde area is commonly regarded as the direct evidence of boundary between Jurassic and Cretaceous systems,and as the evidence of tectonic transformation interfaces in Mesozoic Era in the West Liaoning-North ***,the lower boundary age of the Zhangjiakou Formation in the Chengde was to be thought about 135 Myr in the *** on the detailed study and systematic sampling in Yixian-Beipiao,Lingy- uan,Chengde and Luanping areas in the field,the authors obtained the following isotopic ages by means of LA-ICP-MS dating:In the Lingyuan area,the Zhangjiakou Formation and the Yixian Formation are in angular unconformable contact;the age range of the Zhangjiakou Formation volcanic rock is from 133 to 130 Myr(seven samples),and that of the Yixian Formation volcanic rock is from 126 to 121 Myr(eleven samples).In the Luotuoshan of Chengde,the Tuchengzi Formation and the Zhangjiakou Formation are in angu- lar unconformable contact;the age at the lower Zhangjiakou Formation is about 124 Myr(one sample),which reflects that the age range of the lower Zhangjiakou Formation is from 129 to 124 Myr combined with the previous *** the Luanping basin,there is the larg- est sediment gap in upper Mesozoic,whose lower boundary age is confined in 131 to 130 *** the Yixian-Beipiao area,the second Member of the Yixian Formation,making up more than 3/4 thickness of the Yixian Formation,was formed in 126 to 119 Myr,and the age of the Yixian Formation at the bottom is about 132 ***,the upper boundary age of the Tuchengzi Formation is about 136 Myr in the West Liaoning-North Hebei *** on the above isotopic data combined with the geological characteristics in the field in the West Liaoning-North Hebei region,it reflects that there was a widespread tectonic event in the period of 136 to 126 Myr (mainly in 130-126 Myr)in the West Liaoning-North Hebei,and it formed the

关键词： Dating LA-ICP-MS Angular unconformity Interface of tectonic transformation West Liaoning-North Hebei

Landiolol Hydrochloride for Prevention of Atrial Fibrillation after Cardiac Surgery:A Meta-Analysis

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Landiolol Hydrochloride for Prevention of Atrial Fibrillatio...

2016年浙江省医学会心电生理与起搏学术年会

作者： SHANXIN liu CHANG BIAN YU ZHANG YING JIAN wenmin liu Department of Cardiology the Affiliated Hospital of Hangzhou Normal University Department of Cardiology the Second Affiliated HospitalSchool of MedicineZhejiang University

Background:Atrial fibrillation(AF) is the most common arrhythmic complication after cardiac *** studies have compared the efficacy of landiolol and placebo or other agents in preventing new-onset AF in patients after cardiac *** this study,we conducted a meta-analysis to determine whether landiolol is effective in preventing new-onset AF after cardiac *** and Results:Five randomized controlled trials and two retrospective analyses were included in this *** clinical outcomes of interest were the occurrence of AF after cardiac surgery and major ***-analysis was performed using RevMan 5.0.18 software,and pooled estimates of the effect were reported as risk ratios(RR) with 95% confidence intervals(CI).The results of this meta-analysis indicate that landiolol is significantly associated with a decreased risk of occurrence of AF after cardiac surgery(RR=0.33;95% CI:0.23-0.48;P<0.00001) and is not associated with an increased risk of major complications(RR=0.79;95% CI:0.43-1.45;P=0.45) compared with the control ***:Landiolol administration in the perioperative period can reduce the occurrence of AF after cardiac surgery without increasing the risk of major *** can be used to prevent new-onset AF safely after cardiac surgery.

关键词： landiolol hydrochloride atrial fibrillation cardiac surgery β1-selective blocker

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电信大数据分析下的时空区域经济可视化应用

北京航空航天大学学报 2022年第2期48卷 273-281页

作者：李娜刘文敏孟繁瑞刘岩国家计算机网络应急技术处理协调中心山东分中心济南250002

当前,国内移动电话用户已达15.9亿,在巨大的用户基数下,电信大数据呈现的特征在一定程度上反映了人群活动特征,进一步能够反映特定区域的发展状况。时空区域经济可视化应用利用数据挖掘技术对电信大数据进行处理和提取,以提高数据质量,... 详细信息

当前,国内移动电话用户已达15.9亿,在巨大的用户基数下,电信大数据呈现的特征在一定程度上反映了人群活动特征,进一步能够反映特定区域的发展状况。时空区域经济可视化应用利用数据挖掘技术对电信大数据进行处理和提取,以提高数据质量,并对数据进行不同规则的筛选,通过建模技术进行分析,结合电子地图数据、交通数据等多源信息,多角度分析用户行为特征。该应用分析对时空区域经济状况进行可视化研究,分析居民生活属性,同时,利用双重差分(DID)统计模型对区域经济政策进行评价。基于特征分析结果,为区域经济发展热点选址、指导城市商圈布局提供决策依据,提高了城市系统运行的效率,扩大了经济区域效益范围。

