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Cigarette smoke promotes oral leukoplakia via regulating glutamine metabolism and M2 polarization of macrophage

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International Journal of Oral Science 2021年第3期13卷 261-270页

作者： Yanan Zhu Shuo Zhang Jiahui Sun Tingting wang Qin Liu Guanxi Wu Yajie Qian Weidong Yang Yong wang wenmei wang Nanjing Stomatological Hospital Medical School of Nanjing UniversityNanjingChina State Key Laboratory of Analytical Chemistry for Life Science&Jiangsu Key Laboratory of Molecular Medicine Medical SchoolNanjing UniversityNanjingChina The State Key Laboratory of Pharmaceutical Biotechnology Division of Immunology&Jiangsu Key Laboratory of Molecular MedicineMedical SchoolNanjing UniversityNanjingChina

Oral immunosuppression caused by smoking creates a microenvironment to promote the occurrence and development of oral mucosa precancerous *** study aimed to investigate the role of metabolism and macrophage polarization in cigarette-promoting oral *** effects of cigarette smoke extract(CSE)on macrophage polarization and metabolism were studied in vivo and in *** polarity of macrophages was detected by flow cytometric analysis and q *** chromatography-mass spectrometry(LC-MS)was used to perform a metabolomic analysis of Raw cells stimulated with *** and flow cytometry were used to detect the polarity of macrophages in the condition of glutamine abundance and *** Counting Kit-8(CCK-8),wound-healing assay,and Annexin V-FITC(fluorescein isothiocyanate)/PI(propidium iodide)double-staining flow cytometry were applied to detect the growth and transferability and apoptosis of Leuk-1 cells in the supernatant of Raw cells which were stimulated with CSE,glutamine abundance and *** and dysplasia of the epithelium were evident in smoking mice.M2 macrophages increased under CSE stimulation in vivo and in *** total,162 types of metabolites were detected in the CSE *** metabolites of nicotine,glutamate,arachidic acid,and arginine changed *** significant enrichment pathways were also selected,including nicotine addiction,glutamine and glutamate metabolism,and arginine *** results also showed that the supernatant of Raw cells stimulated by CSE could induce excessive proliferation of Leuk-1 and inhibit *** abundance can facilitate this *** smoke promotes oral leukoplakia via regulating glutamine metabolism and macrophage M2 polarization.

关键词： metabolism macrophage healing

海南岛红树林生态系统总初级生产力分布格局及形成机制

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广西植物 2024年第8期44卷 1415-1427页

作者：郑尹齐史娴陈权乌兰崔嵬王文梅孙仲益谭珂海南省海洋地质资源与环境重点实验室海口570206 海南省生态环境地质调查院海口570206 海南大学生态与环境学院海口570203 黑龙江大学水利电力学院哈尔滨150006 海南省农林环境过程与生态调控重点实验室海口570228 国家林业和草原局发展研究中心北京100714 广西壮族自治区中国科学院广西植物研究所广西喀斯特植物保育与恢复生态学重点实验室广西桂林541006

红树林具有较高的光合速率和较低的光补偿点,表现出较高的总初级生产力(gross primary production,GPP),是“蓝碳”的重要组成。准确估算区域红树林生态系统GPP,并量化其限制因素贡献对于我国实现“双碳”目标具有重要意义。该文以海南... 详细信息

红树林具有较高的光合速率和较低的光补偿点,表现出较高的总初级生产力(gross primary production,GPP),是“蓝碳”的重要组成。准确估算区域红树林生态系统GPP,并量化其限制因素贡献对于我国实现“双碳”目标具有重要意义。该文以海南岛红树林生态系统为研究对象,利用哨兵-2(Sentinel-2)影像和环境因子数据,基于红树植被光合作用-光能利用效率(MVP-LUE)模型估算了2016—2020年期间海南岛红树林生态系统GPP,并探究其时空分布格局及形成机制。结果表明:(1)在研究期间,海南岛红树林生态系统年GPP呈现出增长趋势,在空间上呈现出东部高于西部、北部高于南部的分布格局。(2)在形成机制上,海南岛红树林生态系统月均GPP时空分布格局受到多气象因素的综合影响,年内季节性上GPP在“旱→雨”过渡期随着空气温度(air temperature,T air)的限制降低和光合有效辐射(photosynthetically active radiation,PAR)与海水温度的促进作用,展现出较高的GPP;旱季中期T air低,对GPP限制严重,但随着纬度的降低,红树林生态系统GPP受T air限制的程度被减弱;雨季则因较高的云覆盖而使PAR成为GPP的限制因素。该研究结果为评估区域红树林对全球碳循环的贡献提供了基础数据,为揭示影响红树林生态系统碳动态的关键环境因素提供了理论支撑。