关键词：电信大数据手机信令数据挖掘区域经济可视化

Yap methylation-induced FGL1 expression suppresses anti-tumor immunity and promotes tumor progression in KRAS-driven lung adenocarcinoma

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Cancer Communications 2024年第11期44卷 1350-1373页

作者： Ji Jiang Pengfei Ye Ningning Sun Weihua Zhu Mei Yang Manman Yu Jingjing Yu Hui Zhang Zijie Gao Ningjie Zhang Shijie Guo Yuru Ji Siqi Li Cuncun Zhang Sainan Miao Mengqi Chai wenmin liu Yue An Jian Hong Wei Wei Shihao Zhang Huan Qiu Institute of Clinical Pharmacology Anhui Medical University Key Laboratory of Anti-Inflammatory and Immune Medicine Ministry of EducationAnhui Collaborative Innovation Centre of Anti-Inflammatory and Immune MedicineHefeiAnhuiP.R.China School of Nursing Anhui Medical UniversityHefeiAnhuiP.R.China 3Department of HematologyThe First Affiliated Hospital of Anhui Medical UniversityHefeiAnhuiP.R.China

Background:Despite significant strides in lung cancer immunotherapy,the response rates for Kirsten rat sarcoma viral oncogene homolog(KRAS)-driven lung adenocarcinoma(LUAD)patients remain ***-like protein 1(FGL1)is a newly identified immune checkpoint target,and the study of related resistance mechanisms is crucial for improving the treatment outcomes of LUAD *** study aimed to elucidate the potential mechanism by which FGL1 regulates the tumor microenvironment in KRAS-mutated ***:The expression levels of FGL1 and SET1 histone methyltransferase(SET1A)in lung cancer were assessed using public databases and clinical *** were constructed for transduction to overexpress or silence FGL1 in lung cancer cells and mouse *** effects of FGL1 and Yes-associated protein(Yap)on the immunoreactivity of cytotoxic T cells in tumor tissues were evaluated using immunofluorescence staining and flow *** immunoprecipitation and dual luciferase reporter assays were used to study the SET1A-directed transcriptional ***:Upregulation of FGL1 expression in KRAS-mutated cancer was inversely correlated with the infiltration of CD8^(+)T ***,KRAS activated extracellular signal-regulated kinase 1/2(ERK1/2),which subsequently phosphorylated SET1A and increased its stability and nuclear ***1A-mediated methylation of Yap led to Yap sequestration in the nucleus,thereby promoting Yap-induced transcription of FGL1 and immune evasion in KRAS-driven ***,dual blockade of programmed cell death-1(PD-1)and FGL1 further increased the therapeutic efficacy of anti-PD-1 immunotherapy in LUAD ***:FGL1 could be used as a diagnostic biomarker of KRAS-mutated lung cancer,and targeting the Yap-FGL1 axis could increase the efficacy of anti-PD-1 immunotherapy.

关键词： KRAS immunity Yap

管内固相微萃取-气相色谱法在线联用技术用于水样中的痕量分析

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色谱 2004年第4期22卷 354-357页

作者：关亚风王涵文刘文民 Department of Analytical Chemistry & Micro-Instrumentation Dalian Institute of Chemical PhysicsThe Chinese Academy of Sciences Dalian 116012 China

Since the development of solid phase micro-extraction (SPME) method[1], many modifications have been made to improve the availability and application of the technique[2-5]. The in-tube SPME (ITSPME) was emerged and employed in high performance liquid chromatography (HPLC) as an efficient and simple preparation method, which offers several advantages over the fiber SPME syringe[6]. The ITSPME should preserve the advantages of SPME, and could offer higher enrichment factor, better quantitation, and automation through an on-line coupling with a chromatograph.