关键词： MVP-LUE模型哨兵-2影像时空分布格局限制因子红树林生态系统海南岛

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A viral movement protein targets host catalases for 26S proteasome-mediated degradation to facilitate viral infection and aphid transmission in wheat

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Molecular Plant 2024年第4期17卷 614-630页

作者： Shuyuan Tian Qingting Song wenmei Zhou Jingke wang Yanbin wang Wei An Yunfeng Wu Lei Zhao State Key Laboratory for Crop Stress Resistance and High-Efficiency Production College of Plant ProtectionNorthwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau Ministry of Agriculture and Rural AffairsCollege of Plant ProtectionNorthwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Plant Protection Resources and Pest Management Ministry of EducationCollege of Plant ProtectionNorthwest A&F UniversityYanglingShaanxi 712100China

The infection of host plants by many different viruses causes reactive oxygen species(Ros)accumulation and yellowing symptoms,but the mechanisms through which plant viruses counteract RoS-mediated immunity to facilitate infection and symptom development have not been fully *** plant viruses are transmitted by insect vectors in the field,but the molecular mechanisms underlying virus-host-insect interactions are *** this study,we investigated the interactions among wheat,barley yellow dwarf virus(BYDV),and its aphid vector and found that the BYDV movement protein(MP)interacts with both wheat catalases(CATs)and the 26S proteasomeubiquitin receptor non-ATPase regulatorysubunit2homolog(PSMD2)to facilitate the 26S proteasome-mediateddegradation of CATs,promotingviral infection,disease symptom development,and aphid *** of the BYDV MP gene in wheat enhanced the degradation of CATs,which leading to increased accumulation of ROS and thereby enhanced viral ***,transgenic wheat lines overexpressing BYDV MP showed significantly reduced proliferation of wingless aphids and an increased number of winged *** with this observation,silencing of CAT genes also enhanced viral accumulation and reduced the proliferation of wingless aphids but increased the occurrence of winged *** contrast,transgenic wheat plants overexpressing TaCAT1 exhibited the opposite changes and showed increases in grain size and weight upon infection with *** assays demonstrated that BYDV MP interacts with PSMD2 and promotes 26S proteasome-mediated degradation of TaCAT1 likely in a ubiquitination-independent ***,our study reveals a molecular mechanism by which a plant virus manipulates the Ros production system of host plants to facilitate viral infection and transmission,shedding new light on the sophisticated interactions among viruses,host plants,and insect vectors.

关键词： babarley yellow dwarf virus movement protein reactive oxygen species aphid catalase 26S proteasomeubiquitin receptor PSMD2

A novel Ag/ZnO core-shell structure for efficient sterilization synergizing antibiotics and subsequently removing residuals

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Green Energy & Environment 2024年第2期9卷 366-377页

作者： wenmei Han Wenli wang Jie Fan Runping Jia Xuchun Yang Tong Wu Qingsheng Wu School of Chemical Science and Engineering Shanghai Key Laboratory of Chemical Assessment and SustainabilityInstitute of Advanced StudyTongji UniversityShanghai200092China College of Textile and Clothing Engineering China National Textile and Apparel Council Key Laboratory of Natural DyesSoochow UniversitySuzhou215123China Department of Urology Shanghai First People’s HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai200080China School of Materials Science and Engineering Shanghai Institute of TechnologyShanghai201418China

The massive use of antibiotics has led to the aggravation of bacterial resistance and also brought environmental pollution *** poses a great threat to human *** the dosage of antibiotics is reduced by increasing its bactericidal performance,the emergence of drug resistance is certainly delayed,so that there's not enough time for developing drug resistance during ***,we selected typical representative materials of metal Ag and semiconductor ZnO nano-bactericides to design and synthesize Ag/ZnO hollow core-shell structures(AZ for short).Antibiotics are grafted on the surface of AZ through rational modification to form a composite sterilization *** research results show that the antibacterial efficiency of the composite system is significantly increased,from the sum(34.7%+22.8%-57.5%)of the antibacterial efficiency of AZ and gentamicin to 80.2%,net synergizes 22.7%,which fully reflects the effect of 1+1>***,the dosage of antibiotics can be drastically reduced in this way,which makes both the possibility of bacterial resistance and medical expenses remarkably ***,residual antibiotics can be degraded under simple illumination using AZ-self as a photocatalyst,which cuts off the path of environmental *** short,such an innovative route has guiding significance for drug resistance.