关键词：固相微萃取毛细管气相色谱痕量分析水样在线分析

色谱与色谱/质谱法相结合分析热裂解汽油C_9馏分

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色谱 2006年第6期24卷 615-618页

作者：王华刘文民徐媛关亚风中国科学院大连化学物理研究所仪器分析化学研究室辽宁大连116023

采用毛细管气相色谱-氢火焰离子化检测器(CGC-FID)和气相色谱-质谱法(GC/MS)分析了热裂解汽油C9馏分的组成。实验使用PONA毛细管气相色谱柱(100 m×0.25 mm i.d.×0.5μm),根据烃类化合物在PONA柱上的保留规律,以正构烷烃标样保留值作... 详细信息

采用毛细管气相色谱-氢火焰离子化检测器(CGC-FID)和气相色谱-质谱法(GC/MS)分析了热裂解汽油C9馏分的组成。实验使用PONA毛细管气相色谱柱(100 m×0.25 mm i.d.×0.5μm),根据烃类化合物在PONA柱上的保留规律,以正构烷烃标样保留值作为碳数分布依据,定量分析了裂解汽油C9馏分中烃类化合物的碳数分布和单体烃含量;用GC/MS联用技术和CGC保留值定性法相结合对裂解汽油C9馏分中相对含量大于0.2%的39种化合物进行了定性。

关键词：毛细管气相色谱气相色谱-质谱联用裂解汽油C9馏分保留值定性分析数据交叉定性

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基于双光纤光栅的高灵敏度低频加速度传感器

光电子．激光 2021年第9期32卷 911-918页

作者：刘文敏戴玉堂魏禹武汉理工大学光纤传感技术国家工程实验室湖北武汉430070

针对低频振动信号的高精度测量需求,设计了一种基于双光纤光栅的变宽度椭圆铰链式低频加速度传感器。首先建立传感器的结构模型,理论分析了传感器的振动响应特性,给出该传感器的谐振频率及灵敏度的公式。随后搭建了传感单元的数学模型,... 详细信息

针对低频振动信号的高精度测量需求,设计了一种基于双光纤光栅的变宽度椭圆铰链式低频加速度传感器。首先建立传感器的结构模型,理论分析了传感器的振动响应特性,给出该传感器的谐振频率及灵敏度的公式。随后搭建了传感单元的数学模型,对传感单元结构的关键尺寸参数进行了优化。另外,利用有限元仿真验证了理论分析结果,最后加工制作了传感器样件,对其进行加速度性能测试。实验结果表明:传感器的谐振频率约为36 Hz,工作频带为0-10 Hz,灵敏度为1496 pm/g。所设计的传感器具有较高的灵敏度、良好的温度补偿能力,能够满足工程中低频振动检测的要求。

关键词：加速度传感器低频振动椭圆铰链优化设计

基于PCNN和非线性滤波万有引力的医学图像融合

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计算机工程与应用 2014年第24期50卷 191-198页

作者：刘雯敏陈秀宏江南大学数字媒体学院江苏无锡214122

为了更好地满足现代医学临床诊断和治疗的需要,提高医学图像的融合质量,提出在提升小波变换的基础上,结合脉冲耦合神经网络(PCNN)和像素点的非线性滤波万有引力的医学图像融合方法。低频子系数采用基于区域灰度均值的融合规则;高频子系... 详细信息

为了更好地满足现代医学临床诊断和治疗的需要,提高医学图像的融合质量,提出在提升小波变换的基础上,结合脉冲耦合神经网络(PCNN)和像素点的非线性滤波万有引力的医学图像融合方法。低频子系数采用基于区域灰度均值的融合规则;高频子系数采用自适应PCNN的融合规则,将像素的非线性滤波万有引力作为简化的PCNN模型中的链接强度,使PCNN能够自适应调节链接强度的大小,并根据点火矩阵确定高频子系数。实验结果表明,该方法得到的融合图像比其他融合方法保留了更多的边缘细节信息,各项评价指标均有所提高,有更好的融合性能。

关键词：医学图像融合提升小波变换脉冲耦合神经网络非线性滤波万有引力链接强度

N-邻甲氧基苯甲酰基-N'-芳酰氨基硫脲的合成与抑菌活性研究

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化学通报 2011年第7期74卷 665-668页

作者：柳文敏陈长中牛秋红陈曼化学与制药工程学院生物与生命科学学院南阳师范学院南阳473061

由邻甲氧基苯甲酰氯与硫氰酸钾反应生成邻甲氧基苯甲酰基异硫氰酸酯,再与芳酰肼进行加成反应,合成了8种邻甲氧基苯甲酰基芳酰氨基硫脲衍生物,其结构经元素分析、红外光谱和1H NMR确证。初步的生物活性测试结果表明,该类化合物对枯草杆... 详细信息

由邻甲氧基苯甲酰氯与硫氰酸钾反应生成邻甲氧基苯甲酰基异硫氰酸酯,再与芳酰肼进行加成反应,合成了8种邻甲氧基苯甲酰基芳酰氨基硫脲衍生物,其结构经元素分析、红外光谱和1H NMR确证。初步的生物活性测试结果表明,该类化合物对枯草杆菌有抑制作用,而对大肠杆菌无明显的抑制作用。

关键词：邻甲氧基苯甲酰氯酰氨基硫脲芳基酰肼合成抑菌活性