关键词： Ag/ZnO hollow Core-shell structures Antibiotics Gentamycin Synergistic sterilization Photodegradation

Single-cell mass spectrometry studies of drug metabolism heterogeneity and primary resistance to gefitinib in non-small cell lung cancer cells

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Chinese Chemical Letters 2024年第2期35卷 436-440页

作者： Guizhen Zhu Yaoyao Zhao wenmei Zhang Yuanyuan Wu Yuanxing Liu Guangsheng Guo Xiayan wang Zhihong Liu Center of Excellence for Environmental Safety and Biological Effects Beijing Key Laboratory for Green Catalysis and SeparationDepartment of ChemistryBeijing University of TechnologyBeijing 100124China Minzu University of China Beijing 100081China Key Laboratory for the Synthesis and Application of Organic Functional Molecules College of Health Science and EngineeringHubei UniversityWuhan 430062China

Patients with epidermal growth factor receptor(EGFR)wild-type non-small cell lung cancer(NSCLC)often show primary resistance to gefitinib *** is thus necessary to study the metabolism of gefitinib in NSCLC cells to comprehensively reveal the reasons for the primary resistance of ***,we develop a platform for studying drug metabolism heterogeneity based on single-cell mass spectrometry(sDMH-scMS)by integrating living-cell electrolaunching ionization MS(ILCEI-MS)and high-performance liquid chromatography-MS(HPLC-MS)analysis,and the primary resistance of NSCLC cells to gefitinib was studied using this *** ILCEI-MS analysis showed that approximately 11.9%of NSCLC single cells contained the gefitinib metabolite M11;HPLC-MS detection diluted the intensity of M11 in subpopulations and concealed the heterogeneity of drug metabolism in tumor single *** intensity of gefitinib in EGFR wild-type A549 cells was markedly lower than in mutant PC9 cells,and the intensity of gefitinib metabolites was significantly higher than in PC9 cells,suggesting that the primary resistance of NSCLC cells is related to gefitinib ***,the combination of gefitinib and the drug-metabolizing enzyme inhibitorα-naphthoflavone was shown to overcome the primary resistance of the NSCLC ***,the results of this study are expected to be applicable for clinical drug resistance diagnosis and treatment at the single-cell level.

关键词： Single-cell mass spectrometry Drug metabolism Non-small cell lung cancer Gefitinib Primary resistance

Difficult and complicated oral ulceration:an expert consensus guideline for diagnosis

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International Journal of Oral Science 2022年第2期14卷 140-144页

作者： Xin Zeng Xin Jin Liang Zhong Gang Zhou Ming Zhong wenmei wang Yuan Fan Qing Liu Xiangmin Qi Xiaobing Guan Zhimin Yan Xuemin Shen Yingfang Wu Lijie Fan Zhi wang Yuan He Hongxia Dan Jiantang Yang Hui wang Dongjuan Liu Hui Feng Kai Jiao Qianming Chen State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management West China Hospital of StomatologySichuan UniversityChengduChina College of Stomatology Chongqing Medical UniversityChongqingChina Department of Oral Medicine School and Hospital of StomatologyWuhan UniversityWuhanChina Department of Stomatology Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Oral Medicine Nanjing Stomatological HospitalMedical School of Nanjing UniversityNanjingChina Department of Oral Medicine The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjingChina The Third Affiliated Hospital of Air Force Medical University Xi’anChina School and Hospital of Stomatology Cheeloo College of MedicineShandong UniversityJinanChina Beijing Stomatological Hospital Capital Medical UniversityBeijingChina Department of Oral Medicine Peking University School and Hospital of StomatologyBeijingChina Department of Oral Mucosal Diseases Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina Centre of Stomatology Xiangya HospitalCental South UniversityChangshaChina Stomatology Hospital Zhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesCancer Center of Zhejiang UniversityHangzhouChina Guanghua School of Stomatology Guangdong Provincial Key Laboratory of StomatologyStomatological HospitalSun Yat-Sen UniversityGuangzhouChina Shanghai Engineering Research Center of Tooth Restoration and Regeneration Department of Oral MedicineSchool of StomatologyTongji UniversityShanghaiChina Department of Oral Medicine Hospital of StomatologyZunyi Medical UniversityZunyiChina Department of Oral Medicine School of StomatologyCapital Medical UniversityBeijingChina Department of Emergency and Oral Medicine School and Hospital of Stomatology

The complexity of oral ulcerations poses considerable diagnostic and therapeutic challenges to oral *** expert consensus was conducted to summarize the diagnostic work-up for difficult and complicated oral ulcers,based on factors such as detailed clinical medical history inquiry,histopathological examination,and ulceration-related systemic diseases *** only it can provide a standardized procedure of oral ulceration,but also it can improve the diagnostic efficiency,in order to avoid misdiagnosis and missed diagnosis.

关键词： ulceration diagnosis diseases

Coal Ash Slag Penetration Behavior on Cr_2O_3-Al_2O_3-ZrO_2 Bricks

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China's Refractories 2010年第4期19卷 5-11页

作者： TANG Lihua GAO Ling wang Qiong CHEN Dongxia ZHOU Yarning wang wenmei WU Yongqiang ZHU Zibin Engineering Research Center of Large Scale Reactor Engineering and Technology East China University of Science and Technology Shanghai 200237 China Shanghai Coking ＆ Chemical Corporation Shanghai 200241 China

The penetration behavior of different kinds of coal ash slags into chrome corundum bricks was studied by cup test. As a preliminary attempt,the oxides of Fe2O3 and MgO were added into coal ash to reduce the erosion of refractories. Different cup tests were carried out to study coal slag erosion to the refractories. FactSage was used to simulate the phase diagram of the main chemical compositions in coal ash and in the refractories. Both results agreed with each other. The results show that the elements in coal slag can penetrate into bricks and the penetration deepens with the duration increasing; it is difficult for Fe but easier for Ca and Si to penetrate into bricks; different kinds of melting coal ashes penetrate into refractories differently and the penetration depth of silicon and calcium can be significantly reduced by adding oxides into coal ash.

关键词： Coal ash slag Chrome oxide- aluminazirconia brick Penetrate FactSage

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乳酸菌体外和体内降解胆固醇的机理及其应用

动物营养学报 2014年第2期26卷 295-303页

作者：王文梅许丽东北农业大学动物科技学院哈尔滨150030

乳酸菌作为动物肠道的正常菌群,在维持动物肠道的微生态平衡和调节动物代谢方面发挥重要作用。本文总结了乳酸菌体外和体内对胆固醇的降解机制,并结合影响胆固醇降解效率的因素,阐述了其在动物生产中的应用效果及可能出现的问题,为其进... 详细信息

乳酸菌作为动物肠道的正常菌群,在维持动物肠道的微生态平衡和调节动物代谢方面发挥重要作用。本文总结了乳酸菌体外和体内对胆固醇的降解机制,并结合影响胆固醇降解效率的因素,阐述了其在动物生产中的应用效果及可能出现的问题,为其进一步研究及应用提供理论指导。

关键词：降解胆固醇体内体外机理应用

BEHAVIOUR OF α-NITROSO-β-NAPHTHOL IN HEMATITE FLOTATION

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Acta Metallurgica Sinica(English Letters) 1993年第11期6卷 4-4页

作者： wang wenmei YU Yongfu CHEN Quanyuan Baotou Research Institute of Rare Earth Ministry of Metallurgy Industry Baotou China Changsha Institute of Mining and Metallurgy Ministry of Metallurgy Industry ChangshaChina

Based on theoretical calculation of electronegativity of groups of flotation reagent and method of infrared adsorption spectroscopy,the collection and adsorption of α-nitroso-β- naphthol in hematite flotation have been *** chemical adsorption seems to be predominant owing to formation of pentacyclic nitrosyl chelate compound by atoms of nitrosyl bond in α-nitroso-β-naphthol together with Fe(Ⅲ)on hematite ***- while,the nonuniform multilayer physical adsorption is also occurred.

关键词： α-nitroso-β-naphthol hematite electronegativity chelate property flotation